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- Antibody Data
- Antigen structure
- References [235]
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- Western blot [1]
- Immunocytochemistry [1]
- Immunoprecipitation [1]
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- Product number
- 10268-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10268-1-AP, RRID:AB_2151423
- Product name
- IkB Alpha antibody
- Antibody type
- Polyclonal
- Description
- IkB Alpha antibody (Cat. #10268-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, pig, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice.
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway.
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways.
Gut Microbiota Disorders Promote Inflammation and Aggravate Spinal Cord Injury Through the TLR4/MyD88 Signaling Pathway.
Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model.
Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.
Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy.
Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts.
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-κB Activation in Neutrophils.
The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis Via Modulating Multiple Signaling Pathways in Mice.
MicroLet-7b Regulates Neutrophil Function and Dampens Neutrophilic Inflammation by Suppressing the Canonical TLR4/NF-κB Pathway.
Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress.
Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.
Orf Virus ORF120 Protein Positively Regulates the NF-κB Pathway by Interacting with G3BP1.
Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study.
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
IKKβ-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice.
TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
miR-19a-3p downregulates tissue factor and functions as a potential therapeutic target for sepsis-induced disseminated intravascular coagulation.
Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p.
Cigarette smoking induces aberrant N6-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway.
A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation.
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Allicin Ameliorates Intestinal Barrier Damage via Microbiota-Regulated Short-Chain Fatty Acids-TLR4/MyD88/NF-κB Cascade Response in Acrylamide-Induced Rats.
Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β.
Protective effect of the effective part of Andrographis paniculata (Burm.f.) Nees on PM2.5-induced lung injury in rats by modulating the NF-κB pathway.
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.
Protective effects of curcumin against rat intestinal inflammation‑related motility disorders.
Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF-κB, c-Fos and NFATc1 transcription factors.
Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
Triptolide reduces salivary gland damage in a non-obese diabetic mice model of Sjögren's syndrome via JAK/STAT and NF-κB signaling pathways.
Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages.
A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase.
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Alpinetin protects against hepatic ischemia/reperfusion injury in mice by inhibiting the NF-κB/MAPK signaling pathways.
The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.
Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Rosiglitazone alleviates lipopolysaccharide-induced inflammation in RAW264.7 cells via inhibition of NF-κB and in a PPARγ-dependent manner.
Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling.
Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways.
MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice.
Inhibitory activity of narirutin on RBL-2H3 cells degranulation.
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver.
Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.
ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Bergenin alleviates H2 O2 -induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR-γ/NF-κB pathway.
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway.
Baicalin alleviates Mycoplasma gallisepticum-induced oxidative stress and inflammation via modulating NLRP3 inflammasome-autophagy pathway.
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
ATP-dependent activation of NLRP3 inflammasome in primary murine macrophages infected by pseudorabies virus.
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays.
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
The Critical Role of NLRP6 Inflammasome in Streptococcus pneumoniae Infection In Vitro and In Vivo.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Seco-type β-Apocarotenoid Generated by β-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages.
Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis.
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-κ
Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway.
Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-κB Signaling Pathway.
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Sevoflurane-Induced Neuroapoptosis in Rat Dentate Gyrus Is Activated by Autophagy Through NF-κB Signaling on the Late-Stage Progenitor Granule Cells.
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Changes in inflammatory factors in SV40MES13 mesangial cells after silencing ApoM gene.
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages.
Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway.
Targeting BCL10 by small peptides for the treatment of B cell lymphoma.
Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway.
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
CEACAM1 Inhibited IκB-α/NF-κB Signal Pathway Via Targeting MMP-9/TIMP-1 Axis in Diabetic Atherosclerosis.
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-κB pathway.
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice.
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis.
Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose.
Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes.
Porcine parvovirus nonstructural protein NS1 activates NF-κB and it involves TLR2 signaling pathway.
NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina.
Ketamine attenuates high-glucose-mediated endothelial inflammation in human umbilical vein endothelial cells.
Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation.
Pyrroloquinoline quinone attenuates isoproterenol hydrochloride‑induced cardiac hypertrophy in AC16 cells by inhibiting the NF‑κB signaling pathway.
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
5-HT1AR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice.
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Retinoic acid attenuates cardiac injury induced by hyperglycemia in pre- and post-delivery mice.
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
LncRNA NKILA integrates RXFP1/AKT and NF-κB signalling to regulate osteogenesis of mesenchymal stem cells.
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration.
Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma.
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis.
Silencing of lncRNA MIAT alleviates LPS-induced pneumonia via regulating miR-147a/NKAP/NF-κB axis.
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway.
Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model.
Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury.
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
ETA-mediated anti-TNF-α therapy ameliorates the phenotype of PCOS model induced by letrozole.
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury.
L-Cysteine-Derived H(2)S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice.
Monitoring the Early Antiproliferative Effect of the Analgesic-Antitumor Peptide, BmK AGAP on Breast Cancer Using Intravoxel Incoherent Motion With a Reduced Distribution of Four b-Values.
Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes.
Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.
Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways.
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.
Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages.
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop.
MiR-940 inhibits migration and invasion of tongue squamous cell carcinoma via regulatingCXCR2/NF-κB system-mediated epithelial-mesenchymal transition.
Comprehensive transcriptome analysis based on RNA sequencing identifies critical genes for lipopolysaccharide-induced epididymitis in a rat model.
Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing.
Dietary Stevioside Supplementation Alleviates Lipopolysaccharide-Induced Intestinal Mucosal Damage through Anti-Inflammatory and Antioxidant Effects in Broiler Chickens.
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
Cortistatin binds to TNF-α receptors and protects against osteoarthritis.
Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway.
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.
HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo.
Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome.
Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer.
Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells.
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Protective effect of metformin on a rat model of lipopolysaccharide-induced preeclampsia.
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Protective effect and mechanism of Lactobacillus on cerebral ischemia reperfusion injury in rats.
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways.
Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways.
Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro.
α7nAChR-mediated recruitment of PP1γ promotes TRAF6/NF-κB cascade to facilitate the progression of Hepatocellular Carcinoma.
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
ACT001 can prevent and reverse tamoxifen resistance in human breast cancer cell lines by inhibiting NF-κB activation.
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia.
Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis.
Gelofusine Attenuates Tubulointerstitial Injury Induced by cRGD-Conjugated siRNA by Regulating the TLR3 Signaling Pathway.
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response.
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
Correlation between the expression of IL‑18 and deep venous thrombosis.
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Lipoxin A4 may attenuate the progression of obesity-related glomerulopathy by inhibiting NF-κB and ERK/p38 MAPK-dependent inflammation.
TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System.
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Mechanism of Lycium barbarum polysaccharides on primary cultured rat hippocampal neurons.
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro.
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes.
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury.
Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction.
Knockdown of TREM-1 suppresses IL-1β-induced chondrocyte injury via inhibiting the NF-κB pathway.
Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner.
Glucocorticoid-Induced Leucine Zipper Suppresses ICAM-1 and MCP-1 Expression by Dephosphorylation of NF-κB p65 in Retinal Endothelial Cells.
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Calcitriol Ameliorates AngiotensinII-Induced Renal Injury Partly via Upregulating A20.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.
Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.
Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.
Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1G93A ALS Mice.
Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.
An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction.
Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells.
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65.
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
CD147 promotes IKK/IκB/NF-κB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Etomidate inhibits nuclear factor-κB through decreased expression of glucocorticoid receptor in septic rats.
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.
Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.
Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.
Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma.
Potent effects of dioscin against obesity in mice.
Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice.
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).
Potent effects of dioscin against liver fibrosis.
Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes.
Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation.
14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.
The hepatitis B virus X protein downregulates NF-κB signaling pathways through decreasing the Notch signaling pathway in HBx-transformed L02 cells.
MG132-mediated inhibition of the ubiquitin-proteasome pathway ameliorates cancer cachexia.
Li X, Chu L, Liu S, Zhang W, Lin L, Zheng G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153728
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153728
Irisin lowers blood pressure in Zucker diabetic rats by regulating the functions of renal angiotensin II type 1 receptor via the inhibition of the NF-κB signaling pathway.
Huang Y, Chen Q, Jiang Q, Zhao Z, Fang J, Chen L
Peptides 2022 Jan;147:170688
Peptides 2022 Jan;147:170688
Guizhi-Shaoyao-Zhimu decoction attenuates monosodium urate crystal-induced inflammation through inactivation of NF-κB and NLRP3 inflammasome.
Zhou GQ, Chen G, Yang J, Qin WY, Ping J
Journal of ethnopharmacology 2022 Jan 30;283:114707
Journal of ethnopharmacology 2022 Jan 30;283:114707
Anti-proliferation and anti-inflammation effects of corilagin in rheumatoid arthritis by downregulating NF-κB and MAPK signaling pathways.
Shen Y, Teng L, Qu Y, Liu J, Zhu X, Chen S, Yang L, Huang Y, Song Q, Fu Q
Journal of ethnopharmacology 2022 Feb 10;284:114791
Journal of ethnopharmacology 2022 Feb 10;284:114791
Gut Microbiota Disorders Promote Inflammation and Aggravate Spinal Cord Injury Through the TLR4/MyD88 Signaling Pathway.
Rong Z, Huang Y, Cai H, Chen M, Wang H, Liu G, Zhang Z, Wu J
Frontiers in nutrition 2021;8:702659
Frontiers in nutrition 2021;8:702659
Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model.
Gu L, Ren F, Fang X, Yuan L, Liu G, Wang S
Frontiers in medicine 2021;8:660614
Frontiers in medicine 2021;8:660614
Chemerin promotes microangiopathy in diabetic retinopathy via activation of ChemR23 in rat primary microvascular endothelial cells.
Jun L, Lin-Lin S, Hui S
Molecular vision 2021;27:575-587
Molecular vision 2021;27:575-587
Exploring the Oxidative Stress Mechanism of Buyang Huanwu Decoction in Intervention of Vascular Dementia Based on Systems Biology Strategy.
Yang K, Zeng L, Ge A, Yi Y, Wang S, Ge J
Oxidative medicine and cellular longevity 2021;2021:8879060
Oxidative medicine and cellular longevity 2021;2021:8879060
Punicalin Attenuates Breast Cancer-Associated Osteolysis by Inhibiting the NF-κB Signaling Pathway of Osteoclasts.
Li T, Jiang G, Hu X, Yang D, Tan T, Gao Z, Chen Z, Xiang C, Li S, Ouyang Z, Guo X
Frontiers in pharmacology 2021;12:789552
Frontiers in pharmacology 2021;12:789552
BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss.
