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Targeting: ATM
ATA, ATC, ATD, ATDC, TEL1, TELO1
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- GeneTex Cat#GTX70103, RRID:AB_368161
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- ATM antibody [2C1]
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- Monoclonal
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- Human, Mouse, Rat, Simian
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- Mouse
Submitted references Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair.
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells.
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis.
ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage.
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors.
Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS).
PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.
SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
ATM is required for SOD2 expression and homeostasis within the mammary gland.
RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy.
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.
Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.
Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.
An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL.
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
The dynamic behavior of Ect2 in response to DNA damage.
A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
ATM functions at the peroxisome to induce pexophagy in response to ROS.
Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.
DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.
BLM protein mitigates formaldehyde-induced genomic instability.
Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells.
Direct activation of ATM by resveratrol under oxidizing conditions.
Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.
Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.
Distinct DNA damage determines differential phosphorylation of Chk2.
Translational initiation regulated by ATM in dendritic cells development.
Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair.
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.
An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.
Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.
Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.
APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.
Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.
Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential.
MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer.
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.
A noncatalytic function of the ligation complex during nonhomologous end joining.
Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress.
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
Functional activation of ATM by the prostate cancer suppressor NKX3.1.
Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy.
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Deregulation of DNA damage response pathway by intercellular contact.
58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype.
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin.
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase.
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
A novel role for hSMG-1 in stress granule formation.
ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Autophosphorylation and ATM activation: additional sites add to the complexity.
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
ATM mediated phosphorylation of CHD4 contributes to genome maintenance.
Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM).
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Oligomerization of MDC1 protein is important for proper DNA damage response.
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.
Three-dimensional cell growth confers radioresistance by chromatin density modification.
Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Discovery of putative oocyte quality markers by comparative ExacTag proteomics.
Replication independent DNA double-strand break retention may prevent genomic instability.
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Low levels of ATM in breast cancer patients with clinical radiosensitivity.
Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.
ATM is down-regulated by N-Myc-regulated microRNA-421.
Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
ATM activation in the presence of oxidative stress.
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
NKX3.1 activates cellular response to DNA damage.
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.
ARTEMIS nuclease facilitates apoptotic chromatin cleavage.
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.
ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein.
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint.
Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage.
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors.
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
A subgroup of spinocerebellar ataxias defective in DNA damage responses.
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Regulation of the Atm promoter in vivo.
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.
EDD mediates DNA damage-induced activation of CHK2.
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Involvement of novel autophosphorylation sites in ATM activation.
Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.
Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.
Regulation of CHK2 by DNA-dependent protein kinase.
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.
Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation.
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo.
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Desferrioxamine treatment increases the genomic stability of Ataxia-telangiectasia cells.
Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation.
Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.
Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites.
HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Ku affects the ATM-dependent S phase checkpoint following ionizing radiation.
Specific recruitment of human cohesin to laser-induced DNA damage.
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.
Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer.
Sensing of intermediates in V(D)J recombination by ATM.
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.
Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients.
The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway.
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice.
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH
Cancers 2018 Sep 10;10(9)
Cancers 2018 Sep 10;10(9)
SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer.
Chen XF, Tian MX, Sun RQ, Zhang ML, Zhou LS, Jin L, Chen LL, Zhou WJ, Duan KL, Chen YJ, Gao C, Cheng ZL, Wang F, Zhang JY, Sun YP, Yu HX, Zhao YZ, Yang Y, Liu WR, Shi YH, Xiong Y, Guan KL, Ye D
EMBO reports 2018 May;19(5)
EMBO reports 2018 May;19(5)
7-hydroxy-staurosporine, UCN-01, induces DNA damage response, and autophagy in human osteosarcoma U2-OS cells.
Lien WC, Chen TY, Sheu SY, Lin TC, Kang FC, Yu CH, Kuan TS, Huang BM, Wang CY
Journal of cellular biochemistry 2018 Jun;119(6):4729-4741
Journal of cellular biochemistry 2018 Jun;119(6):4729-4741
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y
Toxicology letters 2018 Jul;291:92-100
Toxicology letters 2018 Jul;291:92-100
Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair.
Li Z, Li Y, Tang M, Peng B, Lu X, Yang Q, Zhu Q, Hou T, Li M, Liu C, Wang L, Xu X, Zhao Y, Wang H, Yang Y, Zhu WG
Cell research 2018 Jul;28(7):756-770
Cell research 2018 Jul;28(7):756-770
Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis.
Li FL, Liu JP, Bao RX, Yan G, Feng X, Xu YP, Sun YP, Yan W, Ling ZQ, Xiong Y, Guan KL, Yuan HX
Nature communications 2018 Feb 6;9(1):508
Nature communications 2018 Feb 6;9(1):508
ATM Is Required for the Prolactin-Induced HSP90-Mediated Increase in Cellular Viability and Clonogenic Growth After DNA Damage.
Karayazi Atici Ö, Urbanska A, Gopinathan SG, Boutillon F, Goffin V, Shemanko CS
Endocrinology 2018 Feb 1;159(2):907-930
Endocrinology 2018 Feb 1;159(2):907-930
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Tu HJ, Lin YJ, Chao MW, Sung TY, Wu YW, Chen YY, Lin MH, Liou JP, Pan SL, Yang CR
Clinical epigenetics 2018 Dec 29;10(1):162
Clinical epigenetics 2018 Dec 29;10(1):162
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Karlin J, Allen J, Ahmad SF, Hughes G, Sheridan V, Odedra R, Farrington P, Cadogan EB, Riches LC, Garcia-Trinidad A, Thomason AG, Patel B, Vincent J, Lau A, Pike KG, Hunt TA, Sule A, Valerie NCK, Biddlestone-Thorpe L, Kahn J, Beckta JM, Mukhopadhyay N, Barlaam B, Degorce SL, Kettle J, Colclough N, Wilson J, Smith A, Barrett IP, Zheng L, Zhang T, Wang Y, Chen K, Pass M, Durant ST, Valerie K
Molecular cancer therapeutics 2018 Aug;17(8):1637-1647
Molecular cancer therapeutics 2018 Aug;17(8):1637-1647
IDH1/2 Mutations Sensitize Acute Myeloid Leukemia to PARP Inhibition and This Is Reversed by IDH1/2-Mutant Inhibitors.
Molenaar RJ, Radivoyevitch T, Nagata Y, Khurshed M, Przychodzen B, Makishima H, Xu M, Bleeker FE, Wilmink JW, Carraway HE, Mukherjee S, Sekeres MA, van Noorden CJF, Maciejewski JP
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Apr 1;24(7):1705-1715
Clinical cancer research : an official journal of the American Association for Cancer Research 2018 Apr 1;24(7):1705-1715
Studies of ATM Kinase Activity Using Engineered ATM Sensitive to ATP Analogues (ATM-AS).
