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antibody from Novus Biologicals
Targeting: ATM
ATA, ATC, ATD, ATDC, TEL1, TELO1
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ELISA Immunocytochemistry Immunoprecipitation Immunohistochemistry Flow cytometry Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [118]
- Comments [0]
- Validations
- Western blot [5]
- Immunohistochemistry [2]
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- Product number
- NB100-309 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NB100-309, RRID:AB_2243346
- Product name
- Mouse Monoclonal ATM Antibody
- Antibody type
- Monoclonal
- Description
- Antigen Affinity-purified. ATM Antibody (2C1) recognizes full-length ATM, a 350-kDa nuclear phosphoprotein.
- Reactivity
- Human, Mouse, Rat, Simian
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 100 ul
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress.
Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest.
HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
Inhibition of S-adenosylhomocysteine hydrolase decreases cell mobility and cell proliferation through cell cycle arrest.
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.
Notch is a direct negative regulator of the DNA-damage response.
Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.
Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus.
Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair.
Host DNA damage response facilitates African swine fever virus infection.
Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy.
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Deregulation of DNA damage response pathway by intercellular contact.
58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin.
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation.
The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase.
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
A novel role for hSMG-1 in stress granule formation.
ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Autophosphorylation and ATM activation: additional sites add to the complexity.
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
ATM mediated phosphorylation of CHD4 contributes to genome maintenance.
Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM).
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer.
Oligomerization of MDC1 protein is important for proper DNA damage response.
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.
Three-dimensional cell growth confers radioresistance by chromatin density modification.
Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Discovery of putative oocyte quality markers by comparative ExacTag proteomics.
Replication independent DNA double-strand break retention may prevent genomic instability.
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Low levels of ATM in breast cancer patients with clinical radiosensitivity.
Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.
ATM is down-regulated by N-Myc-regulated microRNA-421.
Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
ATM activation in the presence of oxidative stress.
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
NKX3.1 activates cellular response to DNA damage.
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.
ARTEMIS nuclease facilitates apoptotic chromatin cleavage.
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.
ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein.
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint.
Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors.
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.
EDD mediates DNA damage-induced activation of CHK2.
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Involvement of novel autophosphorylation sites in ATM activation.
Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.
Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.
Regulation of CHK2 by DNA-dependent protein kinase.
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, Wang Y, Su C, Xin L, Ren Y, Zhang W, Sun X, Ge L, Silvennoinen O, Yao Z, Yang X, Yang J
Cell death and differentiation 2018 Sep;25(9):1625-1637
Cell death and differentiation 2018 Sep;25(9):1625-1637
Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest.
Belužić L, Grbeša I, Belužić R, Park JH, Kong HK, Kopjar N, Espadas G, Sabidó E, Lepur A, Rokić F, Jerić I, Brkljačić L, Vugrek O
Scientific reports 2018 Sep 18;8(1):14012
Scientific reports 2018 Sep 18;8(1):14012
HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, Imhof D, Christmann M, Heinzel T, Schneider G, Krämer OH
Nature communications 2018 Feb 22;9(1):764
Nature communications 2018 Feb 22;9(1):764
Inhibition of S-adenosylhomocysteine hydrolase decreases cell mobility and cell proliferation through cell cycle arrest.
Park SJ, Kong HK, Kim YS, Lee YS, Park JH
American journal of cancer research 2015;5(7):2127-38
American journal of cancer research 2015;5(7):2127-38
Processing by MRE11 is involved in the sensitivity of subtelomeric regions to DNA double-strand breaks.
Muraki K, Han L, Miller D, Murnane JP
Nucleic acids research 2015 Sep 18;43(16):7911-30
Nucleic acids research 2015 Sep 18;43(16):7911-30
Notch is a direct negative regulator of the DNA-damage response.
Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F
Nature structural & molecular biology 2015 May;22(5):417-24
Nature structural & molecular biology 2015 May;22(5):417-24
Cockayne syndrome group B protein regulates DNA double-strand break repair and checkpoint activation.
Batenburg NL, Thompson EL, Hendrickson EA, Zhu XD
The EMBO journal 2015 May 12;34(10):1399-416
The EMBO journal 2015 May 12;34(10):1399-416
Early intranuclear replication of African swine fever virus genome modifies the landscape of the host cell nucleus.
Simões M, Martins C, Ferreira F
Virus research 2015 Dec 2;210:1-7
Virus research 2015 Dec 2;210:1-7
Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.
