651202

antibody from BioLegend

Targeting: ATM ATA, ATC, ATD, ATDC, TEL1, TELO1

Antibody data

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Validation data

Product number: 651202 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#651202, RRID:AB_10900251
Product name: Purified anti-ATM Phospho (Ser1981)
Antibody type: Monoclonal
Antigen: KLH conjugated synthetic peptide SLAFEEGSpQSTTISS
Description: Ataxia telangiectasia mutated kinase (ATM) is a serine/threonine kinase that regulates cell cycle checkpoints and DNA repair. ATM is held inactive in unirradiated cells as a dimer or higher-order multimer. Cellular irradiation induces rapid intermolecular autophosphorylation of serine 1981 that causes dimer dissociation and initiates cellular ATM kinase activity. ATM kinase regulates a number of proteins involved in cell cycle checkpoint control, apoptosis, and DNA repair, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. Mutations in the corresponding ATM gene result in ataxia telangiectasia (AT), an autosomal recessive disease characterized by uncoordinated muscle movement and neurodegeneration. Cells from AT patients display defective DNA damage-induced checkpoint activation, sensitivity to radiation, and a higher frequency of chromosome breakage.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 µg
Concentration: 0.5 mg/ml
Storage: Upon receipt, store undiluted at 4°C.

ATM protein structure - 651202 shown in red.