Enari M, Matsushima-Hibiya Y, Miyazaki M, Otomo R
Methods in molecular biology (Clifton, N.J.) 2017;1599:145-156
Methods in molecular biology (Clifton, N.J.) 2017;1599:145-156
PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.
Clarke TL, Sanchez-Bailon MP, Chiang K, Reynolds JJ, Herrero-Ruiz J, Bandeiras TM, Matias PM, Maslen SL, Skehel JM, Stewart GS, Davies CC
Molecular cell 2017 Mar 2;65(5):900-916.e7
Molecular cell 2017 Mar 2;65(5):900-916.e7
SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
You J, Liu J, Bao Y, Wang L, Yu Y, Wang L, Wu D, Liu C, Wang N, Wang F, Wang F, Xu L, Tian X, Liang H, Gao Y, Guan R, Bai J, Meng X, Sun W, Guan XY, Zhang C, Fu S, Jin Y
Cancer letters 2017 Jan 28;385:271-279
Cancer letters 2017 Jan 28;385:271-279
ATM is required for SOD2 expression and homeostasis within the mammary gland.
Dyer LM, Kepple JD, Ai L, Kim WJ, Stanton VL, Reinhard MK, Backman LRF, Streitfeld WS, Babu NR, Treiber N, Scharffetter-Kochanek K, McKinnon PJ, Brown KD
Breast cancer research and treatment 2017 Dec;166(3):725-741
Breast cancer research and treatment 2017 Dec;166(3):725-741
RNF4 regulates DNA double-strand break repair in a cell cycle-dependent manner.
Kuo CY, Li X, Stark JM, Shih HM, Ann DK
Cell cycle (Georgetown, Tex.) 2016;15(6):787-98
Cell cycle (Georgetown, Tex.) 2016;15(6):787-98
HuR silencing elicits oxidative stress and DNA damage and sensitizes human triple-negative breast cancer cells to radiotherapy.
Mehta M, Basalingappa K, Griffith JN, Andrade D, Babu A, Amreddy N, Muralidharan R, Gorospe M, Herman T, Ding WQ, Ramesh R, Munshi A
Oncotarget 2016 Oct 4;7(40):64820-64835
Oncotarget 2016 Oct 4;7(40):64820-64835
Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis.
Yang Z, Shen Y, Oishi H, Matteson EL, Tian L, Goronzy JJ, Weyand CM
Science translational medicine 2016 Mar 23;8(331):331ra38
Science translational medicine 2016 Mar 23;8(331):331ra38
miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage.
Salzman DW, Nakamura K, Nallur S, Dookwah MT, Metheetrairut C, Slack FJ, Weidhaas JB
Nature communications 2016 Mar 21;7:10954
Nature communications 2016 Mar 21;7:10954
Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks.
Federico MB, Vallerga MB, Radl A, Paviolo NS, Bocco JL, Di Giorgio M, Soria G, Gottifredi V
PLoS genetics 2016 Jan;12(1):e1005792
PLoS genetics 2016 Jan;12(1):e1005792
Femtosecond near-infrared laser microirradiation reveals a crucial role for PARP signaling on factor assemblies at DNA damage sites.
Saquilabon Cruz GM, Kong X, Silva BA, Khatibzadeh N, Thai R, Berns MW, Yokomori K
Nucleic acids research 2016 Feb 18;44(3):e27
Nucleic acids research 2016 Feb 18;44(3):e27
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.
Wang Y, Xu Q, Sack L, Kang C, Elledge SJ
Genes & development 2016 Feb 1;30(3):293-306
Genes & development 2016 Feb 1;30(3):293-306
An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL.
Mai Y, Yu JJ, Bartholdy B, Xu-Monette ZY, Knapp EE, Yuan F, Chen H, Ding BB, Yao Z, Das B, Zou Y, Young KH, Parekh S, Ye BH
Blood 2016 Dec 15;128(24):2797-2807
Blood 2016 Dec 15;128(24):2797-2807
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW
Cancer cell 2016 Aug 8;30(2):337-348
Cancer cell 2016 Aug 8;30(2):337-348
The dynamic behavior of Ect2 in response to DNA damage.
He D, Xiang J, Li B, Liu H
Scientific reports 2016 Apr 14;6:24504
Scientific reports 2016 Apr 14;6:24504
A quasi-quantitative dual multiplexed immunoblot method to simultaneously analyze ATM and H2AX Phosphorylation in human peripheral blood mononuclear cells.
Bakkenist CJ, Czambel RK, Hershberger PA, Tawbi H, Beumer JH, Schmitz JC
Oncoscience 2015;2(5):542-54
Oncoscience 2015;2(5):542-54
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair.
Nakajima NI, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, Shibata A
PloS one 2015;10(3):e0122582
PloS one 2015;10(3):e0122582
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.
Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF
Nucleic acids research 2015 Sep 30;43(17):8352-67
Nucleic acids research 2015 Sep 30;43(17):8352-67
ATM functions at the peroxisome to induce pexophagy in response to ROS.
Zhang J, Tripathi DN, Jing J, Alexander A, Kim J, Powell RT, Dere R, Tait-Mulder J, Lee JH, Paull TT, Pandita RK, Charaka VK, Pandita TK, Kastan MB, Walker CL
Nature cell biology 2015 Oct;17(10):1259-1269
Nature cell biology 2015 Oct;17(10):1259-1269
Poly(ADP-ribosyl) glycohydrolase prevents the accumulation of unusual replication structures during unperturbed S phase.
Ray Chaudhuri A, Ahuja AK, Herrador R, Lopes M
Molecular and cellular biology 2015 Mar;35(5):856-65
Molecular and cellular biology 2015 Mar;35(5):856-65
DNA-PK/Chk2 induces centrosome amplification during prolonged replication stress.
Wang CY, Huang EY, Huang SC, Chung BC
Oncogene 2015 Mar 5;34(10):1263-9
Oncogene 2015 Mar 5;34(10):1263-9
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells.
Zellweger R, Dalcher D, Mutreja K, Berti M, Schmid JA, Herrador R, Vindigni A, Lopes M
The Journal of cell biology 2015 Mar 2;208(5):563-79
The Journal of cell biology 2015 Mar 2;208(5):563-79
A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol.
Sajish M, Schimmel P
Nature 2015 Mar 19;519(7543):370-3
Nature 2015 Mar 19;519(7543):370-3
AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E, Musio A, Biroccio A, Cacchione S, Gatti M, Saggio I
PLoS genetics 2015 Jun;11(6):e1005167
PLoS genetics 2015 Jun;11(6):e1005167
Initiation of the ATM-Chk2 DNA damage response through the base excision repair pathway.
