Antibody data
- Antibody Data
- Antigen structure
- References [227]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
- Other assay [7]
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Validation data
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- Product number
- 35-2500 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Claudin 5 Monoclonal Antibody (4C3C2)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 4C3C2
- Vial size
- 100 µg
- Concentration
- 0.5 mg/mL
- Storage
- -20°C
Submitted references Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins.
miR-623 Targets Metalloproteinase-1 and Attenuates Extravasation of Brain Metastatic Triple-Negative Breast Cancer Cells.
SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells.
Endothelial Unc5B controls blood-brain barrier integrity.
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Blocking C3d(+)/GFAP(+) A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke.
A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury.
Lipopolysaccharide Exposure Differentially Alters Plasma and Brain Inflammatory Markers in Adult Male and Female Rats.
Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood-spinal cord barrier breakdown during acute spinal cord injury in rats.
Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome.
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier.
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Disruption of the pro-inflammatory, anti-inflammatory cytokines and tight junction proteins expression, associated with changes of the composition of the gut microbiota in patients with irritable bowel syndrome.
Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model.
Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages.
Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components.
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy.
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.
Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells.
Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.
Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis.
Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.
Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals.
Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions.
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.
Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain.
Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death.
Proteoglycan 4 Reduces Neuroinflammation and Protects the Blood-Brain Barrier after Traumatic Brain Injury.
Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke.
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke.
Nano-scale architecture of blood-brain barrier tight-junctions.
Impact of chronic smoking on traumatic brain microvascular injury: An in vitro study.
Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging.
Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro.
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups.
Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer's Disease Leads to Neuroglial and Endothelial Cell Degeneration.
Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction.
Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma.
Site-specific opening of the blood-brain barrier by extracellular histones.
Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-Deficient Strains of Bacillus anthracis.
Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease.
Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model.
Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4.
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier.
Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.
Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration.
Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.
Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System.
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin β 1 complex and regulating downstream FAK/RhoA signaling.
RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.
Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Alanyl-Glutamine Restores Tight Junction Organization after Disruption by a Conventional Peritoneal Dialysis Fluid.
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke.
Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke.
Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Prediction of Drug Permeability Using In Vitro Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.
The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats.
Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood-brain-barrier permeability.
Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke.
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
The Contractile Apparatus Is Essential for the Integrity of the Blood-Brain Barrier After Experimental Subarachnoid Hemorrhage.
Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4.
In situ molecular characterization of endoneurial microvessels that form the blood-nerve barrier in normal human adult peripheral nerves.
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins.
The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.
The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.
Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke.
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Response of the neurovascular unit to brain metastatic breast cancer cells.
Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats.
Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.
Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways.
Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model.
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy.
TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.
Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.
Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers.
Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.
Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome.
Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage.
Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.
Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2.
A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport.
Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury.
Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
Altered Cytokine Expression and Barrier Properties after In Vitro Infection of Porcine Epithelial Cells with Enterotoxigenic Escherichia coli and Probiotic Enterococcus faecium.
Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality.
Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator.
Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.
Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria.
Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA(2) inhibitor Darapladib.
In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling.
Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.
In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome.
Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation.
The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels.
The Human Blood-Nerve Barrier Transcriptome.
Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.
Effect of shear stress on iPSC-derived human brain microvascular endothelial cells (dhBMECs).
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders.
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.
Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes.
PEGylation of Reduced Graphene Oxide Induces Toxicity in Cells of the Blood-Brain Barrier: An in Vitro and in Vivo Study.
The role of pericytic laminin in blood brain barrier integrity maintenance.
miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis.
Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.
Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.
Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A).
BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats.
CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.
Peripheral ammonia and blood brain barrier structure and function after methamphetamine.
Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS).
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.
The human urothelial tight junction: claudin 3 and the ZO-1α(+) switch.
Changes in the cerebrospinal fluid circulatory system of the developing rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation.
Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro.
Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases.
Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex.
Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.
Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.
Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion.
Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1.
Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system.
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.
Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice.
Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.
C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation.
A neurovascular blood-brain barrier in vitro model.
Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.
The gut microbiota influences blood-brain barrier permeability in mice.
Mfsd2a is critical for the formation and function of the blood-brain barrier.
An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture.
Claudins as prognostic factors for renal cell cancer.
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line.
Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption.
A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex.
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis.
Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods.
Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules.
Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier.
Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids.
Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier.
Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.
Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model.
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier.
Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.
Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability.
CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support.
Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma.
Tight junction proteins expression and modulation in immune cells and multiple sclerosis.
MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia.
Detection of multiple proteins in intracerebral vessels by confocal microscopy.
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Novel expression of claudin-5 in glomerular podocytes.
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin.
Tight junction proteins vary in the choroid plexus of ewes according to photoperiod.
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas.
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
Retinal vascular changes after glial disruption in rats.
Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep.
Acute and chronic deficits in the urinary bladder after spinal contusion injury in the adult rat.
Perifoveal müller cell depletion in a case of macular telangiectasia type 2.
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement.
Mouse adenovirus type 1-induced breakdown of the blood-brain barrier.
Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery.
Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins.
Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide.
Tight junction proteins in human Schwann cell autotypic junctions.
Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma.
Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus.
Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing.
Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells.
Hepatitis C virus receptor expression in normal and diseased liver tissue.
Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52.
Distribution of tight junction proteins in adult human salivary glands.
Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis.
Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.
Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas.
Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura.
Tight junction proteins and perineurial cells in neurofibromas.
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption.
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development.
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
Expression and localization of tight junction-associated proteins in human hair follicles.
Heterogeneity of claudin expression by alveolar epithelial cells.
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
Brunner N, Stein L, Amasheh S
The Journal of membrane biology 2023 Feb;256(1):51-61
The Journal of membrane biology 2023 Feb;256(1):51-61
miR-623 Targets Metalloproteinase-1 and Attenuates Extravasation of Brain Metastatic Triple-Negative Breast Cancer Cells.
Hammash D, Mahfood M, Khoder G, Ahmed M, Tlili A, Hamoudi R, Harati R
Breast cancer (Dove Medical Press) 2022;14:187-198
Breast cancer (Dove Medical Press) 2022;14:187-198
SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells.
Choi JY, Park JH, Jo C, Kim KC, Koh YH
Biochemical and biophysical research communications 2022 Oct 20;626:66-71
Biochemical and biophysical research communications 2022 Oct 20;626:66-71
Endothelial Unc5B controls blood-brain barrier integrity.
Boyé K, Geraldo LH, Furtado J, Pibouin-Fragner L, Poulet M, Kim D, Nelson B, Xu Y, Jacob L, Maissa N, Agalliu D, Claesson-Welsh L, Ackerman SL, Eichmann A
Nature communications 2022 Mar 4;13(1):1169
Nature communications 2022 Mar 4;13(1):1169
Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.
Yang Z, Huang C, Wen X, Liu W, Huang X, Li Y, Zang J, Weng Z, Lu D, Tsang CK, Li K, Xu A
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Mar 2;30(3):1275-1287
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Mar 2;30(3):1275-1287
Blocking C3d(+)/GFAP(+) A1 Astrocyte Conversion with Semaglutide Attenuates Blood-Brain Barrier Disruption in Mice after Ischemic Stroke.
Zhang Q, Liu C, Shi R, Zhou S, Shan H, Deng L, Chen T, Guo Y, Zhang Z, Yang GY, Wang Y, Tang Y
Aging and disease 2022 Jun;13(3):943-959
Aging and disease 2022 Jun;13(3):943-959
A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury.
Navarrete C, García-Martín A, Correa-Sáez A, Prados ME, Fernández F, Pineda R, Mazzone M, Álvarez-Benito M, Calzado MA, Muñoz E
Journal of neuroinflammation 2022 Jul 9;19(1):177
Journal of neuroinflammation 2022 Jul 9;19(1):177
Lipopolysaccharide Exposure Differentially Alters Plasma and Brain Inflammatory Markers in Adult Male and Female Rats.
Nonoguchi HA, Kouo TWS, Kortagere S, Hillman J, Boyle DL, Mandyam CD
Brain sciences 2022 Jul 24;12(8)
Brain sciences 2022 Jul 24;12(8)
Delayed administration of nafamostat mesylate inhibits thrombin-mediated blood-spinal cord barrier breakdown during acute spinal cord injury in rats.
Zhao C, Zhou T, Zhao X, Pang Y, Li W, Fan B, Li M, Liu X, Ma L, Zhang J, Sun C, Shen W, Kong X, Yao X, Feng S
Journal of neuroinflammation 2022 Jul 16;19(1):189
Journal of neuroinflammation 2022 Jul 16;19(1):189
Extracellular Alterations in pH and K+ Modify the Murine Brain Endothelial Cell Total and Phospho-Proteome.
Wahl JR, Vivek A, Palomino SM, Almuslim M, Cottier KE, Langlais PR, Streicher JM, Vanderah TW, Liktor-Busa E, Largent-Milnes TM
Pharmaceutics 2022 Jul 15;14(7)
Pharmaceutics 2022 Jul 15;14(7)
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Miedema A, Gerrits E, Brouwer N, Jiang Q, Kracht L, Meijer M, Nutma E, Peferoen-Baert R, Pijnacker ATE, Wesseling EM, Wijering MHC, Gabius HJ, Amor S, Eggen BJL, Kooistra SM
Acta neuropathologica communications 2022 Jan 28;10(1):8
Acta neuropathologica communications 2022 Jan 28;10(1):8
Methamphetamine enhances caveolar transport of therapeutic agents across the rodent blood-brain barrier.
Chang JH, Greene C, Frudd K, Araujo Dos Santos L, Futter C, Nichols BJ, Campbell M, Turowski P
Cell reports. Medicine 2022 Jan 18;3(1):100497
Cell reports. Medicine 2022 Jan 18;3(1):100497
Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Yu R, Kim NS, Li Y, Jeong JY, Park SJ, Zhou B, Oh WJ
Translational stroke research 2022 Feb;13(1):142-159
Translational stroke research 2022 Feb;13(1):142-159
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Williams LM, Fujimoto T, Weaver RR, Logsdon AF, Evitts KM, Young JE, Banks WA, Erickson MA
Fluids and barriers of the CNS 2022 Feb 5;19(1):10
Fluids and barriers of the CNS 2022 Feb 5;19(1):10
Disruption of the pro-inflammatory, anti-inflammatory cytokines and tight junction proteins expression, associated with changes of the composition of the gut microbiota in patients with irritable bowel syndrome.
