BS70001

antibody from Bioworld Technology, Inc

Targeting: PARP1 ADPRT, ARTD1, PARP, PPOL

Western blot (Supportive data in Antibodypedia)

Antibody Data

Product number

BS70001

Provider

Bioworld Technology, Inc

Product name

PARP polyclonal antibody

Antibody type

Polyclonal

Antigen

Recombinant full length Human PARP.

Description

PARP, a 116 kDa nuclear poly (ADP-ribose) polymerase, appears to be involved in DNA repair in response to environmental stress. This protein can be cleaved by many ICE-like caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. In human PARP, the cleavage occurs between Asp214 and Gly215, which separates the PARP amino-terminal DNA binding domain (24 kDa) from the carboxy-terminal catalytic domain (89 kDa). PARP helps cells to maintain their viability; cleavage of PARP facilitates cellular disassembly and serves as a marker of cells undergoing apoptosis.

Reactivity

Human, Mouse

Host

Rabbit

Isotype

IgG

Vial size

100ul

Concentration

1 mg/ml

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Western blot

Supportive validation

Submitted by

Bioworld Technology, Inc (provider)

Main image

Experimental details

Western blot(WB) analysis of extracts from A549 cells, The lane on the left is treated with the antigen-specific peptide.