CABT-B9258

CDKN2A antibody from Creative Diagnostics
ARF, CDK4I, CDKN2, CMM2, INK4, INK4a, MLM, MTS1, p14, p14ARF, p16, p16INK4a, p19, p19Arf
Western blot
Recommended by provider
Immunoprecipitation
Recommended by provider

Antibody data

Product number
CABT-B9258
Provider
Creative Diagnostics
Product name
Mouse anti-Human p16 monoclonal antibody, clone H286-2340
Provider product page
Creative Diagnostics - CABT-B9258
Antibody type
Monoclonal
Description
Cyclins and cyclin-dependent kinases (cdks) form active complexes that regulate key events during the progression of the cell cycle and are evolutionarily highly conserved. The p16 protein has been identified as a specific inhibitor of cdk4 because it blocks cdk4 substrate phosphorylation. p16 inhibits cdk4 dependent phosphorylation of the tumor suppressor retinoblastoma protein (Rb) and Rb related proteins, p107 and p130. The biochemical properties of p16 suggest that it may be a tumor suppressor gene product. Recently a gene cloned from the short arm of human chromosome 9, Multiple Tumor Suppressor 1 (MTS1) has been identified as the gene for p16. The gene, now also known as the CDKN2 gene, has been found to be mutated in a very high percentage of tumors, including 75% of melanoma cell lines.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
H286-2340
Vial size
0.1mg
Concentration
0.5 mg/ml
Storage
Store undiluted at 4°C.
Provider Type Product Number
- No reagents -