Antibody data
- Antibody Data
- Antigen structure
- References [212]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10929-2-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10929-2-AP, RRID:AB_2169568
- Product name
- AMPK Alpha 1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AMPK Alpha 1 antibody (Cat. #10929-2-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway.
Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Er-Dong-Xiao-Ke decoction regulates lipid metabolism via PPARG-mediated UCP2/AMPK signaling to alleviate diabetic meibomian gland dysfunction.
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway.
AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy.
Cisplatin induces acute kidney injury by downregulating miR-30e-5p that targets Galnt3 to activate the AMPK signaling pathway.
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.
Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice.
Protective effects of l-cysteine and N-acetyl-l-cysteine on boar sperm quality during hypothermic liquid storage with bovine serum albumin as a protectant.
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Palmatine improves cognitive dysfunction in Alzheimer's disease model rats through autophagy pathway and regulation of gut microbiota.
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
Real-time monitoring of glucose metabolism and effects of metformin on HepG2 cells using (13)C in-cell NMR spectroscopy.
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway.
Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1.
Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPKα pathway.
Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice.
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM.
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway.
Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway.
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Gallotannin Isolated from Pericarp of Water Caltrop Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Regulation of Paracellular Fluxes of Amino Acids by Claudin-8 in Normal Mouse Intestinal MCE301 Cells.
Ferrostatin-1 improves BMSC survival by inhibiting ferroptosis.
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Modulation of the Microbiome-Fat-Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice.
Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling pathways dependent on converting angiotensin II to angiotensin 1-7.
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Quantification and Proteomic Characterization of β-Hydroxybutyrylation Modification in the Hearts of AMPKα2 Knockout Mice.
A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector.
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Increase in Paracellular Leakage of Amino Acids Mediated by Aging-Induced Reduction of Claudin-4 Expression.
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Caffeic Acid Phenethyl Ester (CAPE) Improves Boar Sperm Quality and Antioxidant Capacity in Liquid Preservation (17°C) Linked to AMPK Activity Maintenance.
Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway.
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3.
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
Copper Depletion Strongly Enhances Ferroptosis via Mitochondrial Perturbation and Reduction in Antioxidative Mechanisms.
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition.
Empagliflozin inhibits macrophage inflammation through AMPK signaling pathway and plays an anti-atherosclerosis role.
Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency.
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions.
Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Metformin and MiR-365 synergistically promote the apoptosis of gastric cancer cells via MiR-365-PTEN-AMPK axis.
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Mdivi-1 improves postoperative neurocognitive disorders in aged rats undergoing splenectomy by inhibiting dynamin-related protein-1.
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic β-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux.
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
Effects of Fluorine on Neutrophil Extracellular Trap Formation through Regulating AMPK/p38 Signaling Pathway.
Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway.
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway.
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice.
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1α axis in the development of benign prostatic hyperplasia.
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.
Angiotensin II-mediated improvement of renal mitochondrial function via the AMPK/PGC-1α/NRF-2 pathway is superior to norepinephrine in a rat model of septic shock associated with acute renal injury.
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
The antitumor role of a newly discovered α-d-glucan from Holotrichia diomphalia Bates as a selective blocker of aldolase A.
Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE(-/-) mice.
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
SCF(JFK) is functionally linked to obesity and metabolic syndrome.
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
The Dual Histone Deacetylase-Proteasome Inhibitor RTS-V5 Acts Synergistically With Ritonavir to Induce Endoplasmic Reticulum Stress in Bladder Cancer Cells.
Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes.
Danqi Tablet () Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway.
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice.
Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway.
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis.
S -1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway.
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization.
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma.
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells.
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration.
Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
The balance of apoptosis and autophagy via regulation of the AMPK signal pathway in aging rat striatum during regular aerobic exercise.
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
Lopinavir-Ritonavir Combination Induces Endoplasmic Reticulum Stress and Kills Urological Cancer Cells.
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Effect of CAPE-pNO(2) against type 2 diabetes mellitus via the AMPK/GLUT4/ GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice.
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway.
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis.
Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria.
Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells.
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1.
Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model.
MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene.
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration.
Nelfinavir and Ritonavir Kill Bladder Cancer Cells Synergistically by Inducing Endoplasmic Reticulum Stress.
AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.
Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells.
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress.
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway.
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells.
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control.
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
SIRT1/PGC-1α Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration.
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Chronic metformin treatment facilitates seizure termination.
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats.
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats.
Activation of AMPK α2 inhibits airway smooth muscle cells proliferation.
Knockdown of AMPKα2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway.
Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis.
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.
Zhang Y, Yang Y, Kuang S, Zhang Y, Qin H, Xie J
International journal of clinical practice 2024;2024:6875417
International journal of clinical practice 2024;2024:6875417
Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.
Liu B, Si J, Qi K, Li D, Li T, Tang Y, Ji E, Yang S
PloS one 2024;19(3):e0296792
PloS one 2024;19(3):e0296792
Maresin-1 Attenuates Sepsis-Associated Acute Kidney Injury via Suppressing Inflammation, Endoplasmic Reticulum Stress and Pyroptosis by Activating the AMPK/SIRT3 Pathway.
Sun M, Wang F, Li H, Li M, Wang Y, Wang C, Zhang Y, Zhang D, Li J, Yao S
Journal of inflammation research 2024;17:1349-1364
Journal of inflammation research 2024;17:1349-1364
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Abdel-Wahab BA, Zafaar D, Habeeb MS, El-Shoura EAM
British journal of pharmacology 2024 Sep;181(17):3215-3231
British journal of pharmacology 2024 Sep;181(17):3215-3231
Er-Dong-Xiao-Ke decoction regulates lipid metabolism via PPARG-mediated UCP2/AMPK signaling to alleviate diabetic meibomian gland dysfunction.
Shi L, Li LJ, Sun XY, Chen YY, Luo D, He LP, Ji HJ, Gao WP, Shen HX
Journal of ethnopharmacology 2024 Oct 28;333:118484
Journal of ethnopharmacology 2024 Oct 28;333:118484
Sexual dimorphism in thermogenic regulators and metrnl expression in adipose tissue of offspring mice exposed to maternal and postnatal overnutrition.
Yang Z, Jiang J, Tan Y, Yang G, Chen M, Huang J, Liu J, Wei X, Wang S, Luo X, Han Z
Journal of physiology and biochemistry 2024 May;80(2):407-420
Journal of physiology and biochemistry 2024 May;80(2):407-420
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway.
Hu F, Hu T, Qiao Y, Huang H, Zhang Z, Huang W, Liu J, Lai S
International journal of molecular medicine 2024 May;53(5)
International journal of molecular medicine 2024 May;53(5)
AMPK activation eliminates senescent cells in diabetic wound by inducing NCOA4 mediated ferritinophagy.
Liu M, Wei X, Zheng Z, Xie E, Yu Q, Gao Y, Ma J, Yang L
Molecular medicine (Cambridge, Mass.) 2024 May 17;30(1):63
Molecular medicine (Cambridge, Mass.) 2024 May 17;30(1):63
Cisplatin induces acute kidney injury by downregulating miR-30e-5p that targets Galnt3 to activate the AMPK signaling pathway.
Mao W, Zhang L, Wang Y, Sun S, Wu J, Sun J, Zou X, Chen M, Zhang G
Environmental toxicology 2024 Mar;39(3):1567-1580
Environmental toxicology 2024 Mar;39(3):1567-1580
The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions.
Jia C, Wu Y, Gao F, Liu W, Li N, Chen Y, Sun L, Wang S, Yu C, Bao Y, Song Z
Free radical biology & medicine 2024 Mar;214:2-18
Free radical biology & medicine 2024 Mar;214:2-18
Dihydromyricetin ameliorates hepatic steatosis and insulin resistance via AMPK/PGC-1α and PPARα-mediated autophagy pathway.
Yang Y, Qiu W, Xiao J, Sun J, Ren X, Jiang L
Journal of translational medicine 2024 Mar 26;22(1):309
Journal of translational medicine 2024 Mar 26;22(1):309
FTO-mediated autophagy inhibition promotes non-small cell lung cancer progression by reducing the stability of SESN2 mRNA.
Wang K, Mei Z, Zheng M, Liu X, Li D, Wang H
Heliyon 2024 Mar 15;10(5):e27571
Heliyon 2024 Mar 15;10(5):e27571
Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice.
