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- Antibody Data
- Antigen structure
- References [92]
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- Western blot [2]
- Immunohistochemistry [1]
- Flow cytometry [3]
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- Product number
- NB100-104 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-104, RRID:AB_10078371
- Product name
- Rabbit Polyclonal ATM Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.05 ml
- Concentration
- 2.5 mg/ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references MDM4 expression in fibrolamellar hepatocellular carcinoma.
Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes.
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.
ATM deficiency promotes progression of CRPC by enhancing Warburg effect.
A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling.
High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines.
Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice.
Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.
Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity.
Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.
ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts.
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.
A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity.
Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells.
Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells.
DNA damage to a single chromosome end delays anaphase onset.
Characterization of Epstein-Barr virus reactivation in a modeled spaceflight system.
The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication.
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.
Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036.
ATM-mediated NuSAP phosphorylation induces mitotic arrest.
Cell cycle control and DNA damage response of conditionally immortalized urothelial cells.
Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum.
Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells.
Senescence evasion by MCF-7 human breast tumor-initiating cells.
Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles.
ATM is down-regulated by N-Myc-regulated microRNA-421.
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.
p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage.
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells.
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
Nuclear export of NBN is required for normal cellular responses to radiation.
Circadian oscillation of nucleotide excision repair in mammalian brain.
The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.
Overall Cdk activity modulates the DNA damage response in mammalian cells.
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.
Global chromatin compaction limits the strength of the DNA damage response.
Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.
Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
Silencing of p29 affects DNA damage responses with UV irradiation.
DDB1 maintains genome integrity through regulation of Cdt1.
Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function.
Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy.
Active role for nibrin in the kinetics of atm activation.
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins.
ATM regulates ATR chromatin loading in response to DNA double-strand breaks.
Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole.
Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres.
Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility.
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration.
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice.
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases.
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Interaction of FANCD2 and NBS1 in the DNA damage response.
ATR regulates fragile site stability.
ATR regulates fragile site stability.
UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Karki A, Putra J, Kim SS, Laquaglia MJ, Perez-Atayde AR, Sadri-Vakili G, Vakili K
Oncology reports 2019 Oct;42(4):1487-1496
Oncology reports 2019 Oct;42(4):1487-1496
Inducible SMARCAL1 knockdown in iPSC reveals a link between replication stress and altered expression of master differentiation genes.
Pugliese GM, Salaris F, Palermo V, Marabitti V, Morina N, Rosa A, Franchitto A, Pichierri P
Disease models & mechanisms 2019 Oct 17;12(10)
Disease models & mechanisms 2019 Oct 17;12(10)
N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway.
Yin Y, Xu L, Chang Y, Zeng T, Chen X, Wang A, Groth J, Foo WC, Liang C, Hu H, Huang J
Molecular cancer 2019 Jan 18;18(1):11
Molecular cancer 2019 Jan 18;18(1):11
ATM deficiency promotes progression of CRPC by enhancing Warburg effect.
Xu L, Ma E, Zeng T, Zhao R, Tao Y, Chen X, Groth J, Liang C, Hu H, Huang J
Endocrine-related cancer 2019 Jan 1;26(1):59-71
Endocrine-related cancer 2019 Jan 1;26(1):59-71
A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling.
Dworak N, Makosa D, Chatterjee M, Jividen K, Yang CS, Snow C, Simke WC, Johnson IG, Kelley JB, Paschal BM
Aging cell 2019 Feb;18(1):e12851
Aging cell 2019 Feb;18(1):e12851
High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines.
Morita A, Aoshima K, Gulay KCM, Onishi S, Shibata Y, Yasui H, Kobayashi A, Kimura T
Research in veterinary science 2019 Dec;127:1-10
Research in veterinary science 2019 Dec;127:1-10
Severe hypoxia increases expression of ATM and DNA-PKcs and it increases their activities through Src and AMPK signaling pathways.