Cai C, Hu W, Zhang Y, Hu X, Yang S, Qiu H, Wang R, Ma M, Qiu Y, Chu T
Frontiers in pharmacology 2021;12:772540
Frontiers in pharmacology 2021;12:772540
Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-κB Activation in Neutrophils.
Ren J, Yan D, Wang Y, Zhang J, Li M, Xiong W, Jing X, Li P, Zhao W, Xiong X, Wu M, Zhong G
Frontiers in immunology 2021;12:760999
Frontiers in immunology 2021;12:760999
The Combination of Schisandrol B and Wedelolactone Synergistically Reverses Hepatic Fibrosis Via Modulating Multiple Signaling Pathways in Mice.
Ai Y, Shi W, Zuo X, Sun X, Chen Y, Wang Z, Li R, Song X, Dai W, Mu W, Ding K, Li Z, Li Q, Xiao X, Zhan X, Bai Z
Frontiers in pharmacology 2021;12:655531
Frontiers in pharmacology 2021;12:655531
MicroLet-7b Regulates Neutrophil Function and Dampens Neutrophilic Inflammation by Suppressing the Canonical TLR4/NF-κB Pathway.
Chen B, Han J, Chen S, Xie R, Yang J, Zhou T, Zhang Q, Xia R
Frontiers in immunology 2021;12:653344
Frontiers in immunology 2021;12:653344
Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress.
Yuan Y, Wang Z, Nan B, Yang C, Wang M, Ye H, Xi C, Zhang Y, Yan H
Toxicology 2021 Sep;461:152905
Toxicology 2021 Sep;461:152905
Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats.
Ren Y, Jiang J, Jiang W, Zhou X, Lu W, Wang J, Luo Y
Neurochemical research 2021 Sep;46(9):2262-2275
Neurochemical research 2021 Sep;46(9):2262-2275
Orf Virus ORF120 Protein Positively Regulates the NF-κB Pathway by Interacting with G3BP1.
Zhou Y, Guan J, Gao F, Li Z, Lan Y, Lu H, Song D, Lv L, Lv P, Xu M, Wang Z, He H, Zhao K, He W
Journal of virology 2021 Sep 9;95(19):e0015321
Journal of virology 2021 Sep 9;95(19):e0015321
Chondroprotective and antiarthritic effects of galangin in osteoarthritis: An in vitro and in vivo study.
Huang X, Pei W, Ni B, Zhang R, You H
European journal of pharmacology 2021 Sep 5;906:174232
European journal of pharmacology 2021 Sep 5;906:174232
Conjugation with nanodiamonds via hydrazone bond fundamentally alters intracellular distribution and activity of doxorubicin.
Yuan SJ, Wang C, Xu HZ, Liu Y, Zheng MY, Li K, Sun SK, Komatsu N, Zhao L, Chen X
International journal of pharmaceutics 2021 Sep 5;606:120872
International journal of pharmaceutics 2021 Sep 5;606:120872
IKKβ-NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice.
Catheline SE, Bell RD, Oluoch LS, James MN, Escalera-Rivera K, Maynard RD, Chang ME, Dean C, Botto E, Ketz JP, Boyce BF, Zuscik MJ, Jonason JH
Science signaling 2021 Sep 21;14(701):eabf3535
Science signaling 2021 Sep 21;14(701):eabf3535
TRIM38 protects chondrocytes from IL-1β-induced apoptosis and degeneration via negatively modulating nuclear factor (NF)-κB signaling.
Hu S, Li Y, Wang B, Peng K
International immunopharmacology 2021 Oct;99:108048
International immunopharmacology 2021 Oct;99:108048
miR-19a-3p downregulates tissue factor and functions as a potential therapeutic target for sepsis-induced disseminated intravascular coagulation.
Zhang R, Lu S, Yang X, Li M, Jia H, Liao J, Jing Q, Wu Y, Wang H, Xiao F, Bai X, Na X, Kang Y, Wan L, Yang J
Biochemical pharmacology 2021 Oct;192:114671
Biochemical pharmacology 2021 Oct;192:114671
Myricetin ameliorates ox-LDL-induced HUVECs apoptosis and inflammation via lncRNA GAS5 upregulating the expression of miR-29a-3p.
Bai Y, Liu X, Chen Q, Chen T, Jiang N, Guo Z
Scientific reports 2021 Oct 4;11(1):19637
Scientific reports 2021 Oct 4;11(1):19637
Cigarette smoking induces aberrant N6-methyladenosine of DAPK2 to promote non-small cell lung cancer progression by activating NF-κB pathway.
Jin M, Li G, Liu W, Wu X, Zhu J, Zhao D, Zeng Z, Xiong M, Song Y, He X, Zhang Q, Hu K
Cancer letters 2021 Oct 10;518:214-229
Cancer letters 2021 Oct 10;518:214-229
A novel indazole derivative, compound Cyy-272, attenuates LPS-induced acute lung injury by inhibiting JNK phosphorylation.
Liu Q, Yan H, Zheng X, Fu L, Bao Y, Zheng H, Liu Z, Zhang X, Chen G
Toxicology and applied pharmacology 2021 Oct 1;428:115648
Toxicology and applied pharmacology 2021 Oct 1;428:115648
Resveratrol sustains intestinal barrier integrity, improves antioxidant capacity, and alleviates inflammation in the jejunum of ducks exposed to acute heat stress.
Yang C, Luo P, Chen SJ, Deng ZC, Fu XL, Xu DN, Tian YB, Huang YM, Liu WJ
Poultry science 2021 Nov;100(11):101459
Poultry science 2021 Nov;100(11):101459
Allicin Ameliorates Intestinal Barrier Damage via Microbiota-Regulated Short-Chain Fatty Acids-TLR4/MyD88/NF-κB Cascade Response in Acrylamide-Induced Rats.
Yuan Y, Lu L, Bo N, Chaoyue Y, Haiyang Y
Journal of agricultural and food chemistry 2021 Nov 3;69(43):12837-12852
Journal of agricultural and food chemistry 2021 Nov 3;69(43):12837-12852
Sesquiterpene Lactones from Sigesbeckia glabrescens Possessing Potent Anti-inflammatory Activity by Directly Binding to IKKα/β.
Gao X, Shen X, Zheng Y, Yang L, Zhang X, Hu G, Jia J, Wang A
Journal of natural products 2021 Nov 26;84(11):2808-2821
Journal of natural products 2021 Nov 26;84(11):2808-2821
Protective effect of the effective part of Andrographis paniculata (Burm.f.) Nees on PM2.5-induced lung injury in rats by modulating the NF-κB pathway.
Yao H, Zhao J, Zhu L, Xie Y, Zhao N, Yao R, Sun H, Han G
Journal of ethnopharmacology 2021 Nov 15;280:114420
Journal of ethnopharmacology 2021 Nov 15;280:114420
Astaxanthin attenuated hyperuricemia and kidney inflammation by inhibiting uric acid synthesis and the NF-κ B/NLRP3 signaling pathways in potassium oxonate and hypoxanthine-induced hyperuricemia mice.
Zhuang J, Zhou X, Liu T, Zhang S, Yuan F, Zhang L, Yang Z, Chen Y
Die Pharmazie 2021 Nov 1;76(11):551-558
Die Pharmazie 2021 Nov 1;76(11):551-558
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice.
Lei Y, Guerra Martinez C, Torres-Odio S, Bell SL, Birdwell CE, Bryant JD, Tong CW, Watson RO, West LC, West AP
Science advances 2021 May;7(22)
Science advances 2021 May;7(22)
Protective effects of curcumin against rat intestinal inflammation‑related motility disorders.
Yao Y, Luo R, Xiong S, Zhang C, Zhang Y
Molecular medicine reports 2021 May;23(5)
Molecular medicine reports 2021 May;23(5)
Role of vasodilator-stimulated phosphoprotein in RANKL-differentiated murine macrophage RAW264.7 cells: Modulation of NF-κB, c-Fos and NFATc1 transcription factors.
Hu H, Li C, Zhang H, Wu G, Huang Y
Experimental and therapeutic medicine 2021 May;21(5):412
Experimental and therapeutic medicine 2021 May;21(5):412
Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression.
Li KY, Xiang XJ, Song L, Chen J, Luo B, Wen QX, Zhong BR, Zhou GF, Deng XJ, Ma YL, Hu LT, Chen GJ
Journal of neurochemistry 2021 May;157(4):1351-1365
Journal of neurochemistry 2021 May;157(4):1351-1365
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)
Foods (Basel, Switzerland) 2021 May 26;10(6)
Downregulation of CD151 restricts VCAM-1 mediated leukocyte infiltration to reduce neurobiological injuries after experimental stroke.
Gao C, Jia W, Xu W, Wu Q, Wu J
Journal of neuroinflammation 2021 May 22;18(1):118
Journal of neuroinflammation 2021 May 22;18(1):118
Triptolide reduces salivary gland damage in a non-obese diabetic mice model of Sjögren's syndrome via JAK/STAT and NF-κB signaling pathways.
Guo Y, Ji W, Lu Y, Wang Y
Journal of clinical biochemistry and nutrition 2021 Mar;68(2):131-138
Journal of clinical biochemistry and nutrition 2021 Mar;68(2):131-138
Dehydroepiandrosterone attenuates LPS-induced inflammatory responses via activation of Nrf2 in RAW264.7 macrophages.
Cao J, Li Q, Shen X, Yao Y, Li L, Ma H
Molecular immunology 2021 Mar;131:97-111
Molecular immunology 2021 Mar;131:97-111
A 2-Benzylmalonate Derivative as STAT3 Inhibitor Suppresses Tumor Growth in Hepatocellular Carcinoma by Upregulating β-TrCP E3 Ubiquitin Ligase.
Peng T, Wonganan O, Zhang Z, Yu J, Xi R, Cao Y, Suksamrarn A, Zhang G, Wang F
International journal of molecular sciences 2021 Mar 25;22(7)
International journal of molecular sciences 2021 Mar 25;22(7)
Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis.
Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X, Zhang X
Food & function 2021 Mar 21;12(6):2703-2714
Food & function 2021 Mar 21;12(6):2703-2714
Alpinetin protects against hepatic ischemia/reperfusion injury in mice by inhibiting the NF-κB/MAPK signaling pathways.
