Antibody data

Product number
BS2922 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PUMA (R169) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 132-183 of Human PUMA.
Description
PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAÏ«, ÉÇ, ÎÛ and Ñ´. Both PUMAÏ« and PUMAÉÇ contain a BH3 domain, while PUMAÎÛ and PUMAÑ´ lack this domain. The BH3 domain is essential for binding of PUMAÏ« and PUMAÉÇ to Bcl-2 or Bcl-xL. PUMA is an initiator of ÎÛ-radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic Ï«-helical BH3 region.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BBC3 protein structure - BS2922 shown in red.