200-301-500

antibody from Rockland Immunochemicals, Inc.

Targeting: ATM ATA, ATC, ATD, ATDC, TEL1, TELO1

Provider product page for 200-301-500

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [26]
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Validations
Immunocytochemistry [1]

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Product number: 200-301-500 - Provider product page
Provider: Rockland Immunochemicals, Inc.
Proper citation: Rockland Cat#200-301-500, RRID:AB_828098
Product name: Anti-ATM Protein Kinase pS1981 (MOUSE) Monoclonal Antibody - 200-301-500
Antibody type: Monoclonal
Vial size: 100 µl

ATM protein structure - 200-301-500 shown in red.

Submitted references Hypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes.

Jiang Z, Li H, Schroer SA, Voisin V, Ju Y, Pacal M, Erdmann N, Shi W, Chung PED, Deng T, Chen NJ, Ciavarra G, Datti A, Mak TW, Harrington L, Dick FA, Bader GD, Bremner R, Woo M, Zacksenhaus E
The EMBO journal 2022 Feb 15;41(4):e106825

Asciminib Mitigates DNA Damage Stress Signaling Induced by Cyclophosphamide in the Ovary.

Mattiello L, Pucci G, Marchetti F, Diederich M, Gonfloni S
International journal of molecular sciences 2021 Jan 30;22(3)

Effects of the Cytoplasm and Mitochondrial Specific Hydroxyl Radical Scavengers TA293 and mitoTA293 in Bleomycin-Induced Pulmonary Fibrosis Model Mice.

Sakai T, Takagaki H, Yamagiwa N, Ui M, Hatta S, Imai J
Antioxidants (Basel, Switzerland) 2021 Aug 31;10(9)

Kinase-independent inhibition of cyclophosphamide-induced pathways protects the ovarian reserve and prolongs fertility.

Bellusci G, Mattiello L, Iannizzotto V, Ciccone S, Maiani E, Villani V, Diederich M, Gonfloni S
Cell death & disease 2019 Sep 27;10(10):726

Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response.

Rosina M, Langone F, Giuliani G, Cerquone Perpetuini A, Reggio A, Calderone A, Fuoco C, Castagnoli L, Gargioli C, Cesareni G
Scientific reports 2019 Apr 1;9(1):5447

Ataxia-Telangiectasia Mutated (ATM) Kinase Regulates eNOS Expression and Modulates Radiosensitivity in Endothelial Cells Exposed to Ionizing Radiation.

Nagane M, Kuppusamy ML, An J, Mast JM, Gogna R, Yasui H, Yamamori T, Inanami O, Kuppusamy P
Radiation research 2018 May;189(5):519-528

PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis.

Kim MJ, Xia B, Suh HN, Lee SH, Jun S, Lien EM, Zhang J, Chen K, Park JI
Developmental cell 2018 Mar 12;44(5):582-596.e4

Expression and function of ABCG2 and XIAP in glioblastomas.

Emery IF, Gopalan A, Wood S, Chow KH, Battelli C, George J, Blaszyk H, Florman J, Yun K
Journal of neuro-oncology 2017 May;133(1):47-57

DNA damage signaling and apoptosis in preinvasive tubal lesions of ovarian carcinoma.

Chene G, Ouellet V, Rahimi K, Barres V, Caceres K, Meunier L, Cyr L, De Ladurantaye M, Provencher D, Mes Masson AM
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2015 Jun;25(5):761-9

Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA, Ryan KM
Proceedings of the National Academy of Sciences of the United States of America 2015 Jan 20;112(3):773-8

Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.

Nagane M, Yasui H, Sakai Y, Yamamori T, Niwa K, Hattori Y, Kondo T, Inanami O
Biochemical and biophysical research communications 2015 Jan 2;456(1):541-6

A p53/ARF-dependent anticancer barrier activates senescence and blocks tumorigenesis without impacting apoptosis.

Sinha VC, Qin L, Li Y
Molecular cancer research : MCR 2015 Feb;13(2):231-8

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo.

