353219

CCR7 antibody from BioLegend
BLR2, CD197, CDw197, CMKBR7, EBI1

Antibody data

Product number
353219
Provider
BioLegend
Proper citation
BioLegend Cat#353219, RRID:AB_10915275
Product name
PerCP/Cy5.5 anti-human CD197 (CCR7)
Provider product page
BioLegend - 353219
Antibody type
Monoclonal
Antigen
CCR7-transfected cells
Description
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity through their effects on interactions between T cells and dendritic cells. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B lymphocytes recirculate between B-cell-rich compartments (follicles or B zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.
Reactivity
Human
Host
Mouse
Conjugate
Far-Red dye
Isotype
IgG
Vial size
25 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Provider Type Product Number
- No reagents -