Min W, Bruhn C, Grigaravicius P, Zhou ZW, Li F, Krüger A, Siddeek B, Greulich KO, Popp O, Meisezahl C, Calkhoven CF, Bürkle A, Xu X, Wang ZQ
Nature communications 2013;4:2993
Nature communications 2013;4:2993
Mitochondrial dysfunction in a novel form of autosomal recessive ataxia.
Murad NA, Cullen JK, McKenzie M, Ryan MT, Thorburn D, Gueven N, Kobayashi J, Birrell G, Yang J, Dörk T, Becherel O, Grattan-Smith P, Lavin MF
Mitochondrion 2013 May;13(3):235-45
Mitochondrion 2013 May;13(3):235-45
Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair.
Gutiérrez-González A, Belda-Iniesta C, Bargiela-Iparraguirre J, Dominguez G, García Alfonso P, Perona R, Sanchez-Perez I
Apoptosis : an international journal on programmed cell death 2013 Mar;18(3):347-60
Apoptosis : an international journal on programmed cell death 2013 Mar;18(3):347-60
Host DNA damage response facilitates African swine fever virus infection.
Simões M, Martins C, Ferreira F
Veterinary microbiology 2013 Jul 26;165(1-2):140-7
Veterinary microbiology 2013 Jul 26;165(1-2):140-7
Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy.
Shi Y, Felley-Bosco E, Marti TM, Stahel RA
PloS one 2012;7(9):e45354
PloS one 2012;7(9):e45354
AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation.
Baritaud M, Cabon L, Delavallée L, Galán-Malo P, Gilles ME, Brunelle-Navas MN, Susin SA
Cell death & disease 2012 Sep 13;3:e390
Cell death & disease 2012 Sep 13;3:e390
Ataxia-Telangiectasia, Mutated (ATM)/Nuclear Factor κ light chain enhancer of activated B cells (NFκB) signaling controls basal and DNA damage-induced transglutaminase 2 expression.
Ai L, Skehan RR, Saydi J, Lin T, Brown KD
The Journal of biological chemistry 2012 May 25;287(22):18330-41
The Journal of biological chemistry 2012 May 25;287(22):18330-41
Deregulation of DNA damage response pathway by intercellular contact.
Kang MA, So EY, Ouchi T
The Journal of biological chemistry 2012 May 11;287(20):16246-55
The Journal of biological chemistry 2012 May 11;287(20):16246-55
58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.
Hsu CC, Lee YC, Yeh SH, Chen CH, Wu CC, Wang TY, Chen YN, Hung LY, Liu YW, Chen HK, Hsiao YT, Wang WS, Tsou JH, Tsou YH, Wu MH, Chang WC, Lin DY
The Journal of biological chemistry 2012 Jun 29;287(27):22533-48
The Journal of biological chemistry 2012 Jun 29;287(27):22533-48
Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer.
Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence HR, Engelman RW, Lawrence NJ, Mahajan NP
The Journal of biological chemistry 2012 Jun 22;287(26):22112-22
The Journal of biological chemistry 2012 Jun 22;287(26):22112-22
The E3 ubiquitin ligase Mule acts through the ATM-p53 axis to maintain B lymphocyte homeostasis.
Hao Z, Duncan GS, Su YW, Li WY, Silvester J, Hong C, You H, Brenner D, Gorrini C, Haight J, Wakeham A, You-Ten A, McCracken S, Elia A, Li Q, Detmar J, Jurisicova A, Hobeika E, Reth M, Sheng Y, Lang PA, Ohashi PS, Zhong Q, Wang X, Mak TW
The Journal of experimental medicine 2012 Jan 16;209(1):173-86
The Journal of experimental medicine 2012 Jan 16;209(1):173-86
CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.
Sakasai R, Sakai A, Iimori M, Kiyonari S, Matsuoka K, Kakeji Y, Kitao H, Maehara Y
Genes to cells : devoted to molecular & cellular mechanisms 2012 Dec;17(12):962-70
Genes to cells : devoted to molecular & cellular mechanisms 2012 Dec;17(12):962-70
Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin.
Shi Y, Felley-Bosco E, Marti TM, Orlowski K, Pruschy M, Stahel RA
BMC cancer 2012 Dec 4;12:571
BMC cancer 2012 Dec 4;12:571
Resistance of glioblastoma-initiating cells to radiation mediated by the tumor microenvironment can be abolished by inhibiting transforming growth factor-β.
Hardee ME, Marciscano AE, Medina-Ramirez CM, Zagzag D, Narayana A, Lonning SM, Barcellos-Hoff MH
Cancer research 2012 Aug 15;72(16):4119-29
Cancer research 2012 Aug 15;72(16):4119-29
ATM-dependent phosphorylation of SNEVhPrp19/hPso4 is involved in extending cellular life span and suppression of apoptosis.