Ivashkin V, Poluektov Y, Kogan E, Shifrin O, Sheptulin A, Kovaleva A, Kurbatova A, Krasnov G, Poluektova E
PloS one 2021;16(6):e0252930
PloS one 2021;16(6):e0252930
Repeated Low-Level Blast Acutely Alters Brain Cytokines, Neurovascular Proteins, Mechanotransduction, and Neurodegenerative Markers in a Rat Model.
Heyburn L, Abutarboush R, Goodrich S, Urioste R, Batuure A, Wheel J, Wilder DM, Arun P, Ahlers ST, Long JB, Sajja VS
Frontiers in cellular neuroscience 2021;15:636707
Frontiers in cellular neuroscience 2021;15:636707
Urinary Trypsin Inhibitor Protects Tight Junctions of Septic Pulmonary Capillary Endothelial Cells by Regulating the Functions of Macrophages.
Wang R, Song W, Xie C, Zhong W, Xu H, Zhou Q, Deng Y, Hong Y, Li X, Fang M
Journal of inflammation research 2021;14:1973-1989
Journal of inflammation research 2021;14:1973-1989
Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components.
González-Molina LA, Villar-Vesga J, Henao-Restrepo J, Villegas A, Lopera F, Cardona-Gómez GP, Posada-Duque R
Frontiers in aging neuroscience 2021;13:593927
Frontiers in aging neuroscience 2021;13:593927
Exosome-mediated delivery of an anti-angiogenic peptide inhibits pathological retinal angiogenesis.
Dong X, Lei Y, Yu Z, Wang T, Liu Y, Han G, Zhang X, Li Y, Song Y, Xu H, Du M, Yin H, Wang X, Yan H
Theranostics 2021;11(11):5107-5126
Theranostics 2021;11(11):5107-5126
SARS-CoV-2 crosses the blood-brain barrier accompanied with basement membrane disruption without tight junctions alteration.
Zhang L, Zhou L, Bao L, Liu J, Zhu H, Lv Q, Liu R, Chen W, Tong W, Wei Q, Xu Y, Deng W, Gao H, Xue J, Song Z, Yu P, Han Y, Zhang Y, Sun X, Yu X, Qin C
Signal transduction and targeted therapy 2021 Sep 6;6(1):337
Signal transduction and targeted therapy 2021 Sep 6;6(1):337
Endothelial Thioredoxin-Interacting Protein Depletion Reduces Hemorrhagic Transformation in Hyperglycemic Mice after Embolic Stroke and Thrombolytic Therapy.
Salman M, Ismael S, Li L, Ahmed HA, Puchowicz MA, Ishrat T
Pharmaceuticals (Basel, Switzerland) 2021 Sep 27;14(10)
Pharmaceuticals (Basel, Switzerland) 2021 Sep 27;14(10)
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption.
Pediaditakis I, Kodella KR, Manatakis DV, Le CY, Hinojosa CD, Tien-Street W, Manolakos ES, Vekrellis K, Hamilton GA, Ewart L, Rubin LL, Karalis K
Nature communications 2021 Oct 8;12(1):5907
Nature communications 2021 Oct 8;12(1):5907
Wnt signaling mediates acquisition of blood-brain barrier properties in naïve endothelium derived from human pluripotent stem cells.
Gastfriend BD, Nishihara H, Canfield SG, Foreman KL, Engelhardt B, Palecek SP, Shusta EV
eLife 2021 Nov 10;10
eLife 2021 Nov 10;10
Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability.
Hollier PL, Chapouly C, Diop A, Guimbal S, Cornuault L, Gadeau AP, Renault MA
Cardiovascular research 2021 Nov 1;117(12):2489-2501
Cardiovascular research 2021 Nov 1;117(12):2489-2501
Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis.
Ogata S, Ito S, Masuda T, Ohtsuki S
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 May;41(5):1026-1038
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2021 May;41(5):1026-1038
Endothelial Tpl2 regulates vascular barrier function via JNK-mediated degradation of claudin-5 promoting neuroinflammation or tumor metastasis.
Nanou A, Bourbouli M, Vetrano S, Schaeper U, Ley S, Kollias G
Cell reports 2021 May 25;35(8):109168
Cell reports 2021 May 25;35(8):109168
Cerebral Pericytes and Endothelial Cells Communicate through Inflammasome-Dependent Signals.
Kozma M, Mészáros Á, Nyúl-Tóth Á, Molnár K, Costea L, Hernádi Z, Fazakas C, Farkas AE, Wilhelm I, Krizbai IA
International journal of molecular sciences 2021 Jun 6;22(11)
International journal of molecular sciences 2021 Jun 6;22(11)
Differentiation of human pluripotent stem cells to brain microvascular endothelial cell-like cells suitable to study immune cell interactions.
Nishihara H, Gastfriend BD, Kasap P, Palecek SP, Shusta EV, Engelhardt B
STAR protocols 2021 Jun 18;2(2):100563
STAR protocols 2021 Jun 18;2(2):100563
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.
Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C
Cell metabolism 2021 Jun 1;33(6):1155-1170.e10
Cell metabolism 2021 Jun 1;33(6):1155-1170.e10
Hepatocyte growth factor-regulated tyrosine kinase substrate is essential for endothelial cell polarity and cerebrovascular stability.
Yu Z, Zeng J, Wang J, Cui Y, Song X, Zhang Y, Cheng X, Hou N, Teng Y, Lan Y, Chen Y, Yang X
Cardiovascular research 2021 Jan 21;117(2):533-546
Cardiovascular research 2021 Jan 21;117(2):533-546
Endothelial cell-type-specific molecular requirements for angiogenesis drive fenestrated vessel development in the brain.
Parab S, Quick RE, Matsuoka RL
eLife 2021 Jan 18;10
eLife 2021 Jan 18;10
Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death.
Shin HJ, Jeong EA, Lee JY, An HS, Jang HM, Ahn YJ, Lee J, Kim KE, Roh GS
Antioxidants (Basel, Switzerland) 2021 Jan 12;10(1)
Antioxidants (Basel, Switzerland) 2021 Jan 12;10(1)
Proteoglycan 4 Reduces Neuroinflammation and Protects the Blood-Brain Barrier after Traumatic Brain Injury.
Bennett M, Chin A, Lee HJ, Morales Cestero E, Strazielle N, Ghersi-Egea JF, Threlkeld SW, Schmidt TA, Richendrfer HA, Szmydynger-Chodobska J, Jay GD, Chodobski A
Journal of neurotrauma 2021 Feb 15;38(4):385-398
Journal of neurotrauma 2021 Feb 15;38(4):385-398
Neuroprotective effects of Sonic hedgehog agonist SAG in a rat model of neonatal stroke.
Nguyen V, Chavali M, Larpthaveesarp A, Kodali S, Gonzalez G, Franklin RJM, Rowitch DH, Gonzalez F
Pediatric research 2021 Dec;90(6):1161-1170
Pediatric research 2021 Dec;90(6):1161-1170
Silencing of lncRNA XIST impairs angiogenesis and exacerbates cerebral vascular injury after ischemic stroke.
Wang C, Dong J, Sun J, Huang S, Wu F, Zhang X, Pang D, Fu Y, Li L
Molecular therapy. Nucleic acids 2021 Dec 3;26:148-160
Molecular therapy. Nucleic acids 2021 Dec 3;26:148-160
Nano-scale architecture of blood-brain barrier tight-junctions.
Sasson E, Anzi S, Bell B, Yakovian O, Zorsky M, Deutsch U, Engelhardt B, Sherman E, Vatine G, Dzikowski R, Ben-Zvi A
eLife 2021 Dec 24;10
eLife 2021 Dec 24;10
Impact of chronic smoking on traumatic brain microvascular injury: An in vitro study.
Sivandzade F, Alqahtani F, Cucullo L
Journal of cellular and molecular medicine 2021 Aug;25(15):7122-7134
Journal of cellular and molecular medicine 2021 Aug;25(15):7122-7134
Design and Validation of a Human Brain Endothelial Microvessel-on-a-Chip Open Microfluidic Model Enabling Advanced Optical Imaging.
Salman MM, Marsh G, Kusters I, Delincé M, Di Caprio G, Upadhyayula S, de Nola G, Hunt R, Ohashi KG, Gray T, Shimizu F, Sano Y, Kanda T, Obermeier B, Kirchhausen T
Frontiers in bioengineering and biotechnology 2020;8:573775
Frontiers in bioengineering and biotechnology 2020;8:573775
Increased Catecholamine Levels and Inflammatory Mediators Alter Barrier Properties of Brain Microvascular Endothelial Cells in vitro.
Ittner C, Burek M, Störk S, Nagai M, Förster CY
Frontiers in cardiovascular medicine 2020;7:73
Frontiers in cardiovascular medicine 2020;7:73
Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability.
Cobo-Calvo A, Ruiz A, Richard C, Blondel S, Cavagna S, Strazielle N, Ghersi-Egea JF, Giraudon P, Marignier R
PloS one 2020;15(9):e0238301
PloS one 2020;15(9):e0238301
Specific Frequency Electroacupuncture Stimulation Transiently Enhances the Permeability of the Blood-Brain Barrier and Induces Tight Junction Changes.
Zhang S, Gong P, Zhang J, Mao X, Zhao Y, Wang H, Gan L, Lin X
Frontiers in neuroscience 2020;14:582324
Frontiers in neuroscience 2020;14:582324
A Model of Germinal Matrix Hemorrhage in Preterm Rat Pups.
Jinnai M, Koning G, Singh-Mallah G, Jonsdotter A, Leverin AL, Svedin P, Nair S, Takeda S, Wang X, Mallard C, Ek CJ, Rocha-Ferreira E, Hagberg H
Frontiers in cellular neuroscience 2020;14:535320
Frontiers in cellular neuroscience 2020;14:535320
Differential Profile of Systemic Extracellular Vesicles From Sporadic and Familial Alzheimer's Disease Leads to Neuroglial and Endothelial Cell Degeneration.
Villar-Vesga J, Henao-Restrepo J, Voshart DC, Aguillon D, Villegas A, Castaño D, Arias-Londoño JD, Zuhorn IS, Ribovski L, Barazzuol L, Cardona-Gómez GP, Posada-Duque R
Frontiers in aging neuroscience 2020;12:587989
Frontiers in aging neuroscience 2020;12:587989
Blood-Brain Barrier Protein Claudin-5 Expressed in Paired Xenopus laevis Oocytes Mediates Cell-Cell Interaction.