Pan J, Chen S, Guo W, Cao S, Shi X, Zhang J, Zhang H, Zhang S
International immunopharmacology 2021 Jun;95:107527
International immunopharmacology 2021 Jun;95:107527
The N6-methyladenosine RNA-binding protein YTHDF1 modulates the translation of TRAF6 to mediate the intestinal immune response.
Zong X, Xiao X, Shen B, Jiang Q, Wang H, Lu Z, Wang F, Jin M, Min J, Wang F, Wang Y
Nucleic acids research 2021 Jun 4;49(10):5537-5552
Nucleic acids research 2021 Jun 4;49(10):5537-5552
Damage to intestinal barrier integrity in piglets caused by porcine reproductive and respiratory syndrome virus infection.
Zhao J, Wan S, Sun N, Sun P, Sun Y, Khan A, Guo J, Zheng X, Fan K, Yin W, Li H
Veterinary research 2021 Jun 23;52(1):93
Veterinary research 2021 Jun 23;52(1):93
Identification of a Novel TAR RNA-Binding Protein 2 Modulator with Potential Therapeutic Activity against Hepatocellular Carcinoma.
Zhou Z, Li Y, Ma X, Cao B, Peng T, Sheng Y, Peng H, Li R, Cao Y, Xi R, Li F, Wang M, Sun H, Zhang G, Zhang H, Hu K, Xiao W, Wang F
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Journal of medicinal chemistry 2021 Jun 10;64(11):7404-7421
Rosiglitazone alleviates lipopolysaccharide-induced inflammation in RAW264.7 cells via inhibition of NF-κB and in a PPARγ-dependent manner.
Zhou JP, Yang XN, Song Y, Zhou F, Liu JJ, Hu YQ, Chen LG
Experimental and therapeutic medicine 2021 Jul;22(1):743
Experimental and therapeutic medicine 2021 Jul;22(1):743
Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling.
Cao YY, Wang ZH, Xu QC, Chen Q, Wang Z, Lu WH
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Jul 1;25(4):375-383
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Jul 1;25(4):375-383
Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways.
Lin X, Li Y, Zhang X, Wei Y, Wen S, Lu Z, Huang Q, Wei J
Cell biochemistry and function 2021 Jan;39(1):77-87
Cell biochemistry and function 2021 Jan;39(1):77-87
MicroRNA-150 affects endoplasmic reticulum stress via MALAT1-miR-150 axis-mediated NF-κB pathway in LPS-challenged HUVECs and septic mice.
Liu L, Yan LN, Sui Z
Life sciences 2021 Jan 15;265:118744
Life sciences 2021 Jan 15;265:118744
Inhibitory activity of narirutin on RBL-2H3 cells degranulation.
Niu L, Wei J, Li X, Jin Y, Shi X
Immunopharmacology and immunotoxicology 2021 Feb;43(1):68-76
Immunopharmacology and immunotoxicology 2021 Feb;43(1):68-76
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis.
Yu Q, Cheng P, Wu J, Guo C
Journal of cellular and molecular medicine 2021 Feb;25(3):1645-1660
Journal of cellular and molecular medicine 2021 Feb;25(3):1645-1660
Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver.
Nan B, Yang C, Li L, Ye H, Yan H, Wang M, Yuan Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111937
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2021 Feb;148:111937
Hypothermic oxygenated perfusion inhibits HECTD3-mediated TRAF3 polyubiquitination to alleviate DCD liver ischemia-reperfusion injury.
Zhou W, Zhong Z, Lin D, Liu Z, Zhang Q, Xia H, Peng S, Liu A, Lu Z, Wang Y, Ye S, Ye Q
Cell death & disease 2021 Feb 24;12(2):211
Cell death & disease 2021 Feb 24;12(2):211
ITPR3 facilitates tumor growth, metastasis and stemness by inducing the NF-ĸB/CD44 pathway in urinary bladder carcinoma.
Zhang M, Wang L, Yue Y, Zhang L, Liu T, Jing M, Liang X, Ma M, Xu S, Wang K, Wang X, Fan J
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65
Journal of experimental & clinical cancer research : CR 2021 Feb 11;40(1):65
Red ginseng has stronger anti-aging effects compared to ginseng possibly due to its regulation of oxidative stress and the gut microbiota.
Peng X, Hao M, Zhao Y, Cai Y, Chen X, Chen H, Zhang Y, Dong L, Liu X, Ding C, Liu W, Yang M, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Dec;93:153772
Bergenin alleviates H2 O2 -induced oxidative stress and apoptosis in nucleus pulposus cells: Involvement of the PPAR-γ/NF-κB pathway.
Zhang G, Wang H, Zhang Q, Zhao Z, Zhu W, Zuo X
Environmental toxicology 2021 Dec;36(12):2541-2550
Environmental toxicology 2021 Dec;36(12):2541-2550
Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity.
Song Z, Gao C, Jiang Q, Xu J, Xiong L, Liu K, Sun D, Li H, Chen L
Phytochemistry 2021 Dec;192:112971
Phytochemistry 2021 Dec;192:112971
Bixin protects mice against bronchial asthma though modulating PI3K/Akt pathway.
Zhu Y, Sun D, Liu H, Sun L, Jie J, Luo J, Peng L, Song L
International immunopharmacology 2021 Dec;101(Pt B):108266
International immunopharmacology 2021 Dec;101(Pt B):108266
Baicalin alleviates Mycoplasma gallisepticum-induced oxidative stress and inflammation via modulating NLRP3 inflammasome-autophagy pathway.
Ishfaq M, Wu Z, Wang J, Li R, Chen C, Li J
International immunopharmacology 2021 Dec;101(Pt B):108250
International immunopharmacology 2021 Dec;101(Pt B):108250
Sub-chronic exposure to realgar induces liver injury via upregulating the TXNIP/NLRP3 pathway and disturbing bile acid homeostasis in mice.
Li A, Wu X, Yang J, Li J, Guo H, Zhang Y, Jiang H, Huo T
Journal of ethnopharmacology 2021 Dec 5;281:114584
Journal of ethnopharmacology 2021 Dec 5;281:114584
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Luo Y, Chen H, Huang R, Wu Q, Li Y, He Y
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
ATP-dependent activation of NLRP3 inflammasome in primary murine macrophages infected by pseudorabies virus.
Ye C, Huang Q, Jiang J, Li G, Xu D, Zeng Z, Peng L, Peng Y, Fang R
Veterinary microbiology 2021 Aug;259:109130
Veterinary microbiology 2021 Aug;259:109130
Procyanidin B2 alleviates liver injury caused by cold stimulation through Sonic hedgehog signalling and autophagy.
Ma L, Li C, Lian S, Xu B, Lv H, Liu Y, Lu J, Ji H, Li S, Guo J, Yang H
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Journal of cellular and molecular medicine 2021 Aug;25(16):8015-8027
Glycyrrhizic Acid Alleviates Lipopolysaccharide (LPS)-Induced Acute Lung Injury by Regulating Angiotensin-Converting Enzyme-2 (ACE2) and Caveolin-1 Signaling Pathway.
Chen Y, Qu L, Li Y, Chen C, He W, Shen L, Zhang R
Inflammation 2021 Aug 24;
Inflammation 2021 Aug 24;
Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays.
Zhang Y, Xu L, Zhang Y, Pan J, Wang PQ, Tian S, Li HT, Gao BW, Hou TJ, Zhen XC, Zheng LT
Acta pharmacologica Sinica 2021 Aug 24;
Acta pharmacologica Sinica 2021 Aug 24;
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade.
Yang Z, Xu G, Wang B, Liu Y, Zhang L, Jing T, Tang M, Xu X, Jiao K, Xiang L, Fu Y, Tang D, Zhang X, Jin W, Zhuang G, Zhao X, Liu Y
Nature communications 2021 Aug 11;12(1):4852
Nature communications 2021 Aug 11;12(1):4852
African Swine Fever Virus MGF360-12L Inhibits Type I Interferon Production by Blocking the Interaction of Importin α and NF-κB Signaling Pathway.
Zhuo Y, Guo Z, Ba T, Zhang C, He L, Zeng C, Dai H
Virologica Sinica 2021 Apr;36(2):176-186
Virologica Sinica 2021 Apr;36(2):176-186
The Critical Role of NLRP6 Inflammasome in Streptococcus pneumoniae Infection In Vitro and In Vivo.
Xu D, Wu X, Peng L, Chen T, Huang Q, Wang Y, Ye C, Peng Y, Hu D, Fang R
International journal of molecular sciences 2021 Apr 8;22(8)
International journal of molecular sciences 2021 Apr 8;22(8)
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
Ginsenoside Rh4 alleviates antibiotic-induced intestinal inflammation by regulating the TLR4-MyD88-MAPK pathway and gut microbiota composition.
Bai X, Fu R, Duan Z, Liu Y, Zhu C, Fan D
Food & function 2021 Apr 7;12(7):2874-2885
Food & function 2021 Apr 7;12(7):2874-2885
Seco-type β-Apocarotenoid Generated by β-Carotene Oxidation Exerts Anti-inflammatory Effects against Activated Macrophages.
Takatani N, Beppu F, Yamano Y, Maoka T, Hosokawa M
Journal of oleo science 2021 Apr 2;70(4):549-558
Journal of oleo science 2021 Apr 2;70(4):549-558
Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis.
Lv JJ, Wang H, Cui HY, Liu ZK, Zhang RY, Lu M, Li C, Yong YL, Liu M, Zhang H, Zhang TJ, Zhang K, Li G, Nan G, Zhang C, Guo SP, Wang L, Chen ZN, Bian H
Frontiers in cell and developmental biology 2020;8:609090
Frontiers in cell and developmental biology 2020;8:609090
Koumine Alleviates Lipopolysaccharide-Induced Intestinal Barrier Dysfunction in IPEC-J2 Cells by Regulating Nrf2/NF-
Wu J, Yang CL, Sha YK, Wu Y, Liu ZY, Yuan ZH, Sun ZL
The American journal of Chinese medicine 2020;48(1):127-142
The American journal of Chinese medicine 2020;48(1):127-142
Aloe Emodin Reduces Cardiac Inflammation Induced by a High-Fat Diet through the TLR4 Signaling Pathway.
Chen Y, Feng B, Yuan Y, Hu J, Zhao W, Jiang H, Li W, Fan Z, Du Z
Mediators of inflammation 2020;2020:6318520
Mediators of inflammation 2020;2020:6318520
Negative Regulation of Tec Kinase Alleviates LPS-Induced Acute Kidney Injury in Mice via theTLR4/NF-κB Signaling Pathway.