Hashimoto T, Murata Y, Urushihara Y, Shiga S, Takeda K, Hosoi Y
Biochemical and biophysical research communications 2018 Oct 20;505(1):13-19
Biochemical and biophysical research communications 2018 Oct 20;505(1):13-19
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y
Toxicology letters 2018 Jul;291:92-100
Toxicology letters 2018 Jul;291:92-100
Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice.
Wang Z, He Y, Deng W, Lang L, Yang H, Jin B, Kolhe R, Ding HF, Zhang J, Hai T, Yan C
Oncogene 2018 Jan 4;37(1):18-27
Oncogene 2018 Jan 4;37(1):18-27
Knockdown of AMPKα decreases ATM expression and increases radiosensitivity under hypoxia and nutrient starvation in an SV40-transformed human fibroblast cell line, LM217.
Murata Y, Hashimoto T, Urushihara Y, Shiga S, Takeda K, Jingu K, Hosoi Y
Biochemical and biophysical research communications 2018 Jan 22;495(4):2566-2572
Biochemical and biophysical research communications 2018 Jan 22;495(4):2566-2572
Early Passage Mesenchymal Stem Cells Display Decreased Radiosensitivity and Increased DNA Repair Activity.
Wu PK, Wang JY, Chen CF, Chao KY, Chang MC, Chen WM, Hung SC
Stem cells translational medicine 2017 Jun;6(6):1504-1514
Stem cells translational medicine 2017 Jun;6(6):1504-1514
Plk1 Phosphorylation of Mre11 Antagonizes the DNA Damage Response.
Li Z, Li J, Kong Y, Yan S, Ahmad N, Liu X
Cancer research 2017 Jun 15;77(12):3169-3180
Cancer research 2017 Jun 15;77(12):3169-3180
Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination.
Frum RA, Love IM, Damle PK, Mukhopadhyay ND, Palit Deb S, Deb S, Grossman SR
Molecular cancer research : MCR 2016 May;14(5):423-36
Molecular cancer research : MCR 2016 May;14(5):423-36
Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs.
Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E
PLoS genetics 2016 Feb;12(2):e1005791
PLoS genetics 2016 Feb;12(2):e1005791
ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts.
Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y
Scientific reports 2016 Apr 19;6:24700
Scientific reports 2016 Apr 19;6:24700
NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability.
Parplys AC, Zhao W, Sharma N, Groesser T, Liang F, Maranon DG, Leung SG, Grundt K, Dray E, Idate R, Østvold AC, Schild D, Sung P, Wiese C
Nucleic acids research 2015 Nov 16;43(20):9817-34
Nucleic acids research 2015 Nov 16;43(20):9817-34
Activation of mTORC1 under nutrient starvation conditions increases cellular radiosensitivity in human liver cancer cell lines, HepG2 and HuH6.
Murata Y, Uehara Y, Hosoi Y
Biochemical and biophysical research communications 2015 Dec 25;468(4):684-90
Biochemical and biophysical research communications 2015 Dec 25;468(4):684-90
A-TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early-onset dystonia, cancer, and life-threatening radiotoxicity.
Nakamura K, Fike F, Haghayegh S, Saunders-Pullman R, Dawson AJ, Dörk T, Gatti RA
Molecular genetics & genomic medicine 2014 Jul;2(4):332-40
Molecular genetics & genomic medicine 2014 Jul;2(4):332-40
Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells.
Yoon JY, Ishdorj G, Graham BA, Johnston JB, Gibson SB
Apoptosis : an international journal on programmed cell death 2014 Jan;19(1):191-200
Apoptosis : an international journal on programmed cell death 2014 Jan;19(1):191-200
Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells.
Morita A, Tanimoto K, Murakami T, Morinaga T, Hosoi Y
Biochemical and biophysical research communications 2014 Jan 24;443(4):1286-90
Biochemical and biophysical research communications 2014 Jan 24;443(4):1286-90
DNA damage to a single chromosome end delays anaphase onset.
Silva BA, Stambaugh JR, Yokomori K, Shah JV, Berns MW
The Journal of biological chemistry 2014 Aug 15;289(33):22771-22784
The Journal of biological chemistry 2014 Aug 15;289(33):22771-22784
Characterization of Epstein-Barr virus reactivation in a modeled spaceflight system.