Yuan Y, Deng S, Yang J, Shou Z, Wei C, Zhang L, Zhu F, Gao F, Liu X, Liu Y, Chen Q, Fan H
Aging 2024 Mar 11;16(6):5336-5353
Aging 2024 Mar 11;16(6):5336-5353
Protective effects of l-cysteine and N-acetyl-l-cysteine on boar sperm quality during hypothermic liquid storage with bovine serum albumin as a protectant.
Yang D, Yu X, Li X, Yu B, Peng H
Theriogenology 2024 Mar 1;216:185-195
Theriogenology 2024 Mar 1;216:185-195
Mechanistic of AMPK/ACC2 regulating myoblast differentiation by fatty acid oxidation of goat.
Kang Z, Zhang Z, Li J, Deng K, Wang F, Fan Y
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
International journal of biological macromolecules 2024 Jun;270(Pt 2):132243
TGF β1 promotes the polarization of M2-type macrophages and activates PI3K/mTOR signaling pathway by inhibiting ISG20 to sensitize ovarian cancer to cisplatin.
Wu J, Jiang L, Wang S, Peng L, Zhang R, Liu Z
International immunopharmacology 2024 Jun 15;134:112235
International immunopharmacology 2024 Jun 15;134:112235
N-glycosylation of SCAP exacerbates hepatocellular inflammation and lipid accumulation via ACSS2-mediated histone H3K27 acetylation.
Li X, Tang X, Xiang Y, Zhao Z, Li Y, Ding Q, Zhang L, Xu J, Zhao L, Chen Y
American journal of physiology. Gastrointestinal and liver physiology 2024 Jun 1;326(6):G697-G711
American journal of physiology. Gastrointestinal and liver physiology 2024 Jun 1;326(6):G697-G711
Mechanism Research of DHEA Treatment Improving Diminished Ovarian Reserve by Attenuating the AMPK-SIRT1 Signaling and Mitophagy.
Ma Q, Shen M, Wu J, Ye C, Tan Y
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jul;31(7):2059-2072
Reproductive sciences (Thousand Oaks, Calif.) 2024 Jul;31(7):2059-2072
Podophyllotoxin via SIRT1/PPAR /NF-κB axis induced cardiac injury in rats based on the toxicological evidence chain (TEC) concept.
Jiang T, Sun L, Wang Y, Zhang F, Guo J, Sun L, Jiang Y, Xue J, Duan J, Liu C
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155655
Palmatine improves cognitive dysfunction in Alzheimer's disease model rats through autophagy pathway and regulation of gut microbiota.
Han L, Chen W, Li J, Zhao Y, Zong Y, He Z, Du R
Brain research 2024 Jul 15;1835:148932
Brain research 2024 Jul 15;1835:148932
Mzb1 Attenuates Atherosclerotic Plaque Vulnerability in ApoE-/- Mice by Alleviating Apoptosis and Modulating Mitochondrial Function.
Zhu G, Li Y, Gao H, Li X, Fan H, Fan L
Journal of cardiovascular translational research 2024 Jan 31;
Journal of cardiovascular translational research 2024 Jan 31;
Real-time monitoring of glucose metabolism and effects of metformin on HepG2 cells using (13)C in-cell NMR spectroscopy.
Teng M, Li Z, Gu Y, Fan Y, Wang D, Liu M, Li Y, Wei G, Huang Y
Biochemical and biophysical research communications 2024 Jan 29;694:149383
Biochemical and biophysical research communications 2024 Jan 29;694:149383
CGRP is essential for protection against alveolar epithelial cell necroptosis by activating the AMPK/L-OPA1 signaling pathway during acute lung injury.
Jiang HL, Yang HH, Liu YB, Duan JX, Guan XX, Zhang CY, Zhong WJ, Jin L, Li D, Li Q, Zhou Y, Guan CX
Journal of cellular physiology 2024 Feb;239(2):e31169
Journal of cellular physiology 2024 Feb;239(2):e31169
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Wang Z, Bi M, Zhe X, Wang X, Dai B, Han X, Ren B, Liang H, Liu D
Cell death discovery 2024 Feb 22;10(1):95
Cell death discovery 2024 Feb 22;10(1):95
Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway.
Xia Y, Zhang H, Wu X, Xu Y, Tan Q
Biogerontology 2024 Aug;25(4):649-664
Biogerontology 2024 Aug;25(4):649-664
Exerkine FNDC5/irisin-enriched exosomes promote proliferation and inhibit ferroptosis of osteoblasts through interaction with Caveolin-1.
Tao L, Wang J, Wang K, Liu Q, Li H, Xu S, Gu C, Zhu Y
Aging cell 2024 Aug;23(8):e14181
Aging cell 2024 Aug;23(8):e14181
Neonatal resveratrol administration promotes skeletal muscle growth and insulin sensitivity in intrauterine growth-retarded suckling piglets associated with activation of FGF21-AMPKα pathway.
Bai G, Chen J, Liu Y, Chen J, Yan H, You J, Zou T
Journal of the science of food and agriculture 2024 Apr;104(6):3719-3728
Journal of the science of food and agriculture 2024 Apr;104(6):3719-3728
Canagliflozin protects against hyperglycemia-induced cerebrovascular injury by preventing blood-brain barrier (BBB) disruption via AMPK/Sp1/adenosine A2A receptor.
Liu Z, Hua W, Jin S, Wang Y, Pang Y, Wang B, Zhao N, Song Y, Qi J
European journal of pharmacology 2024 Apr 5;968:176381
European journal of pharmacology 2024 Apr 5;968:176381
AP39 through AMPK-ULK1-FUNDC1 pathway regulates mitophagy, inhibits pyroptosis, and improves doxorubicin-induced myocardial fibrosis.
Zhao J, Yang T, Yi J, Hu H, Lai Q, Nie L, Liu M, Chu C, Yang J
iScience 2024 Apr 19;27(4):109321
iScience 2024 Apr 19;27(4):109321
Complexes of Soluble Dietary Fiber and Polyphenols from Lotus Root Regulate High-Fat Diet-Induced Hyperlipidemia in Mice.
Zheng Z, Gao W, Zhu Z, Li S, Chen X, Cravotto G, Sui Y, Zhou L
Antioxidants (Basel, Switzerland) 2024 Apr 16;13(4)
Antioxidants (Basel, Switzerland) 2024 Apr 16;13(4)
OL-FS13 Alleviates Cerebral Ischemia-reperfusion Injury by Inhibiting miR-21-3p Expression.
Liu N, Fan Y, Li Y, Zhang Y, Li J, Wang Y, Wang Z, Liu Y, Li Y, Kang Z, Peng Y, Ru Z, Yang M, Feng C, Wang Y, Yang X
Current neuropharmacology 2023;21(12):2550-2562
Current neuropharmacology 2023;21(12):2550-2562
ALKBH5-PYCR2 Positive Feedback Loop Promotes Proneural-Mesenchymal Transition Via Proline Synthesis In GBM.
Li L, Yang M, Pu X, Tang Y, Fei F, Li Z, Hou H, Chen Q, Wang Q, Wu Y, Zhang Y, Ren C, Gong A
Journal of Cancer 2023;14(9):1579-1591
Journal of Cancer 2023;14(9):1579-1591
Vitamin D3 promotes gastric cancer cell autophagy by mediating p53/AMPK/mTOR signaling.
Wang Y, He Q, Rong K, Zhu M, Zhao X, Zheng P, Mi Y
Frontiers in pharmacology 2023;14:1338260
Frontiers in pharmacology 2023;14:1338260
Phosphoproteomic and proteomic profiling in post-infarction chronic heart failure.
Wang J, Zhu X, Wang S, Zhang Y, Hua W, Liu Z, Zheng Y, Lu X
Frontiers in pharmacology 2023;14:1181622
Frontiers in pharmacology 2023;14:1181622
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
Zou YY, Tang XB, Chen ZL, Liu B, Zheng L, Song MY, Xiao Q, Zhou ZQ, Peng XY, Tang CF
Frontiers in endocrinology 2023;14:1162485
Frontiers in endocrinology 2023;14:1162485
Extracellular ATP-induced calcium oscillations regulating the differentiation of osteoblasts through aerobic oxidation metabolism pathways.
Gao X, Di X, Li J, Kang Y, Xie W, Sun L, Zhang J
Journal of bone and mineral metabolism 2023 Sep;41(5):606-620
Journal of bone and mineral metabolism 2023 Sep;41(5):606-620
Autophagy blockage and lysosomal dysfunction are involved in diallyl sulfide-induced inhibition of malignant growth in hepatocellular carcinoma cells.
