BS1929

antibody from Bioworld Technology, Inc
Targeting: PRKAR2A PRKAR2
Provider product page for BS1929
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS1929 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1929, RRID:AB_1663908
Product name
PKA IIÏ« reg (P68) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 50-100 of Human PKA IIÏ« reg.
Description
The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated CÏ«, CÉÇ and CÎÛ, that each represent specific gene products. CÏ« and CÉÇ are closely related (93% amino acid sequence similarity), where as CÎÛ displays 83% and 79% similarity to CÏ« and CÉÇ, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the pol II transcription initiation complex.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PRKAR2A protein structure - BS1929 shown in red.