Zhang W, Zhou P, Jiang X, Fan Z, Xu X, Wang F
BioMed research international 2020;2020:3152043
BioMed research international 2020;2020:3152043
Anti-Inflammatory and Antioxidant Effect of Eucommia ulmoides Polysaccharide in Hepatic Ischemia-Reperfusion Injury by Regulating ROS and the TLR-4-NF-κB Pathway.
Gao W, Feng Z, Zhang S, Wu B, Geng X, Fan G, Duan Y, Li K, Liu K, Peng C
BioMed research international 2020;2020:1860637
BioMed research international 2020;2020:1860637
Sevoflurane-Induced Neuroapoptosis in Rat Dentate Gyrus Is Activated by Autophagy Through NF-κB Signaling on the Late-Stage Progenitor Granule Cells.
Tong D, Ma Z, Su P, Wang S, Xu Y, Zhang LM, Wu Z, Liu K, Zhao P
Frontiers in cellular neuroscience 2020;14:590577
Frontiers in cellular neuroscience 2020;14:590577
Emodin Protects Against Acute Pancreatitis-Associated Lung Injury by Inhibiting NLPR3 Inflammasome Activation via Nrf2/HO-1 Signaling.
Gao Z, Sui J, Fan R, Qu W, Dong X, Sun D
Drug design, development and therapy 2020;14:1971-1982
Drug design, development and therapy 2020;14:1971-1982
Changes in inflammatory factors in SV40MES13 mesangial cells after silencing ApoM gene.
Liu J, Zhang Y, Zhang X, Zhang S, Hu Y, Wang L, Gao J, Zhang Y
International journal of clinical and experimental pathology 2020;13(6):1451-1456
International journal of clinical and experimental pathology 2020;13(6):1451-1456
Aucubin Attenuates Liver Ischemia-Reperfusion Injury by Inhibiting the HMGB1/TLR-4/NF-κB Signaling Pathway, Oxidative Stress, and Apoptosis.
Zhang S, Feng Z, Gao W, Duan Y, Fan G, Geng X, Wu B, Li K, Liu K, Peng C
Frontiers in pharmacology 2020;11:544124
Frontiers in pharmacology 2020;11:544124
Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling.
Zhang K, Hussain T, Wang J, Li M, Wang W, Ma X, Liao Y, Yao J, Song Y, Liang Z, Zhou X, Xu L
Frontiers in microbiology 2020;11:433
Frontiers in microbiology 2020;11:433
Selenomethionine Suppressed TLR4/NF-κB Pathway by Activating Selenoprotein S to Alleviate ESBL Escherichia coli-Induced Inflammation in Bovine Mammary Epithelial Cells and Macrophages.
Zhuang C, Liu G, Barkema HW, Zhou M, Xu S, Ur Rahman S, Liu Y, Kastelic JP, Gao J, Han B
Frontiers in microbiology 2020;11:1461
Frontiers in microbiology 2020;11:1461
Eriodictyol Inhibits Proliferation, Metastasis and Induces Apoptosis of Glioma Cells via PI3K/Akt/NF-κB Signaling Pathway.
Li W, Du Q, Li X, Zheng X, Lv F, Xi X, Huang G, Yang J, Liu S
Frontiers in pharmacology 2020;11:114
Frontiers in pharmacology 2020;11:114
Targeting BCL10 by small peptides for the treatment of B cell lymphoma.
Bao W, Sun C, Sun X, He M, Yu H, Yan W, Wen F, Zhang L, Yang C
Theranostics 2020;10(25):11622-11636
Theranostics 2020;10(25):11622-11636
Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway.
Liu L, Xu Y, Dai H, Tan S, Mao X, Chen Z
Cell & bioscience 2020;10:42
Cell & bioscience 2020;10:42
Geraniol-mediated osteoarthritis improvement by down-regulating PI3K/Akt/NF-κB and MAPK signals: In vivo and in vitro studies.
Wu Y, Wang Z, Fu X, Lin Z, Yu K
International immunopharmacology 2020 Sep;86:106713
International immunopharmacology 2020 Sep;86:106713
CEACAM1 Inhibited IκB-α/NF-κB Signal Pathway Via Targeting MMP-9/TIMP-1 Axis in Diabetic Atherosclerosis.
Yu J, Sun G, Chen Y, Li L, Wang H, Tu D, Li L, Meng Z, Wang Y
Journal of cardiovascular pharmacology 2020 Sep;76(3):329-336
Journal of cardiovascular pharmacology 2020 Sep;76(3):329-336
Cinnamaldehyde protects against rat intestinal ischemia/reperfusion injuries by synergistic inhibition of NF-κB and p53.
Almoiliqy M, Wen J, Xu B, Sun YC, Lian MQ, Li YL, Qaed E, Al-Azab M, Chen DP, Shopit A, Wang L, Sun PY, Lin Y
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Acta pharmacologica Sinica 2020 Sep;41(9):1208-1222
Emodin protects against intestinal and lung injury induced by acute intestinal injury by modulating SP-A and TLR4/NF-κB pathway.
Qian J, Li G, Jin X, Ma C, Cai W, Jiang N, Zheng J
Bioscience reports 2020 Sep 30;40(9)
Bioscience reports 2020 Sep 30;40(9)
(-)-Hydroxycitric Acid Alleviates Oleic Acid-Induced Steatosis, Oxidative Stress, and Inflammation in Primary Chicken Hepatocytes by Regulating AMP-Activated Protein Kinase-Mediated Reactive Oxygen Species Levels.
Li L, Chu X, Yao Y, Cao J, Li Q, Ma H
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
Journal of agricultural and food chemistry 2020 Oct 7;68(40):11229-11241
Anti-inflammatory and analgesic activities of indigo through regulating the IKKβ/IκB/NF-κB pathway in mice.
Liu N, Zhang GX, Niu YT, Wang Q, Zheng J, Yang JM, Sun T, Niu JG, Yu JQ
Food & function 2020 Oct 1;11(10):8537-8546
Food & function 2020 Oct 1;11(10):8537-8546
Didymin ameliorates dexamethasone-induced non-alcoholic fatty liver disease by inhibiting TLR4/NF-κB and PI3K/Akt pathways in C57BL/6J mice.
Feng Z, Pang L, Chen S, Pang X, Huang Y, Qiao Q, Wang Y, Vonglorkham S, Huang Q, Lin X, Wei J
International immunopharmacology 2020 Nov;88:107003
International immunopharmacology 2020 Nov;88:107003
Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis.
Geng M, Xu K, Meng L, Xu J, Jiang C, Guo Y, Ren X, Li X, Peng Y, Wang S, Huang F, Zhang J, Wang X, Zhu W, Lu S
Clinical immunology (Orlando, Fla.) 2020 Nov;220:108579
Clinical immunology (Orlando, Fla.) 2020 Nov;220:108579
Active Peptide KF-8 from Rice Bran Attenuates Oxidative Stress in a Mouse Model of Aging Induced by d-Galactose.
Wang Y, Cui X, Lin Q, Cai J, Tang L, Liang Y
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12271-12283
Journal of agricultural and food chemistry 2020 Nov 4;68(44):12271-12283
Activation of NF-κB-Inducing Kinase in Islet β Cells Causes β Cell Failure and Diabetes.
Li X, Wu Y, Song Y, Ding N, Lu M, Jia L, Zhao Y, Liu M, Chen Z
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Nov 4;28(11):2430-2441
Molecular therapy : the journal of the American Society of Gene Therapy 2020 Nov 4;28(11):2430-2441
Porcine parvovirus nonstructural protein NS1 activates NF-κB and it involves TLR2 signaling pathway.
Jin X, Yuan Y, Zhang C, Zhou Y, Song Y, Wei Z, Zhang G
Journal of veterinary science 2020 May;21(3):e50
Journal of veterinary science 2020 May;21(3):e50
NF-κB signaling regulates the formation of proliferating Müller glia-derived progenitor cells in the avian retina.
Palazzo I, Deistler K, Hoang TV, Blackshaw S, Fischer AJ
Development (Cambridge, England) 2020 May 22;147(10)
Development (Cambridge, England) 2020 May 22;147(10)
Ketamine attenuates high-glucose-mediated endothelial inflammation in human umbilical vein endothelial cells.
Wang T, Zhu H, Hou Y, Duan W, Meng F, Liu Y
Canadian journal of physiology and pharmacology 2020 Mar;98(3):156-161
Canadian journal of physiology and pharmacology 2020 Mar;98(3):156-161
Saikosaponin-d attenuated lipopolysaccharide-induced depressive-like behaviors via inhibiting microglia activation and neuroinflammation.
Su J, Pan YW, Wang SQ, Li XZ, Huang F, Ma SP
International immunopharmacology 2020 Mar;80:106181
International immunopharmacology 2020 Mar;80:106181
Pyrroloquinoline quinone attenuates isoproterenol hydrochloride‑induced cardiac hypertrophy in AC16 cells by inhibiting the NF‑κB signaling pathway.
Wen J, Shen J, Zhou Y, Zhao X, Dai Z, Jin Y
International journal of molecular medicine 2020 Mar;45(3):873-885
International journal of molecular medicine 2020 Mar;45(3):873-885
NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology.
He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, Gong Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H
Cellular & molecular immunology 2020 Mar;17(3):283-299
Cellular & molecular immunology 2020 Mar;17(3):283-299
5-HT1AR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice.
Wang M, Zong HF, Chang KW, Han H, Yasir Rizvi M, Iffat Neha S, Li ZY, Yang WN, Qian YH
International immunopharmacology 2020 Mar 3;82:106354
International immunopharmacology 2020 Mar 3;82:106354
The protective effect of hesperetin in osteoarthritis: an in vitro and in vivo study.
Lin Z, Fu C, Yan Z, Wu Y, Zhan J, Lou Z, Liao X, Pan J
Food & function 2020 Mar 26;11(3):2654-2666
Food & function 2020 Mar 26;11(3):2654-2666
Retinoic acid attenuates cardiac injury induced by hyperglycemia in pre- and post-delivery mice.
Liu Y, Zhao J, Lu M, Wang H, Tang F
Canadian journal of physiology and pharmacology 2020 Jan;98(1):6-14
Canadian journal of physiology and pharmacology 2020 Jan;98(1):6-14
The m6A methyltransferase METTL3 cooperates with demethylase ALKBH5 to regulate osteogenic differentiation through NF-κB signaling.
