Antibody data
- Antibody Data
- Antigen structure
- References [220]
- Comments [0]
- Validations
- Western blot [3]
- Other assay [32]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 32-9400 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Claudin 4 Monoclonal Antibody (3E2C1)
- Antibody type
- Monoclonal
- Antigen
- Synthetic peptide
- Description
- Reactivity has been confirmed with human, rat ileum homogenates, and canine MDCK cell lysates by western blotting and immunofluorescence. Reactivity has also been confirmed with formalin-fixed, paraffin-embedded (FFPE) human normal colon and colon cancer tissues by immunohistochemistry. For best results in immunohistochemistry with formalin-fixed, paraffin-embedded (FFPE) tissues, heat induced epitope retrieval (HIER) with citrate buffer, pH 6.0, is required prior to staining. This antibody reacts specifically with the ~ 22 kDa Claudin-4 protein and does not cross-react with the protein at 55 kDa.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 3E2C1
- Vial size
- 100 µg
- Concentration
- 0.5 mg/mL
- Storage
- -20°C
Submitted references Cellular Distribution Pattern of tjp1 (ZO-1) in Xenopus laevis Oocytes Heterologously Expressing Claudins.
MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier.
Functional Analysis of Gastric Tight Junction Proteins in Xenopus laevis Oocytes.
Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention.
Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Leaky Gut as a Potential Culprit for the Paradoxical Dysglycemic Response to Gastric Bypass-Associated Ileal Microbiota.
Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing.
A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications.
Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern.
Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial.
Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Impact of viral disease hypophagia on pig jejunal function and integrity.
E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions.
Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model.
Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?
A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy.
The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction.
All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.
TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection.
Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture.
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
Fusarium Mycotoxins Disrupt the Barrier and Induce IL-6 Release in a Human Placental Epithelium Cell Line.
Association of Cytokeratin 5 and Claudin 3 expression with BRCA1 and BRCA2 germline mutations in women with early breast cancer.
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.
The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.
Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo-obstruction.
Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation.
High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors.
Immunoexpression of claudins 4 and 7 among invasive breast carcinoma subtypes: A large diagnostic study using tissue microarray.
Calprotectin protects against experimental colonic inflammation in mice.
Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique.
Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response.
Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation.
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Imaging of Claudin-4 in Pancreatic Ductal Adenocarcinoma Using a Radiolabelled Anti-Claudin-4 Monoclonal Antibody.
Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium.
Altered Cytokine Expression and Barrier Properties after In Vitro Infection of Porcine Epithelial Cells with Enterotoxigenic Escherichia coli and Probiotic Enterococcus faecium.
Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.
HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation.
Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.
Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps.
Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin.
Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function.
TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium.
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17.
Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines.
The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice.
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.
Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer.
Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation.
Caveolin-1 regulates the expression of tight junction proteins during hyperoxia-induced pulmonary epithelial barrier breakdown.
Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1.
The human urothelial tight junction: claudin 3 and the ZO-1α(+) switch.
Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.
Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum.
Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.
Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways.
Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB-415 breast cancer cell lines.
Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers.
EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum.
Paclitaxel-induced lung injury and its amelioration by parecoxib sodium.
Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes.
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape.
Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation.
Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4.
A CLDN1-negative phenotype predicts poor prognosis in triple-negative breast cancer.
Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.
A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats.
Tricellulin expression and its prognostic significance in primary liver carcinomas.
Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers.
Upregulation of Claudin-4, CAIX and GLUT-1 in distant breast cancer metastases.
Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium.
p38δ mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes.
Diets high in fermentable protein and fibre alter tight junction protein composition with minor effects on barrier function in piglet colon.
A survey of zeb1, twist and claudin 1 and 4 expression during placental development and disease.
N-alkylation of highly quaternized chitosan derivatives affects the paracellular permeation enhancement in bronchial epithelia in vitro.
Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways.
Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration.
Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.
Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease.
Claudins as prognostic factors for renal cell cancer.
CD137 signaling enhances tight junction resistance in intestinal epithelial cells.
Transmigration of neural stem cells across the blood brain barrier induced by glioma cells.
The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells.
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
Think modular: a simple apoferritin-based platform for the multifaceted detection of pancreatic cancer.
Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins.
Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano.
Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis.
Dynamics of thymus organogenesis and colonization in early human development.
Rab25 regulates integrin expression in polarized colonic epithelial cells.
Clinicopathological significance of claudin-4 in gastric carcinoma.
Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions.
Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
Derivation of myoepithelial progenitor cells from bipotent mammary stem/progenitor cells.
The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier.
Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases.
Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.
Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells.
Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer.
Functional characterization and localization of a gill-specific claudin isoform in Atlantic salmon.
Development of tertiary lymphoid structures in the kidneys of pigs with chronic leptospiral nephritis.
Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders.
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis).
Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes.
Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes.
Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma.
Enhanced immunohistochemical resolution of claudin proteins in glycolmethacrylate-embedded tissue biopsies.
Herpes simplex virus-induced epithelial damage and susceptibility to human immunodeficiency virus type 1 infection in human cervical organ culture.
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.
Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells.
Usefulness of Claudin 4 in the cytological diagnosis of serosal effusions.
Matrigel improves functional properties of primary human salivary gland cells.
Low expression of claudin-4 is associated with poor prognosis in esophageal squamous cell carcinoma.
Claudin 4 Is differentially expressed between ovarian cancer subtypes and plays a role in spheroid formation.
Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix.
Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
Ouabain modulates ciliogenesis in epithelial cells.
Minimized and conventional cardiopulmonary bypass damage intestinal mucosal integrity.
Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy.
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
Twist is inversely associated with claudins in germ cell tumors of the testis.
Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.
Somatostatin regulates tight junction function and composition in human keratinocytes.
c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells.
Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism.
Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung.
Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells.
Expression pattern and prognostic significance of claudins 1, 4, and 7 in nasopharyngeal carcinoma.
Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells.
Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients.
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma.
Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma.
Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases.
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression.
Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer.
Tight junction proteins in human Schwann cell autotypic junctions.
Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors).
Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.
Expression of tight-junction proteins in the inflamed and clinically uninvolved skin in patients with venous leg ulcers.
Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells.
Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9.
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation.
Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma.
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line.
Salinity regulates claudin mRNA and protein expression in the teleost gill.
Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.
Osmoregulation and expression of ion transport proteins and putative claudins in the gill of southern flounder (Paralichthys lethostigma).
Early events in HIV transmission through a human reconstructed vaginal mucosa.
Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms.
Low claudin expression is associated with high Gleason grade in prostate adenocarcinoma.
Hepatitis C virus receptor expression in normal and diseased liver tissue.
Histopathologic determinants of regional lymph node metastasis in early colorectal cancer.
Distribution of tight junction proteins in adult human salivary glands.
Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue.
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation.
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer.
Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation.
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Differentiation potential of urothelium from patients with benign bladder dysfunction.
Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells.
Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos.
Decreased expression of claudin-1 correlates with recurrence status in breast cancer.
Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas.
Expression of claudins 1, 4, 5, and 7 in ovarian tumors of diverse types.
Cellular networks of human thymic medullary stromas coordinated by p53-related transcription factors.
Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura.
Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas.
Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine.
Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia.
Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype.
PPARgamma-regulated tight junction development during human urothelial cytodifferentiation.
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.
Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins.
Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition.
Claudins upregulation in human colorectal cancer.
Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin.
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.
Differentiation of epithelial Na+ channel function. An in vitro model.
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.
Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells.
Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation.
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity.
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study.
Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation.
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas.
Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment.
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.
Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target.
Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.
Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma.
Effect of formalin, acetone, and RNAlater fixatives on tissue preservation and different size amplicons by real-time PCR from paraffin-embedded tissue.
Effect of formalin, acetone, and RNAlater fixatives on tissue preservation and different size amplicons by real-time PCR from paraffin-embedded tissue.
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.
Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease.
Role of claudin interactions in airway tight junctional permeability.
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins.
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Defining desmosomal plakophilin-3 interactions.
Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening.
Claudins create charge-selective channels in the paracellular pathway between epithelial cells.
Mechanisms of diarrhea in collagenous colitis.
Mechanisms of diarrhea in collagenous colitis.
Brunner N, Stein L, Amasheh S
The Journal of membrane biology 2023 Feb;256(1):51-61
The Journal of membrane biology 2023 Feb;256(1):51-61
MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier.
Weiß F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, Fromm M, Krug SM
Cells 2022 May 4;11(9)
Cells 2022 May 4;11(9)
Functional Analysis of Gastric Tight Junction Proteins in Xenopus laevis Oocytes.
Stein L, Brunner N, Amasheh S
Membranes 2022 Jul 23;12(8)
Membranes 2022 Jul 23;12(8)
Ablation of Red Stable Transfected Claudin Expressing Canine Prostate Adenocarcinoma and Transitional Cell Carcinoma Cell Lines by C-CPE Gold-Nanoparticle-Mediated Laser Intervention.
Alnajjar S, Nolte I, Becker A, Schille JT, Trakooljul N, Frank M, Ngezahayo A, Murua Escobar H
International journal of molecular sciences 2021 Nov 13;22(22)
International journal of molecular sciences 2021 Nov 13;22(22)
Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.
El-Chami C, Foster AR, Johnson C, Clausen RP, Cornwell P, Haslam IS, Steward MC, Watson REB, Young HS, O'Neill CA
The British journal of dermatology 2021 Mar;184(3):482-494
The British journal of dermatology 2021 Mar;184(3):482-494
Butyrate Alleviates Cytokine-Induced Barrier Dysfunction by Modifying Claudin-2 Levels.
Huang X, Oshima T, Tomita T, Fukui H, Miwa H
Biology 2021 Mar 9;10(3)
Biology 2021 Mar 9;10(3)
Leaky Gut as a Potential Culprit for the Paradoxical Dysglycemic Response to Gastric Bypass-Associated Ileal Microbiota.
Hankir MK, Seyfried F, Schellinger IN, Schlegel N, Arora T
Metabolites 2021 Mar 8;11(3)
Metabolites 2021 Mar 8;11(3)
Standardization of esophageal adenocarcinoma in vitro model and its applicability for model drug testing.
Tratnjek L, Sibinovska N, Kralj S, Makovec D, Kristan K, Kreft ME
Scientific reports 2021 Mar 23;11(1):6664
Scientific reports 2021 Mar 23;11(1):6664
A human surfactant B deficiency air-liquid interface cell culture model suitable for gene therapy applications.
Munis AM, Hyde SC, Gill DR
Molecular therapy. Methods & clinical development 2021 Mar 12;20:237-246
Molecular therapy. Methods & clinical development 2021 Mar 12;20:237-246
Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern.
Tabariès S, Annis MG, Lazaris A, Petrillo SK, Huxham J, Abdellatif A, Palmieri V, Chabot J, Johnson RM, Van Laere S, Verhoef C, Hachem Y, Yumeen S, Meti N, Omeroglu A, Altinel G, Gao ZH, Yu ASL, Grünhagen DJ, Vermeulen P, Metrakos P, Siegel PM
Communications biology 2021 Jun 2;4(1):657
Communications biology 2021 Jun 2;4(1):657
Low-Intensity Extracorporeal Shock Wave Therapy Promotes Bladder Regeneration and Improves Overactive Bladder Induced by Ovarian Hormone Deficiency from Rat Animal Model to Human Clinical Trial.
Lin KL, Lu JH, Chueh KS, Juan TJ, Wu BN, Chuang SM, Lee YC, Shen MC, Long CY, Juan YS
International journal of molecular sciences 2021 Aug 27;22(17)
International journal of molecular sciences 2021 Aug 27;22(17)
Tumor Necrosis Factor Alpha Effects on the Porcine Intestinal Epithelial Barrier Include Enhanced Expression of TNF Receptor 1.
