651201

antibody from BioLegend
Targeting: ATM ATA, ATC, ATD, ATDC, TEL1, TELO1
Provider product page for 651201

Antibody data

Product number
651201 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#651201, RRID:AB_10900815
Product name
Purified anti-ATM Phospho (Ser1981)
Antibody type
Monoclonal
Antigen
KLH conjugated synthetic peptide SLAFEEGSpQSTTISS
Description
Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. ATM is held inactive in unirradiated cells as a dimer or higher-order multimer. Cellular irradiation induces rapid intermolecular autophosphorylation of serine 1981 that causes dimer dissociation and initiates cellular ATM kinase activity. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. Mutations in the corresponding ATM gene result in ataxia telangiectasia (AT), an autosomal recessive disease characterized by uncoordinated muscle movement and neurodegeneration. Cells from AT patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage.
Reactivity
Human, Mouse
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Upon receipt, store undiluted at 4°C.
ATM protein structure - 651201 shown in red.