Brinley AA, Theriot CA, Nelman-Gonzalez M, Crucian B, Stowe RP, Barrett AD, Pierson DL
Journal of cellular biochemistry 2013 Mar;114(3):616-24
Journal of cellular biochemistry 2013 Mar;114(3):616-24
The kinase activity of ataxia-telangiectasia mutated interferes with adenovirus E4 mutant DNA replication.
Gautam D, Bridge E
Journal of virology 2013 Aug;87(15):8687-96
Journal of virology 2013 Aug;87(15):8687-96
Nek4 regulates entry into replicative senescence and the response to DNA damage in human fibroblasts.
Nguyen CL, Possemato R, Bauerlein EL, Xie A, Scully R, Hahn WC
Molecular and cellular biology 2012 Oct;32(19):3963-77
Molecular and cellular biology 2012 Oct;32(19):3963-77
Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations.
Jacquemin V, Rieunier G, Jacob S, Bellanger D, d'Enghien CD, Laugé A, Stoppa-Lyonnet D, Stern MH
European journal of human genetics : EJHG 2012 Mar;20(3):305-12
European journal of human genetics : EJHG 2012 Mar;20(3):305-12
Mechanism of T-oligo-induced cell cycle arrest in Mia-PaCa pancreatic cancer cells.
Rankin AM, Sarkar S, Faller DV
Journal of cellular physiology 2012 Jun;227(6):2586-94
Journal of cellular physiology 2012 Jun;227(6):2586-94
Enhancement of non-homologous end joining DNA repair capacity confers cancer cells resistance to the novel selenophene compound, D-501036.
Yang YN, Chou KM, Pan WY, Chen YW, Tsou TC, Yeh SC, Cheung CH, Chen LT, Chang JY
Cancer letters 2011 Oct 1;309(1):110-8
Cancer letters 2011 Oct 1;309(1):110-8
ATM-mediated NuSAP phosphorylation induces mitotic arrest.
Xie P, Li L, Xing G, Tian C, Yin Y, He F, Zhang L
Biochemical and biophysical research communications 2011 Jan 7;404(1):413-8
Biochemical and biophysical research communications 2011 Jan 7;404(1):413-8
Cell cycle control and DNA damage response of conditionally immortalized urothelial cells.
Dixon BP, Henry J, Siroky BJ, Chu A, Groen PA, Bissler JJ
PloS one 2011 Jan 28;6(1):e16595
PloS one 2011 Jan 28;6(1):e16595
Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum.
Du L, Kayali R, Bertoni C, Fike F, Hu H, Iversen PL, Gatti RA
Human molecular genetics 2011 Aug 15;20(16):3151-60
Human molecular genetics 2011 Aug 15;20(16):3151-60
Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells.
Wang SC, Wu CC, Wei YY, Hong JH, Chiang CS
International journal of radiation biology 2011 Apr;87(4):432-42
International journal of radiation biology 2011 Apr;87(4):432-42
Senescence evasion by MCF-7 human breast tumor-initiating cells.
Karimi-Busheri F, Rasouli-Nia A, Mackey JR, Weinfeld M
Breast cancer research : BCR 2010;12(3):R31
Breast cancer research : BCR 2010;12(3):R31
Spatial and spectral detection of protein monolayers with deterministic aperiodic arrays of metal nanoparticles.
Lee SY, Amsden JJ, Boriskina SV, Gopinath A, Mitropolous A, Kaplan DL, Omenetto FG, Dal Negro L
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 6;107(27):12086-90
Proceedings of the National Academy of Sciences of the United States of America 2010 Jul 6;107(27):12086-90
ATM is down-regulated by N-Myc-regulated microRNA-421.
Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1506-11
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1506-11
Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition.
Macůrek L, Lindqvist A, Voets O, Kool J, Vos HR, Medema RH
Oncogene 2010 Apr 15;29(15):2281-91
Oncogene 2010 Apr 15;29(15):2281-91
Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis.
Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S
Journal of lipid research 2009 Nov;50(11):2299-305
Journal of lipid research 2009 Nov;50(11):2299-305
p27Kip1 stabilization is essential for the maintenance of cell cycle arrest in response to DNA damage.
Cuadrado M, Gutierrez-Martinez P, Swat A, Nebreda AR, Fernandez-Capetillo O
Cancer research 2009 Nov 15;69(22):8726-32
Cancer research 2009 Nov 15;69(22):8726-32
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.
Tian C, Xing G, Xie P, Lu K, Nie J, Wang J, Li L, Gao M, Zhang L, He F
Nature cell biology 2009 May;11(5):580-91
Nature cell biology 2009 May;11(5):580-91
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Nahas SA, Butch AW, Du L, Gatti RA
Clinical chemistry 2009 Mar;55(3):463-72
Clinical chemistry 2009 Mar;55(3):463-72
Differential effects of hepatitis C virus JFH1 on human myeloid and plasmacytoid dendritic cells.
Liang H, Russell RS, Yonkers NL, McDonald D, Rodriguez B, Harding CV, Anthony DD
Journal of virology 2009 Jun;83(11):5693-707
Journal of virology 2009 Jun;83(11):5693-707
Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.
Shao L, Fujii H, Colmegna I, Oishi H, Goronzy JJ, Weyand CM
The Journal of experimental medicine 2009 Jun 8;206(6):1435-49
The Journal of experimental medicine 2009 Jun 8;206(6):1435-49
Nuclear export of NBN is required for normal cellular responses to radiation.
Vissinga CS, Yeo TC, Warren S, Brawley JV, Phillips J, Cerosaletti K, Concannon P
Molecular and cellular biology 2009 Feb;29(4):1000-6
Molecular and cellular biology 2009 Feb;29(4):1000-6
Circadian oscillation of nucleotide excision repair in mammalian brain.
Kang TH, Reardon JT, Kemp M, Sancar A
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 24;106(8):2864-7
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 24;106(8):2864-7
The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.
Gruhne B, Sompallae R, Marescotti D, Kamranvar SA, Gastaldello S, Masucci MG
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 17;106(7):2313-8
Proceedings of the National Academy of Sciences of the United States of America 2009 Feb 17;106(7):2313-8
Overall Cdk activity modulates the DNA damage response in mammalian cells.
Cerqueira A, Santamaría D, Martínez-Pastor B, Cuadrado M, Fernández-Capetillo O, Barbacid M
The Journal of cell biology 2009 Dec 14;187(6):773-80
The Journal of cell biology 2009 Dec 14;187(6):773-80
TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.
Mordes DA, Glick GG, Zhao R, Cortez D
Genes & development 2008 Jun 1;22(11):1478-89
Genes & development 2008 Jun 1;22(11):1478-89
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2'-C-cyano-2'-deoxy-1-beta-D-arabino-pentofuranosylcytosine.
Liu X, Matsuda A, Plunkett W
Molecular cancer therapeutics 2008 Jan;7(1):133-42
Molecular cancer therapeutics 2008 Jan;7(1):133-42
The Mre11 complex mediates the S-phase checkpoint through an interaction with replication protein A.
Olson E, Nievera CJ, Liu E, Lee AY, Chen L, Wu X
Molecular and cellular biology 2007 Sep;27(17):6053-67
Molecular and cellular biology 2007 Sep;27(17):6053-67
Global chromatin compaction limits the strength of the DNA damage response.
Murga M, Jaco I, Fan Y, Soria R, Martinez-Pastor B, Cuadrado M, Yang SM, Blasco MA, Skoultchi AI, Fernandez-Capetillo O
The Journal of cell biology 2007 Sep 24;178(7):1101-8
The Journal of cell biology 2007 Sep 24;178(7):1101-8
Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Babaev VR, Ishiguro H, Ding L, Yancey PG, Dove DE, Kovacs WJ, Semenkovich CF, Fazio S, Linton MF
Circulation 2007 Sep 18;116(12):1404-12
Circulation 2007 Sep 18;116(12):1404-12
Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14.
Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A
Cancer research 2007 Sep 15;67(18):8682-9
Cancer research 2007 Sep 15;67(18):8682-9
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.
Ambrose M, Goldstine JV, Gatti RA
Human molecular genetics 2007 Sep 15;16(18):2154-64
Human molecular genetics 2007 Sep 15;16(18):2154-64
Fanconi anemia pathway-deficient tumor cells are hypersensitive to inhibition of ataxia telangiectasia mutated.
Kennedy RD, Chen CC, Stuckert P, Archila EM, De la Vega MA, Moreau LA, Shimamura A, D'Andrea AD
The Journal of clinical investigation 2007 May;117(5):1440-9
The Journal of clinical investigation 2007 May;117(5):1440-9
Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.
Choi JH, Lindsey-Boltz LA, Sancar A
Proceedings of the National Academy of Sciences of the United States of America 2007 Aug 14;104(33):13301-6
Proceedings of the National Academy of Sciences of the United States of America 2007 Aug 14;104(33):13301-6
Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells.
Hiyama T, Katsura M, Yoshihara T, Ishida M, Kinomura A, Tonda T, Asahara T, Miyagawa K
Nucleic acids research 2006;34(3):880-92
Nucleic acids research 2006;34(3):880-92
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance.
Ho GP, Margossian S, Taniguchi T, D'Andrea AD
Molecular and cellular biology 2006 Sep;26(18):7005-15
Molecular and cellular biology 2006 Sep;26(18):7005-15
CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM.
Zhang L, Tie Y, Tian C, Xing G, Song Y, Zhu Y, Sun Z, He F
Cellular signalling 2006 Sep;18(9):1386-95
Cellular signalling 2006 Sep;18(9):1386-95
Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
Yang S, Jeong JH, Brown AL, Lee CH, Pandolfi PP, Chung JH, Kim MK
The Journal of biological chemistry 2006 Sep 8;281(36):26645-54
The Journal of biological chemistry 2006 Sep 8;281(36):26645-54
Silencing of p29 affects DNA damage responses with UV irradiation.
Chu PC, Yang YC, Lu YT, Chen HT, Yu LC, Chang MS
Cancer research 2006 Sep 1;66(17):8484-91
Cancer research 2006 Sep 1;66(17):8484-91
DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D
Molecular and cellular biology 2006 Nov;26(21):7977-90
Molecular and cellular biology 2006 Nov;26(21):7977-90
Ataxia-telangiectasia-mutated (ATM) protein can enhance human immunodeficiency virus type 1 replication by stimulating Rev function.
Ariumi Y, Trono D
Journal of virology 2006 Mar;80(5):2445-52
Journal of virology 2006 Mar;80(5):2445-52
Hepatic SR-BI-mediated cholesteryl ester selective uptake occurs with unaltered efficiency in the absence of cellular energy.
Harder CJ, Vassiliou G, McBride HM, McPherson R
Journal of lipid research 2006 Mar;47(3):492-503
Journal of lipid research 2006 Mar;47(3):492-503
Active role for nibrin in the kinetics of atm activation.
Cerosaletti K, Wright J, Concannon P
Molecular and cellular biology 2006 Mar;26(5):1691-9
Molecular and cellular biology 2006 Mar;26(5):1691-9
Human cytomegalovirus inhibits a DNA damage response by mislocalizing checkpoint proteins.
Gaspar M, Shenk T
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2821-6
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2821-6
ATM regulates ATR chromatin loading in response to DNA double-strand breaks.
Cuadrado M, Martinez-Pastor B, Murga M, Toledo LI, Gutierrez-Martinez P, Lopez E, Fernandez-Capetillo O
The Journal of experimental medicine 2006 Feb 20;203(2):297-303
The Journal of experimental medicine 2006 Feb 20;203(2):297-303
Time course of microbiologic outcome and gene expression in Candida albicans during and following in vitro and in vivo exposure to fluconazole.
Lepak A, Nett J, Lincoln L, Marchillo K, Andes D
Antimicrobial agents and chemotherapy 2006 Apr;50(4):1311-9
Antimicrobial agents and chemotherapy 2006 Apr;50(4):1311-9
Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres.