Droessler L, Cornelius V, Markov AG, Amasheh S
International journal of molecular sciences 2021 Aug 14;22(16)
International journal of molecular sciences 2021 Aug 14;22(16)
Neonatal Hyperoxia Downregulates Claudin-4, Occludin, and ZO-1 Expression in Rat Kidney Accompanied by Impaired Proximal Tubular Development.
Xu X, Zhang X, Gao L, Liu C, You K
Oxidative medicine and cellular longevity 2020;2020:2641461
Oxidative medicine and cellular longevity 2020;2020:2641461
Impact of viral disease hypophagia on pig jejunal function and integrity.
Helm ET, Curry SM, De Mille CM, Schweer WP, Burrough ER, Gabler NK
PloS one 2020;15(1):e0227265
PloS one 2020;15(1):e0227265
E7 oncoprotein from human papillomavirus 16 alters claudins expression and the sealing of epithelial tight junctions.
Uc PY, Miranda J, Raya-Sandino A, Alarcón L, Roldán ML, Ocadiz-Delgado R, Cortés-Malagón EM, Chávez-Munguía B, Ramírez G, Asomoza R, Shoshani L, Gariglio P, González-Mariscal L
International journal of oncology 2020 Oct;57(4):905-924
International journal of oncology 2020 Oct;57(4):905-924
Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model.
Ziegler AL, Pridgen TA, Blikslager AT
Tissue barriers 2020 Oct 1;8(4):1832421
Tissue barriers 2020 Oct 1;8(4):1832421
Altered Structural Expression and Enzymatic Activity Parameters in Quiescent Ulcerative Colitis: Are These Potential Normalization Criteria?
Kjærgaard S, Damm MMB, Chang J, Riis LB, Rasmussen HB, Hytting-Andreasen R, Krug SM, Schulzke JD, Bindslev N, Hansen MB
International journal of molecular sciences 2020 Mar 10;21(5)
International journal of molecular sciences 2020 Mar 10;21(5)
A Low Cost Antibody Signal Enhancer Improves Immunolabeling in Cell Culture, Primate Brain and Human Cancer Biopsy.
Flores-Maldonado C, Albino-Sánchez ME, Rodríguez-Callejas JD, Estrada-Mondragon A, León-Galicia I, Maqueda-Alfaro R, Perez-Cruz C, Fuchs E, García-Carrancá A, Contreras RG, Missirlis F, Rosas-Arellano A
Neuroscience 2020 Jul 15;439:275-286
Neuroscience 2020 Jul 15;439:275-286
The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction.
Sayoc-Becerra A, Krishnan M, Fan S, Jimenez J, Hernandez R, Gibson K, Preciado R, Butt G, McCole DF
Inflammatory bowel diseases 2020 Feb 11;26(3):407-422
Inflammatory bowel diseases 2020 Feb 11;26(3):407-422
All Benign and Malignant Apocrine Breast Lesions Over-Express Claudin 1 and 3 and Are Negative for Claudin 4.
Shousha S, Anscombe O, McFarlane T
Pathology oncology research : POR 2020 Apr;26(2):1073-1078
Pathology oncology research : POR 2020 Apr;26(2):1073-1078
TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection.
Kumar R, Gong H, Liu L, Ramos-Solis N, Seye CI, Derbigny WA
PloS one 2019;14(1):e0207422
PloS one 2019;14(1):e0207422
Biphenotypic Differentiation of Pancreatic Cancer in 3-Dimensional Culture.
Matsushita Y, Smith B, Delannoy M, Trujillo MA, Chianchiano P, McMillan R, Kamiyama H, Liang H, Thompson ED, Hruban RH, Matsui W, Wood LD, Roberts NJ, Eshleman JR
Pancreas 2019 Oct;48(9):1225-1231
Pancreas 2019 Oct;48(9):1225-1231
Claudins and JAM-A coordinately regulate tight junction formation and epithelial polarity.
Otani T, Nguyen TP, Tokuda S, Sugihara K, Sugawara T, Furuse K, Miura T, Ebnet K, Furuse M
The Journal of cell biology 2019 Oct 7;218(10):3372-3396
The Journal of cell biology 2019 Oct 7;218(10):3372-3396
Fusarium Mycotoxins Disrupt the Barrier and Induce IL-6 Release in a Human Placental Epithelium Cell Line.
Seyed Toutounchi N, Hogenkamp A, Varasteh S, Van't Land B, Garssen J, Kraneveld AD, Folkerts G, Braber S
Toxins 2019 Nov 14;11(11)
Toxins 2019 Nov 14;11(11)
Association of Cytokeratin 5 and Claudin 3 expression with BRCA1 and BRCA2 germline mutations in women with early breast cancer.
Danzinger S, Tan YY, Rudas M, Kastner MT, Weingartshofer S, Muhr D, Singer CF
BMC cancer 2019 Jul 15;19(1):695
BMC cancer 2019 Jul 15;19(1):695
Circulating Tumor Cell Clustering Shapes DNA Methylation to Enable Metastasis Seeding.
Gkountela S, Castro-Giner F, Szczerba BM, Vetter M, Landin J, Scherrer R, Krol I, Scheidmann MC, Beisel C, Stirnimann CU, Kurzeder C, Heinzelmann-Schwarz V, Rochlitz C, Weber WP, Aceto N
Cell 2019 Jan 10;176(1-2):98-112.e14
Cell 2019 Jan 10;176(1-2):98-112.e14
The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system.
Domke LM, Franke WW
Cell and tissue research 2019 Feb;375(2):451-482
Cell and tissue research 2019 Feb;375(2):451-482
Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo-obstruction.
Boschetti E, Accarino A, Malagelada C, Malagelada JR, Cogliandro RF, Gori A, Tugnoli V, Giancola F, Bianco F, Bonora E, Clavenzani P, Volta U, Caio G, Sternini C, Stanghellini V, Azpiroz F, De Giorgio R
Neurogastroenterology and motility 2019 Aug;31(8):e13652
Neurogastroenterology and motility 2019 Aug;31(8):e13652
Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation.