Chou WC, Hu LY, Hsiung CN, Shen CY
Carcinogenesis 2015 Aug;36(8):832-40
Carcinogenesis 2015 Aug;36(8):832-40
P53 deficiency-induced Smad1 upregulation suppresses tumorigenesis and causes chemoresistance in colorectal cancers.
Ruan X, Zuo Q, Jia H, Chau J, Lin J, Ao J, Xia X, Liu H, Habib SL, Fu C, Li B
Journal of molecular cell biology 2015 Apr;7(2):105-18
Journal of molecular cell biology 2015 Apr;7(2):105-18
BLM protein mitigates formaldehyde-induced genomic instability.
Kumari A, Owen N, Juarez E, McCullough AK
DNA repair 2015 Apr;28:73-82
DNA repair 2015 Apr;28:73-82
Lamin A/C-dependent interaction with 53BP1 promotes cellular responses to DNA damage.
Gibbs-Seymour I, Markiewicz E, Bekker-Jensen S, Mailand N, Hutchison CJ
Aging cell 2015 Apr;14(2):162-9
Aging cell 2015 Apr;14(2):162-9
Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells.
Li LH, Wu P, Lee JY, Li PR, Hsieh WY, Ho CC, Ho CL, Chen WJ, Wang CC, Yen MY, Yang SM, Chen HW
PloS one 2014;9(8):e104203
PloS one 2014;9(8):e104203
Direct activation of ATM by resveratrol under oxidizing conditions.
Lee JH, Guo Z, Myler LR, Zheng S, Paull TT
PloS one 2014;9(6):e97969
PloS one 2014;9(6):e97969
Cucurbitacin B induced ATM-mediated DNA damage causes G2/M cell cycle arrest in a ROS-dependent manner.
Guo J, Wu G, Bao J, Hao W, Lu J, Chen X
PloS one 2014;9(2):e88140
PloS one 2014;9(2):e88140
Opposite roles for p38MAPK-driven responses and reactive oxygen species in the persistence and resolution of radiation-induced genomic instability.
Werner E, Wang H, Doetsch PW
PloS one 2014;9(10):e108234
PloS one 2014;9(10):e108234
Distinct DNA damage determines differential phosphorylation of Chk2.
Ouchi M, Ouchi T
Cancer biology & therapy 2014;15(12):1700-4
Cancer biology & therapy 2014;15(12):1700-4
Translational initiation regulated by ATM in dendritic cells development.
So EY, Ouchi T
Cell death & disease 2014 Sep 11;5:e1418
Cell death & disease 2014 Sep 11;5:e1418
Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair.
Du F, Zhang M, Li X, Yang C, Meng H, Wang D, Chang S, Xu Y, Price B, Sun Y
Biochemical and biophysical research communications 2014 Oct 3;452(4):1034-9
Biochemical and biophysical research communications 2014 Oct 3;452(4):1034-9
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.
Ayrapetov MK, Gursoy-Yuzugullu O, Xu C, Xu Y, Price BD
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 24;111(25):9169-74
Proceedings of the National Academy of Sciences of the United States of America 2014 Jun 24;111(25):9169-74
An arginine-rich motif of ring finger protein 4 (RNF4) oversees the recruitment and degradation of the phosphorylated and SUMOylated Krüppel-associated box domain-associated protein 1 (KAP1)/TRIM28 protein during genotoxic stress.
Kuo CY, Li X, Kong XQ, Luo C, Chang CC, Chung Y, Shih HM, Li KK, Ann DK
The Journal of biological chemistry 2014 Jul 25;289(30):20757-72
The Journal of biological chemistry 2014 Jul 25;289(30):20757-72
Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.
Sharma NK, Lebedeva M, Thomas T, Kovalenko OA, Stumpf JD, Shadel GS, Santos JH
DNA repair 2014 Jan;13:22-31
DNA repair 2014 Jan;13:22-31
Whole genome RNAi screens reveal a critical role of REV3 in coping with replication stress.
Kotov IN, Siebring-van Olst E, Knobel PA, van der Meulen-Muileman IH, Felley-Bosco E, van Beusechem VW, Smit EF, Stahel RA, Marti TM
Molecular oncology 2014 Dec;8(8):1747-59
Molecular oncology 2014 Dec;8(8):1747-59
APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM.
Hennig J, McShane MP, Cordes N, Eke I
Cell death & disease 2014 Apr 24;5:e1199
Cell death & disease 2014 Apr 24;5:e1199
Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.
Lim HC, Xie L, Zhang W, Li R, Chen ZC, Wu GZ, Cui SS, Tan EK, Zeng L
PloS one 2013;8(9):e74334
PloS one 2013;8(9):e74334
Identification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potential.
Zhang X, Jia D, Liu H, Zhu N, Zhang W, Feng J, Yin J, Hao B, Cui D, Deng Y, Xie D, He L, Li B
PloS one 2013;8(5):e62527
PloS one 2013;8(5):e62527
MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer.
Wu CW, Dong YJ, Liang QY, He XQ, Ng SS, Chan FK, Sung JJ, Yu J
PloS one 2013;8(2):e57036
PloS one 2013;8(2):e57036
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Murad NA, Cullen JK, McKenzie M, Ryan MT, Thorburn D, Gueven N, Kobayashi J, Birrell G, Yang J, Dörk T, Becherel O, Grattan-Smith P, Lavin MF
Mitochondrion 2013 May;13(3):235-45
Mitochondrion 2013 May;13(3):235-45
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.
Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, Wyman C, Paull TT
The Journal of biological chemistry 2013 May 3;288(18):12840-51
The Journal of biological chemistry 2013 May 3;288(18):12840-51
A patient-derived olfactory stem cell disease model for ataxia-telangiectasia.
Stewart R, Kozlov S, Matigian N, Wali G, Gatei M, Sutharsan R, Bellette B, Wraith-Kijas A, Cochrane J, Coulthard M, Perry C, Sinclair K, Mackay-Sim A, Lavin MF
Human molecular genetics 2013 Jun 15;22(12):2495-509
Human molecular genetics 2013 Jun 15;22(12):2495-509
ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation.
Biddlestone-Thorpe L, Sajjad M, Rosenberg E, Beckta JM, Valerie NC, Tokarz M, Adams BR, Wagner AF, Khalil A, Gilfor D, Golding SE, Deb S, Temesi DG, Lau A, O'Connor MJ, Choe KS, Parada LF, Lim SK, Mukhopadhyay ND, Valerie K
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jun 15;19(12):3189-200
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jun 15;19(12):3189-200
A noncatalytic function of the ligation complex during nonhomologous end joining.
