BS1190

antibody from Bioworld Technology, Inc
Targeting: NFKBIA IkappaBalpha, IKBA, MAD-3, NFKBI
Provider product page for BS1190
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS1190 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1190, RRID:AB_1663995
Product name
IKB Ï« (L26) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to the N-terminal of Human IkB-Ï«.
Description
Activation of NF°ÙB requires that I°ÙB be phosphorylated on specific serine residues, which results in targeted degradation of I°ÙB. I°ÙB kinase Ï« (IKKÏ«), previously designated CHUK, interacts with I°ÙB-Ï« and specifically phosphorylates I°ÙB-Ï« on the sites that trigger its degradation Serines 32 and 36. IKKÏ« appears to be critical for NF°ÙB activation in response to proinflammatory cytokines. Phosphorylation of I°ÙB by IKKÏ« is stimulated by the NF°ÙB inducing kinase (NIK), which itself is a central regulator for NF°ÙB activation in response to TNF and IL-1. The functional IKK complex contains three subunits, IKKÏ«, IKKÉÇ and IKKÎÛ , and each appear to make essential contributions to I°ÙB phosphorylation.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
NFKBIA protein structure - BS1190 shown in red.