Brunner N, Stein L, Cornelius V, Knittel R, Fallier-Becker P, Amasheh S
Frontiers in physiology 2020;11:857
Frontiers in physiology 2020;11:857
Downregulation of uPAR promotes urokinase translocation into the nucleus and epithelial to mesenchymal transition in neuroblastoma.
Semina EV, Rubina KA, Shmakova AA, Rysenkova KD, Klimovich PS, Aleksanrushkina NA, Sysoeva VY, Karagyaur MN, Tkachuk VA
Journal of cellular physiology 2020 Sep;235(9):6268-6286
Journal of cellular physiology 2020 Sep;235(9):6268-6286
Site-specific opening of the blood-brain barrier by extracellular histones.
Villalba N, Baby S, Cha BJ, Yuan SY
Journal of neuroinflammation 2020 Sep 22;17(1):281
Journal of neuroinflammation 2020 Sep 22;17(1):281
Structural Integrity of the Alveolar-Capillary Barrier in Cynomolgus Monkeys Challenged with Fully Virulent and Toxin-Deficient Strains of Bacillus anthracis.
D'Agnillo F, Zhang X, Williams MC
The American journal of pathology 2020 Oct;190(10):2095-2110
The American journal of pathology 2020 Oct;190(10):2095-2110
Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer's disease.
Liu CC, Yamazaki Y, Heckman MG, Martens YA, Jia L, Yamazaki A, Diehl NN, Zhao J, Zhao N, DeTure M, Davis MD, Felton LM, Qiao W, Li Y, Li H, Fu Y, Wang N, Wren M, Aikawa T, Holm ML, Oue H, Linares C, Allen M, Carrasquillo MM, Murray ME, Petersen RC, Ertekin-Taner N, Dickson DW, Kanekiyo T, Bu G
Alzheimer's & dementia : the journal of the Alzheimer's Association 2020 Oct;16(10):1372-1383
Alzheimer's & dementia : the journal of the Alzheimer's Association 2020 Oct;16(10):1372-1383
Non-Human Primate Blood-Brain Barrier and In Vitro Brain Endothelium: From Transcriptome to the Establishment of a New Model.
Chaves C, Do TM, Cegarra C, Roudières V, Tolou S, Thill G, Rocher C, Didier M, Lesuisse D
Pharmaceutics 2020 Oct 14;12(10)
Pharmaceutics 2020 Oct 14;12(10)
Hypertonic saline improves brain edema resulting from traumatic brain injury by suppressing the NF-κB/IL-1β signaling pathway and AQP4.
Zhang H, Liu J, Liu Y, Su C, Fan G, Lu W, Feng L
Experimental and therapeutic medicine 2020 Nov;20(5):71
Experimental and therapeutic medicine 2020 Nov;20(5):71
P7C3-A20 treatment one year after TBI in mice repairs the blood-brain barrier, arrests chronic neurodegeneration, and restores cognition.
Vázquez-Rosa E, Shin MK, Dhar M, Chaubey K, Cintrón-Pérez CJ, Tang X, Liao X, Miller E, Koh Y, Barker S, Franke K, Crosby DR, Schroeder R, Emery J, Yin TC, Fujioka H, Reynolds JD, Harper MM, Jain MK, Pieper AA
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27667-27675
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 3;117(44):27667-27675
Amyloid-β Precursor Protein APP Down-Regulation Alters Actin Cytoskeleton-Interacting Proteins in Endothelial Cells.
Ristori E, Cicaloni V, Salvini L, Tinti L, Tinti C, Simons M, Corti F, Donnini S, Ziche M
Cells 2020 Nov 19;9(11)
Cells 2020 Nov 19;9(11)
Mfsd2a and Spns2 are essential for sphingosine-1-phosphate transport in the formation and maintenance of the blood-brain barrier.
Wang Z, Zheng Y, Wang F, Zhong J, Zhao T, Xie Q, Zhu T, Ma F, Tang Q, Zhou B, Zhu J
Science advances 2020 May;6(22):eaay8627
Science advances 2020 May;6(22):eaay8627
Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.
Lu J, Lu L, Yu Y, Baranowski J, Claud EC
Scientific reports 2020 May 18;10(1):8178
Scientific reports 2020 May 18;10(1):8178
Exposure to Zinc Oxide Nanoparticles Disrupts Endothelial Tight and Adherens Junctions and Induces Pulmonary Inflammatory Cell Infiltration.
Chen CM, Wu ML, Ho YC, Gung PY, Tsai MH, Orekhov AN, Sobenin IA, Lin P, Yet SF
International journal of molecular sciences 2020 May 13;21(10)
International journal of molecular sciences 2020 May 13;21(10)
Laminin 221 fragment is suitable for the differentiation of human induced pluripotent stem cells into brain microvascular endothelial-like cells with robust barrier integrity.
Aoki H, Yamashita M, Hashita T, Iwao T, Matsunaga T
Fluids and barriers of the CNS 2020 Mar 30;17(1):25
Fluids and barriers of the CNS 2020 Mar 30;17(1):25
Chronic Peripheral Inflammation Causes a Region-Specific Myeloid Response in the Central Nervous System.
Süß P, Hoffmann A, Rothe T, Ouyang Z, Baum W, Staszewski O, Schett G, Prinz M, Krönke G, Glass CK, Winkler J, Schlachetzki JCM
Cell reports 2020 Mar 24;30(12):4082-4095.e6
Cell reports 2020 Mar 24;30(12):4082-4095.e6
microRNA-9-5p alleviates blood-brain barrier damage and neuroinflammation after traumatic brain injury.
Wu J, He J, Tian X, Luo Y, Zhong J, Zhang H, Li H, Cen B, Jiang T, Sun X
Journal of neurochemistry 2020 Jun;153(6):710-726
Journal of neurochemistry 2020 Jun;153(6):710-726
TIMP1 preserves the blood-brain barrier through interacting with CD63/integrin β 1 complex and regulating downstream FAK/RhoA signaling.
Tang J, Kang Y, Huang L, Wu L, Peng Y
Acta pharmaceutica Sinica. B 2020 Jun;10(6):987-1003
Acta pharmaceutica Sinica. B 2020 Jun;10(6):987-1003
RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway.
Shen S, Yang C, Liu X, Zheng J, Liu Y, Liu L, Ma J, Ma T, An P, Lin Y, Cai H, Wang D, Li Z, Zhao L, Xue Y
Molecular therapy oncolytics 2020 Jun 26;17:138-152
Molecular therapy oncolytics 2020 Jun 26;17:138-152
Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.
Chavali M, Ulloa-Navas MJ, Pérez-Borredá P, Garcia-Verdugo JM, McQuillen PS, Huang EJ, Rowitch DH
Neuron 2020 Dec 23;108(6):1130-1145.e5
Neuron 2020 Dec 23;108(6):1130-1145.e5
HIF-1α is involved in blood-brain barrier dysfunction and paracellular migration of bacteria in pneumococcal meningitis.
Devraj G, Guérit S, Seele J, Spitzer D, Macas J, Khel MI, Heidemann R, Braczynski AK, Ballhorn W, Günther S, Ogunshola OO, Mittelbronn M, Ködel U, Monoranu CM, Plate KH, Hammerschmidt S, Nau R, Devraj K, Kempf VAJ
Acta neuropathologica 2020 Aug;140(2):183-208
Acta neuropathologica 2020 Aug;140(2):183-208
Alanyl-Glutamine Restores Tight Junction Organization after Disruption by a Conventional Peritoneal Dialysis Fluid.
Bartosova M, Herzog R, Ridinger D, Levai E, Jenei H, Zhang C, González Mateo GT, Marinovic I, Hackert T, Bestvater F, Hausmann M, López Cabrera M, Kratochwill K, Zarogiannis SG, Schmitt CP
Biomolecules 2020 Aug 13;10(8)
Biomolecules 2020 Aug 13;10(8)
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Huang Y, Wang C, Tian X, Mao Y, Hou B, Sun Y, Gu X, Ma Z
Inflammation 2020 Apr;43(2):568-578
Inflammation 2020 Apr;43(2):568-578
KLF4 alleviates cerebral vascular injury by ameliorating vascular endothelial inflammation and regulating tight junction protein expression following ischemic stroke.
Zhang X, Wang L, Han Z, Dong J, Pang D, Fu Y, Li L
Journal of neuroinflammation 2020 Apr 7;17(1):107
Journal of neuroinflammation 2020 Apr 7;17(1):107
Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke.
Ma F, Sun P, Zhang X, Hamblin MH, Yin KJ
Science signaling 2020 Apr 7;13(626)
Science signaling 2020 Apr 7;13(626)
Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles.
Rom S, Heldt NA, Gajghate S, Seliga A, Reichenbach NL, Persidsky Y
Scientific reports 2020 Apr 29;10(1):7274
Scientific reports 2020 Apr 29;10(1):7274
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Curtaz CJ, Schmitt C, Herbert SL, Feldheim J, Schlegel N, Gosselet F, Hagemann C, Roewer N, Meybohm P, Wöckel A, Burek M
Fluids and barriers of the CNS 2020 Apr 22;17(1):31
Fluids and barriers of the CNS 2020 Apr 22;17(1):31
Prediction of Drug Permeability Using In Vitro Blood-Brain Barrier Models with Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells.
Ohshima M, Kamei S, Fushimi H, Mima S, Yamada T, Yamamoto T
BioResearch open access 2019;8(1):200-209
BioResearch open access 2019;8(1):200-209
The effect of endurance training and testosterone supplementation on the expression of blood spinal cord barrier proteins in rats.
Nierwińska K, Nowacka-Chmielewska M, Bernacki J, Jagsz S, Chalimoniuk M, Langfort J, Małecki A
PloS one 2019;14(2):e0211818
PloS one 2019;14(2):e0211818
Infusion of HIV-1 Nef-expressing astrocytes into the rat hippocampus induces enteropathy and interstitial pneumonitis and increases blood-brain-barrier permeability.
Rivera J, Isidro RA, Loucil-Alicea RY, Cruz ML, Appleyard CB, Isidro AA, Chompre G, Colon-Rivera K, Noel RJ Jr
PloS one 2019;14(11):e0225760
PloS one 2019;14(11):e0225760
Delayed Effects of Acute Reperfusion on Vascular Remodeling and Late-Phase Functional Recovery After Stroke.