Cottarel J, Frit P, Bombarde O, Salles B, Négrel A, Bernard S, Jeggo PA, Lieber MR, Modesti M, Calsou P
The Journal of cell biology 2013 Jan 21;200(2):173-86
The Journal of cell biology 2013 Jan 21;200(2):173-86
Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress.
Choi SY, Jang H, Roe JS, Kim ST, Cho EJ, Youn HD
Nucleic acids research 2013 Feb 1;41(4):2180-90
Nucleic acids research 2013 Feb 1;41(4):2180-90
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1.
Tripathi DN, Chowdhury R, Trudel LJ, Tee AR, Slack RS, Walker CL, Wogan GN
Proceedings of the National Academy of Sciences of the United States of America 2013 Aug 6;110(32):E2950-7
Proceedings of the National Academy of Sciences of the United States of America 2013 Aug 6;110(32):E2950-7
Functional activation of ATM by the prostate cancer suppressor NKX3.1.
Bowen C, Ju JH, Lee JH, Paull TT, Gelmann EP
Cell reports 2013 Aug 15;4(3):516-29
Cell reports 2013 Aug 15;4(3):516-29
Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy.
Shi Y, Felley-Bosco E, Marti TM, Stahel RA
PloS one 2012;7(9):e45354
PloS one 2012;7(9):e45354
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
Baritaud M, Cabon L, Delavallée L, Galán-Malo P, Gilles ME, Brunelle-Navas MN, Susin SA
Cell death & disease 2012 Sep 13;3:e390
Cell death & disease 2012 Sep 13;3:e390
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Ai L, Skehan RR, Saydi J, Lin T, Brown KD
The Journal of biological chemistry 2012 May 25;287(22):18330-41
The Journal of biological chemistry 2012 May 25;287(22):18330-41
Deregulation of DNA damage response pathway by intercellular contact.
Kang MA, So EY, Ouchi T
The Journal of biological chemistry 2012 May 11;287(20):16246-55
The Journal of biological chemistry 2012 May 11;287(20):16246-55
58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
Hsu CC, Lee YC, Yeh SH, Chen CH, Wu CC, Wang TY, Chen YN, Hung LY, Liu YW, Chen HK, Hsiao YT, Wang WS, Tsou JH, Tsou YH, Wu MH, Chang WC, Lin DY
The Journal of biological chemistry 2012 Jun 29;287(27):22533-48
The Journal of biological chemistry 2012 Jun 29;287(27):22533-48
Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence HR, Engelman RW, Lawrence NJ, Mahajan NP
The Journal of biological chemistry 2012 Jun 22;287(26):22112-22
The Journal of biological chemistry 2012 Jun 22;287(26):22112-22
Induced pluripotent stem cells from ataxia-telangiectasia recapitulate the cellular phenotype.
Nayler S, Gatei M, Kozlov S, Gatti R, Mar JC, Wells CA, Lavin M, Wolvetang E
Stem cells translational medicine 2012 Jul;1(7):523-35
Stem cells translational medicine 2012 Jul;1(7):523-35
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW
The Journal of experimental medicine 2012 Jan 16;209(1):173-86
The Journal of experimental medicine 2012 Jan 16;209(1):173-86
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, Kitao H, Maehara Y
Genes to cells : devoted to molecular & cellular mechanisms 2012 Dec;17(12):962-70
Genes to cells : devoted to molecular & cellular mechanisms 2012 Dec;17(12):962-70
Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin.
Shi Y, Felley-Bosco E, Marti TM, Orlowski K, Pruschy M, Stahel RA
BMC cancer 2012 Dec 4;12:571
BMC cancer 2012 Dec 4;12:571
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH
Cancer research 2012 Aug 15;72(16):4119-29
Cancer research 2012 Aug 15;72(16):4119-29
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, Mück C, Anrather D, Scheffold A, Ammerer G, Jansen-Dürr P, Rudolph KL, Voglauer-Grillari R, Grillari J
Aging 2012 Apr;4(4):290-304
Aging 2012 Apr;4(4):290-304
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, Mück C, Anrather D, Scheffold A, Ammerer G, Jansen-Dürr P, Rudolph KL, Voglauer-Grillari R, Grillari J
Aging 2012 Apr;4(4):290-304
Aging 2012 Apr;4(4):290-304
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Zhang J, de Toledo SM, Pandey BN, Guo G, Pain D, Li H, Azzam EI
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 17;109(16):E926-33
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 17;109(16):E926-33
The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase.
Xu Y, Parmar K, Du F, Price BD, Sun Y
International journal of biochemistry and molecular biology 2011;2(4):295-302
International journal of biochemistry and molecular biology 2011;2(4):295-302
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control.
Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, Gueven N, Birrell G, Lee JH, Paull TT, Lerenthal Y, Fazry S, Taucher-Scholz G, Kalb R, Schindler D, Waltes R, Dörk T, Lavin MF
The Journal of biological chemistry 2011 Sep 9;286(36):31542-56
The Journal of biological chemistry 2011 Sep 9;286(36):31542-56
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
Shouse GP, Nobumori Y, Panowicz MJ, Liu X
Oncogene 2011 Sep 1;30(35):3755-65
Oncogene 2011 Sep 1;30(35):3755-65
A novel role for hSMG-1 in stress granule formation.
Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham RT, Gueven N, Lavin MF
Molecular and cellular biology 2011 Nov;31(22):4417-29
Molecular and cellular biology 2011 Nov;31(22):4417-29
ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Assaily W, Rubinger DA, Wheaton K, Lin Y, Ma W, Xuan W, Brown-Endres L, Tsuchihara K, Mak TW, Benchimol S
Molecular cell 2011 Nov 4;44(3):491-501
Molecular cell 2011 Nov 4;44(3):491-501
Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M
The Journal of biological chemistry 2011 Nov 11;286(45):39200-10
The Journal of biological chemistry 2011 Nov 11;286(45):39200-10
AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Hada M, Huff JL, Patel ZS, Kawata T, Pluth JM, George KA, Cucinotta FA
Mutation research 2011 Nov 1;716(1-2):76-83
Mutation research 2011 Nov 1;716(1-2):76-83
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S
DNA repair 2011 Mar 7;10(3):314-21
DNA repair 2011 Mar 7;10(3):314-21
Autophosphorylation and ATM activation: additional sites add to the complexity.
Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF
The Journal of biological chemistry 2011 Mar 18;286(11):9107-19
The Journal of biological chemistry 2011 Mar 18;286(11):9107-19
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, Salles B, Muller C
Journal of cell science 2011 Jun 1;124(Pt 11):1943-51
Journal of cell science 2011 Jun 1;124(Pt 11):1943-51
The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, Benihoud K, Saggio I, Rosselli F
Nucleic acids research 2011 Jul;39(13):5459-73
Nucleic acids research 2011 Jul;39(13):5459-73
ATM mediated phosphorylation of CHD4 contributes to genome maintenance.