Yu J, Shen L, Liu Y, Ming H, Zhu X, Chu M, Lin J
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
Molecular and cellular biochemistry 2020 Jan;463(1-2):203-210
MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway.
Yang QY, Yang KP, Li ZZ
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
The Kaohsiung journal of medical sciences 2020 Jan;36(1):20-26
Inhibition of DNM1L and mitochondrial fission attenuates inflammatory response in fibroblast-like synoviocytes of rheumatoid arthritis.
Wang X, Chen Z, Fan X, Li W, Qu J, Dong C, Wang Z, Ji Z, Li Y
Journal of cellular and molecular medicine 2020 Jan;24(2):1516-1528
Journal of cellular and molecular medicine 2020 Jan;24(2):1516-1528
LncRNA NKILA integrates RXFP1/AKT and NF-κB signalling to regulate osteogenesis of mesenchymal stem cells.
Zhang Y, Cao X, Li P, Fan Y, Zhang L, Ma X, Sun R, Liu Y, Li W
Journal of cellular and molecular medicine 2020 Jan;24(1):521-529
Journal of cellular and molecular medicine 2020 Jan;24(1):521-529
Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function.
Wang L, Yu P, Zhou B, Song J, Li Z, Zhang M, Guo G, Wang Y, Chen X, Han L, Hu S
Nature cell biology 2020 Jan;22(1):108-119
Nature cell biology 2020 Jan;22(1):108-119
Resveratrol induces depletion of TRAF6 and suppresses prostate cancer cell proliferation and migration.
Khusbu FY, Zhou X, Roy M, Chen FZ, Cao Q, Chen HC
The international journal of biochemistry & cell biology 2020 Jan;118:105644
The international journal of biochemistry & cell biology 2020 Jan;118:105644
Ginsenoside Rk1 induces apoptosis and downregulates the expression of PD-L1 by targeting the NF-κB pathway in lung adenocarcinoma.
Hu M, Yang J, Qu L, Deng X, Duan Z, Fu R, Liang L, Fan D
Food & function 2020 Jan 29;11(1):456-471
Food & function 2020 Jan 29;11(1):456-471
The potential of Diosgenin in treating psoriasis: Studies from HaCaT keratinocytes and imiquimod-induced murine model.
Wu S, Zhao M, Sun Y, Xie M, Le K, Xu M, Huang C
Life sciences 2020 Jan 15;241:117115
Life sciences 2020 Jan 15;241:117115
Neuroinflammation induced by secretion of acetylated HMGB1 from activated microglia in hippocampi of mice following chronic cold exposure.
Xu B, Lang LM, Lian S, Guo JR, Wang JF, Liu J, Yang HM, Li SZ
Brain research 2020 Jan 1;1726:146495
Brain research 2020 Jan 1;1726:146495
Polyphyllin VII induces apoptotic cell death via inhibition of the PI3K/Akt and NF‑κB pathways in A549 human lung cancer cells.
He H, Xu C, Zheng L, Wang K, Jin M, Sun Y, Yue Z
Molecular medicine reports 2020 Feb;21(2):597-606
Molecular medicine reports 2020 Feb;21(2):597-606
Hepatoprotective effects of Camellia nitidissima aqueous ethanol extract against CCl4-induced acute liver injury in SD rats related to Nrf2 and NF-κB signalling.
Zhang X, Feng J, Su S, Huang L
Pharmaceutical biology 2020 Dec;58(1):239-246
Pharmaceutical biology 2020 Dec;58(1):239-246
Latcripin-7A, derivative of Lentinula edodes C91-3, reduces migration and induces apoptosis, autophagy, and cell cycle arrest at G1 phase in breast cancer cells.
Din SRU, Zhong M, Nisar MA, Saleem MZ, Hussain A, Khinsar KH, Alam S, Ayub G, Kanwal S, Li X, Zhang W, Wang X, Ning A, Cao J, Huang M
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Applied microbiology and biotechnology 2020 Dec;104(23):10165-10179
Hepatitis B virus core protein promotes the expression of neuraminidase 1 to facilitate hepatocarcinogenesis.
Kong F, Li N, Tu T, Tao Y, Bi Y, Yuan D, Zhang N, Yang X, Kong D, You H, Zheng K, Tang R
Laboratory investigation; a journal of technical methods and pathology 2020 Dec;100(12):1602-1617
Laboratory investigation; a journal of technical methods and pathology 2020 Dec;100(12):1602-1617
Silencing of lncRNA MIAT alleviates LPS-induced pneumonia via regulating miR-147a/NKAP/NF-κB axis.
Liu M, Li W, Song F, Zhang L, Sun X
Aging 2020 Dec 9;13(2):2506-2518
Aging 2020 Dec 9;13(2):2506-2518
Akebia Saponin D suppresses inflammation in chondrocytes via the NRF2/HO-1/NF-κB axis and ameliorates osteoarthritis in mice.
Gu M, Jin J, Ren C, Chen X, Gao W, Wang X, Wu Y, Tian N, Pan Z, Wu A, Zhou Y, Zhang X
Food & function 2020 Dec 1;11(12):10852-10863
Food & function 2020 Dec 1;11(12):10852-10863
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Huang X, You Y, Xi Y, Ni B, Chu X, Zhang R, You H
Inflammation 2020 Apr;43(2):619-628
Inflammation 2020 Apr;43(2):619-628
HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway.
Huang M, Guo M, Wang K, Wu K, Li Y, Tian T, Wang Y, Yan W, Zhou Z, Yang H
Neurotoxicity research 2020 Apr;37(4):913-925
Neurotoxicity research 2020 Apr;37(4):913-925
Icariside II attenuates eosinophils-induced airway inflammation and remodeling via inactivation of NF-κB and STAT3 in an asthma mouse model.
Tian C, Gao F, Li X, Li Z
Experimental and molecular pathology 2020 Apr;113:104373
Experimental and molecular pathology 2020 Apr;113:104373
Liquiritin, a novel inhibitor of TRPV1 and TRPA1, protects against LPS-induced acute lung injury.
Liu Z, Wang P, Lu S, Guo R, Gao W, Tong H, Yin Y, Han X, Liu T, Chen X, Zhu MX, Yang Z
Cell calcium 2020 Apr 28;88:102198
Cell calcium 2020 Apr 28;88:102198
4β-Hydroxywithanolide E from Goldenberry (Whole Fruits of Physalis peruviana L.) as a Promising Agent against Chronic Obstructive Pulmonary Disease.
Yang WJ, Chen XM, Wang SQ, Hu HX, Cheng XP, Xu LT, Ren DM, Wang XN, Zhao BB, Lou HX, Shen T
Journal of natural products 2020 Apr 24;83(4):1217-1228
Journal of natural products 2020 Apr 24;83(4):1217-1228
Chlorogenic acid effectively treats cancers through induction of cancer cell differentiation.
Huang S, Wang LL, Xue NN, Li C, Guo HH, Ren TK, Zhan Y, Li WB, Zhang J, Chen XG, Han YX, Zhang JL, Jiang JD
Theranostics 2019;9(23):6745-6763
Theranostics 2019;9(23):6745-6763
Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-κB and CaSR.
Leng B, Zhang Y, Liu X, Zhang Z, Liu Y, Wang H, Lu M
Mediators of inflammation 2019;2019:1082497
Mediators of inflammation 2019;2019:1082497
ETA-mediated anti-TNF-α therapy ameliorates the phenotype of PCOS model induced by letrozole.
Lang Q, Yidong X, Xueguang Z, Sixian W, Wenming X, Tao Z
PloS one 2019;14(6):e0217495
PloS one 2019;14(6):e0217495
Exosomes Derived From Bone Marrow Mesenchymal Stem Cells Inhibit Complement Activation In Rats With Spinal Cord Injury.
Zhao C, Zhou X, Qiu J, Xin D, Li T, Chu X, Yuan H, Wang H, Wang Z, Wang D
Drug design, development and therapy 2019;13:3693-3704
Drug design, development and therapy 2019;13:3693-3704
L-Cysteine-Derived H(2)S Promotes Microglia M2 Polarization via Activation of the AMPK Pathway in Hypoxia-Ischemic Neonatal Mice.
Zhou X, Chu X, Xin D, Li T, Bai X, Qiu J, Yuan H, Liu D, Wang D, Wang Z
Frontiers in molecular neuroscience 2019;12:58
Frontiers in molecular neuroscience 2019;12:58
Monitoring the Early Antiproliferative Effect of the Analgesic-Antitumor Peptide, BmK AGAP on Breast Cancer Using Intravoxel Incoherent Motion With a Reduced Distribution of Four b-Values.
Doudou NR, Kampo S, Liu Y, Ahmmed B, Zeng D, Zheng M, Mohamadou A, Wen QP, Wang S
Frontiers in physiology 2019;10:708
Frontiers in physiology 2019;10:708
Schisandrin A Inhibits the IL-1β-Induced Inflammation and Cartilage Degradation via Suppression of MAPK and NF-κB Signal Pathways in Rat Chondrocytes.
Tu C, Huang X, Xiao Y, Song M, Ma Y, Yan J, You H, Wu H
Frontiers in pharmacology 2019;10:41
Frontiers in pharmacology 2019;10:41
Trichostatin A, a Histone Deacetylase Inhibitor, Alleviates Eosinophilic Meningitis Induced by Angiostrongylus cantonensis Infection in Mice.
Zhang Y, Xie H, Tang W, Zeng X, Lin Y, Xu L, Xiao L, Xu J, Wu Z, Yuan D
Frontiers in microbiology 2019;10:2280
Frontiers in microbiology 2019;10:2280
Vanillic acid attenuates cartilage degeneration by regulating the MAPK and PI3K/AKT/NF-κB pathways.
Huang X, Xi Y, Mao Z, Chu X, Zhang R, Ma X, Ni B, Cheng H, You H
European journal of pharmacology 2019 Sep 15;859:172481
European journal of pharmacology 2019 Sep 15;859:172481
Chrysophanol attenuates airway inflammation and remodeling through nuclear factor-kappa B signaling pathway in asthma.
Song G, Zhang Y, Yu S, Lv W, Guan Z, Sun M, Wang J
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
Phytotherapy research : PTR 2019 Oct;33(10):2702-2713
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer.
Yang J, Zeng Z, Qiao L, Jiang X, Ma J, Wang J, Ye S, Ma Q, Wei J, Wu M, Huang X, Ma D, Gao Q
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028
Induction of PGRN by influenza virus inhibits the antiviral immune responses through downregulation of type I interferons signaling.
