Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Flow cytometry [2]
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- Product number
- FAB197A-025 - Provider product page
- Provider
- R&D Systems
- Product name
- Human CCR7 APC-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human CCR7.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Antigen sequence
AAA58615
- Isotype
- IgG
- Antibody clone number
- 150503
- Vial size
- 25 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Engineering of Nanobodies Recognizing the Human Chemokine Receptor CCR7.
Phosphatidylcholine and phosphatidylethanolamine plasmalogens in lipid loaded human macrophages.
Prospective evaluation of sequential treatment of sclerotic chronic graft versus host disease with rituximab and nilotinib.
Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis.
A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking.
A high migratory capacity of donor T-cells in response to the lymph node homing receptor CCR7 increases the incidence and severity of GvHD.
Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans.
Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells.
Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques.
Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover.
IFNγ/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children.
Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.
Shaping of iNKT cell repertoire after unrelated cord blood transplantation.
Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients.
Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells.
IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.
Jakobs BD, Spannagel L, Purvanov V, Uetz-von Allmen E, Matti C, Legler DF
International journal of molecular sciences 2019 May 27;20(10)
International journal of molecular sciences 2019 May 27;20(10)
Phosphatidylcholine and phosphatidylethanolamine plasmalogens in lipid loaded human macrophages.
Wallner S, Orsó E, Grandl M, Konovalova T, Liebisch G, Schmitz G
PloS one 2018;13(10):e0205706
PloS one 2018;13(10):e0205706
Prospective evaluation of sequential treatment of sclerotic chronic graft versus host disease with rituximab and nilotinib.
van der Wagen L, Te Boome L, Schiffler M, Nijhof I, Schoordijk M, van Dorp S, van Dijk M, Raymakers R, Petersen E, de Witte M, de Jong N, Bellido M, Bär B, Meijer E, Kuball J
Bone marrow transplantation 2018 Oct;53(10):1255-1262
Bone marrow transplantation 2018 Oct;53(10):1255-1262
Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis.
Armas-González E, Domínguez-Luis MJ, Díaz-Martín A, Arce-Franco M, Castro-Hernández J, Danelon G, Hernández-Hernández V, Bustabad-Reyes S, Cantabrana A, Uguccioni M, Díaz-González F
Arthritis research & therapy 2018 Jun 7;20(1):114
Arthritis research & therapy 2018 Jun 7;20(1):114
A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking.
Uetz-von Allmen E, Rippl AV, Farhan H, Legler DF
Journal of leukocyte biology 2018 Aug;104(2):375-389
Journal of leukocyte biology 2018 Aug;104(2):375-389
A high migratory capacity of donor T-cells in response to the lymph node homing receptor CCR7 increases the incidence and severity of GvHD.
Portero-Sainz I, Gómez-García de Soria V, Cuesta-Mateos C, Fernández-Arandojo C, Vega-Piris L, Royg M, Colom-Fernández B, Marcos-Jiménez A, Somovilla-Crespo B, Ramírez-Mengíbar A, López-Huete V, de Rosendo-Serrano A, Kreutzman A, Muñoz-Calleja C
Bone marrow transplantation 2017 May;52(5):745-752
Bone marrow transplantation 2017 May;52(5):745-752
Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans.
Darboe A, Danso E, Clarke E, Umesi A, Touray E, Wegmuller R, Moore SE, Riley EM, Goodier MR
European journal of immunology 2017 Jun;47(6):1040-1050
European journal of immunology 2017 Jun;47(6):1040-1050
Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells.
Bergamaschi C, Kulkarni V, Rosati M, Alicea C, Jalah R, Chen S, Bear J, Sardesai NY, Valentin A, Felber BK, Pavlakis GN
Gene therapy 2015 Jan;22(1):76-86
Gene therapy 2015 Jan;22(1):76-86
Codelivery of Envelope Protein in Alum with MVA Vaccine Induces CXCR3-Biased CXCR5+ and CXCR5- CD4 T Cell Responses in Rhesus Macaques.
Iyer SS, Gangadhara S, Victor B, Gomez R, Basu R, Hong JJ, Labranche C, Montefiori DC, Villinger F, Moss B, Amara RR
Journal of immunology (Baltimore, Md. : 1950) 2015 Aug 1;195(3):994-1005
Journal of immunology (Baltimore, Md. : 1950) 2015 Aug 1;195(3):994-1005
Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover.
Westera L, van Hoeven V, Drylewicz J, Spierenburg G, van Velzen JF, de Boer RJ, Tesselaar K, Borghans JA
Aging cell 2015 Apr;14(2):219-27
Aging cell 2015 Apr;14(2):219-27
IFNγ/IL-10 co-producing cells dominate the CD4 response to malaria in highly exposed children.
Jagannathan P, Eccles-James I, Bowen K, Nankya F, Auma A, Wamala S, Ebusu C, Muhindo MK, Arinaitwe E, Briggs J, Greenhouse B, Tappero JW, Kamya MR, Dorsey G, Feeney ME
PLoS pathogens 2014 Jan;10(1):e1003864
PLoS pathogens 2014 Jan;10(1):e1003864
Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.
Dintwe OB, Day CL, Smit E, Nemes E, Gray C, Tameris M, McShane H, Mahomed H, Hanekom WA, Scriba TJ
European journal of immunology 2013 Sep;43(9):2409-20
European journal of immunology 2013 Sep;43(9):2409-20
Shaping of iNKT cell repertoire after unrelated cord blood transplantation.
Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debré P, Rio B, Vieillard V, French Minicord Study Group.
Clinical immunology (Orlando, Fla.) 2010 Jun;135(3):364-73
Clinical immunology (Orlando, Fla.) 2010 Jun;135(3):364-73
Trapping and apoptosis of novel subsets of memory T lymphocytes expressing CCR6 in the spleen of HIV-infected patients.
Lécureuil C, Combadière B, Mazoyer E, Bonduelle O, Samri A, Autran B, Debré P, Combadière C
Blood 2007 May 1;109(9):3649-57
Blood 2007 May 1;109(9):3649-57
Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells.
Bayry J, Triebel F, Kaveri SV, Tough DF
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 1;178(7):4184-93
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr 1;178(7):4184-93
IL-7Ralpha expression on CD4+ T lymphocytes decreases with HIV disease progression and inversely correlates with immune activation.
Koesters SA, Alimonti JB, Wachihi C, Matu L, Anzala O, Kimani J, Embree JE, Plummer FA, Fowke KR
European journal of immunology 2006 Feb;36(2):336-44
European journal of immunology 2006 Feb;36(2):336-44
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CCR7 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD4 PE-conjugated Monoclonal Antibody (Catalog # FAB3791P) and either (A) Mouse Anti-Human CCR7 APC-conjugated Monoclonal Antibody (Catalog # FAB197A) or (B) Mouse IgG2A Allophycocyanin Isotype Control (Catalog # IC003A). View our protocol for Staining Membrane-associated Proteins.
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of CCR7 in HEK293 Human Cell Line Transfected with Human CCR7 and eGFP by Flow Cytometry. The specificity of Mouse Anti-Human CCR7 Clone 150503 was demonstrated by its ability to react with (A) HEK293 human embryonic kidney cell line transfected with human CCR7 and not react with (B) irrelevant HEK293 transfectants. Antibody binding was monitored using Phycoerythrin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0102B).