Dellago H, Khan A, Nussbacher M, Gstraunthaler A, Lämmermann I, Schosserer M, Mück C, Anrather D, Scheffold A, Ammerer G, Jansen-Dürr P, Rudolph KL, Voglauer-Grillari R, Grillari J
Aging 2012 Apr;4(4):290-304
Aging 2012 Apr;4(4):290-304
Role of the translationally controlled tumor protein in DNA damage sensing and repair.
Zhang J, de Toledo SM, Pandey BN, Guo G, Pain D, Li H, Azzam EI
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 17;109(16):E926-33
Proceedings of the National Academy of Sciences of the United States of America 2012 Apr 17;109(16):E926-33
RAC1 GTPase plays an important role in γ-irradiation induced G2/M checkpoint activation.
Yan Y, Greer PM, Cao PT, Kolb RH, Cowan KH
Breast cancer research : BCR 2012 Apr 11;14(2):R60
Breast cancer research : BCR 2012 Apr 11;14(2):R60
The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase.
Xu Y, Parmar K, Du F, Price BD, Sun Y
International journal of biochemistry and molecular biology 2011;2(4):295-302
International journal of biochemistry and molecular biology 2011;2(4):295-302
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
Shouse GP, Nobumori Y, Panowicz MJ, Liu X
Oncogene 2011 Sep 1;30(35):3755-65
Oncogene 2011 Sep 1;30(35):3755-65
A novel role for hSMG-1 in stress granule formation.
Brown JA, Roberts TL, Richards R, Woods R, Birrell G, Lim YC, Ohno S, Yamashita A, Abraham RT, Gueven N, Lavin MF
Molecular and cellular biology 2011 Nov;31(22):4417-29
Molecular and cellular biology 2011 Nov;31(22):4417-29
ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.
Assaily W, Rubinger DA, Wheaton K, Lin Y, Ma W, Xuan W, Brown-Endres L, Tsuchihara K, Mak TW, Benchimol S
Molecular cell 2011 Nov 4;44(3):491-501
Molecular cell 2011 Nov 4;44(3):491-501
Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M
The Journal of biological chemistry 2011 Nov 11;286(45):39200-10
The Journal of biological chemistry 2011 Nov 11;286(45):39200-10
AT cells are not radiosensitive for simple chromosomal exchanges at low dose.
Hada M, Huff JL, Patel ZS, Kawata T, Pluth JM, George KA, Cucinotta FA
Mutation research 2011 Nov 1;716(1-2):76-83
Mutation research 2011 Nov 1;716(1-2):76-83
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly.
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, Ogi T, Tahara H, Oku S, Hiramoto A, Shiiki T, Fujisawa Y, Ohashi H, Sakemi Y, Matsuura S
DNA repair 2011 Mar 7;10(3):314-21
DNA repair 2011 Mar 7;10(3):314-21
Autophosphorylation and ATM activation: additional sites add to the complexity.
Kozlov SV, Graham ME, Jakob B, Tobias F, Kijas AW, Tanuji M, Chen P, Robinson PJ, Taucher-Scholz G, Suzuki K, So S, Chen D, Lavin MF
The Journal of biological chemistry 2011 Mar 18;286(11):9107-19
The Journal of biological chemistry 2011 Mar 18;286(11):9107-19
A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.
Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, Salles B, Muller C
Journal of cell science 2011 Jun 1;124(Pt 11):1943-51
Journal of cell science 2011 Jun 1;124(Pt 11):1943-51
The FANC pathway is activated by adenovirus infection and promotes viral replication-dependent recombination.
Cherubini G, Naim V, Caruso P, Burla R, Bogliolo M, Cundari E, Benihoud K, Saggio I, Rosselli F
Nucleic acids research 2011 Jul;39(13):5459-73
Nucleic acids research 2011 Jul;39(13):5459-73
ATM mediated phosphorylation of CHD4 contributes to genome maintenance.
Urquhart AJ, Gatei M, Richard DJ, Khanna KK
Genome integrity 2011 Jan 10;2(1):1
Genome integrity 2011 Jan 10;2(1):1
Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM).
Ruiz Z, Mihaylov IS, Cotmore SF, Tattersall P
Virology 2011 Feb 20;410(2):375-84
Virology 2011 Feb 20;410(2):375-84
Nek1 kinase functions in DNA damage response and checkpoint control through a pathway independent of ATM and ATR.
