Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS7818 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- IL1R1 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human IL1R1.
- Description
- Three structurally related ligands for IL-1Rs have been described. These include two agonists, IL-1Ï« and IL-1ÉÇ, and a specific receptor antagonist, IL-1RÏ«. Among the activities regulated by IL-1 are fever, acute phase responses, degradation of connective tissue and immunostimulatory activities. The IL-1RÏ« molecule also binds specifically to IL-1Rs, but fails to initiate intracellular responses. Two distinct IL-1Rs have been identified, each of which belongs to the Ig superfamily and is widely expressed in a broad range of cells and tissues. Although many cell types co-express type I and type II receptors, there is no evidence that these constitute subunits of a single complex. The type II receptor has a short 29 amino acid cytoplasmic domain that does not seem sufficient for signaling while in fact there is considerable evidence arguing that IL-1 signals exclusively through the type I IL-1R.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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