CABT-BL8496

CDKN2A antibody from Creative Diagnostics
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf
Western blot
Recommended by provider
Immunocytochemistry
Recommended by provider
Immunoprecipitation
Recommended by provider
Immunohistochemistry
Recommended by provider
Flow cytometry
Recommended by provider

Antibody data

Product number
CABT-BL8496
Provider
Creative Diagnostics
Product name
Rabbit Anti-Human CDKN2A monoclonal antibody, clone TV1813
Provider product page
Creative Diagnostics - CABT-BL8496
Antibody type
Monoclonal
Description
The progression of cells through the cell cycle is regulated by a family of proteins designated cyclin-dependent kinases (Cdks). Sequential activation of individual members of this family and their consequent phosphorylation of critical substrates, promote orderly progression through the cell cycle. The protein p16INK4A, identified as a negative regulator of the cell cycle, has been shown to bind to and inhibit the activity of the Cdk4/cyclin D complex. p19 ARF, which is unrelated to p16, arises from transcription of an alternative reading frame of the p16 gene. Like p16, p19 ARF has been shown to induce cell cycle arrest. Mice lacking p19 ARF but expressing functional p16 have been shown to develop tumors early in life. Further studies have indicated that p19 ARF may be disrupted in a large percentage of human T cell acute lymphoblastic leukemias.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
TV1813
Vial size
100 _l
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Provider Type Product Number
- No reagents -