Hovest MG, Brüggenolte N, Hosseini KS, Krieg T, Herrmann G
Molecular biology of the cell 2006 Apr;17(4):1758-67
Molecular biology of the cell 2006 Apr;17(4):1758-67
Effects of hepatic expression of the high-density lipoprotein receptor SR-BI on lipoprotein metabolism and female fertility.
Yesilaltay A, Morales MG, Amigo L, Zanlungo S, Rigotti A, Karackattu SL, Donahee MH, Kozarsky KF, Krieger M
Endocrinology 2006 Apr;147(4):1577-88
Endocrinology 2006 Apr;147(4):1577-88
Rapid activation of ATR by ionizing radiation requires ATM and Mre11.
Myers JS, Cortez D
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
The Journal of biological chemistry 2006 Apr 7;281(14):9346-50
DNA damage sensors ATM, ATR, DNA-PKcs, and PARP-1 are dispensable for human immunodeficiency virus type 1 integration.
Ariumi Y, Turelli P, Masutani M, Trono D
Journal of virology 2005 Mar;79(5):2973-8
Journal of virology 2005 Mar;79(5):2973-8
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, Bedford JS
Cancer research 2005 Mar 1;65(5):1670-7
Cancer research 2005 Mar 1;65(5):1670-7
Adenovirus-mediated hepatic overexpression of scavenger receptor class B type I accelerates chylomicron metabolism in C57BL/6J mice.
Out R, Hoekstra M, de Jager SC, de Vos P, van der Westhuyzen DR, Webb NR, Van Eck M, Biessen EA, Van Berkel TJ
Journal of lipid research 2005 Jun;46(6):1172-81
Journal of lipid research 2005 Jun;46(6):1172-81
DNA repair proteins affect the lifecycle of herpes simplex virus 1.
Lilley CE, Carson CT, Muotri AR, Gage FH, Weitzman MD
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
Proceedings of the National Academy of Sciences of the United States of America 2005 Apr 19;102(16):5844-9
DNA damage induced by temozolomide signals to both ATM and ATR: role of the mismatch repair system.
Caporali S, Falcinelli S, Starace G, Russo MT, Bonmassar E, Jiricny J, D'Atri S
Molecular pharmacology 2004 Sep;66(3):478-91
Molecular pharmacology 2004 Sep;66(3):478-91
CHK1 and CHK2 are differentially involved in mismatch repair-mediated 6-thioguanine-induced cell cycle checkpoint responses.
Yan T, Desai AB, Jacobberger JW, Sramkoski RM, Loh T, Kinsella TJ
Molecular cancer therapeutics 2004 Sep;3(9):1147-57
Molecular cancer therapeutics 2004 Sep;3(9):1147-57
Independent roles for nibrin and Mre11-Rad50 in the activation and function of Atm.
Cerosaletti K, Concannon P
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
The Journal of biological chemistry 2004 Sep 10;279(37):38813-9
The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.
Dow GS, Koenig ML, Wolf L, Gerena L, Lopez-Sanchez M, Hudson TH, Bhattacharjee AK
Antimicrobial agents and chemotherapy 2004 Jul;48(7):2624-32
Antimicrobial agents and chemotherapy 2004 Jul;48(7):2624-32
Immunoassay to measure ataxia-telangiectasia mutated protein in cellular lysates.
Butch AW, Chun HH, Nahas SA, Gatti RA
Clinical chemistry 2004 Dec;50(12):2302-8
Clinical chemistry 2004 Dec;50(12):2302-8
Caffeine inhibits checkpoint responses without inhibiting the ataxia-telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) protein kinases.
Cortez D
The Journal of biological chemistry 2003 Sep 26;278(39):37139-45
The Journal of biological chemistry 2003 Sep 26;278(39):37139-45
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J
Cancer cell 2003 Mar;3(3):247-58
Cancer cell 2003 Mar;3(3):247-58
Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.
