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LearnPAB4902
antibody from Abnova Corporation
Targeting: HSD17B10
17b-HSD10, ABAD, CAMR, ERAB, HADH2, MHBD, MRPP2, MRXS10, SDR5C1
Western blotAntibody data
- Antibody Data
- Antigen structure
- References [3]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- PAB4902 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB4902, RRID:AB_1575691
- Product name
- HSD17B10 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of HSD17B10.
- Storage
- Store at 4°C. For long term storage store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references ABAD enhances Abeta-induced cell stress via mitochondrial dysfunction.
Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics.
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Takuma K, Yao J, Huang J, Xu H, Chen X, Luddy J, Trillat AC, Stern DM, Arancio O, Yan SS
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 Apr;19(6):597-8
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005 Apr;19(6):597-8
Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics.
Kissinger CR, Rejto PA, Pelletier LA, Thomson JA, Showalter RE, Abreo MA, Agree CS, Margosiak S, Meng JJ, Aust RM, Vanderpool D, Li B, Tempczyk-Russell A, Villafranca JE
Journal of molecular biology 2004 Sep 17;342(3):943-52
Journal of molecular biology 2004 Sep 17;342(3):943-52
ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease.
Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H
Science (New York, N.Y.) 2004 Apr 16;304(5669):448-52
Science (New York, N.Y.) 2004 Apr 16;304(5669):448-52
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Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of HSD17B10 polyclonal antibody (Cat # PAB4902) in mouse kidney tissue lysate. HSD17B10 (arrow) was detected using the purified polyclonal antibody.
Supportive validation
- Submitted by
- Abnova Corporation (provider)
- Main image
- Experimental details
- Immunohistochemistry on formalin-fixed and paraffin-embedded human prostate tissue.(Top) Coloration with the HSD17B10 polyclonal antibody (Cat # PAB4902) at a 1 : 20 concentration.(Bottom) Antibody adsorbed to the antigen (peptide), negative control.Disappearance of cytoplasmic staining indicating the antibody is specific.Data and protocol courtesy of Marie-Helene Levesque, Centre de Recherche du CHUL, Canada.
- Validation comment
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
