APR03720G

antibody from Leading Biology
Targeting: CDKN2B CDK4I, INK4B, MTS2, P15, p15INK4b, TP15
Provider product page for APR03720G
Western blot
Immunocytochemistry
Immunohistochemistry
Flow cytometry

Antibody data

Product number
APR03720G - Provider product page
Provider
Leading Biology
Product name
CDKN2B Antibody (C-term)
Antibody type
Polyclonal
Description
This gene lies adjacent to the tumor suppressor geneCDKN2A in a region that is frequently mutated and deleted in a widevariety of tumors. This gene encodes a cyclin-dependent kinaseinhibitor, which forms a complex with CDK4 or CDK6, and preventsthe activation of the CDK kinases, thus the encoded proteinfunctions as a cell growth regulator that controls cell cycle G1progression. The expression of this gene was found to bedramatically induced by TGF beta, which suggested its role in theTGF beta induced growth inhibition. Two alternatively splicedtranscript variants of this gene, which encode distinct proteins,have been reported.
Reactivity
Human
Host
Rabbit
Storage
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
CDKN2B protein structure - APR03720G shown in red.