BS1713

antibody from Bioworld Technology, Inc

Targeting: HSD17B10 17b-HSD10, ABAD, CAMR, ERAB, HADH2, MHBD, MRPP2, MRXS10, SDR5C1

Immunohistochemistry

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Validation data

Product number: BS1713 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS1713, RRID:AB_1663148
Product name: ERAB (E135) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic peptide, corresponding to amino acids 102-150 of Human ERAB.
Description: ÉÇ-Amyloid is a neurotoxic peptide that is associated with the pathogenesis of Alzheimer£ªs disease. ÉÇ-Amyloid aggregates induce cell death of neurons through the disruption of cell membranes and the generation of reactive oxygen intermediates.These neurotoxic effects are also attributed to the interaction of ÉÇ-Amyloid with intracellular proteins, specifically ERAB, the endoplasmic reticulum-associated ÉÇ-Amyloid-binding protein. ERAB is characterized as a NAD+-dependent dehydrogenase that is constitutively expressed in tissues and overexpressed in neurons affected in Alzheimer£ªs disease. Cells overexpressing ERAB in vitro have been shown to be more sensitive to ÉÇ-Amyloid-induced stress, and blocking the activity of ERAB has been shown to inhibit this cell death, indicating that ÉÇ-Amyloid induced cell death is mediated by ERAB.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

HSD17B10 protein structure - BS1713 shown in red.