Yu H, Hao Z, Liu X, Wei Z, Tan R, Liu X, Chen Q, Chen Y, Zhou H, Liu Y, Fu Z
Environmental toxicology 2023 Sep;38(9):2100-2110
Environmental toxicology 2023 Sep;38(9):2100-2110
Ginsenoside Rb1 alleviates chronic intermittent hypoxia-induced diabetic cardiomyopathy in db/db mice by regulating the adenosine monophosphate-activated protein kinase/Nrf2/heme oxygenase-1 signaling pathway.
Bingbing L, Jieru LI, Jianchao SI, Qi C, Shengchang Y, Ensheng JI
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(5):906-914
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Oct;43(5):906-914
Tanshinone IIA inhibited intermittent hypoxia induced neuronal injury through promoting autophagy via AMPK-mTOR signaling pathway.
Si J, Liu B, Qi K, Chen X, Li D, Yang S, Ji E
Journal of ethnopharmacology 2023 Oct 28;315:116677
Journal of ethnopharmacology 2023 Oct 28;315:116677
Oral administration of sophoricoside (SOP) inhibits neuronal damage and neuroinflammation to curb neurodegeneration in Parkinson's disease.
Wang H, He D, Li Z, Gao X, Yang S, Cui M, Ye B, Huang B, Fu S, Liu D
Chemico-biological interactions 2023 Oct 1;384:110726
Chemico-biological interactions 2023 Oct 1;384:110726
3D Elastomeric Stent Functionalized with Antioxidative and Perivascular Tissue Regenerative Activities Ameliorated PVT Deprivation-Induced Vein Graft Failure.
Wang Y, Fu M, Xiao W, Zhao Y, Yuan P, Zhang X, Wu W
Advanced healthcare materials 2023 Nov;12(29):e2301247
Advanced healthcare materials 2023 Nov;12(29):e2301247
CAB39 promotes cisplatin resistance in bladder cancer via the LKB1-AMPK-LC3 pathway.
Gao D, Wang R, Gong Y, Yu X, Niu Q, Yang E, Fan G, Ma J, Chen C, Tao Y, Lu J, Wang Z
Free radical biology & medicine 2023 Nov 1;208:587-601
Free radical biology & medicine 2023 Nov 1;208:587-601
Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction.
Wang K, Li Z, Ding Y, Liu Z, Li Y, Liu X, Sun Y, Hong J, Zheng W, Qian L, Xu D
Journal of physiology and biochemistry 2023 May;79(2):341-353
Journal of physiology and biochemistry 2023 May;79(2):341-353
Gallotannin Isolated from Pericarp of Water Caltrop Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease in Mice.
Lü H, Meng X, Ding X, Jian T, Zuo Y, Liu Y, Ren B, Li W, Chen J
Journal of agricultural and food chemistry 2023 May 10;71(18):7046-7057
Journal of agricultural and food chemistry 2023 May 10;71(18):7046-7057
Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy.
Zhou Y, Liu L, Jin B, Wu Y, Xu L, Chang X, Hu L, Wang G, Huang Y, Song L, Zhang T, Wang Y, Xiao Y, Zhang F, Shi M, Liu L, Wang T, Yan R, Guo B
Diabetes 2023 May 1;72(5):611-626
Diabetes 2023 May 1;72(5):611-626
Linear ubiquitination of LKB1 activates AMPK pathway to inhibit NLRP3 inflammasome response and reduce chondrocyte pyroptosis in osteoarthritis.
Chen Y, Liu Y, Jiang K, Wen Z, Cao X, Wu S
Journal of orthopaedic translation 2023 Mar;39:1-11
Journal of orthopaedic translation 2023 Mar;39:1-11
Regulation of Paracellular Fluxes of Amino Acids by Claudin-8 in Normal Mouse Intestinal MCE301 Cells.
Okamoto E, Matsuda S, Yoshino Y, Morikawa Y, Suenami K, Tabuchi Y, Matsunaga T, Ikari A
Nutrients 2023 Mar 10;15(6)
Nutrients 2023 Mar 10;15(6)
Ferrostatin-1 improves BMSC survival by inhibiting ferroptosis.
Xie Q, Sun Y, Xu H, Chen T, Xiang H, Liu H, Wang R, Tan B, Yi Q, Tian J, Zhu J
Archives of biochemistry and biophysics 2023 Mar 1;736:109535
Archives of biochemistry and biophysics 2023 Mar 1;736:109535
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
SIRT3-mediated autophagy contributes to ferroptosis-induced anticancer by inducing the formation of BECN1-SLC7A11 complex.
Huang P, Zhao H, Pan X, Li J, Pan W, Dai H, Wang J, Xia C, Liu F
Biochemical pharmacology 2023 Jul;213:115592
Biochemical pharmacology 2023 Jul;213:115592
Cabernet sauvignon dry red wine ameliorates atherosclerosis in mice by regulating inflammation and endothelial function, activating AMPK phosphorylation, and modulating gut microbiota.
Cheng X, Han X, Zhou L, Sun Y, Zhou Q, Lin X, Gao Z, Wang J, Zhao W
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Food research international (Ottawa, Ont.) 2023 Jul;169:112942
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Jie Li Z, Bing Luo C, Liang Wang H, Sun J, Qian Yang Q, Lang Zhou Y
International journal of pharmaceutics 2023 Jul 25;642:123190
International journal of pharmaceutics 2023 Jul 25;642:123190
Modulation of the Microbiome-Fat-Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice.
Wei B, Peng Z, Xiao M, Huang T, Yang S, Liu K, Wu M, Zheng W, Xie M, Xiong T
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10361-10374
Journal of agricultural and food chemistry 2023 Jul 12;71(27):10361-10374
Enhanced autophagy reversed aflatoxin B1-induced decrease in lactate secretion of dairy goat Sertoli cells.
Han S, Zhang H, Liu X, Wen F, Li B, Bie Z, Qiu H, Hu J
Ecotoxicology and environmental safety 2023 Jul 1;259:115063
Ecotoxicology and environmental safety 2023 Jul 1;259:115063
Resveratrol reverses TGF-β1-mediated invasion and metastasis of breast cancer cells via the SIRT3/AMPK/autophagy signal axis.
Wang J, Huang P, Pan X, Xia C, Zhang H, Zhao H, Yuan Z, Liu J, Meng C, Liu F
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Phytotherapy research : PTR 2023 Jan;37(1):211-230
Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling pathways dependent on converting angiotensin II to angiotensin 1-7.
Wu C, Chen Y, Zhou P, Hu Z
Annals of translational medicine 2023 Jan 15;11(1):13
Annals of translational medicine 2023 Jan 15;11(1):13
Knockout of ICAT in Adipose Tissue Alleviates Fibro-inflammation in Obese Mice.
Song Z, Liu N, He Y, Chen J, Li J, Wang F, Wu Z
Inflammation 2023 Feb;46(1):404-417
Inflammation 2023 Feb;46(1):404-417
Quantification and Proteomic Characterization of β-Hydroxybutyrylation Modification in the Hearts of AMPKα2 Knockout Mice.
Ding WJ, Li XH, Tang CM, Yang XC, Sun Y, Song YP, Ling MY, Yan R, Gao HQ, Zhang WH, Yu N, Feng JC, Zhang Z, Xing YQ
Molecular & cellular proteomics : MCP 2023 Feb;22(2):100494
Molecular & cellular proteomics : MCP 2023 Feb;22(2):100494
A plant nonenveloped double-stranded RNA virus activates and co-opts BNIP3-mediated mitophagy to promote persistent infection in its insect vector.
Liang Q, Wan J, Liu H, Jia D, Chen Q, Wang A, Wei T
Autophagy 2023 Feb;19(2):616-631
Autophagy 2023 Feb;19(2):616-631
Tetrathiomolybdate Decreases the Expression of Alkaline Phosphatase in Dermal Papilla Cells by Increasing Mitochondrial ROS Production.
Li F, Liu H, Wu X, Song Z, Tang H, Gong M, Liu L, Li F
International journal of molecular sciences 2023 Feb 4;24(4)
International journal of molecular sciences 2023 Feb 4;24(4)
The Degree of Hydrolysis and Peptide Profile Affect the Anti-Fatigue Activities of Whey Protein Hydrolysates in Promoting Energy Metabolism in Exercise Mice.
Zhao C, Gong Y, Zheng L, Zhao M
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
Journal of agricultural and food chemistry 2023 Feb 15;71(6):3010-3021
Xiaojianzhong decoction attenuates aspirin-induced gastric mucosal injury via the PI3K/AKT/mTOR/ULK1 and AMPK/ULK1 pathways.