Chen Y, Chen CF, Riley DJ, Chen PL
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Cell cycle (Georgetown, Tex.) 2011 Feb 15;10(4):655-63
Inhibition of telomerase activity preferentially targets aldehyde dehydrogenase-positive cancer stem-like cells in lung cancer.
Serrano D, Bleau AM, Fernandez-Garcia I, Fernandez-Marcelo T, Iniesta P, Ortiz-de-Solorzano C, Calvo A
Molecular cancer 2011 Aug 9;10:96
Molecular cancer 2011 Aug 9;10:96
Oligomerization of MDC1 protein is important for proper DNA damage response.
Luo K, Yuan J, Lou Z
The Journal of biological chemistry 2011 Aug 12;286(32):28192-9
The Journal of biological chemistry 2011 Aug 12;286(32):28192-9
The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.
Xu Y, Sun Y, Jiang X, Ayrapetov MK, Moskwa P, Yang S, Weinstock DM, Price BD
The Journal of cell biology 2010 Oct 4;191(1):31-43
The Journal of cell biology 2010 Oct 4;191(1):31-43
Regulation of DNA polymerase POLD4 influences genomic instability in lung cancer.
Huang QM, Tomida S, Masuda Y, Arima C, Cao K, Kasahara TA, Osada H, Yatabe Y, Akashi T, Kamiya K, Takahashi T, Suzuki M
Cancer research 2010 Nov 1;70(21):8407-16
Cancer research 2010 Nov 1;70(21):8407-16
Three-dimensional cell growth confers radioresistance by chromatin density modification.
Storch K, Eke I, Borgmann K, Krause M, Richter C, Becker K, Schröck E, Cordes N
Cancer research 2010 May 15;70(10):3925-34
Cancer research 2010 May 15;70(10):3925-34
Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison.
Sakasai R, Teraoka H, Takagi M, Tibbetts RS
The Journal of biological chemistry 2010 May 14;285(20):15201-8
The Journal of biological chemistry 2010 May 14;285(20):15201-8
Discovery of putative oocyte quality markers by comparative ExacTag proteomics.
Powell MD, Manandhar G, Spate L, Sutovsky M, Zimmerman S, Sachdev SC, Hannink M, Prather RS, Sutovsky P
Proteomics. Clinical applications 2010 Mar;4(3):337-51
Proteomics. Clinical applications 2010 Mar;4(3):337-51
Replication independent DNA double-strand break retention may prevent genomic instability.
Kongruttanachok N, Phuangphairoj C, Thongnak A, Ponyeam W, Rattanatanyong P, Pornthanakasem W, Mutirangura A
Molecular cancer 2010 Mar 31;9:70
Molecular cancer 2010 Mar 31;9:70
Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway.
Wilhelm MT, Rufini A, Wetzel MK, Tsuchihara K, Inoue S, Tomasini R, Itie-Youten A, Wakeham A, Arsenian-Henriksson M, Melino G, Kaplan DR, Miller FD, Mak TW
Genes & development 2010 Mar 15;24(6):549-60
Genes & development 2010 Mar 15;24(6):549-60
Low levels of ATM in breast cancer patients with clinical radiosensitivity.
Fang Z, Kozlov S, McKay MJ, Woods R, Birrell G, Sprung CN, Murrell DF, Wangoo K, Teng L, Kearsley JH, Lavin MF, Graham PH, Clarke RA
Genome integrity 2010 Jun 24;1(1):9
Genome integrity 2010 Jun 24;1(1):9
Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.
Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, Salles B, Muller C
Cell cycle (Georgetown, Tex.) 2010 Jul 15;9(14):2814-22
Cell cycle (Georgetown, Tex.) 2010 Jul 15;9(14):2814-22
ATM is down-regulated by N-Myc-regulated microRNA-421.
Hu H, Du L, Nagabayashi G, Seeger RC, Gatti RA
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1506-11
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 26;107(4):1506-11
Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin.
Sakasai R, Teraoka H, Tibbetts RS
DNA repair 2010 Jan 2;9(1):76-82
DNA repair 2010 Jan 2;9(1):76-82
CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.
Yoshida K, Sugimoto N, Iwahori S, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M
Journal of cell science 2010 Jan 15;123(Pt 2):225-35
Journal of cell science 2010 Jan 15;123(Pt 2):225-35
ATM activation in the presence of oxidative stress.
