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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [1]
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- Validations
- Flow cytometry [1]
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- Product number
- 353219 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#353219, RRID:AB_10915275
- Product name
- PerCP/Cy5.5 anti-human CD197 (CCR7)
- Antibody type
- Monoclonal
- Antigen
- CCR7-transfected cells
- Description
- CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity through their effects on interactions between T cells and dendritic cells. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B lymphocytes recirculate between B-cell-rich compartments (follicles or B zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Far-Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Modulation of the central memory and Tr1-like regulatory T cells in multiple sclerosis patients responsive to interferon-beta therapy.
Chiarini M, Serana F, Zanotti C, Capra R, Rasia S, Rottoli M, Rovaris M, Caputo D, Cavaletti G, Frigo M, Frigeni B, Clerici R, Rezzonico M, Caimi L, Imberti L
Multiple sclerosis (Houndmills, Basingstoke, England) 2012 Jun;18(6):788-98
Multiple sclerosis (Houndmills, Basingstoke, England) 2012 Jun;18(6):788-98
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood leucocytes were stained with PerCP/Cy5.5 CD197 (clone G043H7) (top) or PerCP/Cy5.5 mouse IgG2a, κ isotype control (bottom).