Chen T, Bao S, Chen J, Zhang J, Wei H, Hu X, Liang Y, Li J, Yan S
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Pharmaceutical biology 2023 Dec;61(1):1234-1248
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy.
Wang K, Fu S, Dong L, Zhang D, Wang M, Wu X, Shen E, Luo L, Li C, Nice EC, Huang C, Zou B
Autophagy 2023 Dec;19(12):3132-3150
Autophagy 2023 Dec;19(12):3132-3150
Metformin exhibits antineoplastic effects on Pten-deficient endometrial cancer by interfering with TGF-β and p38/ERK MAPK signalling.
Ruiz-Mitjana A, Vidal-Sabanés M, Navaridas R, Perramon-Güell A, Yeramian A, Nicholson-Sabaté N, Egea J, Encinas M, Matias-Guiu X, Dolcet X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115817
Increase in Paracellular Leakage of Amino Acids Mediated by Aging-Induced Reduction of Claudin-4 Expression.
Okamoto E, Matsuda S, Yoshino Y, Morikawa Y, Suenami K, Tabuchi Y, Matsunaga T, Hayashi H, Ikari A
The Journal of nutrition 2023 Dec;153(12):3360-3372
The Journal of nutrition 2023 Dec;153(12):3360-3372
[Linagliptin improves diabetic kidney disease in rats by promoting mitochondrial biogenesis through the AMPK/PGC-1α/TFAM pathway].
Wan L, Qian Y, Ni W, Lu Y, Li W, Pan Y, Chen W
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Dec 20;43(12):2053-2060
Cdo1-Camkk2-AMPK axis confers the protective effects of exercise against NAFLD in mice.
Chen M, Zhu JY, Mu WJ, Luo HY, Li Y, Li S, Yan LJ, Li RY, Guo L
Nature communications 2023 Dec 18;14(1):8391
Nature communications 2023 Dec 18;14(1):8391
Lipopolysaccharide-induced persistent inflammation ameliorates fat accumulation by promoting adipose browning in vitro and in vivo.
Zhang W, Liu S, Kong L, Wu S, Zhong Z, Yu L, Yang Q, Zhang J, Li J, Zheng G
International journal of biological macromolecules 2023 Dec 1;252:126511
International journal of biological macromolecules 2023 Dec 1;252:126511
Guf1 overexpression improves pancreatic β cell functions in type 2 diabetes mellitus rats with Roux-en-Y gastric bypass (RYGB) surgery.
Li P, Dai S, Gao X, Li W
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
Journal of physiology and biochemistry 2023 Aug;79(3):569-582
Salidroside ameliorates acetaminophen-induced acute liver injury through the inhibition of endoplasmic reticulum stress-mediated ferroptosis by activating the AMPK/SIRT1 pathway.
Xu J, Zhao L, Zhang X, Ying K, Zhou R, Cai W, Wu X, Jiang H, Xu Q, Miao D, Zeng Y, Yu F
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
Ecotoxicology and environmental safety 2023 Aug 7;262:115331
GAS6/Axl is associated with AMPK activation and attenuates H(2)O(2)-induced oxidative stress.
Liang Z, Yang Y, Wu X, Lu C, Zhao H, Chen K, Zhao A, Li X, Xu J
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Apoptosis : an international journal on programmed cell death 2023 Apr;28(3-4):485-497
Caffeic Acid Phenethyl Ester (CAPE) Improves Boar Sperm Quality and Antioxidant Capacity in Liquid Preservation (17°C) Linked to AMPK Activity Maintenance.
Lan Q, Xue L, Cao J, Xie Y, Xiao T, Fang S
Frontiers in veterinary science 2022;9:904886
Frontiers in veterinary science 2022;9:904886
Gandi Capsule Improved Podocyte Lipid Metabolism of Diabetic Nephropathy Mice through SIRT1/AMPK/HNF4A Pathway.
Zhang Y, Yao H, Li C, Sun W, Chen X, Cao Y, Liu Y, Liu Y, Chen J, Qi J, Zhang Q, Zhang H, Xu A, Zhang J
Oxidative medicine and cellular longevity 2022;2022:6275505
Oxidative medicine and cellular longevity 2022;2022:6275505
Honokiol Ameliorates DSS-Induced Mouse Colitis by Inhibiting Inflammation and Oxidative Stress and Improving the Intestinal Barrier.
Wang L, Wang J
Oxidative medicine and cellular longevity 2022;2022:1755608
Oxidative medicine and cellular longevity 2022;2022:1755608
Targeting USP9X-AMPK Axis in ARID1A-Deficient Hepatocellular Carcinoma.
Zhang FK, Ni QZ, Wang K, Cao HJ, Guan DX, Zhang EB, Ma N, Wang YK, Zheng QW, Xu S, Zhu B, Chen TW, Xia J, Qiu XS, Ding XF, Jiang H, Qiu L, Wang X, Chen W, Cheng SQ, Xie D, Li JJ
Cellular and molecular gastroenterology and hepatology 2022;14(1):101-127
Cellular and molecular gastroenterology and hepatology 2022;14(1):101-127
Photobiomodulation promotes repair following spinal cord injury by restoring neuronal mitochondrial bioenergetics via AMPK/PGC-1α/TFAM pathway.
Zhu Z, Wang X, Song Z, Zuo X, Ma Y, Zhang Z, Ju C, Liang Z, Li K, Hu X, Wang Z
Frontiers in pharmacology 2022;13:991421
Frontiers in pharmacology 2022;13:991421
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274
Frontiers in pharmacology 2022;13:1007274
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
Yu C, Liu S, Niu Y, Fu L
The Journal of nutritional biochemistry 2022 Sep;107:109059
The Journal of nutritional biochemistry 2022 Sep;107:109059
Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function.
He L, Zhou X, Wu Z, Feng Y, Liu D, Li T, Yin Y
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Sep;10:137-147
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2022 Sep;10:137-147
Mitigation of honokiol on fluoride-induced mitochondrial oxidative stress, mitochondrial dysfunction, and cognitive deficits through activating AMPK/PGC-1α/Sirt3.
Wang D, Cao L, Zhou X, Wang G, Ma Y, Hao X, Fan H
Journal of hazardous materials 2022 Sep 5;437:129381
Journal of hazardous materials 2022 Sep 5;437:129381
Hepatic AMPK signaling dynamic activation in response to REDOX balance are sentinel biomarkers of exercise and antioxidant intervention to improve blood glucose control.
Wu M, Zhao A, Yan X, Gao H, Zhang C, Liu X, Luo Q, Xie F, Liu S, Shi D
eLife 2022 Sep 26;11
eLife 2022 Sep 26;11
A Photoannealed Granular Hydrogel Facilitating Hyaline Cartilage Regeneration via Improving Chondrogenic Phenotype.
Zhu Y, Sun Y, Rui B, Lin J, Shen J, Xiao H, Liu X, Chai Y, Xu J, Yang Y
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
ACS applied materials & interfaces 2022 Sep 14;14(36):40674-40687
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Long-Term Protein Restriction Modulates Lipid Metabolism in White Adipose Tissues and Alters Colonic Microbiota of Shaziling Pigs.
Zheng J, Duan Y, Zheng C, Yu J, Li F, Guo Q, Yin Y
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
Animals : an open access journal from MDPI 2022 Oct 26;12(21)
Copper Depletion Strongly Enhances Ferroptosis via Mitochondrial Perturbation and Reduction in Antioxidative Mechanisms.
Li F, Wu X, Liu H, Liu M, Yue Z, Wu Z, Liu L, Li F
Antioxidants (Basel, Switzerland) 2022 Oct 22;11(11)
Antioxidants (Basel, Switzerland) 2022 Oct 22;11(11)
RhFGF21 Protects Epidermal Cells against UVB-Induced Apoptosis through Activating AMPK-Mediated Autophagy.
Zhao Y, Lin J, Li J, Bwalya C, Xu Y, Niu Y, Zhang Y, Wu J, Xu Y, Chen J, Ye S, Lin L
International journal of molecular sciences 2022 Oct 18;23(20)
International journal of molecular sciences 2022 Oct 18;23(20)
Trpc5-regulated AMPKα/mTOR autophagy pathway is associated with glucose metabolism disorders in low birth weight mice under overnutrition.
Zhou F, Yang L, Yang L, Wang X, Guo N, Sun W, Ma H
Biochemical and biophysical research communications 2022 Nov 19;630:1-7
Biochemical and biophysical research communications 2022 Nov 19;630:1-7
Empagliflozin inhibits macrophage inflammation through AMPK signaling pathway and plays an anti-atherosclerosis role.