Urquhart AJ, Gatei M, Richard DJ, Khanna KK
Genome integrity 2011 Jan 10;2(1):1
Genome integrity 2011 Jan 10;2(1):1
Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM).
Ruiz Z, Mihaylov IS, Cotmore SF, Tattersall P
Virology 2011 Feb 20;410(2):375-84
Virology 2011 Feb 20;410(2):375-84
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Chen Y, Chen CF, Riley DJ, Chen PL
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Oligomerization of MDC1 protein is important for proper DNA damage response.
Luo K, Yuan J, Lou Z
The Journal of biological chemistry 2011 Aug 12;286(32):28192-9
The Journal of biological chemistry 2011 Aug 12;286(32):28192-9
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
Xu Y, Sun Y, Jiang X, Ayrapetov MK, Moskwa P, Yang S, Weinstock DM, Price BD
The Journal of cell biology 2010 Oct 4;191(1):31-43
The Journal of cell biology 2010 Oct 4;191(1):31-43
Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.
Huang QM, Tomida S, Masuda Y, Arima C, Cao K, Kasahara TA, Osada H, Yatabe Y, Akashi T, Kamiya K, Takahashi T, Suzuki M
Cancer research 2010 Nov 1;70(21):8407-16
Cancer research 2010 Nov 1;70(21):8407-16
Three-dimensional cell growth confers radioresistance by chromatin density modification.
Storch K, Eke I, Borgmann K, Krause M, Richter C, Becker K, Schröck E, Cordes N
Cancer research 2010 May 15;70(10):3925-34
Cancer research 2010 May 15;70(10):3925-34
Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Sakasai R, Teraoka H, Takagi M, Tibbetts RS
The Journal of biological chemistry 2010 May 14;285(20):15201-15208
The Journal of biological chemistry 2010 May 14;285(20):15201-15208
Discovery of putative oocyte quality markers by comparative ExacTag proteomics.
Powell MD, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev SC, Hannink M, Prather RS, Sutovsky P
Proteomics. Clinical applications 2010 Mar;4(3):337-51
Proteomics. Clinical applications 2010 Mar;4(3):337-51
Replication independent DNA double-strand break retention may prevent genomic instability.
Kongruttanachok N, Phuangphairoj C, Thongnak A, Ponyeam W, Rattanatanyong P, Pornthanakasem W, Mutirangura A
Molecular cancer 2010 Mar 31;9:70
Molecular cancer 2010 Mar 31;9:70
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW
Genes & development 2010 Mar 15;24(6):549-60
Genes & development 2010 Mar 15;24(6):549-60
Low levels of ATM in breast cancer patients with clinical radiosensitivity.
Fang Z, Kozlov S, McKay MJ, Woods R, Birrell G, Sprung CN, Murrell DF, Wangoo K, Teng L, Kearsley JH, Lavin MF, Graham PH, Clarke RA
Genome integrity 2010 Jun 24;1(1):9
Genome integrity 2010 Jun 24;1(1):9
Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.
Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, Salles B, Muller C
Cell cycle (Georgetown, Tex.) 2010 Jul 15;9(14):2814-22
Cell cycle (Georgetown, Tex.) 2010 Jul 15;9(14):2814-22
ATM is down-regulated by N-Myc-regulated microRNA-421.
Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1506-11
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1506-11
Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.
Sakasai R, Teraoka H, Tibbetts RS
DNA repair 2010 Jan 2;9(1):76-82
DNA repair 2010 Jan 2;9(1):76-82
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M
Journal of cell science 2010 Jan 15;123(Pt 2):225-35
Journal of cell science 2010 Jan 15;123(Pt 2):225-35
ATM activation in the presence of oxidative stress.
Guo Z, Deshpande R, Paull TT
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Lee JH, Choy ML, Ngo L, Foster SS, Marks PA
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 17;107(33):14639-44
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 17;107(33):14639-44
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.
Shanware NP, Zhan L, Hutchinson JA, Kim SH, Williams LM, Tibbetts RS
PloS one 2010 Aug 13;5(8):e12173
PloS one 2010 Aug 13;5(8):e12173
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.
Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK
Nucleic acids research 2010 Apr;38(6):1821-31
Nucleic acids research 2010 Apr;38(6):1821-31
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y
Molecular and cellular biology 2010 Apr;30(7):1620-33
Molecular and cellular biology 2010 Apr;30(7):1620-33
NKX3.1 activates cellular response to DNA damage.
Bowen C, Gelmann EP
Cancer research 2010 Apr 15;70(8):3089-97
Cancer research 2010 Apr 15;70(8):3089-97
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.
Papp LV, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, Khanna KK
Antioxidants & redox signaling 2010 Apr 1;12(7):797-808
Antioxidants & redox signaling 2010 Apr 1;12(7):797-808
ARTEMIS nuclease facilitates apoptotic chromatin cleavage.
Britton S, Frit P, Biard D, Salles B, Calsou P
Cancer research 2009 Oct 15;69(20):8120-6
Cancer research 2009 Oct 15;69(20):8120-6
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD
Nature cell biology 2009 Nov;11(11):1376-82
Nature cell biology 2009 Nov;11(11):1376-82
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Nahas SA, Butch AW, Du L, Gatti RA
Clinical chemistry 2009 Mar;55(3):463-72
Clinical chemistry 2009 Mar;55(3):463-72
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Cui B, Johnson SP, Bullock N, Ali-Osman F, Bigner DD, Friedman HS
Molecular pharmacology 2009 Jun;75(6):1356-63
Molecular pharmacology 2009 Jun;75(6):1356-63
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.
Martin LJ, Liu Z, Pipino J, Chestnut B, Landek MA
Cerebral cortex (New York, N.Y. : 1991) 2009 Jun;19(6):1273-93
Cerebral cortex (New York, N.Y. : 1991) 2009 Jun;19(6):1273-93
ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P
The Journal of investigative dermatology 2009 Jul;129(7):1805-15
The Journal of investigative dermatology 2009 Jul;129(7):1805-15
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat PS, Roberts TM, Gjoerup OV
Journal of virology 2009 Jan;83(1):117-27
Journal of virology 2009 Jan;83(1):117-27
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
So S, Davis AJ, Chen DJ
The Journal of cell biology 2009 Dec 28;187(7):977-90
The Journal of cell biology 2009 Dec 28;187(7):977-90
Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa-Saito M, Waga S, Kiyono T, Fujita M
Journal of cell science 2009 Apr 15;122(Pt 8):1184-91
Journal of cell science 2009 Apr 15;122(Pt 8):1184-91
Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Meulle A, Salles B, Daviaud D, Valet P, Muller C
PloS one 2008;3(10):e3345
PloS one 2008;3(10):e3345
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, Sarkar A, Grisotto M, Taneja R, Ghaffari S
The Journal of biological chemistry 2008 Sep 12;283(37):25692-705
The Journal of biological chemistry 2008 Sep 12;283(37):25692-705
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, Kato N
Journal of virology 2008 Oct;82(19):9639-46
Journal of virology 2008 Oct;82(19):9639-46
RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
Sakasai R, Tibbetts R
The Journal of biological chemistry 2008 May 16;283(20):13549-55
The Journal of biological chemistry 2008 May 16;283(20):13549-55
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.
