AMM00004G

antibody from Leading Biology

Targeting: NFKBIA IkappaBalpha, IKBA, MAD-3, NFKBI

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

AMM00004G

Provider

Leading Biology

Product name

IkBalpha Antibody (Clone 6A055)

Antibody type

Monoclonal

Description

NF-kB is silenced in the cytoplasm by an inhibitory protein, IkB. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/α, IKK2/β, and IKK3/g. External stimuli such TNF-α or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Six members of IkB family members have been identified. One of the first gene induced following NF-kB activation is IkBα.

Reactivity

Human

Host

Mouse

Antibody clone number

6A055

Storage

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.