Rankin CR, Lokhandwala ZA, Huang R, Pekow J, Pothoulakis C, Padua D
Life sciences 2019 Aug 15;231:116571
Life sciences 2019 Aug 15;231:116571
High MUC2 Mucin Biosynthesis in Goblet Cells Impedes Restitution and Wound Healing by Elevating Endoplasmic Reticulum Stress and Altered Production of Growth Factors.
Tawiah A, Moreau F, Kumar M, Tiwari S, Falguera J, Chadee K
The American journal of pathology 2018 Sep;188(9):2025-2041
The American journal of pathology 2018 Sep;188(9):2025-2041
Immunoexpression of claudins 4 and 7 among invasive breast carcinoma subtypes: A large diagnostic study using tissue microarray.
Logullo AF, Pasini FS, Nonogaki S, Rocha RM, Soares FA, Brentani MM
Molecular and clinical oncology 2018 Oct;9(4):377-388
Molecular and clinical oncology 2018 Oct;9(4):377-388
Calprotectin protects against experimental colonic inflammation in mice.
Aranda CJ, Ocón B, Arredondo-Amador M, Suárez MD, Zarzuelo A, Chazin WJ, Martínez-Augustin O, Sánchez de Medina F
British journal of pharmacology 2018 Oct;175(19):3797-3812
British journal of pharmacology 2018 Oct;175(19):3797-3812
Functionalization of gold-nanoparticles by the Clostridium perfringens enterotoxin C-terminus for tumor cell ablation using the gold nanoparticle-mediated laser perforation technique.
Becker A, Leskau M, Schlingmann-Molina BL, Hohmeier SC, Alnajjar S, Murua Escobar H, Ngezahayo A
Scientific reports 2018 Oct 8;8(1):14963
Scientific reports 2018 Oct 8;8(1):14963
Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response.
Martín de la Fuente L, Malander S, Hartman L, Jönsson JM, Ebbesson A, Nilbert M, Måsbäck A, Hedenfalk I
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2018 Mar;37(2):101-109
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2018 Mar;37(2):101-109
Enteropathogenic E. coli effectors EspF and Map independently disrupt tight junctions through distinct mechanisms involving transcriptional and post-transcriptional regulation.
Singh AP, Sharma S, Pagarware K, Siraji RA, Ansari I, Mandal A, Walling P, Aijaz S
Scientific reports 2018 Feb 27;8(1):3719
Scientific reports 2018 Feb 27;8(1):3719
Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.
Liu J, Ma'ayeh S, Peirasmaki D, Lundström-Stadelmann B, Hellman L, Svärd SG
Virulence 2018 Dec 31;9(1):879-894
Virulence 2018 Dec 31;9(1):879-894
Imaging of Claudin-4 in Pancreatic Ductal Adenocarcinoma Using a Radiolabelled Anti-Claudin-4 Monoclonal Antibody.
Torres JB, Knight JC, Mosley MJ, Kersemans V, Koustoulidou S, Allen D, Kinchesh P, Smart S, Cornelissen B
Molecular imaging and biology 2018 Apr;20(2):292-299
Molecular imaging and biology 2018 Apr;20(2):292-299
Entamoeba histolytica EhCP112 Dislocates and Degrades Claudin-1 and Claudin-2 at Tight Junctions of the Intestinal Epithelium.
Cuellar P, Hernández-Nava E, García-Rivera G, Chávez-Munguía B, Schnoor M, Betanzos A, Orozco E
Frontiers in cellular and infection microbiology 2017;7:372
Frontiers in cellular and infection microbiology 2017;7:372
Altered Cytokine Expression and Barrier Properties after In Vitro Infection of Porcine Epithelial Cells with Enterotoxigenic Escherichia coli and Probiotic Enterococcus faecium.
Kern M, Günzel D, Aschenbach JR, Tedin K, Bondzio A, Lodemann U
Mediators of inflammation 2017;2017:2748192
Mediators of inflammation 2017;2017:2748192
Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells.
Tokuda S, Hirai T, Furuse M
PloS one 2017;12(8):e0182521
PloS one 2017;12(8):e0182521
HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation.
Ahmad R, Kumar B, Pan K, Dhawan P, Singh AB
Oncotarget 2017 Oct 20;8(50):87718-87736
Oncotarget 2017 Oct 20;8(50):87718-87736
Claudin-5-Binders Enhance Permeation of Solutes across the Blood-Brain Barrier in a Mammalian Model.
Hashimoto Y, Shirakura K, Okada Y, Takeda H, Endo K, Tamura M, Watari A, Sadamura Y, Sawasaki T, Doi T, Yagi K, Kondoh M
The Journal of pharmacology and experimental therapeutics 2017 Nov;363(2):275-283
The Journal of pharmacology and experimental therapeutics 2017 Nov;363(2):275-283
Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps.
Yokoyama N, Ohta H, Kagawa Y, Leela-Arporn R, Dermlim A, Nisa K, Morita T, Osuga T, Sasaki N, Morishita K, Nakamura K, Takiguchi M
The Journal of veterinary medical science 2017 Mar 18;79(3):456-463
The Journal of veterinary medical science 2017 Mar 18;79(3):456-463
Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin.
Nighot PK, Leung L, Ma TY
Experimental cell research 2017 Mar 1;352(1):113-122
Experimental cell research 2017 Mar 1;352(1):113-122
Epidermal equivalents of filaggrin null keratinocytes do not show impaired skin barrier function.
Niehues H, Schalkwijk J, van Vlijmen-Willems IMJJ, Rodijk-Olthuis D, van Rossum MM, Wladykowski E, Brandner JM, van den Bogaard EHJ, Zeeuwen PLJM
The Journal of allergy and clinical immunology 2017 Jun;139(6):1979-1981.e13
The Journal of allergy and clinical immunology 2017 Jun;139(6):1979-1981.e13
TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium.
Martínez-Rendón J, Sánchez-Guzmán E, Rueda A, González J, Gulias-Cañizo R, Aquino-Jarquín G, Castro-Muñozledo F, García-Villegas R
Journal of cellular physiology 2017 Jul;232(7):1794-1807
Journal of cellular physiology 2017 Jul;232(7):1794-1807
Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.
Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR
The Journal of clinical investigation 2017 Aug 1;127(8):3136-3151
The Journal of clinical investigation 2017 Aug 1;127(8):3136-3151
Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17.
Yuki T, Tobiishi M, Kusaka-Kikushima A, Ota Y, Tokura Y
PloS one 2016;11(9):e0161759
PloS one 2016;11(9):e0161759
Longitudinal Claudin Gene Expression Analyses in Canine Mammary Tissues and Thereof Derived Primary Cultures and Cell Lines.
Hammer SC, Becker A, Rateitschak K, Mohr A, Lüder Ripoli F, Hennecke S, Junginger J, Hewicker-Trautwein M, Brenig B, Ngezahayo A, Nolte I, Murua Escobar H
International journal of molecular sciences 2016 Sep 29;17(10)
International journal of molecular sciences 2016 Sep 29;17(10)
The glucocorticoid budesonide has protective and deleterious effects in experimental colitis in mice.
Ocón B, Aranda CJ, Gámez-Belmonte R, Suárez MD, Zarzuelo A, Martínez-Augustin O, Sánchez de Medina F
Biochemical pharmacology 2016 Sep 15;116:73-88
Biochemical pharmacology 2016 Sep 15;116:73-88
The serine protease-mediated increase in intestinal epithelial barrier function is dependent on occludin and requires an intact tight junction.
Ronaghan NJ, Shang J, Iablokov V, Zaheer R, Colarusso P, Dion S, Désilets A, Leduc R, Turner JR, MacNaughton WK
American journal of physiology. Gastrointestinal and liver physiology 2016 Sep 1;311(3):G466-79
American journal of physiology. Gastrointestinal and liver physiology 2016 Sep 1;311(3):G466-79
Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs.
Ahn C, Shin DH, Lee D, Kang SM, Seok JH, Kang HY, Jeung EB
Molecular medicine reports 2016 Oct;14(4):3697-703
Molecular medicine reports 2016 Oct;14(4):3697-703
Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer.
Thakkar A, Wang B, Picon-Ruiz M, Buchwald P, Ince TA
Breast cancer research and treatment 2016 May;157(1):77-90
Breast cancer research and treatment 2016 May;157(1):77-90
Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation.
Ling KH, Wan ML, El-Nezami H, Wang M
Chemical research in toxicology 2016 May 16;29(5):823-33
Chemical research in toxicology 2016 May 16;29(5):823-33
Caveolin-1 regulates the expression of tight junction proteins during hyperoxia-induced pulmonary epithelial barrier breakdown.
Xu S, Xue X, You K, Fu J
Respiratory research 2016 May 12;17(1):50
Respiratory research 2016 May 12;17(1):50
Candida albicans infection leads to barrier breakdown and a MAPK/NF-κB mediated stress response in the intestinal epithelial cell line C2BBe1.
Böhringer M, Pohlers S, Schulze S, Albrecht-Eckardt D, Piegsa J, Weber M, Martin R, Hünniger K, Linde J, Guthke R, Kurzai O
Cellular microbiology 2016 Jul;18(7):889-904
Cellular microbiology 2016 Jul;18(7):889-904
The human urothelial tight junction: claudin 3 and the ZO-1α(+) switch.
Smith NJ, Hinley J, Varley CL, Eardley I, Trejdosiewicz LK, Southgate J
Bladder (San Francisco, Calif.) 2015;2(1):e9
Bladder (San Francisco, Calif.) 2015;2(1):e9
Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells.
Tokuda S, Furuse M
PloS one 2015;10(3):e0119869
PloS one 2015;10(3):e0119869
Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum.
Takahashi S, Kohashi K, Yamamoto H, Hirahashi M, Kumagai R, Takizawa N, Nakamura K, Maehara Y, Tanaka M, Takayanagi R, Oda Y
Human pathology 2015 Sep;46(9):1257-66
Human pathology 2015 Sep;46(9):1257-66
Junctional abnormalities in human airway epithelial cells expressing F508del CFTR.
Molina SA, Stauffer B, Moriarty HK, Kim AH, McCarty NA, Koval M
American journal of physiology. Lung cellular and molecular physiology 2015 Sep 1;309(5):L475-87
American journal of physiology. Lung cellular and molecular physiology 2015 Sep 1;309(5):L475-87
Heterogeneity between triple negative breast cancer cells due to differential activation of Wnt and PI3K/AKT pathways.
Martínez-Revollar G, Garay E, Martin-Tapia D, Nava P, Huerta M, Lopez-Bayghen E, Meraz-Cruz N, Segovia J, González-Mariscal L
Experimental cell research 2015 Nov 15;339(1):67-80
Experimental cell research 2015 Nov 15;339(1):67-80
Overexpression and delocalization of claudin-3 protein in MCF-7 and MDA-MB-415 breast cancer cell lines.
Todd MC, Petty HM, King JM, Piana Marshall BN, Sheller RA, Cuevas ME
Oncology letters 2015 Jul;10(1):156-162
Oncology letters 2015 Jul;10(1):156-162
Homoharringtonine increases intestinal epithelial permeability by modulating specific claudin isoforms in Caco-2 cell monolayers.
Watari A, Hashegawa M, Yagi K, Kondoh M
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2015 Jan;89:232-8
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2015 Jan;89:232-8
EGF regulates claudin-2 and -4 expression through Src and STAT3 in MDCK cells.
García-Hernández V, Flores-Maldonado C, Rincon-Heredia R, Verdejo-Torres O, Bonilla-Delgado J, Meneses-Morales I, Gariglio P, Contreras RG
Journal of cellular physiology 2015 Jan;230(1):105-15
Journal of cellular physiology 2015 Jan;230(1):105-15
Expression of tight-junction proteins in human proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.
Casselbrant A, Elias E, Fändriks L, Wallenius V
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2015 Jan-Feb;11(1):45-53
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 2015 Jan-Feb;11(1):45-53
Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum.
