624001

antibody from BioLegend

Targeting: PXN

Western blot (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

624001

Provider

BioLegend

Proper citation

BioLegend Cat#624001, RRID:AB_2300550

Product name

Purified anti-Paxillin

Antibody type

Monoclonal

Antigen

Recombinant full length

Description

Paxillin (also known as peroxisomal membrane protein 3) is a cytoplasmic protein with LIM metal-binding repeat homology and LIM domains. There are three isoforms of this protein designated as α, β, γ; approximate molecular weight 68 kD. Paxillin is localized to actin-membrane attachment at sites of cell adhesion to extracellular matrix (focal adhesion). This protein undergoes cell adhesion-dependent tyrosine phosphorylation. Paxillin has been shown to interact with FAK, vinculin, src, Crk, p210BRC / ABL, talin, and integrin-β1. The PAX227 monoclonal antibody recognizes human and mouse paxillin and has been shown to be useful for Western blotting.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 µl

Storage

Upon receipt, store frozen at -20° C.

References

Submitted references

Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.

Heinhuis B, Koenders MI, van den Berg WB, Netea MG, Dinarello CA, Joosten LA
The Journal of biological chemistry 2012 Feb 17;287(8):5733-43

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Fibronectin promotes tyrosine phosphorylation of paxillin and cell invasiveness in the gastric cancer cell line AGS.

Li D, Ding J, Wang X, Wang C, Wu T
Tumori 2009 Nov-Dec;95(6):769-79

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RhoC GTPase is required for PC-3 prostate cancer cell invasion but not motility.

Yao H, Dashner EJ, van Golen CM, van Golen KL
Oncogene 2006 Apr 13;25(16):2285-96