Fu J, Xu H, Wu F, Tu Q, Dong X, Xie H, Cao Z
International journal of cardiology 2022 Nov 15;367:56-62
International journal of cardiology 2022 Nov 15;367:56-62
Metformin can mitigate skeletal dysplasia caused by Pck2 deficiency.
Li Z, Yue M, Heng BC, Liu Y, Zhang P, Zhou Y
International journal of oral science 2022 Nov 15;14(1):54
International journal of oral science 2022 Nov 15;14(1):54
Ginsenoside Rd ameliorates high glucose-induced retinal endothelial injury through AMPK-STRT1 interdependence.
Tang K, Qin W, Wei R, Jiang Y, Fan L, Wang Z, Tan N
Pharmacological research 2022 May;179:106123
Pharmacological research 2022 May;179:106123
Stanniocalcin2 inhibits the epithelial-mesenchymal transition and invasion of trophoblasts via activation of autophagy under high-glucose conditions.
Lai R, Ji L, Zhang X, Xu Y, Zhong Y, Chen L, Hu H, Wang L
Molecular and cellular endocrinology 2022 May 1;547:111598
Molecular and cellular endocrinology 2022 May 1;547:111598
Thioredoxin upregulation delays diabetes-induced photoreceptor cell degeneration via AMPK-mediated autophagy and exosome secretion.
Ren X, Lv J, Wang N, Liu J, Gao C, Wu X, Yu Y, Teng Q, Dong W, Kong H, Kong L
Diabetes research and clinical practice 2022 Mar;185:109788
Diabetes research and clinical practice 2022 Mar;185:109788
Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect.
Wang Q, Wang L, Abdullah, Tian W, Song M, Cao Y, Xiao J
Food & function 2022 Mar 21;13(6):3419-3430
Food & function 2022 Mar 21;13(6):3419-3430
Adiponectin Alleviates Intestinal Fibrosis by Enhancing AMP-Activated Protein Kinase Phosphorylation.
Xie M, Xiong Z, Yin S, Xiong J, Li X, Jin L, Zhang F, Chen H, Lan P, Lian L
Digestive diseases and sciences 2022 Jun;67(6):2232-2243
Digestive diseases and sciences 2022 Jun;67(6):2232-2243
Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome.
Xiao N, Wang J, Wang T, Xiong X, Zhou J, Su X, Peng J, Yang C, Li X, Lin G, Lu G, Gong F, Cheng L
eLife 2022 Jun 24;11
eLife 2022 Jun 24;11
Capsaicin Attenuates Oleic Acid-Induced Lipid Accumulation via the Regulation of Circadian Clock Genes in HepG2 Cells.
Li R, Xiao J, Cao Y, Huang Q, Ho CT, Lu M
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Journal of agricultural and food chemistry 2022 Jan 26;70(3):794-803
Metformin and MiR-365 synergistically promote the apoptosis of gastric cancer cells via MiR-365-PTEN-AMPK axis.
Huang F, Xiang Y, Li T, Huang Y, Wang J, Zhang HM, Li HH, Dai ZT, Li JP, Li H, Zhou J, Liao XH
Pathology, research and practice 2022 Feb;230:153740
Pathology, research and practice 2022 Feb;230:153740
Ginsenoside CK ameliorates hepatic lipid accumulation via activating the LKB1/AMPK pathway in vitro and in vivo.
Zhang J, Ma X, Fan D
Food & function 2022 Feb 7;13(3):1153-1167
Food & function 2022 Feb 7;13(3):1153-1167
Mdivi-1 improves postoperative neurocognitive disorders in aged rats undergoing splenectomy by inhibiting dynamin-related protein-1.
Lin N, Jin JW, Lai ZM, Zhang DF, Chen Y, Guo HG, Liu JL
Annals of translational medicine 2022 Dec;10(24):1338
Annals of translational medicine 2022 Dec;10(24):1338
Metformin mitigates cholesterol accumulation via the AMPK/SIRT1 pathway to protect osteoarthritis chondrocytes.
Xing H, Liang C, Wang C, Xu X, Hu Y, Qiu B
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
Biochemical and biophysical research communications 2022 Dec 3;632:113-121
Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion.
Wang JQ, Li LL, Hu A, Deng G, Wei J, Li YF, Liu YB, Lu XY, Qiu ZP, Shi XJ, Zhao X, Luo J, Song BL
Nature 2022 Aug;608(7922):413-420
Nature 2022 Aug;608(7922):413-420
Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK/NF-κB/NLRP3 pathway.
Wang Z, Li C, He X, Xu K, Xue Z, Wang T, Xu Z, Liu X
Food & function 2022 Apr 4;13(7):3946-3956
Food & function 2022 Apr 4;13(7):3946-3956
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Wu M, Cong Y, Wang K, Yu H, Zhang X, Ma M, Duan Z, Pei X
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
GLP-1-Induced AMPK Activation Inhibits PARP-1 and Promotes LXR-Mediated ABCA1 Expression to Protect Pancreatic β-Cells Against Cholesterol-Induced Toxicity Through Cholesterol Efflux.
Li R, Sun X, Li P, Li W, Zhao L, Zhu L, Zhu S
Frontiers in cell and developmental biology 2021;9:646113
Frontiers in cell and developmental biology 2021;9:646113
Qingjie Fuzheng Granule Inhibits EMT and Induces Autophagy in Colorectal Cancer via mTOR Signaling Pathways.
Zhu X, Chen Y, Lin M, Huang B, Lin J
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
Evidence-based complementary and alternative medicine : eCAM 2021;2021:9950499
Effects of Fluorine on Neutrophil Extracellular Trap Formation through Regulating AMPK/p38 Signaling Pathway.
Song Y, Zhang Y, Zhang P, Yu P, Shang X, Lu Y, Li Y, Gao H
Oxidative medicine and cellular longevity 2021;2021:6693921
Oxidative medicine and cellular longevity 2021;2021:6693921
Geniposide from Gardenia jasminoides var. radicans Makino Attenuates Myocardial Injury in Spontaneously Hypertensive Rats via Regulating Apoptotic and Energy Metabolism Signalling Pathway.
Hou Y, Yuan P, Fu Y, Zhang Q, Gao L, Wei Y, Zheng X, Feng W
Drug design, development and therapy 2021;15:949-962
Drug design, development and therapy 2021;15:949-962
Geniposide Combined With Notoginsenoside R1 Attenuates Inflammation and Apoptosis in Atherosclerosis via the AMPK/mTOR/Nrf2 Signaling Pathway.
Liu X, Xu Y, Cheng S, Zhou X, Zhou F, He P, Hu F, Zhang L, Chen Y, Jia Y
Frontiers in pharmacology 2021;12:687394
Frontiers in pharmacology 2021;12:687394
NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway.
Zhao Y, Ye S, Lin J, Liang F, Chen J, Hu J, Chen K, Fang Y, Chen X, Xiong Y, Lin L, Tan X
Frontiers in pharmacology 2021;12:680351
Frontiers in pharmacology 2021;12:680351
Compound essential oils relieve oxidative stress caused by PM(2) (.5) exposure by inhibiting autophagy through the AMPK/mTOR pathway.
Ren F, Xu X, Xu J, Mei Y, Zhang J, Wang X, Li F
Environmental toxicology 2021 Sep;36(9):1765-1774
Environmental toxicology 2021 Sep;36(9):1765-1774
Simvastatin-romidepsin combination kills bladder cancer cells synergistically.
Okubo K, Miyai K, Kato K, Asano T, Sato A
Translational oncology 2021 Sep;14(9):101154
Translational oncology 2021 Sep;14(9):101154
Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice.
Bai X, Zhang X, Fang R, Wang J, Ma Y, Liu Z, Dong H, Li Q, Ge J, Yu M, Fei J, Sun R, Huang F
Aging 2021 Sep 20;13(18):22390-22411
Aging 2021 Sep 20;13(18):22390-22411
Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis.
Xing Y, Ren X, Li X, Sui L, Shi X, Sun Y, Quan C, Xiu Z, Dong Y
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Journal of agricultural and food chemistry 2021 Sep 1;69(34):9822-9836
Adiponectin regulates osteocytic MLO-Y4 cell apoptosis in a high-glucose environment through the AMPK/FoxO3a signaling pathway.
Zeng Y, Liang H, Guo Y, Feng Y, Yao Q
Journal of cellular physiology 2021 Oct;236(10):7088-7096
Journal of cellular physiology 2021 Oct;236(10):7088-7096
Co-modification with MSC membrane and PDA prevents Fe(3)O(4)-induced pulmonary toxicity in mice via AMPK-ULK1 axis.