Rimkus SA, Katzenberger RJ, Trinh AT, Dodson GE, Tibbetts RS, Wassarman DA
Genes & development 2008 May 1;22(9):1205-20
Genes & development 2008 May 1;22(9):1205-20
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita M
Molecular biology of the cell 2008 Mar;19(3):1007-21
Molecular biology of the cell 2008 Mar;19(3):1007-21
Regulation of intra-S phase checkpoint by ionizing radiation (IR)-dependent and IR-independent phosphorylation of SMC3.
Luo H, Li Y, Mu JJ, Zhang J, Tonaka T, Hamamori Y, Jung SY, Wang Y, Qin J
The Journal of biological chemistry 2008 Jul 11;283(28):19176-83
The Journal of biological chemistry 2008 Jul 11;283(28):19176-83
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Stohr BA, Blackburn EH
Cancer research 2008 Jul 1;68(13):5309-17
Cancer research 2008 Jul 1;68(13):5309-17
Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.
Lai CK, Jeng KS, Machida K, Cheng YS, Lai MM
Virology 2008 Jan 20;370(2):295-309
Virology 2008 Jan 20;370(2):295-309
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shieh SY, Shen CY
The EMBO journal 2008 Dec 3;27(23):3140-50
The EMBO journal 2008 Dec 3;27(23):3140-50
Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK
Cancer research 2008 Apr 1;68(7):2214-22
Cancer research 2008 Apr 1;68(7):2214-22
Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein.
Iwahori S, Shirata N, Kawaguchi Y, Weller SK, Sato Y, Kudoh A, Nakayama S, Isomura H, Tsurumi T
Journal of virology 2007 Sep;81(18):9653-64
Journal of virology 2007 Sep;81(18):9653-64
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
Wood JL, Singh N, Mer G, Chen J
The Journal of biological chemistry 2007 Nov 30;282(48):35416-23
The Journal of biological chemistry 2007 Nov 30;282(48):35416-23
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint.
Stauffer D, Chang B, Huang J, Dunn A, Thayer M
The Journal of biological chemistry 2007 Mar 30;282(13):9678-87
The Journal of biological chemistry 2007 Mar 30;282(13):9678-87
Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
Shi Y, Dodson GE, Mukhopadhyay PS, Shanware NP, Trinh AT, Tibbetts RS
The Journal of biological chemistry 2007 Mar 23;282(12):9236-43
The Journal of biological chemistry 2007 Mar 23;282(12):9236-43
Coregulated ataxia telangiectasia-mutated and casein kinase sites modulate cAMP-response element-binding protein-coactivator interactions in response to DNA damage.
Shanware NP, Trinh AT, Williams LM, Tibbetts RS
The Journal of biological chemistry 2007 Mar 2;282(9):6283-91
The Journal of biological chemistry 2007 Mar 2;282(9):6283-91
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
Fernandes ND, Sun Y, Price BD
The Journal of biological chemistry 2007 Jun 1;282(22):16577-84
The Journal of biological chemistry 2007 Jun 1;282(22):16577-84
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.
Wu X, Shell SM, Liu Y, Zou Y
Oncogene 2007 Feb 1;26(5):757-64
Oncogene 2007 Feb 1;26(5):757-64
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Sun Y, Xu Y, Roy K, Price BD
Molecular and cellular biology 2007 Dec;27(24):8502-9
Molecular and cellular biology 2007 Dec;27(24):8502-9
Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors.
Hong X, Lei L, Künert B, Naredla R, Applequist SE, Grandien A, Glas R
Cancer research 2007 Aug 1;67(15):7165-74
Cancer research 2007 Aug 1;67(15):7165-74
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.
Geng L, Zhang X, Zheng S, Legerski RJ
Molecular and cellular biology 2007 Apr;27(7):2625-35
Molecular and cellular biology 2007 Apr;27(7):2625-35
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
Inoue Y, Kitagawa M, Taya Y
The EMBO journal 2007 Apr 18;26(8):2083-93
The EMBO journal 2007 Apr 18;26(8):2083-93
A subgroup of spinocerebellar ataxias defective in DNA damage responses.
Gueven N, Chen P, Nakamura J, Becherel OJ, Kijas AW, Grattan-Smith P, Lavin MF
Neuroscience 2007 Apr 14;145(4):1418-25
Neuroscience 2007 Apr 14;145(4):1418-25
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection.
Bai L, Kao JY, Law DJ, Merchant JL
Gastroenterology 2006 Sep;131(3):841-52
Gastroenterology 2006 Sep;131(3):841-52
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, Timofeev ON, Dudgeon C, Fornace AJ, Anderson CW, Minami Y, Appella E, Bulavin DV
Molecular cell 2006 Sep 1;23(5):757-64
Molecular cell 2006 Sep 1;23(5):757-64
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH
Cancer research 2006 Nov 15;66(22):10861-9
Cancer research 2006 Nov 15;66(22):10861-9
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y
Journal of cell science 2006 Nov 15;119(Pt 22):4644-9
Journal of cell science 2006 Nov 15;119(Pt 22):4644-9
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ
Molecular and cellular biology 2006 Mar;26(5):1598-609
Molecular and cellular biology 2006 Mar;26(5):1598-609
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Gueven N, Becherel OJ, Birrell G, Chen P, DelSal G, Carney JP, Grattan-Smith P, Lavin MF
Cancer research 2006 Mar 15;66(6):2907-12
Cancer research 2006 Mar 15;66(6):2907-12
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Jiang X, Sun Y, Chen S, Roy K, Price BD
The Journal of biological chemistry 2006 Jun 9;281(23):15741-6
The Journal of biological chemistry 2006 Jun 9;281(23):15741-6
Regulation of the Atm promoter in vivo.
Gueven N, Fukao T, Luff J, Paterson C, Kay G, Kondo N, Lavin MF
Genes, chromosomes & cancer 2006 Jan;45(1):61-71
Genes, chromosomes & cancer 2006 Jan;45(1):61-71
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
Dodson GE, Tibbetts RS
The Journal of biological chemistry 2006 Jan 20;281(3):1692-7
The Journal of biological chemistry 2006 Jan 20;281(3):1692-7
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K
Molecular cancer research : MCR 2006 Feb;4(2):125-33
Molecular cancer research : MCR 2006 Feb;4(2):125-33
Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Wang HC, Chou WC, Shieh SY, Shen CY
Cancer research 2006 Feb 1;66(3):1391-400
Cancer research 2006 Feb 1;66(3):1391-400
Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.