Liu KM, Chuang SM, Long CY, Lee YL, Wang CC, Lu MC, Lin RJ, Lu JH, Jang MY, Wu WJ, Ho WT, Juan YS
American journal of physiology. Renal physiology 2015 Aug 15;309(4):F318-31
American journal of physiology. Renal physiology 2015 Aug 15;309(4):F318-31
Paclitaxel-induced lung injury and its amelioration by parecoxib sodium.
Liu WJ, Zhong ZJ, Cao LH, Li HT, Zhang TH, Lin WQ
Scientific reports 2015 Aug 10;5:12977
Scientific reports 2015 Aug 10;5:12977
Cell type of origin as well as genetic alterations contribute to breast cancer phenotypes.
Bhagirath D, Zhao X, West WW, Qiu F, Band H, Band V
Oncotarget 2015 Apr 20;6(11):9018-30
Oncotarget 2015 Apr 20;6(11):9018-30
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape.
Tokuda S, Higashi T, Furuse M
PloS one 2014;9(8):e104994
PloS one 2014;9(8):e104994
Diurnal variation of tight junction integrity associates inversely with matrix metalloproteinase expression in Xenopus laevis corneal epithelium: implications for circadian regulation of homeostatic surface cell desquamation.
Wiechmann AF, Ceresa BP, Howard EW
PloS one 2014;9(11):e113810
PloS one 2014;9(11):e113810
Loss of EP2 receptor subtype in colonic cells compromise epithelial barrier integrity by altering claudin-4.
Lejeune M, Moreau F, Chadee K
PloS one 2014;9(11):e113270
PloS one 2014;9(11):e113270
A CLDN1-negative phenotype predicts poor prognosis in triple-negative breast cancer.
Ma F, Ding X, Fan Y, Ying J, Zheng S, Lu N, Xu B
PloS one 2014;9(11):e112765
PloS one 2014;9(11):e112765
Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion.
Qiao X, Roth I, Féraille E, Hasler U
Cell cycle (Georgetown, Tex.) 2014;13(19):3059-75
Cell cycle (Georgetown, Tex.) 2014;13(19):3059-75
A high-concentrate diet induced colonic epithelial barrier disruption is associated with the activating of cell apoptosis in lactating goats.
Tao S, Duanmu Y, Dong H, Tian J, Ni Y, Zhao R
BMC veterinary research 2014 Sep 26;10:235
BMC veterinary research 2014 Sep 26;10:235
Tricellulin expression and its prognostic significance in primary liver carcinomas.
Somorácz A, Korompay A, Törzsök P, Patonai A, Erdélyi-Belle B, Lotz G, Schaff Z, Kiss A
Pathology oncology research : POR 2014 Oct;20(4):755-64
Pathology oncology research : POR 2014 Oct;20(4):755-64
Universal antibody conjugation to nanoparticles using the Fcγ receptor I (FcγRI): quantitative profiling of membrane biomarkers.
Kim C, Galloway JF, Lee KH, Searson PC
Bioconjugate chemistry 2014 Oct 15;25(10):1893-901
Bioconjugate chemistry 2014 Oct 15;25(10):1893-901
Upregulation of Claudin-4, CAIX and GLUT-1 in distant breast cancer metastases.
Jiwa LS, van Diest PJ, Hoefnagel LD, Wesseling J, Wesseling P, Dutch Distant Breast Cancer Metastases Consortium, Moelans CB
BMC cancer 2014 Nov 22;14:864
BMC cancer 2014 Nov 22;14:864
Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium.
Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen NJ, Orlando RC, Chen X
Gut 2014 May;63(5):711-9
Gut 2014 May;63(5):711-9
p38δ mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes.
Siljamäki E, Raiko L, Toriseva M, Nissinen L, Näreoja T, Peltonen J, Kähäri VM, Peltonen S
Archives of dermatological research 2014 Mar;306(2):131-41
Archives of dermatological research 2014 Mar;306(2):131-41
Diets high in fermentable protein and fibre alter tight junction protein composition with minor effects on barrier function in piglet colon.
Richter JF, Pieper R, Zakrzewski SS, Günzel D, Schulzke JD, Van Kessel AG
The British journal of nutrition 2014 Mar 28;111(6):1040-9
The British journal of nutrition 2014 Mar 28;111(6):1040-9
A survey of zeb1, twist and claudin 1 and 4 expression during placental development and disease.
Pirinen E, Soini Y
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2014 Jun;122(6):530-8
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2014 Jun;122(6):530-8
N-alkylation of highly quaternized chitosan derivatives affects the paracellular permeation enhancement in bronchial epithelia in vitro.
Benediktsdóttir BE, Gudjónsson T, Baldursson Ó, Másson M
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2014 Jan;86(1):55-63
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2014 Jan;86(1):55-63
Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways.
Rincon-Heredia R, Flores-Benitez D, Flores-Maldonado C, Bonilla-Delgado J, García-Hernández V, Verdejo-Torres O, Castillo AM, Larré I, Poot-Hernández AC, Franco M, Gariglio P, Reyes JL, Contreras RG
Experimental cell research 2014 Jan 1;320(1):108-18
Experimental cell research 2014 Jan 1;320(1):108-18
Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration.
Glotfelty LG, Zahs A, Hodges K, Shan K, Alto NM, Hecht GA
Cellular microbiology 2014 Dec;16(12):1767-83
Cellular microbiology 2014 Dec;16(12):1767-83
Tight junction protein claudin-4 is modulated via ΔNp63 in human keratinocytes.
Kubo T, Sugimoto K, Kojima T, Sawada N, Sato N, Ichimiya S
Biochemical and biophysical research communications 2014 Dec 12;455(3-4):205-11
Biochemical and biophysical research communications 2014 Dec 12;455(3-4):205-11
Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease.
Ohta H, Sunden Y, Yokoyama N, Osuga T, Lim SY, Tamura Y, Morishita K, Nakamura K, Yamasaki M, Takiguchi M
American journal of veterinary research 2014 Aug;75(8):746-51
American journal of veterinary research 2014 Aug;75(8):746-51
Claudins as prognostic factors for renal cell cancer.