Yao H, Yan J, Shao P, Wang Y, Liu T, Jiang J, Liu T
Toxicology letters 2021 Oct 15;351:145-154
Toxicology letters 2021 Oct 15;351:145-154
Exercise Intervention Mitigates Pathological Liver Changes in NAFLD Zebrafish by Activating SIRT1/AMPK/NRF2 Signaling.
Zou Y, Chen Z, Sun C, Yang D, Zhou Z, Peng X, Zheng L, Tang C
International journal of molecular sciences 2021 Oct 10;22(20)
International journal of molecular sciences 2021 Oct 10;22(20)
SIRT3 affects mitochondrial metabolic reprogramming via the AMPK-PGC-1α axis in the development of benign prostatic hyperplasia.
Li Y, Wang Q, Li J, Shi B, Liu Y, Wang P
The Prostate 2021 Nov;81(15):1135-1148
The Prostate 2021 Nov;81(15):1135-1148
Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart.
Chen Z, Zhou Z, Peng X, Sun C, Yang D, Li C, Zhu R, Zhang P, Zheng L, Tang C
The journal of physiological sciences : JPS 2021 Nov 8;71(1):33
The journal of physiological sciences : JPS 2021 Nov 8;71(1):33
The AMPK-MFN2 axis regulates MAM dynamics and autophagy induced by energy stresses.
Hu Y, Chen H, Zhang L, Lin X, Li X, Zhuang H, Fan H, Meng T, He Z, Huang H, Gong Q, Zhu D, Xu Y, He P, Li L, Feng D
Autophagy 2021 May;17(5):1142-1156
Autophagy 2021 May;17(5):1142-1156
Angiotensin II-mediated improvement of renal mitochondrial function via the AMPK/PGC-1α/NRF-2 pathway is superior to norepinephrine in a rat model of septic shock associated with acute renal injury.
An H, Hu Z, Chen Y, Cheng L, Shi J, Han L
Annals of translational medicine 2021 Mar;9(6):481
Annals of translational medicine 2021 Mar;9(6):481
Metformin attenuates hyperlipidaemia-associated vascular calcification through anti-ferroptotic effects.
Ma WQ, Sun XJ, Zhu Y, Liu NF
Free radical biology & medicine 2021 Mar;165:229-242
Free radical biology & medicine 2021 Mar;165:229-242
The antitumor role of a newly discovered α-d-glucan from Holotrichia diomphalia Bates as a selective blocker of aldolase A.
Wang J, Li Z, Yang X, Qiao Y, Feng C, Yu S, Jing H, Liu W, Ren L, Duan Q, Li XQ, Cao W
Carbohydrate polymers 2021 Mar 1;255:117532
Carbohydrate polymers 2021 Mar 1;255:117532
Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE(-/-) mice.
Wu H, Feng K, Zhang C, Zhang H, Zhang J, Hua Y, Dong Z, Zhu Y, Yang S, Ma C
Biochemical and biophysical research communications 2021 Jun 11;557:334-341
Biochemical and biophysical research communications 2021 Jun 11;557:334-341
Selenium triggers Nrf2-AMPK crosstalk to alleviate cadmium-induced autophagy in rabbit cerebrum.
Xue H, Cao H, Xing C, Feng J, Zhang L, Zhang C, Hu G, Yang F
Toxicology 2021 Jul;459:152855
Toxicology 2021 Jul;459:152855
SCF(JFK) is functionally linked to obesity and metabolic syndrome.
He L, Yan R, Yang Z, Zhang Y, Liu X, Yang J, Liu X, Liu X, Xia L, Wang Y, Wu J, Wu X, Shan L, Yang X, Liang J, Shang Y, Sun L
EMBO reports 2021 Jul 5;22(7):e52036
EMBO reports 2021 Jul 5;22(7):e52036
A rapid juvenile murine model of nonalcoholic steatohepatitis (NASH): Chronic intermittent hypoxia exacerbates Western diet-induced NASH.
Zhou J, Zhao Y, Guo YJ, Zhao YS, Liu H, Ren J, Li JR, Ji ES
Life sciences 2021 Jul 1;276:119403
Life sciences 2021 Jul 1;276:119403
Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses.
Gong X, Li T, Wan R, Sha L
International immunopharmacology 2021 Feb;91:107173
International immunopharmacology 2021 Feb;91:107173
The Dual Histone Deacetylase-Proteasome Inhibitor RTS-V5 Acts Synergistically With Ritonavir to Induce Endoplasmic Reticulum Stress in Bladder Cancer Cells.
Okubo K, REßING N, Schulz WA, Hansen FK, Asano T, Sato A
Anticancer research 2021 Dec;41(12):5987-5996
Anticancer research 2021 Dec;41(12):5987-5996
Naringin induces skeletal muscle fiber type transformation via AMPK/PGC-1α signaling pathway in mice and C2C12 myotubes.
Xue Y, Huang Z, Chen X, Jia G, Zhao H, Liu G
Nutrition research (New York, N.Y.) 2021 Aug;92:99-108
Nutrition research (New York, N.Y.) 2021 Aug;92:99-108
Danqi Tablet () Regulates Energy Metabolism in Ischemic Heart Rat Model through AMPK/SIRT1-PGC-1α Pathway.
Meng H, Wang QY, Li N, He H, Lu WJ, Wang QX, Sun XQ, Jiao SH, Wang Y, Tu PF
Chinese journal of integrative medicine 2021 Aug;27(8):597-603
Chinese journal of integrative medicine 2021 Aug;27(8):597-603
Fisetin mitigates hepatic ischemia-reperfusion injury by regulating GSK3β/AMPK/NLRP3 inflammasome pathway.
Pu JL, Huang ZT, Luo YH, Mou T, Li TT, Li ZT, Wei XF, Wu ZJ
Hepatobiliary & pancreatic diseases international : HBPD INT 2021 Aug;20(4):352-360
Hepatobiliary & pancreatic diseases international : HBPD INT 2021 Aug;20(4):352-360
Ginsenoside Rg5 Improves Insulin Resistance and Mitochondrial Biogenesis of Liver via Regulation of the Sirt1/PGC-1α Signaling Pathway in db/db Mice.
Zhu Y, Yang H, Deng J, Fan D
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Journal of agricultural and food chemistry 2021 Aug 4;69(30):8428-8439
Graphene oxide disrupted mitochondrial homeostasis through inducing intracellular redox deviation and autophagy-lysosomal network dysfunction in SH-SY5Y cells.
Xiaoli F, Yaqing Z, Ruhui L, Xuan L, Aijie C, Yanli Z, Chen H, Lili C, Longquan S
Journal of hazardous materials 2021 Aug 15;416:126158
Journal of hazardous materials 2021 Aug 15;416:126158
Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish.
Sun CC, Zhou ZQ, Chen ZL, Zhu RK, Yang D, Peng XY, Zheng L, Tang CF
Biology 2021 Aug 10;10(8)
Biology 2021 Aug 10;10(8)
The protective role of Zingerone in a murine asthma model via activation of the AMPK/Nrf2/HO-1 pathway.
Zhu Y, Wang C, Luo J, Hua S, Li D, Peng L, Liu H, Song L
Food & function 2021 Apr 7;12(7):3120-3131
Food & function 2021 Apr 7;12(7):3120-3131
Environmentally relevant concentration of sulfamethoxazole-induced oxidative stress-cascaded damages in the intestine of grass carp and the therapeutic application of exogenous lycopene.
Wang Y, Zhao H, Liu Y, Li J, Nie X, Huang P, Xing M
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
Environmental pollution (Barking, Essex : 1987) 2021 Apr 1;274:116597
Chicoric Acid Ameliorates Nonalcoholic Fatty Liver Disease via the AMPK/Nrf2/NFκB Signaling Pathway and Restores Gut Microbiota in High-Fat-Diet-Fed Mice.
Ding X, Jian T, Li J, Lv H, Tong B, Li J, Meng X, Ren B, Chen J
Oxidative medicine and cellular longevity 2020;2020:9734560
Oxidative medicine and cellular longevity 2020;2020:9734560
Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway.
Jiang X, Ruan XL, Xue YX, Yang S, Shi M, Wang LN
Oxidative medicine and cellular longevity 2020;2020:8708236
Oxidative medicine and cellular longevity 2020;2020:8708236
FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway.
Zhou B, Qiu Y, Wu N, Chen AD, Zhou H, Chen Q, Kang YM, Li YH, Zhu GQ
Oxidative medicine and cellular longevity 2020;2020:6384803
Oxidative medicine and cellular longevity 2020;2020:6384803
CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism.