Ahmed KM, Dong S, Fan M, Li JJ
Molecular cancer research : MCR 2006 Dec;4(12):945-55
Molecular cancer research : MCR 2006 Dec;4(12):945-55
EDD mediates DNA damage-induced activation of CHK2.
Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK
The Journal of biological chemistry 2006 Dec 29;281(52):39990-40000
The Journal of biological chemistry 2006 Dec 29;281(52):39990-40000
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ Jr, Anderson CW, Appella E, Bulavin DV
The Journal of experimental medicine 2006 Dec 25;203(13):2793-9
The Journal of experimental medicine 2006 Dec 25;203(13):2793-9
Involvement of novel autophosphorylation sites in ATM activation.
Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF
The EMBO journal 2006 Aug 9;25(15):3504-14
The EMBO journal 2006 Aug 9;25(15):3504-14
Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
Tatsumi Y, Sugimoto N, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M
Journal of cell science 2006 Aug 1;119(Pt 15):3128-40
Journal of cell science 2006 Aug 1;119(Pt 15):3128-40
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T
The Journal of biological chemistry 2006 Apr 7;281(14):9710-8
The Journal of biological chemistry 2006 Apr 7;281(14):9710-8
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Sun Y, Jiang X, Chen S, Fernandes N, Price BD
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13182-7
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13182-7
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.
Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, Yannone SM
DNA repair 2005 May 2;4(5):556-70
DNA repair 2005 May 2;4(5):556-70
Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.
Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, Isomura H, Nishiyama Y, Tsurumi T
The Journal of biological chemistry 2005 Mar 4;280(9):8156-63
The Journal of biological chemistry 2005 Mar 4;280(9):8156-63
Regulation of CHK2 by DNA-dependent protein kinase.
Li J, Stern DF
The Journal of biological chemistry 2005 Mar 25;280(12):12041-50
The Journal of biological chemistry 2005 Mar 25;280(12):12041-50
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, Bedford JS
Cancer research 2005 Mar 1;65(5):1670-7
Cancer research 2005 Mar 1;65(5):1670-7
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Young DB, Jonnalagadda J, Gatei M, Jans DA, Meyn S, Khanna KK
The Journal of biological chemistry 2005 Jul 29;280(30):27587-94
The Journal of biological chemistry 2005 Jul 29;280(30):27587-94
Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.
Shi Y, Dodson GE, Shaikh S, Rundell K, Tibbetts RS
The Journal of biological chemistry 2005 Dec 2;280(48):40195-200
The Journal of biological chemistry 2005 Dec 2;280(48):40195-200
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Gibson SL, Bindra RS, Glazer PM
Cancer research 2005 Dec 1;65(23):10734-41
Cancer research 2005 Dec 1;65(23):10734-41
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Kim JS, Krasieva TB, Kurumizaka H, Chen DJ, Taylor AM, Yokomori K
The Journal of cell biology 2005 Aug 1;170(3):341-7
The Journal of cell biology 2005 Aug 1;170(3):341-7
Human Rif1, ortholog of a yeast telomeric protein, is regulated by ATM and 53BP1 and functions in the S-phase checkpoint.
Silverman J, Takai H, Buonomo SB, Eisenhaber F, de Lange T
Genes & development 2004 Sep 1;18(17):2108-19
Genes & development 2004 Sep 1;18(17):2108-19
Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response.
Zhang X, Succi J, Feng Z, Prithivirajsingh S, Story MD, Legerski RJ
Molecular and cellular biology 2004 Oct;24(20):9207-20
Molecular and cellular biology 2004 Oct;24(20):9207-20
Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons.
Lai CH, Chun HH, Nahas SA, Mitui M, Gamo KM, Du L, Gatti RA
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 2;101(44):15676-81
Proceedings of the National Academy of Sciences of the United States of America 2004 Nov 2;101(44):15676-81
Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation.
Fujiuchi N, Aglipay JA, Ohtsuka T, Maehara N, Sahin F, Su GH, Lee SW, Ouchi T
The Journal of biological chemistry 2004 May 7;279(19):20339-44
The Journal of biological chemistry 2004 May 7;279(19):20339-44
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.
Panta GR, Kaur S, Cavin LG, Cortés ML, Mercurio F, Lothstein L, Sweatman TW, Israel M, Arsura M
Molecular and cellular biology 2004 Mar;24(5):1823-35
Molecular and cellular biology 2004 Mar;24(5):1823-35
BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage.
Fabbro M, Savage K, Hobson K, Deans AJ, Powell SN, McArthur GA, Khanna KK
The Journal of biological chemistry 2004 Jul 23;279(30):31251-8
The Journal of biological chemistry 2004 Jul 23;279(30):31251-8
Functional expression of ATM gene carried by HSV amplicon vector in vitro and in vivo.
Qi J, Shackelford R, Manuszak R, Cheng D, Smith M, Link CJ, Wang S
Gene therapy 2004 Jan;11(1):25-33
Gene therapy 2004 Jan;11(1):25-33
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
Naka K, Tachibana A, Ikeda K, Motoyama N
The Journal of biological chemistry 2004 Jan 16;279(3):2030-7
The Journal of biological chemistry 2004 Jan 16;279(3):2030-7
Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.
Ali A, Zhang J, Bao S, Liu I, Otterness D, Dean NM, Abraham RT, Wang XF
Genes & development 2004 Feb 1;18(3):249-54
Genes & development 2004 Feb 1;18(3):249-54
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
Butch AW, Chun HH, Nahas SA, Gatti RA
Clinical chemistry 2004 Dec;50(12):2302-8
Clinical chemistry 2004 Dec;50(12):2302-8
DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.
Dodson GE, Shi Y, Tibbetts RS
The Journal of biological chemistry 2004 Aug 6;279(32):34010-4
The Journal of biological chemistry 2004 Aug 6;279(32):34010-4
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Xu X, Lee J, Stern DF
The Journal of biological chemistry 2004 Aug 13;279(33):34091-4
The Journal of biological chemistry 2004 Aug 13;279(33):34091-4
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Dörk T, Bendix-Waltes R, Wegner RD, Stumm M
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
Desferrioxamine treatment increases the genomic stability of Ataxia-telangiectasia cells.
Shackelford RE, Manuszak RP, Johnson CD, Hellrung DJ, Steele TA, Link CJ, Wang S
DNA repair 2003 Sep 18;2(9):971-81
DNA repair 2003 Sep 18;2(9):971-81
Site-directed mutagenesis of the ATM promoter: consequences for response to proliferation and ionizing radiation.