Virman J, Soini Y, Kujala P, Luukkaala T, Salminen T, Sunela K, Kellokumpu-Lehtinen PL
Anticancer research 2014 Aug;34(8):4181-7
Anticancer research 2014 Aug;34(8):4181-7
CD137 signaling enhances tight junction resistance in intestinal epithelial cells.
Gusti V, Bennett KM, Lo DD
Physiological reports 2014 Aug 1;2(8)
Physiological reports 2014 Aug 1;2(8)
Transmigration of neural stem cells across the blood brain barrier induced by glioma cells.
Díaz-Coránguez M, Segovia J, López-Ornelas A, Puerta-Guardo H, Ludert J, Chávez B, Meraz-Cruz N, González-Mariscal L
PloS one 2013;8(4):e60655
PloS one 2013;8(4):e60655
The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells.
Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, Sawada N, Chiba H
PloS one 2013;8(10):e75106
PloS one 2013;8(10):e75106
Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin.
Hintsala HR, Siponen M, Haapasaari KM, Karihtala P, Soini Y
International journal of clinical and experimental pathology 2013;6(12):2855-63
International journal of clinical and experimental pathology 2013;6(12):2855-63
Think modular: a simple apoferritin-based platform for the multifaceted detection of pancreatic cancer.
Hwang MP, Lee JW, Lee KE, Lee KH
ACS nano 2013 Sep 24;7(9):8167-74
ACS nano 2013 Sep 24;7(9):8167-74
Build them up and break them down: Tight junctions of cell lines expressing typical hepatocyte polarity with a varied repertoire of claudins.
Grosse B, Degrouard J, Jaillard D, Cassio D
Tissue barriers 2013 Oct 1;1(4):e25210
Tissue barriers 2013 Oct 1;1(4):e25210
Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano.
Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N
Cell and tissue research 2013 Nov;354(2):481-94
Cell and tissue research 2013 Nov;354(2):481-94
Divergence of tight and adherens junction factors in alveolar epithelium in pulmonary fibrosis.
Lappi-Blanco E, Lehtonen ST, Sormunen R, Merikallio HM, Soini Y, Kaarteenaho RL
Human pathology 2013 May;44(5):895-907
Human pathology 2013 May;44(5):895-907
Dynamics of thymus organogenesis and colonization in early human development.
Farley AM, Morris LX, Vroegindeweij E, Depreter ML, Vaidya H, Stenhouse FH, Tomlinson SR, Anderson RA, Cupedo T, Cornelissen JJ, Blackburn CC
Development (Cambridge, England) 2013 May;140(9):2015-26
Development (Cambridge, England) 2013 May;140(9):2015-26
Rab25 regulates integrin expression in polarized colonic epithelial cells.
Krishnan M, Lapierre LA, Knowles BC, Goldenring JR
Molecular biology of the cell 2013 Mar;24(6):818-31
Molecular biology of the cell 2013 Mar;24(6):818-31
Clinicopathological significance of claudin-4 in gastric carcinoma.
Zhu JL, Gao P, Wang ZN, Song YX, Li AL, Xu YY, Wang MX, Xu HM
World journal of surgical oncology 2013 Jul 4;11:150
World journal of surgical oncology 2013 Jul 4;11:150
Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions.
Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N
Cell and tissue research 2013 Jan;351(1):73-84
Cell and tissue research 2013 Jan;351(1):73-84
Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system.
D'Amato NC, Ostrander JH, Bowie ML, Sistrunk C, Borowsky A, Cardiff RD, Bell K, Young LJ, Simin K, Bachelder RE, Delrow J, Dawson A, Yee LD, Mrózek K, Clay TM, Osada T, Seewaldt VL
PloS one 2012;7(9):e45684
PloS one 2012;7(9):e45684
Derivation of myoepithelial progenitor cells from bipotent mammary stem/progenitor cells.
Zhao X, Malhotra GK, Band H, Band V
PloS one 2012;7(4):e35338
PloS one 2012;7(4):e35338
The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.
Dukes JD, Whitley P, Chalmers AD
PloS one 2012;7(3):e28659
PloS one 2012;7(3):e28659
GLP-2 enhances barrier formation and attenuates TNFα-induced changes in a Caco-2 cell model of the intestinal barrier.
Moran GW, O'Neill C, McLaughlin JT
Regulatory peptides 2012 Oct 10;178(1-3):95-101
Regulatory peptides 2012 Oct 10;178(1-3):95-101
Toxicity of deoxynivalenol and its acetylated derivatives on the intestine: differential effects on morphology, barrier function, tight junction proteins, and mitogen-activated protein kinases.
Pinton P, Tsybulskyy D, Lucioli J, Laffitte J, Callu P, Lyazhri F, Grosjean F, Bracarense AP, Kolf-Clauw M, Oswald IP
Toxicological sciences : an official journal of the Society of Toxicology 2012 Nov;130(1):180-90
Toxicological sciences : an official journal of the Society of Toxicology 2012 Nov;130(1):180-90
Prostaglandin-induced cervical remodelling in humans in the first trimester is associated with increased expression of specific tight junction, but not gap junction proteins.
Ghulé VV, Gray C, Galimberti A, Anumba DO
Journal of translational medicine 2012 Mar 7;10:40
Journal of translational medicine 2012 Mar 7;10:40
Phosphorylation of Rab11-FIP2 regulates polarity in MDCK cells.
Lapierre LA, Avant KM, Caldwell CM, Oztan A, Apodaca G, Knowles BC, Roland JT, Ducharme NA, Goldenring JR
Molecular biology of the cell 2012 Jun;23(12):2302-18
Molecular biology of the cell 2012 Jun;23(12):2302-18
Twist1 causes the transcriptional repression of claudin-4 with prognostic significance in esophageal cancer.
Lee KW, Lee NK, Kim JH, Kang MS, Yoo HY, Kim HH, Um SH, Kim SH
Biochemical and biophysical research communications 2012 Jul 6;423(3):454-60
Biochemical and biophysical research communications 2012 Jul 6;423(3):454-60
Functional characterization and localization of a gill-specific claudin isoform in Atlantic salmon.