Durán-Laforet V, Fernández-López D, García-Culebras A, González-Hijón J, Moraga A, Palma-Tortosa S, García-Yébenes I, Vega-Pérez A, Lizasoain I, Moro MÁ
Frontiers in neuroscience 2019;13:767
Frontiers in neuroscience 2019;13:767
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
Yang Z, Huang C, Wu Y, Chen B, Zhang W, Zhang J
Frontiers in physiology 2019;10:2
Frontiers in physiology 2019;10:2
The Contractile Apparatus Is Essential for the Integrity of the Blood-Brain Barrier After Experimental Subarachnoid Hemorrhage.
Luh C, Feiler S, Frauenknecht K, Meyer S, Lubomirov LT, Neulen A, Thal SC
Translational stroke research 2019 Oct;10(5):534-545
Translational stroke research 2019 Oct;10(5):534-545
Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4.
Abdul Y, Abdelsaid M, Li W, Webb RC, Sullivan JC, Dong G, Ergul A
Molecular neurobiology 2019 Mar;56(3):1607-1617
Molecular neurobiology 2019 Mar;56(3):1607-1617
In situ molecular characterization of endoneurial microvessels that form the blood-nerve barrier in normal human adult peripheral nerves.
Ouyang X, Dong C, Ubogu EE
Journal of the peripheral nervous system : JPNS 2019 Jun;24(2):195-206
Journal of the peripheral nervous system : JPNS 2019 Jun;24(2):195-206
Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications.
Vatine GD, Barrile R, Workman MJ, Sances S, Barriga BK, Rahnama M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Spivia WR, Chen Z, Van Eyk J, Svendsen CN
Cell stem cell 2019 Jun 6;24(6):995-1005.e6
Cell stem cell 2019 Jun 6;24(6):995-1005.e6
DL-3-n-butylphthalide protects the blood-brain barrier against ischemia/hypoxia injury via upregulation of tight junction proteins.
Ye ZY, Xing HY, Wang B, Liu M, Lv PY
Chinese medical journal 2019 Jun 5;132(11):1344-1353
Chinese medical journal 2019 Jun 5;132(11):1344-1353
The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model.
Katt ME, Mayo LN, Ellis SE, Mahairaki V, Rothstein JD, Cheng L, Searson PC
Fluids and barriers of the CNS 2019 Jul 15;16(1):20
Fluids and barriers of the CNS 2019 Jul 15;16(1):20
The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.
Domke LM, Franke WW
Cell and tissue research 2019 Feb;375(2):451-482
Cell and tissue research 2019 Feb;375(2):451-482
Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke.
Nirwane A, Johnson J, Nguyen B, Miner JH, Yao Y
Acta neuropathologica communications 2019 Feb 18;7(1):23
Acta neuropathologica communications 2019 Feb 18;7(1):23
Brain Endothelial Cells Maintain Lactate Homeostasis and Control Adult Hippocampal Neurogenesis.
Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, Guo S, Zhou Q, Wu N, Chen Y, Chen Y, Song X, Jiang H, Wang Y, Lan Y, Zhou B, Mao L, Li J, Yang H, Guo W, Yang X
Cell stem cell 2019 Dec 5;25(6):754-767.e9
Cell stem cell 2019 Dec 5;25(6):754-767.e9
Dual microglia effects on blood brain barrier permeability induced by systemic inflammation.
Haruwaka K, Ikegami A, Tachibana Y, Ohno N, Konishi H, Hashimoto A, Matsumoto M, Kato D, Ono R, Kiyama H, Moorhouse AJ, Nabekura J, Wake H
Nature communications 2019 Dec 20;10(1):5816
Nature communications 2019 Dec 20;10(1):5816
Response of the neurovascular unit to brain metastatic breast cancer cells.
Haskó J, Fazakas C, Molnár K, Mészáros Á, Patai R, Szabó G, Erdélyi F, Nyúl-Tóth Á, Győri F, Kozma M, Farkas AE, Krizbai IA, Wilhelm I
Acta neuropathologica communications 2019 Aug 19;7(1):133
Acta neuropathologica communications 2019 Aug 19;7(1):133
Electrical Stimulation of the Mesencephalic Locomotor Region Has No Impact on Blood-Brain Barrier Alterations after Cerebral Photothrombosis in Rats.
Schuhmann MK, Stoll G, Papp L, Bohr A, Volkmann J, Fluri F
International journal of molecular sciences 2019 Aug 19;20(16)
International journal of molecular sciences 2019 Aug 19;20(16)
Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele.
Korecki AJ, Hickmott JW, Lam SL, Dreolini L, Mathelier A, Baker O, Kuehne C, Bonaguro RJ, Smith J, Tan CV, Zhou M, Goldowitz D, Deussing JM, Stewart AF, Wasserman WW, Holt RA, Simpson EM
Genetics 2019 Apr;211(4):1155-1177
Genetics 2019 Apr;211(4):1155-1177
Ulinastatin Ameliorates Pulmonary Capillary Endothelial Permeability Induced by Sepsis Through Protection of Tight Junctions via Inhibition of TNF-α and Related Pathways.
Fang M, Zhong WH, Song WL, Deng YY, Yang DM, Xiong B, Zeng HK, Wang HD
Frontiers in pharmacology 2018;9:823
Frontiers in pharmacology 2018;9:823
Interleukin-10 attenuates impairment of the blood-brain barrier in a severe acute pancreatitis rat model.
Lin R, Chen F, Wen S, Teng T, Pan Y, Huang H
Journal of inflammation (London, England) 2018;15:4
Journal of inflammation (London, England) 2018;15:4
Activated Microglia Disrupt the Blood-Brain Barrier and Induce Chemokines and Cytokines in a Rat in vitro Model.
Shigemoto-Mogami Y, Hoshikawa K, Sato K
Frontiers in cellular neuroscience 2018;12:494
Frontiers in cellular neuroscience 2018;12:494
Vascular and Neurogenic Rejuvenation in Aging Mice by Modulation of ASM.
Park MH, Lee JY, Park KH, Jung IK, Kim KT, Lee YS, Ryu HH, Jeong Y, Kang M, Schwaninger M, Gulbins E, Reichel M, Kornhuber J, Yamaguchi T, Kim HJ, Kim SH, Schuchman EH, Jin HK, Bae JS
Neuron 2018 Oct 10;100(1):167-182.e9
Neuron 2018 Oct 10;100(1):167-182.e9
Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy.
Rempe RG, Hartz AMS, Soldner ELB, Sokola BS, Alluri SR, Abner EL, Kryscio RJ, Pekcec A, Schlichtiger J, Bauer B
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 May 2;38(18):4301-4315
The Journal of neuroscience : the official journal of the Society for Neuroscience 2018 May 2;38(18):4301-4315
TNFα disrupts blood brain barrier integrity to maintain prolonged depressive-like behavior in mice.
Cheng Y, Desse S, Martinez A, Worthen RJ, Jope RS, Beurel E
Brain, behavior, and immunity 2018 Mar;69:556-567
Brain, behavior, and immunity 2018 Mar;69:556-567
Inhibition of MicroRNA-155 Supports Endothelial Tight Junction Integrity Following Oxygen-Glucose Deprivation.
Pena-Philippides JC, Gardiner AS, Caballero-Garrido E, Pan R, Zhu Y, Roitbak T
Journal of the American Heart Association 2018 Jun 26;7(13)
Journal of the American Heart Association 2018 Jun 26;7(13)
Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers.
Pierce RW, Zahr RA, Kandil S, Faustino EVS, Pober JS
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018 Jul;19(7):609-618
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018 Jul;19(7):609-618
Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.
Cottier KE, Galloway EA, Calabrese EC, Tome ME, Liktor-Busa E, Kim J, Davis TP, Vanderah TW, Largent-Milnes TM
eNeuro 2018 Jul-Aug;5(4)
eNeuro 2018 Jul-Aug;5(4)
Post-Injury Administration of Galantamine Reduces Traumatic Brain Injury Pathology and Improves Outcome.
Zhao J, Hylin MJ, Kobori N, Hood KN, Moore AN, Dash PK
Journal of neurotrauma 2018 Jan 15;35(2):362-374
Journal of neurotrauma 2018 Jan 15;35(2):362-374
Activation of RARα, RARγ, or RXRα Increases Barrier Tightness in Human Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Stebbins MJ, Lippmann ES, Faubion MG, Daneman R, Palecek SP, Shusta EV
Biotechnology journal 2018 Feb;13(2)
Biotechnology journal 2018 Feb;13(2)
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage.
Qiu Z, Yang J, Deng G, Fang Y, Li D, Zhang S
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 12;24:880-890
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 12;24:880-890
Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity.
Boussadia B, Lakhal L, Payrastre L, Ghosh C, Pascussi JM, Gangarossa G, Marchi N
Neuroscience 2018 Feb 1;370:130-138
Neuroscience 2018 Feb 1;370:130-138
Effect of tryptase on mouse brain microvascular endothelial cells via protease-activated receptor 2.
Zhou Q, Wang YW, Ni PF, Chen YN, Dong HQ, Qian YN
Journal of neuroinflammation 2018 Aug 31;15(1):248
Journal of neuroinflammation 2018 Aug 31;15(1):248
A perfused human blood-brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport.
Wevers NR, Kasi DG, Gray T, Wilschut KJ, Smith B, van Vught R, Shimizu F, Sano Y, Kanda T, Marsh G, Trietsch SJ, Vulto P, Lanz HL, Obermeier B
Fluids and barriers of the CNS 2018 Aug 31;15(1):23
Fluids and barriers of the CNS 2018 Aug 31;15(1):23
Apolipoprotein E4 impairs spontaneous blood brain barrier repair following traumatic brain injury.
Main BS, Villapol S, Sloley SS, Barton DJ, Parsadanian M, Agbaegbu C, Stefos K, McCann MS, Washington PM, Rodriguez OC, Burns MP
Molecular neurodegeneration 2018 Apr 4;13(1):17
Molecular neurodegeneration 2018 Apr 4;13(1):17
Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment.
Van Skike CE, Jahrling JB, Olson AB, Sayre NL, Hussong SA, Ungvari Z, Lechleiter JD, Galvan V
American journal of physiology. Heart and circulatory physiology 2018 Apr 1;314(4):H693-H703
American journal of physiology. Heart and circulatory physiology 2018 Apr 1;314(4):H693-H703
Altered Cytokine Expression and Barrier Properties after In Vitro Infection of Porcine Epithelial Cells with Enterotoxigenic Escherichia coli and Probiotic Enterococcus faecium.