Wei F, Jiang Z, Sun H, Pu J, Sun Y, Wang M, Tong Q, Bi Y, Ma X, Gao GF, Liu J
PLoS pathogens 2019 Oct;15(10):e1008062
PLoS pathogens 2019 Oct;15(10):e1008062
Dehydroepiandrosterone alleviates E. Coli O157:H7-induced inflammation by preventing the activation of p38 MAPK and NF-κB pathways in mice peritoneal macrophages.
Zhao J, Cao J, Yu L, Ma H
Molecular immunology 2019 Oct;114:114-122
Molecular immunology 2019 Oct;114:114-122
Anti-Inflammatory and Anti-Apoptotic Effects of Stybenpropol A on Human Umbilical Vein Endothelial Cells.
Zhang L, Wang F, Zhang Q, Liang Q, Wang S, Xian M, Wang F
International journal of molecular sciences 2019 Oct 29;20(21)
International journal of molecular sciences 2019 Oct 29;20(21)
Decreased RIPK1 expression in chondrocytes alleviates osteoarthritis via the TRIF/MyD88-RIPK1-TRAF2 negative feedback loop.
Liang S, Wang ZG, Zhang ZZ, Chen K, Lv ZT, Wang YT, Cheng P, Sun K, Yang Q, Chen AM
Aging 2019 Oct 11;11(19):8664-8680
Aging 2019 Oct 11;11(19):8664-8680
MiR-940 inhibits migration and invasion of tongue squamous cell carcinoma via regulatingCXCR2/NF-κB system-mediated epithelial-mesenchymal transition.
Ma T, Zhao Z, Wang Z, Wang C, Zhang L
Naunyn-Schmiedeberg's archives of pharmacology 2019 Nov;392(11):1359-1369
Naunyn-Schmiedeberg's archives of pharmacology 2019 Nov;392(11):1359-1369
Comprehensive transcriptome analysis based on RNA sequencing identifies critical genes for lipopolysaccharide-induced epididymitis in a rat model.
Song X, Lin NH, Wang YL, Chen B, Wang HX, Hu K
Asian journal of andrology 2019 Nov-Dec;21(6):605-611
Asian journal of andrology 2019 Nov-Dec;21(6):605-611
Repression of eEF2K transcription by NF-κB tunes translation elongation to inflammation and dsDNA-sensing.
Bianco C, Thompson L, Mohr I
Proceedings of the National Academy of Sciences of the United States of America 2019 Nov 5;116(45):22583-22590
Proceedings of the National Academy of Sciences of the United States of America 2019 Nov 5;116(45):22583-22590
Dietary Stevioside Supplementation Alleviates Lipopolysaccharide-Induced Intestinal Mucosal Damage through Anti-Inflammatory and Antioxidant Effects in Broiler Chickens.
Jiang J, Qi L, Lv Z, Jin S, Wei X, Shi F
Antioxidants (Basel, Switzerland) 2019 Nov 21;8(12)
Antioxidants (Basel, Switzerland) 2019 Nov 21;8(12)
Ameliorative effects of echinacoside against spinal cord injury via inhibiting NLRP3 inflammasome signaling pathway.
Gao S, Xu T, Guo H, Deng Q, Xun C, Liang W, Sheng W
Life sciences 2019 Nov 15;237:116978
Life sciences 2019 Nov 15;237:116978
Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs.
Jia YN, Peng YL, Zhao YP, Cheng XF, Zhou Y, Chai CL, Zeng LS, Pan MH, Xu L
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Journal of agricultural and food chemistry 2019 May 15;67(19):5521-5529
Hepatoprotective effects and structure-activity relationship of five flavonoids against lipopolysaccharide/d-galactosamine induced acute liver failure in mice.
He Y, Xia Z, Yu D, Wang J, Jin L, Huang D, Ye X, Li X, Zhang B
International immunopharmacology 2019 Mar;68:171-178
International immunopharmacology 2019 Mar;68:171-178
Cortistatin binds to TNF-α receptors and protects against osteoarthritis.
Zhao Y, Li Y, Qu R, Chen X, Wang W, Qiu C, Liu B, Pan X, Liu L, Vasilev K, Hayball J, Dong S, Li W
EBioMedicine 2019 Mar;41:556-570
EBioMedicine 2019 Mar;41:556-570
Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-κB/c-Myc pathway.
Jiao L, Wang S, Zheng Y, Wang N, Yang B, Wang D, Yang D, Mei W, Zhao Z, Wang Z
Biochemical pharmacology 2019 Mar;161:149-162
Biochemical pharmacology 2019 Mar;161:149-162
Curcumin upregulates the Nrf2 system by repressing inflammatory signaling-mediated Keap1 expression in insulin-resistant conditions.
Ren L, Zhan P, Wang Q, Wang C, Liu Y, Yu Z, Zhang S
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Biochemical and biophysical research communications 2019 Jun 30;514(3):691-698
Leonurine alleviates LPS-induced myocarditis through suppressing the NF-кB signaling pathway.
Wang R, Li D, Ouyang J, Tian X, Zhao Y, Peng X, Li S, Yu G, Yang J
Toxicology 2019 Jun 15;422:1-13
Toxicology 2019 Jun 15;422:1-13
HBOA ameliorates CCl4-incuded liver fibrosis through inhibiting TGF-β1/Smads, NF-κB and ERK signaling pathways.
Sun X, Huang X, Zhu X, Liu L, Mo S, Wang H, Wei X, Lu S, Bai F, Wang D, Lin X, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108901
Polysaccharides from Nostoc commune Vaucher activate macrophages via NF-κB and AKT/JNK1/2 pathways to suppress colorectal cancer growth in vivo.
Guo M, Li Z, Huang Y, Shi M
Food & function 2019 Jul 17;10(7):4269-4279
Food & function 2019 Jul 17;10(7):4269-4279
Matrine inhibits IL-1β secretion in primary porcine alveolar macrophages through the MyD88/NF-κB pathway and NLRP3 inflammasome.
Sun P, Sun N, Yin W, Sun Y, Fan K, Guo J, Khan A, He Y, Li H
Veterinary research 2019 Jul 12;50(1):53
Veterinary research 2019 Jul 12;50(1):53
Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer.
Hwang WL, Lan HY, Cheng WC, Huang SC, Yang MH
Journal of hematology & oncology 2019 Jan 25;12(1):10
Journal of hematology & oncology 2019 Jan 25;12(1):10
Effects of Betaine on LPS-Stimulated Activation of Microglial M1/M2 Phenotypes by Suppressing TLR4/NF-κB Pathways in N9 Cells.
Shi H, Wang XL, Quan HF, Yan L, Pei XY, Wang R, Peng XD
Molecules (Basel, Switzerland) 2019 Jan 21;24(2)
Molecules (Basel, Switzerland) 2019 Jan 21;24(2)
HMGB1-mediated differential response on hippocampal neurotransmitter disorder and neuroinflammation in adolescent male and female mice following cold exposure.
Xu B, Zang SC, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Brain, behavior, and immunity 2019 Feb;76:223-235
Brain, behavior, and immunity 2019 Feb;76:223-235
Protective effect of metformin on a rat model of lipopolysaccharide-induced preeclampsia.
Hu J, Zhang J, Zhu B
Fundamental & clinical pharmacology 2019 Dec;33(6):649-658
Fundamental & clinical pharmacology 2019 Dec;33(6):649-658
Rice Protein Exerts Anti-Inflammatory Effect in Growing and Adult Rats via Suppressing NF-κB Pathway.
Wang Z, Liang M, Li H, Cai L, Yang L
International journal of molecular sciences 2019 Dec 6;20(24)
International journal of molecular sciences 2019 Dec 6;20(24)
Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis.
Huang X, Ni B, Xi Y, Chu X, Zhang R, You H
Aging 2019 Dec 16;11(24):12532-12545
Aging 2019 Dec 16;11(24):12532-12545
Dietary resveratrol supplementation inhibits heat stress-induced high-activated innate immunity and inflammatory response in spleen of yellow-feather broilers.
He S, Yu Q, He Y, Hu R, Xia S, He J
Poultry science 2019 Dec 1;98(12):6378-6387
Poultry science 2019 Dec 1;98(12):6378-6387
Bilirubin alleviates alum-induced peritonitis through inactivation of NLRP3 inflammasome.
Lin Y, Wang S, Yang Z, Gao L, Zhou Z, Yu P, Wu B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Aug;116:108973
Knockdown of cathepsin D protects dopaminergic neurons against neuroinflammation-mediated neurotoxicity through inhibition of NF-κB signalling pathway in Parkinson's disease model.
Gan P, Xia Q, Hang G, Zhou Y, Qian X, Wang X, Ding L
Clinical and experimental pharmacology & physiology 2019 Apr;46(4):337-349
Clinical and experimental pharmacology & physiology 2019 Apr;46(4):337-349
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis.
Gou Y, Li X, Li P, Zhang H, Xu T, Wang H, Wang B, Ma X, Jiang X, Zhang Z
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
Human reproduction (Oxford, England) 2019 Apr 1;34(4):646-658
Protective Effects of Costunolide Against D-Galactosamine and Lipopolysaccharide-Induced Acute Liver Injury in Mice.
Mao J, Yi M, Wang R, Huang Y, Chen M
Frontiers in pharmacology 2018;9:1469
Frontiers in pharmacology 2018;9:1469
Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.
Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378
Frontiers in pharmacology 2018;9:1378
Protective effect and mechanism of Lactobacillus on cerebral ischemia reperfusion injury in rats.
Wanchao S, Chen M, Zhiguo S, Futang X, Mengmeng S
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2018;51(7):e7172
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2018;51(7):e7172
Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H2O2-Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice.
Shen D, Tian L, Shen T, Sun H, Liu P
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;47(6):2261-2277
Salidroside ameliorates autophagy and activation of hepatic stellate cells in mice via NF-κB and TGF-β1/Smad3 pathways.
Feng J, Chen K, Xia Y, Wu L, Li J, Li S, Wang W, Lu X, Liu T, Guo C
Drug design, development and therapy 2018;12:1837-1853
Drug design, development and therapy 2018;12:1837-1853
Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-κB signaling pathways.
Jouda JB, Mfotie Njoya E, Mbazoa CD, Zhou Z, Meli Lannang A, Wandji J, Shiono Y, Wang F
Bioorganic chemistry 2018 Oct;80:216-222
Bioorganic chemistry 2018 Oct;80:216-222
Salvianolic Acid B-Alleviated Angiotensin II Induces Cardiac Fibrosis by Suppressing NF-κB Pathway In Vitro.