Guo Z, Deshpande R, Paull TT
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
Cell cycle (Georgetown, Tex.) 2010 Dec 15;9(24):4805-11
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Lee JH, Choy ML, Ngo L, Foster SS, Marks PA
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 17;107(33):14639-44
Proceedings of the National Academy of Sciences of the United States of America 2010 Aug 17;107(33):14639-44
Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress.
Shanware NP, Zhan L, Hutchinson JA, Kim SH, Williams LM, Tibbetts RS
PloS one 2010 Aug 13;5(8):e12173
PloS one 2010 Aug 13;5(8):e12173
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.
Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK
Nucleic acids research 2010 Apr;38(6):1821-31
Nucleic acids research 2010 Apr;38(6):1821-31
Requirement of ATM for rapid p53 phosphorylation at Ser46 without Ser/Thr-Gln sequences.
Kodama M, Otsubo C, Hirota T, Yokota J, Enari M, Taya Y
Molecular and cellular biology 2010 Apr;30(7):1620-33
Molecular and cellular biology 2010 Apr;30(7):1620-33
NKX3.1 activates cellular response to DNA damage.
Bowen C, Gelmann EP
Cancer research 2010 Apr 15;70(8):3089-97
Cancer research 2010 Apr 15;70(8):3089-97
SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.
Papp LV, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, Khanna KK
Antioxidants & redox signaling 2010 Apr 1;12(7):797-808
Antioxidants & redox signaling 2010 Apr 1;12(7):797-808
ARTEMIS nuclease facilitates apoptotic chromatin cleavage.
Britton S, Frit P, Biard D, Salles B, Calsou P
Cancer research 2009 Oct 15;69(20):8120-6
Cancer research 2009 Oct 15;69(20):8120-6
Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.
Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD
Nature cell biology 2009 Nov;11(11):1376-82
Nature cell biology 2009 Nov;11(11):1376-82
Rapid flow cytometry-based structural maintenance of chromosomes 1 (SMC1) phosphorylation assay for identification of ataxia-telangiectasia homozygotes and heterozygotes.
Nahas SA, Butch AW, Du L, Gatti RA
Clinical chemistry 2009 Mar;55(3):463-72
Clinical chemistry 2009 Mar;55(3):463-72
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway.
Cui B, Johnson SP, Bullock N, Ali-Osman F, Bigner DD, Friedman HS
Molecular pharmacology 2009 Jun;75(6):1356-63
Molecular pharmacology 2009 Jun;75(6):1356-63
Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex.
Martin LJ, Liu Z, Pipino J, Chestnut B, Landek MA
Cerebral cortex (New York, N.Y. : 1991) 2009 Jun;19(6):1273-93
Cerebral cortex (New York, N.Y. : 1991) 2009 Jun;19(6):1273-93
ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
Heffernan TP, Kawasumi M, Blasina A, Anderes K, Conney AH, Nghiem P
The Journal of investigative dermatology 2009 Jul;129(7):1805-15
The Journal of investigative dermatology 2009 Jul;129(7):1805-15
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.
Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat PS, Roberts TM, Gjoerup OV
Journal of virology 2009 Jan;83(1):117-27
Journal of virology 2009 Jan;83(1):117-27
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.
So S, Davis AJ, Chen DJ
The Journal of cell biology 2009 Dec 28;187(7):977-90
The Journal of cell biology 2009 Dec 28;187(7):977-90
Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa-Saito M, Waga S, Kiyono T, Fujita M
Journal of cell science 2009 Apr 15;122(Pt 8):1184-91
Journal of cell science 2009 Apr 15;122(Pt 8):1184-91
Positive regulation of DNA double strand break repair activity during differentiation of long life span cells: the example of adipogenesis.
Meulle A, Salles B, Daviaud D, Valet P, Muller C
PloS one 2008;3(10):e3345
PloS one 2008;3(10):e3345
Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells.
Yalcin S, Zhang X, Luciano JP, Mungamuri SK, Marinkovic D, Vercherat C, Sarkar A, Grisotto M, Taneja R, Ghaffari S
The Journal of biological chemistry 2008 Sep 12;283(37):25692-705
The Journal of biological chemistry 2008 Sep 12;283(37):25692-705
The DNA damage sensors ataxia-telangiectasia mutated kinase and checkpoint kinase 2 are required for hepatitis C virus RNA replication.
Ariumi Y, Kuroki M, Dansako H, Abe K, Ikeda M, Wakita T, Kato N
Journal of virology 2008 Oct;82(19):9639-46
Journal of virology 2008 Oct;82(19):9639-46
RNF8-dependent and RNF8-independent regulation of 53BP1 in response to DNA damage.