Kern M, Günzel D, Aschenbach JR, Tedin K, Bondzio A, Lodemann U
Mediators of inflammation 2017;2017:2748192
Mediators of inflammation 2017;2017:2748192
Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality.
Kim JG, Bae SJ, Lee HS, Park JH, Kim KW
PloS one 2017;12(8):e0182047
PloS one 2017;12(8):e0182047
Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator.
Wang CK, Ahmed MM, Jiang Q, Lu NN, Tan C, Gao YP, Mahmood Q, Chen DY, Fukunaga K, Li M, Chen Z, Wilcox CS, Lu YM, Qin ZH, Han F
Journal of pineal research 2017 Nov;63(4)
Journal of pineal research 2017 Nov;63(4)
Modeling Group B Streptococcus and Blood-Brain Barrier Interaction by Using Induced Pluripotent Stem Cell-Derived Brain Endothelial Cells.
Kim BJ, Bee OB, McDonagh MA, Stebbins MJ, Palecek SP, Doran KS, Shusta EV
mSphere 2017 Nov-Dec;2(6)
mSphere 2017 Nov-Dec;2(6)
Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.
Lopez-Ramirez MA, Fonseca G, Zeineddine HA, Girard R, Moore T, Pham A, Cao Y, Shenkar R, de Kreuk BJ, Lagarrigue F, Lawler J, Glass CK, Awad IA, Ginsberg MH
The Journal of experimental medicine 2017 Nov 6;214(11):3331-3346
The Journal of experimental medicine 2017 Nov 6;214(11):3331-3346
Perforin Expression by CD8 T Cells Is Sufficient To Cause Fatal Brain Edema during Experimental Cerebral Malaria.
Huggins MA, Johnson HL, Jin F, N Songo A, Hanson LM, LaFrance SJ, Butler NS, Harty JT, Johnson AJ
Infection and immunity 2017 May;85(5)
Infection and immunity 2017 May;85(5)
Retinal pathology is associated with increased blood-retina barrier permeability in a diabetic and hypercholesterolaemic pig model: Beneficial effects of the LpPLA(2) inhibitor Darapladib.
Acharya NK, Qi X, Goldwaser EL, Godsey GA, Wu H, Kosciuk MC, Freeman TA, Macphee CH, Wilensky RL, Venkataraman V, Nagele RG
Diabetes & vascular disease research 2017 May;14(3):200-213
Diabetes & vascular disease research 2017 May;14(3):200-213
In Vitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling.
Yamamizu K, Iwasaki M, Takakubo H, Sakamoto T, Ikuno T, Miyoshi M, Kondo T, Nakao Y, Nakagawa M, Inoue H, Yamashita JK
Stem cell reports 2017 Mar 14;8(3):634-647
Stem cell reports 2017 Mar 14;8(3):634-647
Two common human CLDN5 alleles encode different open reading frames but produce one protein isoform.
Cornely RM, Schlingmann B, Shepherd WS, Chandler JD, Neujahr DC, Koval M
Annals of the New York Academy of Sciences 2017 Jun;1397(1):119-129
Annals of the New York Academy of Sciences 2017 Jun;1397(1):119-129
In vivo intrabursal administration of bioactive lipid sphingosine-1-phosphate enhances vascular integrity in a rat model of ovarian hyperstimulation syndrome.
Di Pietro M, Pascuali N, Scotti L, Irusta G, Bas D, May M, Tesone M, Abramovich D, Parborell F
Molecular human reproduction 2017 Jun 1;23(6):417-427
Molecular human reproduction 2017 Jun 1;23(6):417-427
Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation.
Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Jul;37(7):2471-2484
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Jul;37(7):2471-2484
The Wnt Inhibitor Apcdd1 Coordinates Vascular Remodeling and Barrier Maturation of Retinal Blood Vessels.
Mazzoni J, Smith JR, Shahriar S, Cutforth T, Ceja B, Agalliu D
Neuron 2017 Dec 6;96(5):1055-1069.e6
Neuron 2017 Dec 6;96(5):1055-1069.e6
The Human Blood-Nerve Barrier Transcriptome.
Palladino SP, Helton ES, Jain P, Dong C, Crowley MR, Crossman DK, Ubogu EE
Scientific reports 2017 Dec 12;7(1):17477
Scientific reports 2017 Dec 12;7(1):17477
Brain microvascular injury and white matter disease provoked by diabetes-associated hyperamylinemia.
Ly H, Verma N, Wu F, Liu M, Saatman KE, Nelson PT, Slevin JT, Goldstein LB, Biessels GJ, Despa F
Annals of neurology 2017 Aug;82(2):208-222
Annals of neurology 2017 Aug;82(2):208-222
Effect of shear stress on iPSC-derived human brain microvascular endothelial cells (dhBMECs).
DeStefano JG, Xu ZS, Williams AJ, Yimam N, Searson PC
Fluids and barriers of the CNS 2017 Aug 4;14(1):20
Fluids and barriers of the CNS 2017 Aug 4;14(1):20
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR
The Journal of clinical investigation 2017 Aug 1;127(8):3136-3151
The Journal of clinical investigation 2017 Aug 1;127(8):3136-3151
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Chehaibi K, le Maire L, Bradoni S, Escola JC, Blanco-Vaca F, Slimane MN
Translational research : the journal of laboratory and clinical medicine 2017 Apr;182:27-48
Translational research : the journal of laboratory and clinical medicine 2017 Apr;182:27-48
Size-selective opening of the blood-brain barrier by targeting endothelial sphingosine 1-phosphate receptor 1.
Yanagida K, Liu CH, Faraco G, Galvani S, Smith HK, Burg N, Anrather J, Sanchez T, Iadecola C, Hla T
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4531-4536
Proceedings of the National Academy of Sciences of the United States of America 2017 Apr 25;114(17):4531-4536
Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders.
Fiorentino M, Sapone A, Senger S, Camhi SS, Kadzielski SM, Buie TM, Kelly DL, Cascella N, Fasano A
Molecular autism 2016;7:49
Molecular autism 2016;7:49
Poly(I:C) Induces Human Lung Endothelial Barrier Dysfunction by Disrupting Tight Junction Expression of Claudin-5.
Huang LY, Stuart C, Takeda K, D'Agnillo F, Golding B
PloS one 2016;11(8):e0160875
PloS one 2016;11(8):e0160875
Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo.
Boussadia B, Gangarossa G, Mselli-Lakhal L, Rousset MC, de Bock F, Lassere F, Ghosh C, Pascussi JM, Janigro D, Marchi N
Experimental neurology 2016 Sep;283(Pt A):39-48
Experimental neurology 2016 Sep;283(Pt A):39-48
Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model.
Clark PA, Al-Ahmad AJ, Qian T, Zhang RR, Wilson HK, Weichert JP, Palecek SP, Kuo JS, Shusta EV
Molecular pharmaceutics 2016 Sep 6;13(9):3341-9
Molecular pharmaceutics 2016 Sep 6;13(9):3341-9
Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
Ahn C, Shin DH, Lee D, Kang SM, Seok JH, Kang HY, Jeung EB
Molecular medicine reports 2016 Oct;14(4):3697-703
Molecular medicine reports 2016 Oct;14(4):3697-703
Hypertonic saline alleviates experimentally induced cerebral oedema through suppression of vascular endothelial growth factor and its receptor VEGFR2 expression in astrocytes.
Huang L, Cao W, Deng Y, Zhu G, Han Y, Zeng H
BMC neuroscience 2016 Oct 13;17(1):64
BMC neuroscience 2016 Oct 13;17(1):64
PEGylation of Reduced Graphene Oxide Induces Toxicity in Cells of the Blood-Brain Barrier: An in Vitro and in Vivo Study.
Mendonça MC, Soares ES, de Jesus MB, Ceragioli HJ, Batista ÂG, Nyúl-Tóth Á, Molnár J, Wilhelm I, Maróstica MR Jr, Krizbai I, da Cruz-Höfling MA
Molecular pharmaceutics 2016 Nov 7;13(11):3913-3924
Molecular pharmaceutics 2016 Nov 7;13(11):3913-3924
The role of pericytic laminin in blood brain barrier integrity maintenance.
Gautam J, Zhang X, Yao Y
Scientific reports 2016 Nov 3;6:36450
Scientific reports 2016 Nov 3;6:36450
miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis.
Ge X, Huang S, Gao H, Han Z, Chen F, Zhang S, Wang Z, Kang C, Jiang R, Yue S, Lei P, Zhang J
Brain research 2016 Nov 1;1650:31-40
Brain research 2016 Nov 1;1650:31-40
Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling.
Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, Sommer K, Di Tacchio M, Vutukuri R, Beck H, Mittelbronn M, Foerch C, Pfeilschifter W, Liebner S, Peters KG, Plate KH, Reiss Y
Acta neuropathologica 2016 May;131(5):753-73
Acta neuropathologica 2016 May;131(5):753-73
Differentiation and characterization of human pluripotent stem cell-derived brain microvascular endothelial cells.
Stebbins MJ, Wilson HK, Canfield SG, Qian T, Palecek SP, Shusta EV
Methods (San Diego, Calif.) 2016 May 15;101:93-102
Methods (San Diego, Calif.) 2016 May 15;101:93-102
Ectodomain Shedding of Lymphatic Vessel Endothelial Hyaluronan Receptor 1 (LYVE-1) Is Induced by Vascular Endothelial Growth Factor A (VEGF-A).
Nishida-Fukuda H, Araki R, Shudou M, Okazaki H, Tomono Y, Nakayama H, Fukuda S, Sakaue T, Shirakata Y, Sayama K, Hashimoto K, Detmar M, Higashiyama S, Hirakawa S
The Journal of biological chemistry 2016 May 13;291(20):10490-500
The Journal of biological chemistry 2016 May 13;291(20):10490-500
BACE-1 is expressed in the blood-brain barrier endothelium and is upregulated in a murine model of Alzheimer's disease.
Devraj K, Poznanovic S, Spahn C, Schwall G, Harter PN, Mittelbronn M, Antoniello K, Paganetti P, Muhs A, Heilemann M, Hawkins RA, Schrattenholz A, Liebner S
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Jul;36(7):1281-94
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2016 Jul;36(7):1281-94
Opposite roles of bradykinin B1 and B2 receptors during cerebral ischaemia-reperfusion injury in experimental diabetic rats.