Sørensen CS, Syljuåsen RG, Falck J, Schroeder T, Rönnstrand L, Khanna KK, Zhou BB, Bartek J, Lukas J
Cancer cell 2003 Mar;3(3):247-58
Cancer cell 2003 Mar;3(3):247-58
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex.
Stracker TH, Carson CT, Weitzman MD
Nature 2002 Jul 18;418(6895):348-52
Nature 2002 Jul 18;418(6895):348-52
Interaction of FANCD2 and NBS1 in the DNA damage response.
Nakanishi K, Taniguchi T, Ranganathan V, New HV, Moreau LA, Stotsky M, Mathew CG, Kastan MB, Weaver DT, D'Andrea AD
Nature cell biology 2002 Dec;4(12):913-20
Nature cell biology 2002 Dec;4(12):913-20
ATR regulates fragile site stability.
Casper AM, Nghiem P, Arlt MF, Glover TW
Cell 2002 Dec 13;111(6):779-89
Cell 2002 Dec 13;111(6):779-89
ATR regulates fragile site stability.
Casper AM, Nghiem P, Arlt MF, Glover TW
Cell 2002 Dec 13;111(6):779-89
Cell 2002 Dec 13;111(6):779-89
UV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.
Oakley GG, Loberg LI, Yao J, Risinger MA, Yunker RL, Zernik-Kobak M, Khanna KK, Lavin MF, Carty MP, Dixon K
Molecular biology of the cell 2001 May;12(5):1199-213
Molecular biology of the cell 2001 May;12(5):1199-213
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Vemuri MC, Schiller E, Naegele JR
Cell death and differentiation 2001 Mar;8(3):245-55
Cell death and differentiation 2001 Mar;8(3):245-55
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Scherthan H, Jerratsch M, Dhar S, Wang YA, Goff SP, Pandita TK
Molecular and cellular biology 2000 Oct;20(20):7773-83
Molecular and cellular biology 2000 Oct;20(20):7773-83
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Scherthan H, Jerratsch M, Dhar S, Wang YA, Goff SP, Pandita TK
Molecular and cellular biology 2000 Oct;20(20):7773-83
Molecular and cellular biology 2000 Oct;20(20):7773-83
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Wang Y, Cortez D, Yazdi P, Neff N, Elledge SJ, Qin J
Genes & development 2000 Apr 15;14(8):927-39
Genes & development 2000 Apr 15;14(8):927-39
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Cortez D, Wang Y, Qin J, Elledge SJ
Science (New York, N.Y.) 1999 Nov 5;286(5442):1162-6
Science (New York, N.Y.) 1999 Nov 5;286(5442):1162-6
Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks.
Cortez D, Wang Y, Qin J, Elledge SJ
Science (New York, N.Y.) 1999 Nov 5;286(5442):1162-6
Science (New York, N.Y.) 1999 Nov 5;286(5442):1162-6
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM Antibody [NB100-104] - Detection of ATM in HeLa nuclear extract using ATM antibody [NB100-104]. Theoretical molecular weight 351 kDa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM Antibody [NB100-104] - Detection of ATM in Raji whole cell lysate using [NB100-104]. Observed molecular weight ~300 kDa. Theoretical molecular weight 351 kDa.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ATM Antibody [NB100-104] - Staining of human tonsil, germinal center and mantle zone with ATM Antibody [NB100-104].
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: ATM Antibody [NB100-104] - Analysis of PE conjugate of ATM Antibody [NB100-104PE]. An intracellular stain was performed on HeLa cells with ATM antibody [NB100-104PE] (blue) and a matched isotype control [NBP2-24893PE] (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: ATM Antibody [NB100-104] - An intracellular stain was performed on HepG2 cells with PE-conjugated ATM antibody [NB100-104PE] (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Phycoerythrin.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Flow Cytometry: ATM Antibody [NB100-104] - An intracellular stain was performed on HeLa cells with Dylight 550-conjugated ATM Antibody [NB100-104R] (blue) and a matched isotype control (orange). Cells were fixed with 4% PFA and then permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 5 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to DyLight 550.