Sakasai R, Tibbetts R
The Journal of biological chemistry 2008 May 16;283(20):13549-55
The Journal of biological chemistry 2008 May 16;283(20):13549-55
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia.
Rimkus SA, Katzenberger RJ, Trinh AT, Dodson GE, Tibbetts RS, Wassarman DA
Genes & development 2008 May 1;22(9):1205-20
Genes & development 2008 May 1;22(9):1205-20
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita M
Molecular biology of the cell 2008 Mar;19(3):1007-21
Molecular biology of the cell 2008 Mar;19(3):1007-21
ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.
Stohr BA, Blackburn EH
Cancer research 2008 Jul 1;68(13):5309-17
Cancer research 2008 Jul 1;68(13):5309-17
Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair.
Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shieh SY, Shen CY
The EMBO journal 2008 Dec 3;27(23):3140-50
The EMBO journal 2008 Dec 3;27(23):3140-50
Elevated ornithine decarboxylase levels activate ataxia telangiectasia mutated-DNA damage signaling in normal keratinocytes.
Wei G, DeFeo K, Hayes CS, Woster PM, Mandik-Nayak L, Gilmour SK
Cancer research 2008 Apr 1;68(7):2214-22
Cancer research 2008 Apr 1;68(7):2214-22
Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated protein.
Iwahori S, Shirata N, Kawaguchi Y, Weller SK, Sato Y, Kudoh A, Nakayama S, Isomura H, Tsurumi T
Journal of virology 2007 Sep;81(18):9653-64
Journal of virology 2007 Sep;81(18):9653-64
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage.
Wood JL, Singh N, Mer G, Chen J
The Journal of biological chemistry 2007 Nov 30;282(48):35416-23
The Journal of biological chemistry 2007 Nov 30;282(48):35416-23
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint.
Stauffer D, Chang B, Huang J, Dunn A, Thayer M
The Journal of biological chemistry 2007 Mar 30;282(13):9678-87
The Journal of biological chemistry 2007 Mar 30;282(13):9678-87
Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies.
Shi Y, Dodson GE, Mukhopadhyay PS, Shanware NP, Trinh AT, Tibbetts RS
The Journal of biological chemistry 2007 Mar 23;282(12):9236-43
The Journal of biological chemistry 2007 Mar 23;282(12):9236-43
Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells.
Fernandes ND, Sun Y, Price BD
The Journal of biological chemistry 2007 Jun 1;282(22):16577-84
The Journal of biological chemistry 2007 Jun 1;282(22):16577-84
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation.
Wu X, Shell SM, Liu Y, Zou Y
Oncogene 2007 Feb 1;26(5):757-64
Oncogene 2007 Feb 1;26(5):757-64
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity.
Sun Y, Xu Y, Roy K, Price BD
Molecular and cellular biology 2007 Dec;27(24):8502-9
Molecular and cellular biology 2007 Dec;27(24):8502-9
Tripeptidyl-peptidase II controls DNA damage responses and in vivo gamma-irradiation resistance of tumors.
Hong X, Lei L, Künert B, Naredla R, Applequist SE, Grandien A, Glas R
Cancer research 2007 Aug 1;67(15):7165-74
Cancer research 2007 Aug 1;67(15):7165-74
Artemis links ATM to G2/M checkpoint recovery via regulation of Cdk1-cyclin B.
Geng L, Zhang X, Zheng S, Legerski RJ
Molecular and cellular biology 2007 Apr;27(7):2625-35
Molecular and cellular biology 2007 Apr;27(7):2625-35
Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.
Inoue Y, Kitagawa M, Taya Y
The EMBO journal 2007 Apr 18;26(8):2083-93
The EMBO journal 2007 Apr 18;26(8):2083-93
Wip1 phosphatase modulates ATM-dependent signaling pathways.
Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, Kek C, Timofeev ON, Dudgeon C, Fornace AJ, Anderson CW, Minami Y, Appella E, Bulavin DV
Molecular cell 2006 Sep 1;23(5):757-64
Molecular cell 2006 Sep 1;23(5):757-64
Inhibition of transforming growth factor-beta1 signaling attenuates ataxia telangiectasia mutated activity in response to genotoxic stress.
Kirshner J, Jobling MF, Pajares MJ, Ravani SA, Glick AB, Lavin MJ, Koslov S, Shiloh Y, Barcellos-Hoff MH
Cancer research 2006 Nov 15;66(22):10861-9
Cancer research 2006 Nov 15;66(22):10861-9
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.