Sang H, Liu L, Wang L, Qiu Z, Li M, Yu L, Zhang H, Shi R, Yu S, Guo R, Ye R, Liu X, Zhang R
The European journal of neuroscience 2016 Jan;43(1):53-65
The European journal of neuroscience 2016 Jan;43(1):53-65
CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature.
Swanson PA 2nd, Hart GT, Russo MV, Nayak D, Yazew T, Peña M, Khan SM, Janse CJ, Pierce SK, McGavern DB
PLoS pathogens 2016 Dec;12(12):e1006022
PLoS pathogens 2016 Dec;12(12):e1006022
Peripheral ammonia and blood brain barrier structure and function after methamphetamine.
Northrop NA, Halpin LE, Yamamoto BK
Neuropharmacology 2016 Aug;107:18-26
Neuropharmacology 2016 Aug;107:18-26
Evidence That Cingulin Regulates Endothelial Barrier Function In Vitro and In Vivo.
Schossleitner K, Rauscher S, Gröger M, Friedl HP, Finsterwalder R, Habertheuer A, Sibilia M, Brostjan C, Födinger D, Citi S, Petzelbauer P
Arteriosclerosis, thrombosis, and vascular biology 2016 Apr;36(4):647-54
Arteriosclerosis, thrombosis, and vascular biology 2016 Apr;36(4):647-54
Inhibition of angiopoietin-1 (ANGPT1) affects vascular integrity in ovarian hyperstimulation syndrome (OHSS).
Scotti L, Abramovich D, Pascuali N, Durand LH, Irusta G, de Zúñiga I, Tesone M, Parborell F
Reproduction, fertility, and development 2016 Apr;28(6):690-9
Reproduction, fertility, and development 2016 Apr;28(6):690-9
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions.
Sreekanthreddy P, Gromnicova R, Davies H, Phillips J, Romero IA, Male D
F1000Research 2015;4:1279
F1000Research 2015;4:1279
The human urothelial tight junction: claudin 3 and the ZO-1α(+) switch.
Smith NJ, Hinley J, Varley CL, Eardley I, Trejdosiewicz LK, Southgate J
Bladder (San Francisco, Calif.) 2015;2(1):e9
Bladder (San Francisco, Calif.) 2015;2(1):e9
Changes in the cerebrospinal fluid circulatory system of the developing rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation.
Ghersi-Egea JF, Babikian A, Blondel S, Strazielle N
Fluids and barriers of the CNS 2015;12:8
Fluids and barriers of the CNS 2015;12:8
Altered Nrf2 signaling mediates hypoglycemia-induced blood-brain barrier endothelial dysfunction in vitro.
Sajja RK, Green KN, Cucullo L
PloS one 2015;10(3):e0122358
PloS one 2015;10(3):e0122358
Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases.
Clark PR, Kim RK, Pober JS, Kluger MS
PloS one 2015;10(3):e0120075
PloS one 2015;10(3):e0120075
Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex.
Zehendner CM, Sebastiani A, Hugonnet A, Bischoff F, Luhmann HJ, Thal SC
Scientific reports 2015 Sep 3;5:13497
Scientific reports 2015 Sep 3;5:13497
Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.
Brkic M, Balusu S, Van Wonterghem E, Gorlé N, Benilova I, Kremer A, Van Hove I, Moons L, De Strooper B, Kanazir S, Libert C, Vandenbroucke RE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Sep 16;35(37):12766-78
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Sep 16;35(37):12766-78
Planar cell polarity-mediated induction of neural stem cell expansion during axolotl spinal cord regeneration.
Rodrigo Albors A, Tazaki A, Rost F, Nowoshilow S, Chara O, Tanaka EM
eLife 2015 Nov 14;4:e10230
eLife 2015 Nov 14;4:e10230
Ligustrazine reduces blood-brain barrier permeability in a rat model of focal cerebral ischemia and reperfusion.
Tan F, Fu W, Cheng N, Meng DI, Gu Y
Experimental and therapeutic medicine 2015 May;9(5):1757-1762
Experimental and therapeutic medicine 2015 May;9(5):1757-1762
Claudin-5 levels are reduced from multiple cell types in human failing hearts and are associated with mislocalization of ephrin-B1.
Swager SA, Delfín DA, Rastogi N, Wang H, Canan BD, Fedorov VV, Mohler PJ, Kilic A, Higgins RSD, Ziolo MT, Janssen PML, Rafael-Fortney JA
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2015 May-Jun;24(3):160-167
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2015 May-Jun;24(3):160-167
Prostacyclin prevents pericyte loss and demyelination induced by lysophosphatidylcholine in the central nervous system.
Muramatsu R, Kuroda M, Matoba K, Lin H, Takahashi C, Koyama Y, Yamashita T
The Journal of biological chemistry 2015 May 1;290(18):11515-25
The Journal of biological chemistry 2015 May 1;290(18):11515-25
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Casselbrant A, Elias E, Fändriks L, Wallenius V
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2015 Jan-Feb;11(1):45-53
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2015 Jan-Feb;11(1):45-53
Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.
Pienaar IS, Lee CH, Elson JL, McGuinness L, Gentleman SM, Kalaria RN, Dexter DT
Neurobiology of disease 2015 Feb;74:392-405
Neurobiology of disease 2015 Feb;74:392-405
Overexpression of miR-18a negatively regulates myocyte enhancer factor 2D to increase the permeability of the blood-tumor barrier via Krüppel-like factor 4-mediated downregulation of zonula occluden-1, claudin-5, and occludin.
Zhao YY, Zhao LN, Wang P, Miao YS, Liu YH, Wang ZH, Ma J, Li Z, Li ZQ, Xue YX
Journal of neuroscience research 2015 Dec;93(12):1891-902
Journal of neuroscience research 2015 Dec;93(12):1891-902
Nicotine pre-exposure reduces stroke-induced glucose transporter-1 activity at the blood-brain barrier in mice.
Shah KK, Boreddy PR, Abbruscato TJ
Fluids and barriers of the CNS 2015 Apr 29;12:10
Fluids and barriers of the CNS 2015 Apr 29;12:10
Perforin competent CD8 T cells are sufficient to cause immune-mediated blood-brain barrier disruption.
Johnson HL, Willenbring RC, Jin F, Manhart WA, LaFrance SJ, Pirko I, Johnson AJ
PloS one 2014;9(10):e111401
PloS one 2014;9(10):e111401
C1-Inhibitor protects from focal brain trauma in a cortical cryolesion mice model by reducing thrombo-inflammation.
Albert-Weissenberger C, Mencl S, Schuhmann MK, Salur I, Göb E, Langhauser F, Hopp S, Hennig N, Meuth SG, Nolte MW, Sirén AL, Kleinschnitz C
Frontiers in cellular neuroscience 2014;8:269
Frontiers in cellular neuroscience 2014;8:269
A neurovascular blood-brain barrier in vitro model.
Zehendner CM, White R, Hedrich J, Luhmann HJ
Methods in molecular biology (Clifton, N.J.) 2014;1135:403-13
Methods in molecular biology (Clifton, N.J.) 2014;1135:403-13
Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome.
Scotti L, Abramovich D, Pascuali N, Irusta G, Meresman G, Tesone M, Parborell F
The Journal of steroid biochemistry and molecular biology 2014 Oct;144 Pt B:392-401
The Journal of steroid biochemistry and molecular biology 2014 Oct;144 Pt B:392-401
The gut microbiota influences blood-brain barrier permeability in mice.
Braniste V, Al-Asmakh M, Kowal C, Anuar F, Abbaspour A, Tóth M, Korecka A, Bakocevic N, Ng LG, Kundu P, Gulyás B, Halldin C, Hultenby K, Nilsson H, Hebert H, Volpe BT, Diamond B, Pettersson S
Science translational medicine 2014 Nov 19;6(263):263ra158
Science translational medicine 2014 Nov 19;6(263):263ra158
Mfsd2a is critical for the formation and function of the blood-brain barrier.
Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, Gu C
Nature 2014 May 22;509(7501):507-11
Nature 2014 May 22;509(7501):507-11
An in vitro blood-brain barrier model combining shear stress and endothelial cell/astrocyte co-culture.
Takeshita Y, Obermeier B, Cotleur A, Sano Y, Kanda T, Ransohoff RM
Journal of neuroscience methods 2014 Jul 30;232:165-72
Journal of neuroscience methods 2014 Jul 30;232:165-72
Claudins as prognostic factors for renal cell cancer.
Virman J, Soini Y, Kujala P, Luukkaala T, Salminen T, Sunela K, Kellokumpu-Lehtinen PL
Anticancer research 2014 Aug;34(8):4181-7
Anticancer research 2014 Aug;34(8):4181-7
Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke.
Hawkins KE, DeMars KM, Singh J, Yang C, Cho HS, Frankowski JC, Doré S, Candelario-Jalil E
Journal of neurochemistry 2014 Apr;129(1):130-42
Journal of neurochemistry 2014 Apr;129(1):130-42
Impact of altered glycaemia on blood-brain barrier endothelium: an in vitro study using the hCMEC/D3 cell line.
Sajja RK, Prasad S, Cucullo L
Fluids and barriers of the CNS 2014 Apr 5;11(1):8
Fluids and barriers of the CNS 2014 Apr 5;11(1):8
Oxidative and pro-inflammatory impact of regular and denicotinized cigarettes on blood brain barrier endothelial cells: is smoking reduced or nicotine-free products really safe?
Naik P, Fofaria N, Prasad S, Sajja RK, Weksler B, Couraud PO, Romero IA, Cucullo L
BMC neuroscience 2014 Apr 23;15:51
BMC neuroscience 2014 Apr 23;15:51
Anthrax lethal toxin downregulates claudin-5 expression in human endothelial tight junctions.
D'Agnillo F, Williams MC, Moayeri M, Warfel JM
PloS one 2013;8(4):e62576
PloS one 2013;8(4):e62576
Moderate hypoxia followed by reoxygenation results in blood-brain barrier breakdown via oxidative stress-dependent tight-junction protein disruption.
Zehendner CM, Librizzi L, Hedrich J, Bauer NM, Angamo EA, de Curtis M, Luhmann HJ
PloS one 2013;8(12):e82823
PloS one 2013;8(12):e82823
A novel in vitro model to study pericytes in the neurovascular unit of the developing cortex.