Xie T, Wang C, Jin Y, Meng Q, Liu Q, Wu J, Sun H
Frontiers in pharmacology 2020;11:1034
Frontiers in pharmacology 2020;11:1034
Solasonine Suppresses the Proliferation of Acute Monocytic Leukemia Through the Activation of the AMPK/FOXO3A Axis.
Zhang H, Tian F, Jiang P, Qian S, Dai X, Ma B, Wang M, Dai H, Sha X, Yang Z, Zhu X, Sun X
Frontiers in oncology 2020;10:614067
Frontiers in oncology 2020;10:614067
S -1-Propenylcysteine, a sulfur compound in aged garlic extract, alleviates cold-induced reduction in peripheral blood flow in rat via activation of the AMPK/eNOS/NO pathway.
Ushijima M, Kunimura K, Suzuki JI
Experimental and therapeutic medicine 2020 Sep;20(3):2815-2821
Experimental and therapeutic medicine 2020 Sep;20(3):2815-2821
The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models.
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, Kong W, Kong W
Experimental cell research 2020 Sep 1;394(1):112093
Experimental cell research 2020 Sep 1;394(1):112093
Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L
Metabolism: clinical and experimental 2020 Oct;111:154334
Metabolism: clinical and experimental 2020 Oct;111:154334
The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization.
Ye W, Wang J, Lin D, Ding Z
International journal of biological macromolecules 2020 Mar 1;146:25-35
International journal of biological macromolecules 2020 Mar 1;146:25-35
BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer.
Liu JZ, Hu YL, Feng Y, Jiang Y, Guo YB, Liu YF, Chen X, Yang JL, Chen YY, Mao QS, Xue WJ
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
Journal of experimental & clinical cancer research : CR 2020 Jun 30;39(1):123
COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma.
Chu YD, Lin WR, Lin YH, Kuo WH, Tseng CJ, Lim SN, Huang YL, Huang SC, Wu TJ, Lin KH, Yeh CT
Cancers 2020 Jun 22;12(6)
Cancers 2020 Jun 22;12(6)
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells.
Okubo K, Isono M, Miyai K, Asano T, Sato A
Cancer science 2020 Jan;111(1):112-126
Cancer science 2020 Jan;111(1):112-126
UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop.
Liu X, Ma F, Liu C, Zhu K, Li W, Xu Y, Li G, Niu Z, Liu J, Chen D, Li Z, Fu Y, Qian C
Cell death & disease 2020 Jan 6;11(1):10
Cell death & disease 2020 Jan 6;11(1):10
Anti-insulin resistance effects of salidroside through mitochondrial quality control.
You B, Dun Y, Zhang W, Jiang L, Li H, Xie M, Liu Y, Liu S
The Journal of endocrinology 2020 Feb;244(2):383-393
The Journal of endocrinology 2020 Feb;244(2):383-393
Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis.
Lu XY, Shi XJ, Hu A, Wang JQ, Ding Y, Jiang W, Sun M, Zhao X, Luo J, Qi W, Song BL
Nature 2020 Dec;588(7838):479-484
Nature 2020 Dec;588(7838):479-484
Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration.
Lv J, Bao S, Liu T, Wei L, Wang D, Ye W, Wang N, Song S, Li J, Chudhary M, Ren X, Kong L
Cell and tissue research 2020 Dec;382(3):477-486
Cell and tissue research 2020 Dec;382(3):477-486
Galectin-3 expression and secretion by tumor-associated macrophages in hypoxia promotes breast cancer progression.
Wang L, Li YS, Yu LG, Zhang XK, Zhao L, Gong FL, Yang XX, Guo XL
Biochemical pharmacology 2020 Aug;178:114113
Biochemical pharmacology 2020 Aug;178:114113
Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice.
Wang C, Le Y, Lu D, Zhao M, Dou X, Zhang Q
Journal of hazardous materials 2020 Apr 15;388:121732
Journal of hazardous materials 2020 Apr 15;388:121732
The balance of apoptosis and autophagy via regulation of the AMPK signal pathway in aging rat striatum during regular aerobic exercise.
Liu W, Wang Z, Xia Y, Kuang H, Liu S, Li L, Tang C, Yin D
Experimental gerontology 2019 Sep;124:110647
Experimental gerontology 2019 Sep;124:110647
Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells.
Lu J, Meng Z, Cheng B, Liu M, Tao S, Guan S
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
Experimental and therapeutic medicine 2019 Oct;18(4):2965-2971
Lopinavir-Ritonavir Combination Induces Endoplasmic Reticulum Stress and Kills Urological Cancer Cells.
Okubo K, Isono M, Asano T, Sato A
Anticancer research 2019 Nov;39(11):5891-5901
Anticancer research 2019 Nov;39(11):5891-5901
Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling.
Meng Z, Liu Q, Sun F, Qiao L
Lipids in health and disease 2019 Nov 4;18(1):191
Lipids in health and disease 2019 Nov 4;18(1):191
Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy.
Chen C, Jiang L, Zhang M, Pan X, Peng C, Huang W, Jiang Q
Food & function 2019 May 22;10(5):2651-2657
Food & function 2019 May 22;10(5):2651-2657
Effect of CAPE-pNO(2) against type 2 diabetes mellitus via the AMPK/GLUT4/ GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice.
Li S, Huang Q, Zhang L, Qiao X, Zhang Y, Tang F, Li Z
European journal of pharmacology 2019 Jun 15;853:1-10
European journal of pharmacology 2019 Jun 15;853:1-10
APS could potentially activate hepatic insulin signaling in HFD-induced IR mice.
Sun J, Liu Y, Yu J, Wu J, Gao W, Ran L, Jiang R, Guo M, Han D, Liu B, Wang N, Li Y, Huang H, Zeng L, Gao Y, Li X, Wu Y
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Journal of molecular endocrinology 2019 Jul;63(1):77-91
Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway.
Wang H, Zhong P, Sun L
Biology open 2019 Jul 17;8(7)
Biology open 2019 Jul 17;8(7)
The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming.
Yang Y, Zhu G, Dong B, Piao J, Chen L, Lin Z
Cancer letters 2019 Jul 1;453:170-183
Cancer letters 2019 Jul 1;453:170-183
Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis.
Ma WQ, Sun XJ, Wang Y, Zhu Y, Han XQ, Liu NF
Molecular and cellular endocrinology 2019 Jan 5;479:39-53
Molecular and cellular endocrinology 2019 Jan 5;479:39-53
Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria.
Han X, Zhang Y, Guo J, You Y, Zhan J, Huang W
Journal of food science 2019 Dec;84(12):3815-3824
Journal of food science 2019 Dec;84(12):3815-3824
Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells.
Bao H, Zhang Q, Liu X, Song Y, Li X, Wang Z, Li C, Peng A, Gong R
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):14370-14381
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Dec;33(12):14370-14381
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov LN, Zhang X, Ma H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology.
Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, Zhang H, Chai Y
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
Evidence-based complementary and alternative medicine : eCAM 2018;2018:6503126
Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy.
Fang J, Zhu Y, Wang H, Cao B, Fei M, Niu W, Zhou Y, Wang X, Li X, Zhou M
Frontiers in neuroscience 2018;12:1006
Frontiers in neuroscience 2018;12:1006
lncRNA DLEU1 contributes to tumorigenesis and development of endometrial carcinoma by targeting mTOR.
Du Y, Wang L, Chen S, Liu Y, Zhao Y
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Molecular carcinogenesis 2018 Sep;57(9):1191-1200
Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice.
Guo XF, Sinclair AJ, Kaur G, Li D
Prostaglandins, leukotrienes, and essential fatty acids 2018 Sep;136:47-55
Prostaglandins, leukotrienes, and essential fatty acids 2018 Sep;136:47-55
Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress.
Okubo K, Isono M, Asano T, Sato A
Anticancer research 2018 Oct;38(10):5615-5626
Anticancer research 2018 Oct;38(10):5615-5626
Anti-hypertrophy effect of atorvastatin on myocardium depends on AMPK activation-induced miR-143-3p suppression via Foxo1.
Yu B, Liu D, Zhang H, Xie D, Nie W, Shi K, Yang P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1390-1395
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Oct;106:1390-1395
Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model.
Lee HW, Lee SM, Lee MH, Son YK, Kim SE, An WS
Marine drugs 2018 Oct 23;16(11)
Marine drugs 2018 Oct 23;16(11)
MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene.
