Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Flow cytometry [1]
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- AF269 - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal IL-1 RI Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human IL-1 RI in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Expression and function of IL-1R8 (TIR8/SIGIRR): a regulatory member of the IL-1 receptor family in platelets.
Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma.
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.
IL-1β promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes.
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Chorionic gonadotropin down-regulates the expression of the decoy inhibitory interleukin 1 receptor type II in human endometrial epithelial cells.
Interleukin 1 in oviductal tissues of viviparous, oviparous, and ovuliparous species of amphibians.
Anselmo A, Riva F, Gentile S, Soldani C, Barbagallo M, Mazzon C, Feruglio F, Polentarutti N, Somma P, Carullo P, Angelini C, Bacci M, Mendolicchio GL, Voza A, Nebuloni M, Mantovani A, Garlanda C
Cardiovascular research 2016 Sep;111(4):373-84
Cardiovascular research 2016 Sep;111(4):373-84
Crucial role of IL1beta and C3a in the in vitro-response of multipotent mesenchymal stromal cells to inflammatory mediators of polytrauma.
Hengartner NE, Fiedler J, Schrezenmeier H, Huber-Lang M, Brenner RE
PloS one 2015;10(1):e0116772
PloS one 2015;10(1):e0116772
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.
Mattiola I, Pesant M, Tentorio PF, Molgora M, Marcenaro E, Lugli E, Locati M, Mavilio D
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 15;195(6):2818-28
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 15;195(6):2818-28
IL-1β promotes the differentiation of polyfunctional human CCR6+CXCR3+ Th1/17 cells that are specific for pathogenic and commensal microbes.
Duhen T, Campbell DJ
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):120-9
Journal of immunology (Baltimore, Md. : 1950) 2014 Jul 1;193(1):120-9
Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β.
Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F
Nature 2012 Apr 26;484(7395):514-8
Nature 2012 Apr 26;484(7395):514-8
Chorionic gonadotropin down-regulates the expression of the decoy inhibitory interleukin 1 receptor type II in human endometrial epithelial cells.
Herrmann-Lavoie C, Rao CV, Akoum A
Endocrinology 2007 Nov;148(11):5377-84
Endocrinology 2007 Nov;148(11):5377-84
Interleukin 1 in oviductal tissues of viviparous, oviparous, and ovuliparous species of amphibians.
Jantra S, Bigliardi E, Brizzi R, Ietta F, Bechi N, Paulesu L
Biology of reproduction 2007 Jun;76(6):1009-15
Biology of reproduction 2007 Jun;76(6):1009-15
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of IL-1 RI in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were labeled with Human IL-1 RI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF269, filled histogram) or control antibody (Catalog # AB-108-C, open histogram), followed by Phycoerythrin-conjugated Anti-Goat IgG Secondary Antibody (Catalog # F0107).
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- CXCL1/GROa Secretion Induced by IL-1ß/IL-1F2 and Neutralization by Human IL-1 RI Antibody. CXCL1/GROa Secretion Induced by IL-1ß/IL-1F2 and Neutralization by Human IL-1 RI Antibody.