Zehendner CM, Wedler HE, Luhmann HJ
PloS one 2013;8(11):e81637
PloS one 2013;8(11):e81637
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
Hintsala HR, Siponen M, Haapasaari KM, Karihtala P, Soini Y
International journal of clinical and experimental pathology 2013;6(12):2855-63
International journal of clinical and experimental pathology 2013;6(12):2855-63
Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis.
Lappi-Blanco E, Lehtonen ST, Sormunen R, Merikallio HM, Soini Y, Kaarteenaho RL
Human pathology 2013 May;44(5):895-907
Human pathology 2013 May;44(5):895-907
Effect of a two-week treatment with a low dose of 2,2'4,4',5,5'-hexachlorobiphenyl (PCB153) on tight junction protein expression in ovine choroid plexus during long and short photoperiods.
Szczepkowska A, Lagaraine C, Robert V, Dufourny L, Thiéry JC, Skipor J
Neurotoxicology and teratology 2013 May-Jun;37:63-7
Neurotoxicology and teratology 2013 May-Jun;37:63-7
Physiology of blood-brain interfaces in relation to brain disposition of small compounds and macromolecules.
Strazielle N, Ghersi-Egea JF
Molecular pharmaceutics 2013 May 6;10(5):1473-91
Molecular pharmaceutics 2013 May 6;10(5):1473-91
Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier.
Watson PM, Paterson JC, Thom G, Ginman U, Lundquist S, Webster CI
BMC neuroscience 2013 Jun 18;14:59
BMC neuroscience 2013 Jun 18;14:59
Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids.
Géraud C, Evdokimov K, Straub BK, Peitsch WK, Demory A, Dörflinger Y, Schledzewski K, Schmieder A, Schemmer P, Augustin HG, Schirmacher P, Goerdt S
PloS one 2012;7(4):e34206
PloS one 2012;7(4):e34206
Effect of Phoneutria nigriventer venom on the expression of junctional protein and P-gp efflux pump function in the blood-brain barrier.
Rapôso C, Odorissi PA, Oliveira AL, Aoyama H, Ferreira CV, Verinaud L, Fontana K, Ruela-de-Sousa RR, da Cruz-Höfling MA
Neurochemical research 2012 Sep;37(9):1967-81
Neurochemical research 2012 Sep;37(9):1967-81
Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.
Ghulé VV, Gray C, Galimberti A, Anumba DO
Journal of translational medicine 2012 Mar 7;10:40
Journal of translational medicine 2012 Mar 7;10:40
Sustaining cardiac claudin-5 levels prevents functional hallmarks of cardiomyopathy in a muscular dystrophy mouse model.
Delfín DA, Xu Y, Schill KE, Mays TA, Canan BD, Zang KE, Barnum JA, Janssen PM, Rafael-Fortney JA
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jul;20(7):1378-83
Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jul;20(7):1378-83
Two strikingly different signaling pathways are induced by meningococcal type IV pili on endothelial and epithelial cells.
Lécuyer H, Nassif X, Coureuil M
Infection and immunity 2012 Jan;80(1):175-86
Infection and immunity 2012 Jan;80(1):175-86
Persistent neuroinflammatory effects of serial exposure to stress and methamphetamine on the blood-brain barrier.
Northrop NA, Yamamoto BK
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Dec;7(4):951-68
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Dec;7(4):951-68
Complexity and developmental changes in the expression pattern of claudins at the blood-CSF barrier.
Kratzer I, Vasiljevic A, Rey C, Fevre-Montange M, Saunders N, Strazielle N, Ghersi-Egea JF
Histochemistry and cell biology 2012 Dec;138(6):861-79
Histochemistry and cell biology 2012 Dec;138(6):861-79
Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability.
Krouwer VJ, Hekking LH, Langelaar-Makkinje M, Regan-Klapisz E, Post JA
Vascular cell 2012 Aug 28;4(1):12
Vascular cell 2012 Aug 28;4(1):12
CD8 T cell-initiated blood-brain barrier disruption is independent of neutrophil support.
Johnson HL, Chen Y, Jin F, Hanson LM, Gamez JD, Pirko I, Johnson AJ
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 15;189(4):1937-45
Journal of immunology (Baltimore, Md. : 1950) 2012 Aug 15;189(4):1937-45
Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma.
Riski M, Santala M, Soini Y, Talvensaari-Mattila A
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012 Apr;33(2):537-42
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012 Apr;33(2):537-42
Tight junction proteins expression and modulation in immune cells and multiple sclerosis.
Mandel I, Paperna T, Glass-Marmor L, Volkowich A, Badarny S, Schwartz I, Vardi P, Koren I, Miller A
Journal of cellular and molecular medicine 2012 Apr;16(4):765-75
Journal of cellular and molecular medicine 2012 Apr;16(4):765-75
MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia.
Yang Y, Rosenberg GA
Methods in molecular biology (Clifton, N.J.) 2011;762:333-45
Methods in molecular biology (Clifton, N.J.) 2011;762:333-45
Detection of multiple proteins in intracerebral vessels by confocal microscopy.
Manias JL, Kapadia A, Nag S
Methods in molecular biology (Clifton, N.J.) 2011;686:177-92
Methods in molecular biology (Clifton, N.J.) 2011;686:177-92
Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.
Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren-Wiemers N, Deutsch U, Engelhardt B
Acta neuropathologica 2011 Nov;122(5):601-14
Acta neuropathologica 2011 Nov;122(5):601-14
Novel expression of claudin-5 in glomerular podocytes.
Koda R, Zhao L, Yaoita E, Yoshida Y, Tsukita S, Tamura A, Nameta M, Zhang Y, Fujinaka H, Magdeldin S, Xu B, Narita I, Yamamoto T
Cell and tissue research 2011 Mar;343(3):637-48
Cell and tissue research 2011 Mar;343(3):637-48
Blood-brain barrier disruption and oxidative stress in guinea pig after systemic exposure to modified cell-free hemoglobin.
Butt OI, Buehler PW, D'Agnillo F
The American journal of pathology 2011 Mar;178(3):1316-28
The American journal of pathology 2011 Mar;178(3):1316-28
Tight junction proteins vary in the choroid plexus of ewes according to photoperiod.
Lagaraine C, Skipor J, Szczepkowska A, Dufourny L, Thiery JC
Brain research 2011 Jun 1;1393:44-51
Brain research 2011 Jun 1;1393:44-51
Caspase-3 contributes to ZO-1 and Cl-5 tight-junction disruption in rapid anoxic neurovascular unit damage.
Zehendner CM, Librizzi L, de Curtis M, Kuhlmann CR, Luhmann HJ
PloS one 2011 Feb 22;6(2):e16760
PloS one 2011 Feb 22;6(2):e16760
Claudin-5 as an immunohistochemical marker for angiosarcoma and hemangioendotheliomas.
Miettinen M, Sarlomo-Rikala M, Wang ZF
The American journal of surgical pathology 2011 Dec;35(12):1848-56
The American journal of surgical pathology 2011 Dec;35(12):1848-56
Calcium dobesilate inhibits the alterations in tight junction proteins and leukocyte adhesion to retinal endothelial cells induced by diabetes.
Leal EC, Martins J, Voabil P, Liberal J, Chiavaroli C, Bauer J, Cunha-Vaz J, Ambrósio AF
Diabetes 2010 Oct;59(10):2637-45
Diabetes 2010 Oct;59(10):2637-45
Retinal vascular changes after glial disruption in rats.
Shen W, Li S, Chung SH, Gillies MC
Journal of neuroscience research 2010 May 15;88(7):1485-99
Journal of neuroscience research 2010 May 15;88(7):1485-99
Maternal glucocorticoid exposure alters tight junction protein expression in the brain of fetal sheep.
Sadowska GB, Malaeb SN, Stonestreet BS
American journal of physiology. Heart and circulatory physiology 2010 Jan;298(1):H179-88
American journal of physiology. Heart and circulatory physiology 2010 Jan;298(1):H179-88
Acute and chronic deficits in the urinary bladder after spinal contusion injury in the adult rat.
Herrera JJ, Haywood-Watson RJ 2nd, Grill RJ
Journal of neurotrauma 2010 Feb;27(2):423-31
Journal of neurotrauma 2010 Feb;27(2):423-31
Perifoveal müller cell depletion in a case of macular telangiectasia type 2.
Powner MB, Gillies MC, Tretiach M, Scott A, Guymer RH, Hageman GS, Fruttiger M
Ophthalmology 2010 Dec;117(12):2407-16
Ophthalmology 2010 Dec;117(12):2407-16
Annexin 2 regulates endothelial morphogenesis by controlling AKT activation and junctional integrity.
Su SC, Maxwell SA, Bayless KJ
The Journal of biological chemistry 2010 Dec 24;285(52):40624-34
The Journal of biological chemistry 2010 Dec 24;285(52):40624-34
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
Fang X, Neyrinck AP, Matthay MA, Lee JW
The Journal of biological chemistry 2010 Aug 20;285(34):26211-22
The Journal of biological chemistry 2010 Aug 20;285(34):26211-22
Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement.
Bauer AT, Bürgers HF, Rabie T, Marti HH
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010 Apr;30(4):837-48
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2010 Apr;30(4):837-48
Mouse adenovirus type 1-induced breakdown of the blood-brain barrier.
Gralinski LE, Ashley SL, Dixon SD, Spindler KR
Journal of virology 2009 Sep;83(18):9398-410
Journal of virology 2009 Sep;83(18):9398-410
Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery.
Yemisci M, Gursoy-Ozdemir Y, Vural A, Can A, Topalkara K, Dalkara T
Nature medicine 2009 Sep;15(9):1031-7
Nature medicine 2009 Sep;15(9):1031-7
Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins.
Regan-Klapisz E, Krouwer V, Langelaar-Makkinje M, Nallan L, Gelb M, Gerritsen H, Verkleij AJ, Post JA
Molecular biology of the cell 2009 Oct;20(19):4225-34
Molecular biology of the cell 2009 Oct;20(19):4225-34
Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide.
Waldow T, Witt W, Janke A, Ulmer A, Buzin A, Matschke K
The Journal of surgical research 2009 Nov;157(1):30-42
The Journal of surgical research 2009 Nov;157(1):30-42
Tight junction proteins in human Schwann cell autotypic junctions.
Alanne MH, Pummi K, Heape AM, Grènman R, Peltonen J, Peltonen S
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Jun;57(6):523-9
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Jun;57(6):523-9
Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma.