Wang C, Luo H, Xu Y, Tao L, Chang C, Shen X
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 26;24:7654-7664
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 26;24:7654-7664
α7nAChR-mediated recruitment of PP1γ promotes TRAF6/NF-κB cascade to facilitate the progression of Hepatocellular Carcinoma.
Wan C, Wu M, Zhang S, Chen Y, Lu C
Molecular carcinogenesis 2018 Nov;57(11):1626-1639
Molecular carcinogenesis 2018 Nov;57(11):1626-1639
Interleukin-18 binding protein attenuates lipopolysaccharide-induced acute lung injury in mice via suppression NF-κB and activation Nrf2 pathway.
Zhang LM, Zhang J, Zhang Y, Wang L, Fei C, Yi ZW, Dong L
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
Biochemical and biophysical research communications 2018 Nov 2;505(3):837-842
ACT001 can prevent and reverse tamoxifen resistance in human breast cancer cell lines by inhibiting NF-κB activation.
Jin XH, Jia YS, Shi YH, Li QY, Bao SQ, Lu WP, Tong ZS
Journal of cellular biochemistry 2018 Nov 18;
Journal of cellular biochemistry 2018 Nov 18;
TLR4 signaling pathway mediates the LPS/ischemia-induced expression of monocytechemotactic protein-induced protein 1 in microglia.
Chen S, Lyu C, Zhou J, Huang S, Zhang Y, Liu G, Liu K, Chen D, Hu Y, Zhou L, Gu Y
Neuroscience letters 2018 Nov 1;686:33-40
Neuroscience letters 2018 Nov 1;686:33-40
Downregulation of HS6ST2 by miR-23b-3p enhances matrix degradation through p38 MAPK pathway in osteoarthritis.
Guo Y, Min Z, Jiang C, Wang W, Yan J, Xu P, Xu K, Xu J, Sun M, Zhao Y, Hussain S, Zhang R, Wang Q, Han Y, Zhang F, Zhu W, Li D, Meng L, Sun J, Lu S
Cell death & disease 2018 Jun 13;9(6):699
Cell death & disease 2018 Jun 13;9(6):699
Gelofusine Attenuates Tubulointerstitial Injury Induced by cRGD-Conjugated siRNA by Regulating the TLR3 Signaling Pathway.
Cen B, Liao W, Wang Z, Gao L, Wei Y, Huang W, He S, Wang W, Liu X, Pan X, Ji A
Molecular therapy. Nucleic acids 2018 Jun 1;11:300-311
Molecular therapy. Nucleic acids 2018 Jun 1;11:300-311
Asperuloside and Asperulosidic Acid Exert an Anti-Inflammatory Effect via Suppression of the NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Lu X, Wei T, Dong Y, Cai Z, Tang L, Liu M
International journal of molecular sciences 2018 Jul 12;19(7)
International journal of molecular sciences 2018 Jul 12;19(7)
Dietary restriction delays the secretion of senescence associated secretory phenotype by reducing DNA damage response in the process of renal aging.
Wang W, Cai G, Chen X
Experimental gerontology 2018 Jul 1;107:4-10
Experimental gerontology 2018 Jul 1;107:4-10
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Ji Y, Cao L, Zeng L, Zhang Z, Xiao Q, Guan P, Chen S, Chen Y, Wang M, Guo D
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Journal of cellular biochemistry 2018 Feb;119(2):1979-1991
Scandoside Exerts Anti-Inflammatory Effect Via Suppressing NF-κB and MAPK Signaling Pathways in LPS-Induced RAW 264.7 Macrophages.
He J, Li J, Liu H, Yang Z, Zhou F, Wei T, Dong Y, Xue H, Tang L, Liu M
International journal of molecular sciences 2018 Feb 3;19(2)
International journal of molecular sciences 2018 Feb 3;19(2)
N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response.
Jiao YF, Lu M, Zhao YP, Liu N, Niu YT, Niu Y, Zhou R, Yu JQ
Molecules (Basel, Switzerland) 2018 Feb 25;23(3)
Molecules (Basel, Switzerland) 2018 Feb 25;23(3)
Protective effects of dioscin against systemic inflammatory response syndromevia adjusting TLR2/MyD88/NF‑κb signal pathway.
Zhao X, Yin L, Fang L, Xu L, Sun P, Xu M, Liu K, Peng J
International immunopharmacology 2018 Dec;65:458-469
International immunopharmacology 2018 Dec;65:458-469
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice.
Fan L, Xiao Q, Zhang L, Wang X, Huang Q, Li S, Zhao X, Li Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Dec;108:1640-1650
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β.
Rubio RM, Depledge DP, Bianco C, Thompson L, Mohr I
Genes & development 2018 Dec 1;32(23-24):1472-1484
Genes & development 2018 Dec 1;32(23-24):1472-1484
Correlation between the expression of IL‑18 and deep venous thrombosis.
Li G, Zhou R, Zhao X, Liu R, Ye C
International journal of molecular medicine 2018 Aug;42(2):883
International journal of molecular medicine 2018 Aug;42(2):883
MEL-pep, an analog of melittin, disrupts cell membranes and reverses 5-fluorouracil resistance in human hepatocellular carcinoma cells.
Ke M, Dong J, Wang Y, Zhang J, Zhang M, Wu Z, Lv Y, Wu R
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
The international journal of biochemistry & cell biology 2018 Aug;101:39-48
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong H, Bai Y, Qin Y, Li J, Feng S, Zhao P
Molecular medicine reports 2018 Apr;17(4):5484-5491
Molecular medicine reports 2018 Apr;17(4):5484-5491
Lipoxin A4 may attenuate the progression of obesity-related glomerulopathy by inhibiting NF-κB and ERK/p38 MAPK-dependent inflammation.
Guo YP, Jiang HK, Jiang H, Tian HY, Li L
Life sciences 2018 Apr 1;198:112-118
Life sciences 2018 Apr 1;198:112-118
TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System.
Peng J, Tang ZH, Ren Z, He B, Zeng Y, Liu LS, Wang Z, Wei DH, Zheng XL, Jiang ZS
Frontiers in pharmacology 2017;8:486
Frontiers in pharmacology 2017;8:486
Protective Effects of Dioscin against Lipopolysaccharide-Induced Acute Lung Injury through Inhibition of Oxidative Stress and Inflammation.
Yao H, Sun Y, Song S, Qi Y, Tao X, Xu L, Yin L, Han X, Xu Y, Li H, Sun H, Peng J
Frontiers in pharmacology 2017;8:120
Frontiers in pharmacology 2017;8:120
Mechanism of Lycium barbarum polysaccharides on primary cultured rat hippocampal neurons.
Zhao P, Ma NT, Chang RY, Li YX, Hao YJ, Yang WL, Zheng J, Niu Y, Sun T, Yu JQ
Cell and tissue research 2017 Sep;369(3):455-465
Cell and tissue research 2017 Sep;369(3):455-465
Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.
Chen HB, Luo CD, Liang JL, Zhang ZB, Lin GS, Wu JZ, Li CL, Tan LH, Yang XB, Su ZR, Xie JH, Zeng HF
European journal of pharmacology 2017 Sep 15;811:222-231
European journal of pharmacology 2017 Sep 15;811:222-231
Calcitonin gene-related peptide exerts anti-inflammatory property through regulating murine macrophages polarization in vitro.
Duan JX, Zhou Y, Zhou AY, Guan XX, Liu T, Yang HH, Xie H, Chen P
Molecular immunology 2017 Nov;91:105-113
Molecular immunology 2017 Nov;91:105-113
Antioxidation, anti-inflammation and anti-apoptosis by paeonol in LPS/d-GalN-induced acute liver failure in mice.
Gong X, Yang Y, Huang L, Zhang Q, Wan RZ, Zhang P, Zhang B
International immunopharmacology 2017 May;46:124-132
International immunopharmacology 2017 May;46:124-132
ZNF545 suppresses human hepatocellular carcinoma growth by inhibiting NF-kB signaling.
Yang W, Yang S, Zhang M, Gao D, He T, Guo M
Genes & cancer 2017 Mar;8(3-4):528-535
Genes & cancer 2017 Mar;8(3-4):528-535
Chemical characterization of a novel polysaccharide ASKP-1 from Artemisia sphaerocephala Krasch seed and its macrophage activation via MAPK, PI3k/Akt and NF-κB signaling pathways in RAW264.7 cells.
Ren D, Lin D, Alim A, Zheng Q, Yang X
Food & function 2017 Mar 22;8(3):1299-1312
Food & function 2017 Mar 22;8(3):1299-1312
An excessive increase in glutamate contributes to glucose-toxicity in β-cells via activation of pancreatic NMDA receptors in rodent diabetes.
Huang XT, Li C, Peng XP, Guo J, Yue SJ, Liu W, Zhao FY, Han JZ, Huang YH, Yang-Li, Cheng QM, Zhou ZG, Chen C, Feng DD, Luo ZQ
Scientific reports 2017 Mar 17;7:44120
Scientific reports 2017 Mar 17;7:44120
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Dalet A, Argüello RJ, Combes A, Spinelli L, Jaeger S, Fallet M, Vu Manh TP, Mendes A, Perego J, Reverendo M, Camosseto V, Dalod M, Weil T, Santos MA, Gatti E, Pierre P
The EMBO journal 2017 Mar 15;36(6):761-782
The EMBO journal 2017 Mar 15;36(6):761-782
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
ApoE Influences the Blood-Brain Barrier Through the NF-κB/MMP-9 Pathway After Traumatic Brain Injury.
Teng Z, Guo Z, Zhong J, Cheng C, Huang Z, Wu Y, Tang S, Luo C, Peng X, Wu H, Sun X, Jiang L
Scientific reports 2017 Jul 27;7(1):6649
Scientific reports 2017 Jul 27;7(1):6649
Dihydroartemisinin counteracts fibrotic portal hypertension via farnesoid X receptor-dependent inhibition of hepatic stellate cell contraction.
Xu W, Lu C, Zhang F, Shao J, Yao S, Zheng S
The FEBS journal 2017 Jan;284(1):114-133
The FEBS journal 2017 Jan;284(1):114-133
Knockdown of TREM-1 suppresses IL-1β-induced chondrocyte injury via inhibiting the NF-κB pathway.
Tang J, Dong Q
Biochemical and biophysical research communications 2017 Jan 22;482(4):1240-1245
Biochemical and biophysical research communications 2017 Jan 22;482(4):1240-1245
Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner.