Zeng N, Huang R, Li N, Jiang H, Li R, Wang F, Chen W, Xia M, Wang Q
Molecular and cellular endocrinology 2018 Oct 15;474:260-271
Molecular and cellular endocrinology 2018 Oct 15;474:260-271
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Dai J, Huang Q, Niu K, Wang B, Li Y, Dai C, Chen Z, Tao K, Dai J
Cancer medicine 2018 Nov;7(11):5691-5703
Cancer medicine 2018 Nov;7(11):5691-5703
3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5.
Chen Y, Wei L, Zhang X, Liu X, Chen Y, Zhang S, Zhou L, Li Q, Pan Q, Zhao S, Liu H
Oncology reports 2018 Nov;40(5):2435-2444
Oncology reports 2018 Nov;40(5):2435-2444
The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN).
Gao J, Xiong R, Xiong D, Zhao W, Zhang S, Yin T, Zhang X, Jiang G, Yin Z
Medical science monitor : international medical journal of experimental and clinical research 2018 Nov 26;24:8533-8543
Medical science monitor : international medical journal of experimental and clinical research 2018 Nov 26;24:8533-8543
Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration.
Luo X, Wang D, Zhu X, Wang G, You Y, Ning Z, Li Y, Jin S, Huang Y, Hu Y, Chen T, Meng Y, Li X
Cell death & disease 2018 May 1;9(5):576
Cell death & disease 2018 May 1;9(5):576
Nelfinavir and Ritonavir Kill Bladder Cancer Cells Synergistically by Inducing Endoplasmic Reticulum Stress.
Sato A, Asano T, Okubo K, Isono M, Asano T
Oncology research 2018 Mar 5;26(2):323-332
Oncology research 2018 Mar 5;26(2):323-332
AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis.
Liu JQ, Zhang L, Yao J, Yao S, Yuan T
Biochemical and biophysical research communications 2018 Mar 4;497(2):564-570
Biochemical and biophysical research communications 2018 Mar 4;497(2):564-570
Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells.
Isono M, Sato A, Asano T, Okubo K, Asano T
Anticancer research 2018 Jun;38(6):3493-3500
Anticancer research 2018 Jun;38(6):3493-3500
Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo.
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, Han X, Liu K, Peng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jan;97:481-488
LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress.
Cheng G, Li B, Sun X, Cao Z, Zhang G, Zhao Z, Zhao Y, Yu Q, Liu W
Biochemical and biophysical research communications 2018 Jan 29;496(1):1-6
Biochemical and biophysical research communications 2018 Jan 29;496(1):1-6
Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPKα1/SIRT1 pathway.
Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, Wang L, Gao D, Tian X, Yao J
Toxicology and applied pharmacology 2018 Jan 15;339:172-180
Toxicology and applied pharmacology 2018 Jan 15;339:172-180
Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells.
Li CF, Sun JX, Gao Y, Shi F, Pan YK, Wang YC, Sun XQ
Cell death & disease 2018 Feb 2;9(2):147
Cell death & disease 2018 Feb 2;9(2):147
Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism.
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, Bai F, Sun X, Lin X, Wei J
International immunopharmacology 2018 Dec;65:256-267
International immunopharmacology 2018 Dec;65:256-267
9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells.
Cao S, Yu S, Cheng L, Yan J, Zhu Y, Deng Y, Qiu F, Kang N
Environmental toxicology and pharmacology 2018 Dec;64:11-17
Environmental toxicology and pharmacology 2018 Dec;64:11-17
1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells.
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, Guan S
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 Dec;122:143-150
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway.
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, Liu K, Sun H
Pharmacological research 2018 Apr;130:466-480
Pharmacological research 2018 Apr;130:466-480
Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats.
Cao M, Fang J, Wang X, Wang Y, Duan K, Ye F, Ouyang W, Tong J
Brain research 2018 Apr 1;1684:21-29
Brain research 2018 Apr 1;1684:21-29
Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control.
Dun Y, Liu S, Zhang W, Xie M, Qiu L
Oxidative medicine and cellular longevity 2017;2017:8024857
Oxidative medicine and cellular longevity 2017;2017:8024857
Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio).
Ran G, Ying L, Li L, Yan Q, Yi W, Ying C, Wu H, Ye X
PloS one 2017;12(7):e0180865
PloS one 2017;12(7):e0180865
SIRT1/PGC-1α Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats.
Zhou Y, Wang S, Li Y, Yu S, Zhao Y
Frontiers in molecular neuroscience 2017;10:443
Frontiers in molecular neuroscience 2017;10:443
Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration.
Luo X, Dan Wang, Luo X, Zhu X, Wang G, Ning Z, Li Y, Ma X, Yang R, Jin S, Huang Y, Meng Y, Li X
Redox biology 2017 Oct;13:508-521
Redox biology 2017 Oct;13:508-521
Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells.
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, Tan N
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Molecules (Basel, Switzerland) 2017 Nov 11;22(11)
Chronic metformin treatment facilitates seizure termination.
Yang Y, Zhu B, Zheng F, Li Y, Zhang Y, Hu Y, Wang X
Biochemical and biophysical research communications 2017 Mar 4;484(2):450-455
Biochemical and biophysical research communications 2017 Mar 4;484(2):450-455
Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells.
La X, Zhang L, Li Z, Yang P, Wang Y
Oncotarget 2017 Mar 28;8(13):20909-20924
Oncotarget 2017 Mar 28;8(13):20909-20924
AMPK/α-Ketoglutarate Axis Regulates Intestinal Water and Ion Homeostasis in Young Pigs.
He L, Huang N, Li H, Tian J, Zhou X, Li T, Yao K, Wu G, Yin Y
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
Journal of agricultural and food chemistry 2017 Mar 22;65(11):2287-2298
AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice.
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, Shi D, Dai J, Li J, Ju H, Cao Y, Qin J, Chen S, Teng H, Jiang Q
Scientific reports 2017 Feb 22;7:43245
Scientific reports 2017 Feb 22;7:43245
AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats.
Li D, Ye F, Ouyang W, Wang Y
Journal of anesthesia 2017 Dec;31(6):806-812
Journal of anesthesia 2017 Dec;31(6):806-812
Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.
Li M, Jin C, Xu M, Zhou L, Li D, Yin Y
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Cell communication and signaling : CCS 2017 Dec 16;15(1):52
Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, Dong S, Yang F, Zhang L, Zhong X, Xu C, Lu F, Zhang W
Cell & bioscience 2016;6:33
Cell & bioscience 2016;6:33
The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats.
Xia C, Zhu L, Shao W, Mi S, Du S, Ye L, Liu M, Pang Y, Nong L, Jiang C, Zhao H, Qi G
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38(2):609-18
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2016;38(2):609-18
Activation of AMPK α2 inhibits airway smooth muscle cells proliferation.
Liu L, Pan Y, Song Y, Su X, Ke R, Yang L, Gao L, Li M
European journal of pharmacology 2016 Nov 15;791:235-243
European journal of pharmacology 2016 Nov 15;791:235-243
Knockdown of AMPKα2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway.
Ke R, Liu L, Zhu Y, Li S, Xie X, Li F, Song Y, Yang L, Gao L, Li M
International journal of molecular sciences 2016 May 31;17(6)
International journal of molecular sciences 2016 May 31;17(6)
Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis.
Liu Q, Yuan W, Tong D, Liu G, Lan W, Zhang D, Xiao H, Zhang Y, Huang Z, Yang J, Zhang J, Jiang J
Oncotarget 2016 May 10;7(19):28235-46
Oncotarget 2016 May 10;7(19):28235-46
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Li L, Xiao L, Hou Y, He Q, Zhu J, Li Y, Wu J, Zhao J, Yu S, Zhao Y
Scientific reports 2016 Jul 25;6:30272
Scientific reports 2016 Jul 25;6:30272
Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes.
Dong K, Wu M, Liu X, Huang Y, Zhang D, Wang Y, Yan LJ, Shi D
Free radical biology & medicine 2016 Dec;101:334-347
Free radical biology & medicine 2016 Dec;101:334-347
Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration.
Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y
International journal of clinical and experimental pathology 2015;8(12):15836-44
International journal of clinical and experimental pathology 2015;8(12):15836-44
AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.
Zhu K, Chen X, Liu J, Ye H, Zhu L, Wu JY
Protein & cell 2013 Feb;4(2):155-61
Protein & cell 2013 Feb;4(2):155-61
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 10929-2-AP(PRKAA1 antibody) at dilution of 1:300
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AMPK alpha 1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human AMPK alpha 1. This antibody recognizes human,mouse,rat antigen. The AMPK alpha 1 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 10929-2-AP(PRKAA1 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue