ABIN252471

antibody from antibodies-online

Targeting: NFKBIA IkappaBalpha, IKBA, MAD-3, NFKBI

Provider product page for ABIN252471

Western blot

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [33]
Comments [0]
Validations
Western blot [3]
Immunohistochemistry [1]
Flow cytometry [1]

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Product number: ABIN252471 - Provider product page
Provider: antibodies-online
Product name: anti-Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha (NFKBIA) (AA 32-291) antibody
Antibody type: Monoclonal
Description: Protein G purified
Reactivity: Human, Mouse, Rat
Host: Mouse
Epitope: AA 32-291
Isotype: IgG
Antibody clone number: 6A920
Vial size: 0.1 mg
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Handling: Avoid freeze-thaw cycles

NFKBIA protein structure - ABIN252471 shown in red.

Submitted references Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.

Zhu F, Willette-Brown J, Song NY, Lomada D, Song Y, Xue L, Gray Z, Zhao Z, Davis SR, Sun Z, Zhang P, Wu X, Zhan Q, Richie ER, Hu Y
Cell host & microbe 2017 Apr 12;21(4):478-493.e7

Ubiquitin-Conjugating Enzyme 9 Phosphorylation as a Novel Mechanism for Potentiation of the Inflammatory Response.

Tomasi ML, Ramani K, Ryoo M
The American journal of pathology 2016 Sep;186(9):2326-36

IL-17 intensifies IFN-γ-induced NOS2 upregulation in RAW 264.7 cells by further activating STAT1 and NF-κB.

Gao Q, Liu Y, Wu Y, Zhao Q, Wang L, Gao S, Wen W, Zhang W, Guo N, Zhou J, Yuan Z
International journal of molecular medicine 2016 Feb;37(2):347-58

L-Ascorbyl-2-phosphate attenuates NF-κB signaling in SZ95 sebocytes without affecting IL-6 and IL-8 secretion.

Ikeno H, Apel M, Zouboulis C, Luger TA, Böhm M
Archives of dermatological research 2015 Sep;307(7):595-605

The ubiquitin ligase HERC3 attenuates NF-κB-dependent transcription independently of its enzymatic activity by delivering the RelA subunit for degradation.

Hochrainer K, Pejanovic N, Olaseun VA, Zhang S, Iadecola C, Anrather J
Nucleic acids research 2015 Nov 16;43(20):9889-904

Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury.

Yang XY, Zhao N, Liu YY, Hu BH, Sun K, Chang X, Wei XH, Fan JY, Han JY
Evidence-based complementary and alternative medicine : eCAM 2013;2013:728020

Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus.

Tabit CE, Shenouda SM, Holbrook M, Fetterman JL, Kiani S, Frame AA, Kluge MA, Held A, Dohadwala MM, Gokce N, Farb MG, Rosenzweig J, Ruderman N, Vita JA, Hamburg NM
Circulation 2013 Jan 1;127(1):86-95

Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT).

Pejanovic N, Hochrainer K, Liu T, Aerne BL, Soares MP, Anrather J
PloS one 2012;7(7):e42020

TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.

Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 24;109(4):E177-86

Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway.

Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB
Molecular pharmacology 2010 May;77(5):818-27

DHMEQ, a novel nuclear factor-kappaB inhibitor, induces selective depletion of alloreactive or phytohaemagglutinin-stimulated peripheral blood mononuclear cells, decreases production of T helper type 1 cytokines, and blocks maturation of dendritic cells.

Nishioka C, Ikezoe T, Jing Y, Umezawa K, Yokoyama A
Immunology 2008 Jun;124(2):198-205

An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.

Yu MC, Su LL, Zou L, Liu Y, Wu N, Kong L, Zhuang ZH, Sun L, Liu HP, Hu JH, Li D, Strominger JL, Zang JW, Pei G, Ge BX
Nature immunology 2008 Aug;9(8):898-907

Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis.

Shakibaei M, John T, Schulze-Tanzil G, Lehmann I, Mobasheri A
Biochemical pharmacology 2007 May 1;73(9):1434-45

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

Vilimas T, Mascarenhas J, Palomero T, Mandal M, Buonamici S, Meng F, Thompson B, Spaulding C, Macaroun S, Alegre ML, Kee BL, Ferrando A, Miele L, Aifantis I
Nature medicine 2007 Jan;13(1):70-7

BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway.

Endo T, Nishio M, Enzler T, Cottam HB, Fukuda T, James DF, Karin M, Kipps TJ
Blood 2007 Jan 15;109(2):703-10

NF-kappaB and COX-2 during oral tumorigenesis and in assessment of minimal residual disease in surgical margins.

Santhi WS, Sebastian P, Varghese BT, Prakash O, Pillai MR
Experimental and molecular pathology 2006 Oct;81(2):123-30

Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome.

Strozyk E, Pöppelmann B, Schwarz T, Kulms D
Oncogene 2006 Oct 12;25(47):6239-51

Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation.

Ishiguro K, Ando T, Maeda O, Hasegawa M, Kadomatsu K, Ohmiya N, Niwa Y, Xavier R, Goto H
Toxicology and applied pharmacology 2006 Nov 15;217(1):35-42

A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression.

Macagno A, Molteni M, Rinaldi A, Bertoni F, Lanzavecchia A, Rossetti C, Sallusto F
The Journal of experimental medicine 2006 Jun 12;203(6):1481-92

p120-catenin mediates inflammatory responses in the skin.

Perez-Moreno M, Davis MA, Wong E, Pasolli HA, Reynolds AB, Fuchs E
Cell 2006 Feb 10;124(3):631-44

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

Chang L, Kamata H, Solinas G, Luo JL, Maeda S, Venuprasad K, Liu YC, Karin M
Cell 2006 Feb 10;124(3):601-13

B cell maturation antigen, the receptor for a proliferation-inducing ligand and B cell-activating factor of the TNF family, induces antigen presentation in B cells.

Yang M, Hase H, Legarda-Addison D, Varughese L, Seed B, Ting AT
Journal of immunology (Baltimore, Md. : 1950) 2005 Sep 1;175(5):2814-24

The IkappaB kinase is a key factor in triggering influenza A virus-induced inflammatory cytokine production in airway epithelial cells.

Bernasconi D, Amici C, La Frazia S, Ianaro A, Santoro MG
The Journal of biological chemistry 2005 Jun 24;280(25):24127-34

Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells.

Napolitani G, Rinaldi A, Bertoni F, Sallusto F, Lanzavecchia A
Nature immunology 2005 Aug;6(8):769-76

Andrographolide attenuates inflammation by inhibition of NF-kappa B activation through covalent modification of reduced cysteine 62 of p50.

Xia YF, Ye BQ, Li YD, Wang JG, He XJ, Lin X, Yao X, Ma D, Slungaard A, Hebbel RP, Key NS, Geng JG
Journal of immunology (Baltimore, Md. : 1950) 2004 Sep 15;173(6):4207-17

Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response.

Saccani S, Marazzi I, Beg AA, Natoli G
The Journal of experimental medicine 2004 Jul 5;200(1):107-13

IkappaB kinase and NF-kappaB signaling in response to pro-inflammatory cytokines.

Delhase M
Methods in molecular biology (Clifton, N.J.) 2003;225:7-17

Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke.

Han HS, Karabiyikoglu M, Kelly S, Sobel RA, Yenari MA
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2003 May;23(5):589-98

Modulation of NF-kappaB activity by exchange of dimers.

Saccani S, Pantano S, Natoli G
Molecular cell 2003 Jun;11(6):1563-74

NF-kappaB is required for apoptosis prevention during herpes simplex virus type 1 infection.

Goodkin ML, Ting AT, Blaho JA
Journal of virology 2003 Jul;77(13):7261-80

PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock.

Ikezoe T, Yang Y, Heber D, Taguchi H, Koeffler HP
Molecular pharmacology 2003 Dec;64(6):1521-9

p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment.

Saccani S, Pantano S, Natoli G
Nature immunology 2002 Jan;3(1):69-75

Two waves of nuclear factor kappaB recruitment to target promoters.

Saccani S, Pantano S, Natoli G
The Journal of experimental medicine 2001 Jun 18;193(12):1351-9

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