Liu Y, Rusinol A, Sinensky M, Wang Y, Zou Y
Journal of cell science 2006 Nov 15;119(Pt 22):4644-9
Journal of cell science 2006 Nov 15;119(Pt 22):4644-9
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ
Molecular and cellular biology 2006 Mar;26(5):1598-609
Molecular and cellular biology 2006 Mar;26(5):1598-609
Defective p53 response and apoptosis associated with an ataxia-telangiectasia-like phenotype.
Gueven N, Becherel OJ, Birrell G, Chen P, DelSal G, Carney JP, Grattan-Smith P, Lavin MF
Cancer research 2006 Mar 15;66(6):2907-12
Cancer research 2006 Mar 15;66(6):2907-12
The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.
Jiang X, Sun Y, Chen S, Roy K, Price BD
The Journal of biological chemistry 2006 Jun 9;281(23):15741-6
The Journal of biological chemistry 2006 Jun 9;281(23):15741-6
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.
Shiotani B, Kobayashi M, Watanabe M, Yamamoto K, Sugimura T, Wakabayashi K
Molecular cancer research : MCR 2006 Feb;4(2):125-33
Molecular cancer research : MCR 2006 Feb;4(2):125-33
Ataxia telangiectasia mutated and checkpoint kinase 2 regulate BRCA1 to promote the fidelity of DNA end-joining.
Wang HC, Chou WC, Shieh SY, Shen CY
Cancer research 2006 Feb 1;66(3):1391-400
Cancer research 2006 Feb 1;66(3):1391-400
Nuclear factor-kappaB p65 inhibits mitogen-activated protein kinase signaling pathway in radioresistant breast cancer cells.
Ahmed KM, Dong S, Fan M, Li JJ
Molecular cancer research : MCR 2006 Dec;4(12):945-55
Molecular cancer research : MCR 2006 Dec;4(12):945-55
EDD mediates DNA damage-induced activation of CHK2.
Henderson MJ, Munoz MA, Saunders DN, Clancy JL, Russell AJ, Williams B, Pappin D, Khanna KK, Jackson SP, Sutherland RL, Watts CK
The Journal of biological chemistry 2006 Dec 29;281(52):39990-40000
The Journal of biological chemistry 2006 Dec 29;281(52):39990-40000
Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase.
Shreeram S, Hee WK, Demidov ON, Kek C, Yamaguchi H, Fornace AJ Jr, Anderson CW, Appella E, Bulavin DV
The Journal of experimental medicine 2006 Dec 25;203(13):2793-9
The Journal of experimental medicine 2006 Dec 25;203(13):2793-9
Involvement of novel autophosphorylation sites in ATM activation.
Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF
The EMBO journal 2006 Aug 9;25(15):3504-14
The EMBO journal 2006 Aug 9;25(15):3504-14
Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
Tatsumi Y, Sugimoto N, Yugawa T, Narisawa-Saito M, Kiyono T, Fujita M
Journal of cell science 2006 Aug 1;119(Pt 15):3128-40
Journal of cell science 2006 Aug 1;119(Pt 15):3128-40
ATM activation by ionizing radiation requires BRCA1-associated BAAT1.
Aglipay JA, Martin SA, Tawara H, Lee SW, Ouchi T
The Journal of biological chemistry 2006 Apr 7;281(14):9710-8
The Journal of biological chemistry 2006 Apr 7;281(14):9710-8
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
Sun Y, Jiang X, Chen S, Fernandes N, Price BD
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13182-7
Proceedings of the National Academy of Sciences of the United States of America 2005 Sep 13;102(37):13182-7
Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression.
Wang J, Pluth JM, Cooper PK, Cowan MJ, Chen DJ, Yannone SM
DNA repair 2005 May 2;4(5):556-70
DNA repair 2005 May 2;4(5):556-70
Epstein-Barr virus lytic replication elicits ATM checkpoint signal transduction while providing an S-phase-like cellular environment.
Kudoh A, Fujita M, Zhang L, Shirata N, Daikoku T, Sugaya Y, Isomura H, Nishiyama Y, Tsurumi T
The Journal of biological chemistry 2005 Mar 4;280(9):8156-63
The Journal of biological chemistry 2005 Mar 4;280(9):8156-63
Regulation of CHK2 by DNA-dependent protein kinase.
Li J, Stern DF
The Journal of biological chemistry 2005 Mar 25;280(12):12041-50
The Journal of biological chemistry 2005 Mar 25;280(12):12041-50
Deficiency in the catalytic subunit of DNA-dependent protein kinase causes down-regulation of ATM.
