Antibody data
- Antibody Data
- Antigen structure
- References [7]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [2]
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Validation data
Reference
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- Product number
- GTX61739 - Provider product page
- Provider
- GeneTex
- Proper citation
- GeneTex Cat#GTX61739, RRID:AB_10633021
- Product name
- ATM (phospho Ser1981) antibody [EP1890Y]
- Antibody type
- Monoclonal
- Reactivity
- Human
- Host
- Rabbit
- Storage
- Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Submitted references NOX2-dependent ATM kinase activation dictates pro-inflammatory macrophage phenotype and improves effectiveness to radiation therapy.
Loss of ATM in Airway Epithelial Cells Is Associated with Susceptibility to Oxidative Stress.
The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.
RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells.
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity.
Wu Q, Allouch A, Paoletti A, Leteur C, Mirjolet C, Martins I, Voisin L, Law F, Dakhli H, Mintet E, Thoreau M, Muradova Z, Gauthier M, Caron O, Milliat F, Ojcius DM, Rosselli F, Solary E, Modjtahedi N, Deutsch E, Perfettini JL
Cell death and differentiation 2017 Sep;24(9):1632-1644
Cell death and differentiation 2017 Sep;24(9):1632-1644
Loss of ATM in Airway Epithelial Cells Is Associated with Susceptibility to Oxidative Stress.
Yeo AJ, Fantino E, Czovek D, Wainwright CE, Sly PD, Lavin MF
American journal of respiratory and critical care medicine 2017 Aug 1;196(3):391-393
American journal of respiratory and critical care medicine 2017 Aug 1;196(3):391-393
The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.
Chen CW, Tsao N, Huang LY, Yen Y, Liu X, Lehman C, Wang YH, Tseng MC, Chen YJ, Ho YC, Chen CF, Chang ZF
Cell reports 2016 Aug 2;16(5):1287-1299
Cell reports 2016 Aug 2;16(5):1287-1299
RCC1-dependent activation of Ran accelerates cell cycle and DNA repair, inhibiting DNA damage-induced cell senescence.
Cekan P, Hasegawa K, Pan Y, Tubman E, Odde D, Chen JQ, Herrmann MA, Kumar S, Kalab P
Molecular biology of the cell 2016 Apr 15;27(8):1346-57
Molecular biology of the cell 2016 Apr 15;27(8):1346-57
Hinokitiol induces DNA damage and autophagy followed by cell cycle arrest and senescence in gefitinib-resistant lung adenocarcinoma cells.
Li LH, Wu P, Lee JY, Li PR, Hsieh WY, Ho CC, Ho CL, Chen WJ, Wang CC, Yen MY, Yang SM, Chen HW
PloS one 2014;9(8):e104203
PloS one 2014;9(8):e104203
Collaborator of ARF (CARF) regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Cheung CT, Singh R, Kalra RS, Kaul SC, Wadhwa R
The Journal of biological chemistry 2014 Jun 27;289(26):18258-69
The Journal of biological chemistry 2014 Jun 27;289(26):18258-69
Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity.
Huang FC, Chang CC, Wang JM, Chang TC, Lin JJ
British journal of pharmacology 2012 Sep;167(2):393-406
British journal of pharmacology 2012 Sep;167(2):393-406
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Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- A. Western blot analysis on HEK293 cell lysates using anti-ATM Phospho (pS1981) RabMAb (cat # GTX61739) dilution at 1:10000. Cells were either (A) untreated or (B) treated with doxorubicin.
- Validation comment
- WB
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- WB analysis of lysates from (1) untreated and (2) doxorubicin-treated HEK293 cells (10 μg per lane) using ATM (phospho Ser1981) antibody [EP1890Y] at a dilution of 1:10,000.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- IHC analysis of endometrial carcinoma tissue using ATM (phospho Ser1981) antibody [EP1890Y].
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- IHC-P analysis of human gastric carcinoma using ATM (phospho Ser1981) antibody [EP1890Y] at a dilution of 1:100.