Phesse TJ, Myant KB, Cole AM, Ridgway RA, Pearson H, Muncan V, van den Brink GR, Vousden KH, Sears R, Vassilev LT, Clarke AR, Sansom OJ
Cell death and differentiation 2014 Jun;21(6):956-66

BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.

Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH
The Journal of cell biology 2014 Jun 9;205(5):663-75

Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes.

Schwab KR, Smith GD, Dressler GR
Developmental biology 2013 Jan 1;373(1):64-71

ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.

Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, Doki Y, Okamoto T, Kohno S, Muranaka H, Kitajima S, Yamamoto K, Takahashi C
Molecular and cellular biology 2013 Aug;33(16):3113-24

DNA structure-specific priming of ATR activation by DNA-PKcs.

Vidal-Eychenié S, Décaillet C, Basbous J, Constantinou A
The Journal of cell biology 2013 Aug 5;202(3):421-9

Mouse tissues that undergo neoplastic progression after K-Ras activation are distinguished by nuclear translocation of phospho-Erk1/2 and robust tumor suppressor responses.

Parikh N, Shuck RL, Nguyen TA, Herron A, Donehower LA
Molecular cancer research : MCR 2012 Jun;10(6):845-55

Telomere maintenance and DNA damage responses during lung carcinogenesis.

Lantuejoul S, Raynaud C, Salameire D, Gazzeri S, Moro-Sibilot D, Soria JC, Brambilla C, Brambilla E
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jun 1;16(11):2979-88

DNA damage repair and telomere length in normal breast, preneoplastic lesions, and invasive cancer.

Raynaud CM, Hernandez J, Llorca FP, Nuciforo P, Mathieu MC, Commo F, Delaloge S, Sabatier L, André F, Soria JC
American journal of clinical oncology 2010 Aug;33(4):341-5

ATM localization and gene expression in the adult mouse eye.

Leemput J, Masson C, Bigot K, Errachid A, Dansault A, Provost A, Gadin S, Aoufouchi S, Menasche M, Abitbol M
Molecular vision 2009;15:393-416

Reduced cell death, invasive and angiogenic features conferred by BRCA1-deficiency in mammary epithelial cells transformed with H-Ras.

Navaraj A, Finnberg N, Dicker DT, Yang W, Matthew EM, El-Deiry WS
Cancer biology & therapy 2009 Dec;8(24):2417-44

Telomere length, telomeric proteins and DNA damage repair proteins are differentially expressed between primary lung tumors and their adrenal metastases.

Raynaud CM, Mercier O, Commo F, Dartevelle P, Gomez-Roca C, de Montpreville V, Sabatier L, Soria JC
Lung cancer (Amsterdam, Netherlands) 2009 Aug;65(2):144-9

Telomere shortening is correlated with the DNA damage response and telomeric protein down-regulation in colorectal preneoplastic lesions.

Raynaud CM, Jang SJ, Nuciforo P, Lantuejoul S, Brambilla E, Mounier N, Olaussen KA, André F, Morat L, Sabatier L, Soria JC
Annals of oncology : official journal of the European Society for Medical Oncology 2008 Nov;19(11):1875-81

ATM activation in normal human tissues and testicular cancer.

Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB, Bartek J
Cell cycle (Georgetown, Tex.) 2005 Jun;4(6):838-45

Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.

Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB
Genes & development 2004 Jun 15;18(12):1423-38

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Submitted by: Rockland Immunochemicals, Inc. (provider)
Main image
Experimental details: Anti ATM monoclonal Antibody was used to show constitutive activation of the ATM pathway in human urinary bladder cancer. Anti-ATM Protein Kinase pS1981 (clone # 7C10D8 ) was used to stain normal uroepithelium, early superficial lesions (Ta), and earliest invasive (T1) primary carcinomas. ATM protein is ubiquitously expressed, but Ser 1981-phosphorylated ATM (pS-ATM) is detectable only in tumor tissues. See Bartkova et al. for additional details. Reprinted by permission from Nature (Cell Cycle 4;(6), 2005) Macmillan Publishers Ltd.
Sample type: IF Microscopy