Gueven N, Keating K, Fukao T, Loeffler H, Kondo N, Rodemann HP, Lavin MF
Genes, chromosomes & cancer 2003 Oct;38(2):157-67
Genes, chromosomes & cancer 2003 Oct;38(2):157-67
Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress.
Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S
Cell 2003 Nov 26;115(5):565-76
Cell 2003 Nov 26;115(5):565-76
ATP activates ataxia-telangiectasia mutated (ATM) in vitro. Importance of autophosphorylation.
Kozlov S, Gueven N, Keating K, Ramsay J, Lavin MF
The Journal of biological chemistry 2003 Mar 14;278(11):9309-17
The Journal of biological chemistry 2003 Mar 14;278(11):9309-17
Loss of atm sensitises p53-deficient cells to topoisomerase poisons and antimetabolites.
Fedier A, Schlamminger M, Schwarz VA, Haller U, Howell SB, Fink D
Annals of oncology : official journal of the European Society for Medical Oncology 2003 Jun;14(6):938-45
Annals of oncology : official journal of the European Society for Medical Oncology 2003 Jun;14(6):938-45
HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Cortés ML, Bakkenist CJ, Di Maria MV, Kastan MB, Breakefield XO
Gene therapy 2003 Aug;10(16):1321-7
Gene therapy 2003 Aug;10(16):1321-7
Ku affects the ATM-dependent S phase checkpoint following ionizing radiation.
Zhou XY, Wang X, Wang H, Chen DJ, Li GC, Iliakis G, Wang Y
Oncogene 2002 Sep 12;21(41):6377-81
Oncogene 2002 Sep 12;21(41):6377-81
Specific recruitment of human cohesin to laser-induced DNA damage.
Kim JS, Krasieva TB, LaMorte V, Taylor AM, Yokomori K
The Journal of biological chemistry 2002 Nov 22;277(47):45149-53
The Journal of biological chemistry 2002 Nov 22;277(47):45149-53
Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest.
Girard PM, Riballo E, Begg AC, Waugh A, Jeggo PA
Oncogene 2002 Jun 20;21(27):4191-9
Oncogene 2002 Jun 20;21(27):4191-9
Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer.
Scott SP, Bendix R, Chen P, Clark R, Dork T, Lavin MF
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 22;99(2):925-30
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 22;99(2):925-30
Sensing of intermediates in V(D)J recombination by ATM.
Perkins EJ, Nair A, Cowley DO, Van Dyke T, Chang Y, Ramsden DA
Genes & development 2002 Jan 15;16(2):159-64
Genes & development 2002 Jan 15;16(2):159-64
Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM.
Beamish H, Kedar P, Kaneko H, Chen P, Fukao T, Peng C, Beresten S, Gueven N, Purdie D, Lees-Miller S, Ellis N, Kondo N, Lavin MF
The Journal of biological chemistry 2002 Aug 23;277(34):30515-23
The Journal of biological chemistry 2002 Aug 23;277(34):30515-23
Spectrum of ATM gene mutations in a hospital-based series of unselected breast cancer patients.
Dörk T, Bendix R, Bremer M, Rades D, Klöpper K, Nicke M, Skawran B, Hector A, Yamini P, Steinmann D, Weise S, Stuhrmann M, Karstens JH
Cancer research 2001 Oct 15;61(20):7608-15
Cancer research 2001 Oct 15;61(20):7608-15
The radioresistance to killing of A1-5 cells derives from activation of the Chk1 pathway.
Hu B, Zhou XY, Wang X, Zeng ZC, Iliakis G, Wang Y
The Journal of biological chemistry 2001 May 25;276(21):17693-8
The Journal of biological chemistry 2001 May 25;276(21):17693-8
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Vemuri MC, Schiller E, Naegele JR
Cell death and differentiation 2001 Mar;8(3):245-55
Cell death and differentiation 2001 Mar;8(3):245-55
Radiation induces genomic instability and mammary ductal dysplasia in Atm heterozygous mice.
Weil MM, Kittrell FS, Yu Y, McCarthy M, Zabriskie RC, Ullrich RL
Oncogene 2001 Jul 19;20(32):4409-11
Oncogene 2001 Jul 19;20(32):4409-11
Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells.
Smilenov LB, Brenner DJ, Hall EJ
Cancer research 2001 Aug 1;61(15):5710-3
Cancer research 2001 Aug 1;61(15):5710-3
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Scherthan H, Jerratsch M, Dhar S, Wang YA, Goff SP, Pandita TK
Molecular and cellular biology 2000 Oct;20(20):7773-83
Molecular and cellular biology 2000 Oct;20(20):7773-83
Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice.
Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y
Proceedings of the National Academy of Sciences of the United States of America 2000 Mar 28;97(7):3336-41
Proceedings of the National Academy of Sciences of the United States of America 2000 Mar 28;97(7):3336-41
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes & development 2000 Apr 15;14(8):927-39
Genes & development 2000 Apr 15;14(8):927-39
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Enhanced validation
Supportive validation
- Submitted by
- GeneTex (provider)
- Enhanced method
- Genetic validation
- Main image
- Experimental details
- Non-transfected (¡V) and transfected (+) HeLa whole cell extracts (60 ?g) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Detection of human ATM protein using anti-ATM 2C1 monoclonal antibody (GTX70103) by western blot or immunoprecipitation.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- ATM antibody [2C1] detects ATM protein by western blot analysis.A. 30 ?g NT2D1 whole cell lysate/extractB. 30 ?g PC-3 whole cell lysate/extractC. 30 ?g SK-N-SH whole cell lysate/extract5% SDS-PAGEATM antibody [2C1] (GTX70103) dilution: 1:1000 The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- ATM antibody [2C1] detects ATM protein by western blot analysis.A. 30 ?g U87-MG whole cell lysate/extract B. 30 ?g SK-N-SH whole cell lysate/extract C. 30 ?g IMR32 whole cell lysate/extract D. 30 ?g SK-N-AS whole cell lysate/extract5 % SDS-PAGEATM antibody [2C1] (GTX70103) dilution: 1:1000
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Detection of ATM (Anti-ATM 2C1, GTX70103) or ATR (Anti-ATR 2B5,GTX70109) by western blot in human Raji whole cell extract.
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- HeLa whole cell and nuclear extracts (30 ?g) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Whole cell extract (30 ?g) was separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:1000. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Non-transfected (¡V) and transfected (+) HeLa whole cell extracts (60 ?g) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Whole cell extract (30 ?g) was separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] (GTX70103) diluted at 1:1000.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Human Kidney (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Human Testis (formalin-fixed, paraffin-embedded) stained with ATM antibody at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