Peng Y, Woods RG, Beamish H, Ye R, Lees-Miller SP, Lavin MF, Bedford JS
Cancer research 2005 Mar 1;65(5):1670-7
Cancer research 2005 Mar 1;65(5):1670-7
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association.
Young DB, Jonnalagadda J, Gatei M, Jans DA, Meyn S, Khanna KK
The Journal of biological chemistry 2005 Jul 29;280(30):27587-94
The Journal of biological chemistry 2005 Jul 29;280(30):27587-94
Ataxia-telangiectasia-mutated (ATM) is a T-antigen kinase that controls SV40 viral replication in vivo.
Shi Y, Dodson GE, Shaikh S, Rundell K, Tibbetts RS
The Journal of biological chemistry 2005 Dec 2;280(48):40195-200
The Journal of biological chemistry 2005 Dec 2;280(48):40195-200
Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner.
Gibson SL, Bindra RS, Glazer PM
Cancer research 2005 Dec 1;65(23):10734-41
Cancer research 2005 Dec 1;65(23):10734-41
Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.
Kim JS, Krasieva TB, Kurumizaka H, Chen DJ, Taylor AM, Yokomori K
The Journal of cell biology 2005 Aug 1;170(3):341-7
The Journal of cell biology 2005 Aug 1;170(3):341-7
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts.
Naka K, Tachibana A, Ikeda K, Motoyama N
The Journal of biological chemistry 2004 Jan 16;279(3):2030-7
The Journal of biological chemistry 2004 Jan 16;279(3):2030-7
DNA replication defects, spontaneous DNA damage, and ATM-dependent checkpoint activation in replication protein A-deficient cells.
Dodson GE, Shi Y, Tibbetts RS
The Journal of biological chemistry 2004 Aug 6;279(32):34010-4
The Journal of biological chemistry 2004 Aug 6;279(32):34010-4
Microcephalin is a DNA damage response protein involved in regulation of CHK1 and BRCA1.
Xu X, Lee J, Stern DF
The Journal of biological chemistry 2004 Aug 13;279(33):34091-4
The Journal of biological chemistry 2004 Aug 13;279(33):34091-4
Slow progression of ataxia-telangiectasia with double missense and in frame splice mutations.
Dörk T, Bendix-Waltes R, Wegner RD, Stumm M
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
American journal of medical genetics. Part A 2004 Apr 30;126A(3):272-7
Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.
Vemuri MC, Schiller E, Naegele JR
Cell death and differentiation 2001 Mar;8(3):245-55
Cell death and differentiation 2001 Mar;8(3):245-55
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Scherthan H, Jerratsch M, Dhar S, Wang YA, Goff SP, Pandita TK
Molecular and cellular biology 2000 Oct;20(20):7773-83
Molecular and cellular biology 2000 Oct;20(20):7773-83
Meiotic telomere distribution and Sertoli cell nuclear architecture are altered in Atm- and Atm-p53-deficient mice.
Scherthan H, Jerratsch M, Dhar S, Wang YA, Goff SP, Pandita TK
Molecular and cellular biology 2000 Oct;20(20):7773-83
Molecular and cellular biology 2000 Oct;20(20):7773-83
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM Antibody (2C1) [NB100-309] - Analysis of ATM in U2OS sarcoma cells using ATM antibody (2C1) [NB100-309]. Image from verified customer review. Theoretical molecular weight 351 kDa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM Antibody (2C1) [NB100-309] - Non-transfected (-) and transfected (+) HeLa whole cell extracts (60 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody [2C1] diluted at 1:500.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM Antibody (2C1) [NB100-309] - HeLa whole cell and nuclear extracts (30 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody (2C1) [NB100-309] diluted at 1:1000. Theoretical molecular weight 351 kDa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM Antibody (2C1) [NB100-309] - Whole cell extract (30 ug) was separated by 5% SDS-PAGE, and the membrane was blotted with ATM antibody (2C1) [NB100-309] diluted at 1:1000. Theoretical molecular weight 351 kDa.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: ATM Antibody (2C1) [NB100-309] - Detection of human ATM protein using ATM antibody (2C1) [NB100-309] by western blot or immunoprecipitation. Theoretical molecular weight 351 kDa.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ATM Antibody (2C1) [NB100-309] - Human Kidney (formalin-fixed, paraffin-embedded) stained with ATM antibody (2C1) [NB100-309] at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: ATM Antibody (2C1) [NB100-309] - Human Testis (formalin-fixed, paraffin-embedded) stained with ATM antibody (2C1) [NB100-309] at 5 ug/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