Xu W, Lu C, Yao L, Zhang F, Shao J, Zheng S
Toxicology and applied pharmacology 2017 Jan 15;315:23-34
Toxicology and applied pharmacology 2017 Jan 15;315:23-34
Glucocorticoid-Induced Leucine Zipper Suppresses ICAM-1 and MCP-1 Expression by Dephosphorylation of NF-κB p65 in Retinal Endothelial Cells.
Gu R, Lei B, Jiang C, Xu G
Investigative ophthalmology & visual science 2017 Jan 1;58(1):631-641
Investigative ophthalmology & visual science 2017 Jan 1;58(1):631-641
TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway.
Fan W, Liu T, Li X, Zhou Y, Wu M, Cui X, Chen H, Qian P
Molecular immunology 2017 Feb;82:114-122
Molecular immunology 2017 Feb;82:114-122
Calcitriol Ameliorates AngiotensinII-Induced Renal Injury Partly via Upregulating A20.
Zhao H, Xia Y, Gan H
Inflammation 2017 Dec;40(6):1884-1893
Inflammation 2017 Dec;40(6):1884-1893
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
CAPE-pNO2 ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation.
Khan MR, Xiang S, Song Z, Wu M
The EMBO journal 2017 Dec 1;36(23):3483-3500
The EMBO journal 2017 Dec 1;36(23):3483-3500
Chlorogenic acid prevents inflammatory responses in IL‑1β‑stimulated human SW‑1353 chondrocytes, a model for osteoarthritis.
Liu CC, Zhang Y, Dai BL, Ma YJ, Zhang Q, Wang Y, Yang H
Molecular medicine reports 2017 Aug;16(2):1369-1375
Molecular medicine reports 2017 Aug;16(2):1369-1375
Seneca Valley Virus Suppresses Host Type I Interferon Production by Targeting Adaptor Proteins MAVS, TRIF, and TANK for Cleavage.
Qian S, Fan W, Liu T, Wu M, Zhang H, Cui X, Zhou Y, Hu J, Wei S, Chen H, Li X, Qian P
Journal of virology 2017 Aug 15;91(16)
Journal of virology 2017 Aug 15;91(16)
Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1G93A ALS Mice.
Wang W, Duan W, Wang Y, Wen D, Liu Y, Li Z, Hu H, Cui H, Cui C, Lin H, Li C
Neurochemical research 2017 Apr;42(4):986-996
Neurochemical research 2017 Apr;42(4):986-996
Daphnetin Protects against Cerebral Ischemia/Reperfusion Injury in Mice via Inhibition of TLR4/NF-κB Signaling Pathway.
Liu J, Chen Q, Jian Z, Xiong X, Shao L, Jin T, Zhu X, Wang L
BioMed research international 2016;2016:2816056
BioMed research international 2016;2016:2816056
An injectable silk sericin hydrogel promotes cardiac functional recovery after ischemic myocardial infarction.
Song Y, Zhang C, Zhang J, Sun N, Huang K, Li H, Wang Z, Huang K, Wang L
Acta biomaterialia 2016 Sep 1;41:210-23
Acta biomaterialia 2016 Sep 1;41:210-23
Inhibitory effects of S-allylmercaptocysteine against benzo(a)pyrene-induced precancerous carcinogenesis in human lung cells.
Wang K, Wang Y, Qi Q, Zhang F, Zhang Y, Zhu X, Liu G, Luan Y, Zhao Z, Cai J, Cao J, Li S
International immunopharmacology 2016 May;34:37-43
International immunopharmacology 2016 May;34:37-43
The ORF3 Protein of Genotype 1 Hepatitis E Virus Suppresses TLR3-induced NF-κB Signaling via TRADD and RIP1.
He M, Wang M, Huang Y, Peng W, Zheng Z, Xia N, Xu J, Tian D
Scientific reports 2016 Jun 8;6:27597
Scientific reports 2016 Jun 8;6:27597
Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65.
Liu Q, Zhang Z, Zheng Z, Zheng C, Liu Y, Hu Q, Ke X, Wang H
Scientific reports 2016 Jun 22;6:28481
Scientific reports 2016 Jun 22;6:28481
Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.
Huang Q, Zhan L, Cao H, Li J, Lyu Y, Guo X, Zhang J, Ji L, Ren T, An J, Liu B, Nie Y, Xing J
Autophagy 2016 Jun 2;12(6):999-1014
Autophagy 2016 Jun 2;12(6):999-1014
Dioscin alleviates dimethylnitrosamine-induced acute liver injury through regulating apoptosis, oxidative stress and inflammation.
Zhang W, Yin L, Tao X, Xu L, Zheng L, Han X, Xu Y, Wang C, Peng J
Environmental toxicology and pharmacology 2016 Jul;45:193-201
Environmental toxicology and pharmacology 2016 Jul;45:193-201
CD147 promotes IKK/IκB/NF-κB pathway to resist TNF-induced apoptosis in rheumatoid arthritis synovial fibroblasts.
Zhai Y, Wu B, Li J, Yao XY, Zhu P, Chen ZN
Journal of molecular medicine (Berlin, Germany) 2016 Jan;94(1):71-82
Journal of molecular medicine (Berlin, Germany) 2016 Jan;94(1):71-82
SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells.
Wu J, Yang C, Guo C, Li X, Yang N, Zhao L, Hang H, Liu S, Chu P, Sun Z, Sun B, Lin Y, Peng J, Han G, Wang S, Tang Z
Chemico-biological interactions 2016 Jan 25;244:94-104
Chemico-biological interactions 2016 Jan 25;244:94-104
Etomidate inhibits nuclear factor-κB through decreased expression of glucocorticoid receptor in septic rats.
Zhang Y, Li RM, Wang C, Liu N, Lv S, Xiong JY
Molecular medicine reports 2016 Dec;14(6):5760-5766
Molecular medicine reports 2016 Dec;14(6):5760-5766
Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling.
Zhou ZY, Ren LW, Zhan P, Yang HY, Chai DD, Yu ZW
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Acta pharmacologica Sinica 2016 Aug;37(8):1063-75
Matrine displayed antiviral activity in porcine alveolar macrophages co-infected by porcine reproductive and respiratory syndrome virus and porcine circovirus type 2.
Sun N, Sun P, Lv H, Sun Y, Guo J, Wang Z, Luo T, Wang S, Li H
Scientific reports 2016 Apr 15;6:24401
Scientific reports 2016 Apr 15;6:24401
Ghrelin Attenuates Liver Fibrosis through Regulation of TGF-β1 Expression and Autophagy.
Mao Y, Zhang S, Yu F, Li H, Guo C, Fan X
International journal of molecular sciences 2015 Sep 10;16(9):21911-30
International journal of molecular sciences 2015 Sep 10;16(9):21911-30
Scutellarein inhibits cancer cell metastasis in vitro and attenuates the development of fibrosarcoma in vivo.
Shi X, Chen G, Liu X, Qiu Y, Yang S, Zhang Y, Fang X, Zhang C, Liu X
International journal of molecular medicine 2015 Jan;35(1):31-8
International journal of molecular medicine 2015 Jan;35(1):31-8
Activation of the NF-κB pathway as a mechanism of alcohol enhanced progression and metastasis of human hepatocellular carcinoma.
Wang F, Yang JL, Yu KK, Xu M, Xu YZ, Chen L, Lu YM, Fang HS, Wang XY, Hu ZQ, Li FF, Kan L, Luo J, Wang SY
Molecular cancer 2015 Jan 27;14:10
Molecular cancer 2015 Jan 27;14:10
Potent effects of dioscin against obesity in mice.
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, Zhao Y, Sun H, Yao J, Lin Y, Liu K, Peng J
Scientific reports 2015 Jan 22;5:7973
Scientific reports 2015 Jan 22;5:7973
Diallyl trisulfide inhibits naphthalene-induced oxidative injury and the production of inflammatory responses in A549 cells and mice.
Zhang F, Zhang Y, Wang K, Zhu X, Lin G, Zhao Z, Li S, Cai J, Cao J
International immunopharmacology 2015 Dec;29(2):326-333
International immunopharmacology 2015 Dec;29(2):326-333
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).
Zheng C, Zheng Z, Zhang Z, Meng J, Liu Y, Ke X, Hu Q, Wang H
Cellular signalling 2015 Dec;27(12):2343-54
Cellular signalling 2015 Dec;27(12):2343-54
Potent effects of dioscin against liver fibrosis.
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, Sun H, Lin Y, Liu K, Peng J
Scientific reports 2015 Apr 8;5:9713
Scientific reports 2015 Apr 8;5:9713
Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes.
Li Y, Shen D, Tang X, Li X, Wo D, Yan H, Song R, Feng J, Li P, Zhang J, Li J
Toxicology letters 2014 May 2;226(3):257-63
Toxicology letters 2014 May 2;226(3):257-63
Herpes simplex virus 1 protein kinase US3 hyperphosphorylates p65/RelA and dampens NF-κB activation.
Wang K, Ni L, Wang S, Zheng C
Journal of virology 2014 Jul;88(14):7941-51
Journal of virology 2014 Jul;88(14):7941-51
14-3-3ε mediates the cell fate decision-making pathways in response of hepatocellular carcinoma to Bleomycin-induced DNA damage.
Tang S, Bao H, Zhang Y, Yao J, Yang P, Chen X
PloS one 2013;8(3):e55268
PloS one 2013;8(3):e55268
The hepatitis B virus X protein downregulates NF-κB signaling pathways through decreasing the Notch signaling pathway in HBx-transformed L02 cells.
Luo J, Zhou H, Wang F, Xia X, Sun Q, Wang R, Cheng B
International journal of oncology 2013 May;42(5):1636-43
International journal of oncology 2013 May;42(5):1636-43
MG132-mediated inhibition of the ubiquitin-proteasome pathway ameliorates cancer cachexia.
Zhang L, Tang H, Kou Y, Li R, Zheng Y, Wang Q, Zhou X, Jin L
Journal of cancer research and clinical oncology 2013 Jul;139(7):1105-15
Journal of cancer research and clinical oncology 2013 Jul;139(7):1105-15
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10268-1-AP(NFKBIA antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using NFKBIA antibody 10268-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-NFKBIA (IP:10268-1-AP, 3ug; Detection:10268-1-AP 1:400) with HeLa cells lysate 1000ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human ovary tumor using 10268-1-AP(NFKBIA antibody) at dilution of 1:100 (under 25x lens)
- Sample type
- tissue