Turunen M, Talvensaari-Mattila A, Soini Y, Santala M
Anticancer research 2009 Dec;29(12):5185-9
Anticancer research 2009 Dec;29(12):5185-9
Protein components of the blood-brain barrier (BBB) in the mediobasal hypothalamus.
Norsted E, Gömüç B, Meister B
Journal of chemical neuroanatomy 2008 Oct;36(2):107-21
Journal of chemical neuroanatomy 2008 Oct;36(2):107-21
Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing.
Su SC, Mendoza EA, Kwak HI, Bayless KJ
American journal of physiology. Cell physiology 2008 Nov;295(5):C1215-29
American journal of physiology. Cell physiology 2008 Nov;295(5):C1215-29
Localization of claudin-5 and ZO-1 in rat spleen sinus endothelial cells.
Uehara K, Uehara A
Histochemistry and cell biology 2008 Jan;129(1):95-103
Histochemistry and cell biology 2008 Jan;129(1):95-103
Hepatitis C virus receptor expression in normal and diseased liver tissue.
Reynolds GM, Harris HJ, Jennings A, Hu K, Grove J, Lalor PF, Adams DH, Balfe P, Hübscher SG, McKeating JA
Hepatology (Baltimore, Md.) 2008 Feb;47(2):418-27
Hepatology (Baltimore, Md.) 2008 Feb;47(2):418-27
Characterization of a novel type of adherens junction in meningiomas and the derived cell line HBL-52.
Akat K, Bleck CK, Lee YM, Haselmann-Weiss U, Kartenbeck J
Cell and tissue research 2008 Feb;331(2):401-12
Cell and tissue research 2008 Feb;331(2):401-12
Distribution of tight junction proteins in adult human salivary glands.
Maria OM, Kim JW, Gerstenhaber JA, Baum BJ, Tran SD
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Dec;56(12):1093-8
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Dec;56(12):1093-8
Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.
Neuhaus W, Wirth M, Plattner VE, Germann B, Gabor F, Noe CR
Neuroscience letters 2008 Dec 3;446(2-3):59-64
Neuroscience letters 2008 Dec 3;446(2-3):59-64
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
Paschoud S, Bongiovanni M, Pache JC, Citi S
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007 Sep;20(9):947-54
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007 Sep;20(9):947-54
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Peltonen S, Riehokainen J, Pummi K, Peltonen J
The British journal of dermatology 2007 Mar;156(3):466-72
The British journal of dermatology 2007 Mar;156(3):466-72
Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis.
Morgan L, Shah B, Rivers LE, Barden L, Groom AJ, Chung R, Higazi D, Desmond H, Smith T, Staddon JM
Neuroscience 2007 Jul 13;147(3):664-73
Neuroscience 2007 Jul 13;147(3):664-73
Tight junctions contain oligomeric protein assembly critical for maintaining blood-brain barrier integrity in vivo.
McCaffrey G, Staatz WD, Quigley CA, Nametz N, Seelbach MJ, Campos CR, Brooks TA, Egleton RD, Davis TP
Journal of neurochemistry 2007 Dec;103(6):2540-55
Journal of neurochemistry 2007 Dec;103(6):2540-55
Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas.
Sheehan GM, Kallakury BV, Sheehan CE, Fisher HA, Kaufman RP Jr, Ross JS
Human pathology 2007 Apr;38(4):564-9
Human pathology 2007 Apr;38(4):564-9
Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura.
Soini Y, Kinnula V, Kahlos K, Pääkkö P
Journal of clinical pathology 2006 Mar;59(3):250-4
Journal of clinical pathology 2006 Mar;59(3):250-4
Tight junction proteins and perineurial cells in neurofibromas.
Pummi KP, Aho HJ, Laato MK, Peltonen JT, Peltonen SA
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Jan;54(1):53-61
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Jan;54(1):53-61
Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption.
Musch MW, Walsh-Reitz MM, Chang EB
American journal of physiology. Gastrointestinal and liver physiology 2006 Feb;290(2):G222-31
American journal of physiology. Gastrointestinal and liver physiology 2006 Feb;290(2):G222-31
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
Weng XH, Beyenbach KW, Quaroni A
American journal of physiology. Gastrointestinal and liver physiology 2005 Apr;288(4):G705-17
American journal of physiology. Gastrointestinal and liver physiology 2005 Apr;288(4):G705-17
The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development.
Rahner C, Fukuhara M, Peng S, Kojima S, Rizzolo LJ
Journal of cell science 2004 Jul 1;117(Pt 15):3307-18
Journal of cell science 2004 Jul 1;117(Pt 15):3307-18
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
Pummi KP, Heape AM, Grénman RA, Peltonen JT, Peltonen SA
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Aug;52(8):1037-46
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Aug;52(8):1037-46
Expression and localization of tight junction-associated proteins in human hair follicles.
Brandner JM, McIntyre M, Kief S, Wladykowski E, Moll I
Archives of dermatological research 2003 Sep;295(5):211-21
Archives of dermatological research 2003 Sep;295(5):211-21
Heterogeneity of claudin expression by alveolar epithelial cells.
Wang F, Daugherty B, Keise LL, Wei Z, Foley JP, Savani RC, Koval M
American journal of respiratory cell and molecular biology 2003 Jul;29(1):62-70
American journal of respiratory cell and molecular biology 2003 Jul;29(1):62-70
Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells.
Poliak S, Matlis S, Ullmer C, Scherer SS, Peles E
The Journal of cell biology 2002 Oct 28;159(2):361-72
The Journal of cell biology 2002 Oct 28;159(2):361-72
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Supportive validation
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- Western blot analysis of Claudin-5 was performed by loading 20 µg of Mouse Placenta (lane1) and Mouse Small Intestine (lane2) lysates using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX), XCell SureLock Electrophoresis System (Product # EI0002), Novex® Sharp Pre-Stained Protein Standard (LC5800), and iBlot® Dry Blotting System (IB21001). Proteins were transferred to a nitrocellulose membrane and blocked with 5 % skim milk for 1 hour at room temperature. Claudin-5 was detected at ~23 kDa using Claudin-5 Mouse Monoclonal Antibody (Product # 35-2500) at 0.5-1 µg/mL in 2.5 % skim milk at 4°C overnight on a rocking platform. Goat Anti-Mouse IgG - HRP Secondary Antibody (Product # 62-6520) at 1:4000 dilution was used and chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).
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- Western blot was performed using Anti-Claudin 5 Monoclonal Antibody (Product # 35-2500) and an 18kDa band corresponding to Claudin 5 was observed to be downregulated upon treatment with VEGF and TGF beta. In addition, expression of Claudin 5 was observed only in HUVEC as compared to THP-1 and MOLT-4 which are reported to be negative. Membrane enriched extracts (30 µg lysate) of HUVEC (Lane 1), HUVEC treated with VEGF (5ng/ml for 48 hours) (Lane 2), HUVEC treated with TGF beta (30ng/ml for 48 hours) (Lane 3), THP-1 (Lane 4) and MOLT-4 (Lane 5) were electrophoresed using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1:1000 dilution) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L), Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:4000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005)..
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- Immunohistochemistry analysis of Claudin 5 showing staining in the Membrane and Cytoplasm of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a Claudin 5 Mouse Monoclonal Antibody (Product # 35-2500) diluted in 3% BSA-PBS at a dilution of 1:20 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
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- Figure 3 Protein expression (Western blot) of claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, and claudin-8 after treatment with bacterial strains (Ecf, ETEC, and Ecf + ETEC). (a) Protein expression relative to respective controls [means +- SEM]. Samples were taken after 8 h. No differences were observed between treatment groups. N = 3 independent experiments per bar. (b) Exemplarily, data of one Western blot is shown. 1 = control (8 h), 2 = Ecf (8 h), 3 = ETEC (8 h), 4 = Ecf (8 h) + ETEC (6 h), and 5 = Ecf (10 h) + ETEC (8 h). Sample 4 was included as a control to rule out effects of longer total bacterial incubation (preincubation) and was not included in the statistical analysis shown in (a).
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- Fig 1 Expression of TJPs in different leukocyte subsets. Immunofluorescence staining of PBLs from healthy controls with antibodies against claudin 1 or claudin 5 (green) and CD20 (A,B), CD14 (C,D), CD3 (E,F), CD4 (G,H), CD8 (I,J), ZO-1 (K,L) and ZO-2 (M,N) (all red) and a nuclear dye (TO-PRO 3-blue). Scale bar: 5 mum. Representative results from three independent experiments are shown.
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- Fig. 6 Claudin-5 and claudin-4 are expressed in endothelial cells in the developing brain a - d . Cld-5 immunoreactivity in the developing and adult brain. Parenchymal vessels are labeled ( green ) in E19 ( arrows a ) or adult ( arrows b , d ) animals. In c , the anti-Cld-5 polyclonal antibody was used to show the colocalization of the TJ protein ( red ) with the endothelial marker RECA-1 ( green ) in a P2 animal. In all CPs immunodetection revealed a signal associated with the largest vessels penetrating the choroidal stroma ( arrowheads b , d ), but not with the choroidal epithelium, labeled in red by anti-Cld-1 Ab ( d ). Note that all cisternal vessels such as the vein of Galen are also labeled by anti-Cld-5 Ab. DAPI was used for nuclei staining. e Representative Western blot of Cld-4. Brain cortex ( lane 1 20 mug) and MV ( lanes 2 and 3 40 mug) were isolated from adult animals. Lane 4 was loaded with MDCK (10 mug) as positive control. A low, but specific Cld-4 signal was detected in MV ( upper panel lane 3 band at 22 kDa), but not in cortex or in MV when the primary antibody was omitted ( lane 2 ). Actin used as a loading indicator is shown in the lower panel (42 kDa band). Due to the high expression of Cld-4 in MDCK cells, lane 4 was treated separately from the other lanes for HRP detection. f - h Cld-4 immunoreactivity ( red ) in the developing and adult brain. Double immunolabeling with anti-RECA-1Ab ( green ) allowed visualizing the parenchymal vessels that were posit
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- Fig. 8 Representative immunofluorescence images of dhBMEC monolayers fixed and stained after 40 h at 0, 4, and 12 dyne cm -2 . a , e , i CLDN-5. b , f , j OCLN. c , g , k ZO-1. d , h , l F-actin. Note that CLDN-5/OCLN and ZO-1/f-actin were obtained for different monolayers