Engelund MB, Yu AS, Li J, Madsen SS, Færgeman NJ, Tipsmark CK
American journal of physiology. Regulatory, integrative and comparative physiology 2012 Jan 15;302(2):R300-11
American journal of physiology. Regulatory, integrative and comparative physiology 2012 Jan 15;302(2):R300-11
Development of tertiary lymphoid structures in the kidneys of pigs with chronic leptospiral nephritis.
Pezzolato M, Maina E, Lonardi S, Bozzetta E, Grassi F, Scanziani E, Radaelli E
Veterinary immunology and immunopathology 2012 Jan 15;145(1-2):546-50
Veterinary immunology and immunopathology 2012 Jan 15;145(1-2):546-50
Folliculocentric B-cell-rich follicular dendritic cells sarcoma: a hitherto unreported morphological variant mimicking lymphoproliferative disorders.
Lorenzi L, Lonardi S, Petrilli G, Tanda F, Bella M, Laurino L, Rossi G, Facchetti F
Human pathology 2012 Feb;43(2):209-15
Human pathology 2012 Feb;43(2):209-15
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.
Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alzheimer's Disease Genetics Consortium, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Coté GA, Cotton PB, DiSario J, Farrer LA, Forsmark CE, Johnstone M, Gardner TB, Gelrud A, Greenhalf W, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem NM, Money ME, Muniraj T, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Simon P, Singh VP, Slivka A, Stolz D, Sutton R, Weiss FU, Wilcox CM, Zarnescu NO, Wisniewski SR, O'Connell MR, Kienholz ML, Roeder K, Barmada MM, Yadav D, Devlin B
Nature genetics 2012 Dec;44(12):1349-54
Nature genetics 2012 Dec;44(12):1349-54
Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis).
Kinoshita S, Kawasaki S, Kitazawa K, Shinomiya K
Transactions of the American Ophthalmological Society 2012 Dec;110:166-77
Transactions of the American Ophthalmological Society 2012 Dec;110:166-77
Claudin-2 promotes breast cancer liver metastasis by facilitating tumor cell interactions with hepatocytes.
Tabariès S, Dupuy F, Dong Z, Monast A, Annis MG, Spicer J, Ferri LE, Omeroglu A, Basik M, Amir E, Clemons M, Siegel PM
Molecular and cellular biology 2012 Aug;32(15):2979-91
Molecular and cellular biology 2012 Aug;32(15):2979-91
Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes.
Raiko L, Siljamäki E, Mahoney MG, Putaala H, Suominen E, Peltonen J, Peltonen S
Experimental dermatology 2012 Aug;21(8):586-91
Experimental dermatology 2012 Aug;21(8):586-91
Claudins 1, 3M, 3S, 4, 5 and 7 in vulvar neoplasms compared with vulvar squamous cell carcinoma.
Riski M, Santala M, Soini Y, Talvensaari-Mattila A
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012 Apr;33(2):537-42
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2012 Apr;33(2):537-42
Enhanced immunohistochemical resolution of claudin proteins in glycolmethacrylate-embedded tissue biopsies.
Collins JE, Kirk A, Campbell SK, Mason J, Wilson SJ
Methods in molecular biology (Clifton, N.J.) 2011;762:371-82
Methods in molecular biology (Clifton, N.J.) 2011;762:371-82
Herpes simplex virus-induced epithelial damage and susceptibility to human immunodeficiency virus type 1 infection in human cervical organ culture.
Horbul JE, Schmechel SC, Miller BR, Rice SA, Southern PJ
PloS one 2011;6(7):e22638
PloS one 2011;6(7):e22638
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.
Dukes JD, Fish L, Richardson JD, Blaikley E, Burns S, Caunt CJ, Chalmers AD, Whitley P
Molecular biology of the cell 2011 Sep;22(17):3192-205
Molecular biology of the cell 2011 Sep;22(17):3192-205
Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells.
Yamaguchi H, Kojima T, Ito T, Kyuno D, Kimura Y, Imamura M, Hirata K, Sawada N
Cellular & molecular biology letters 2011 Sep;16(3):385-97
Cellular & molecular biology letters 2011 Sep;16(3):385-97
Usefulness of Claudin 4 in the cytological diagnosis of serosal effusions.
Lonardi S, Manera C, Marucci R, Santoro A, Lorenzi L, Facchetti F
Diagnostic cytopathology 2011 May;39(5):313-7
Diagnostic cytopathology 2011 May;39(5):313-7
Matrigel improves functional properties of primary human salivary gland cells.
Maria OM, Zeitouni A, Gologan O, Tran SD
Tissue engineering. Part A 2011 May;17(9-10):1229-38
Tissue engineering. Part A 2011 May;17(9-10):1229-38
Low expression of claudin-4 is associated with poor prognosis in esophageal squamous cell carcinoma.
Sung CO, Han SY, Kim SH
Annals of surgical oncology 2011 Jan;18(1):273-81
Annals of surgical oncology 2011 Jan;18(1):273-81
Claudin 4 Is differentially expressed between ovarian cancer subtypes and plays a role in spheroid formation.
Boylan KL, Misemer B, De Rycke MS, Andersen JD, Harrington KM, Kalloger SE, Gilks CB, Pambuccian SE, Skubitz AP
International journal of molecular sciences 2011 Feb 22;12(2):1334-58
International journal of molecular sciences 2011 Feb 22;12(2):1334-58
Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix.
Buckner LR, Schust DJ, Ding J, Nagamatsu T, Beatty W, Chang TL, Greene SJ, Lewis ME, Ruiz B, Holman SL, Spagnuolo RA, Pyles RB, Quayle AJ
Journal of reproductive immunology 2011 Dec;92(1-2):8-20
Journal of reproductive immunology 2011 Dec;92(1-2):8-20
Protein kinase Cα inhibitor enhances the sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4.
Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
Cell and tissue research 2011 Dec;346(3):369-81
Cell and tissue research 2011 Dec;346(3):369-81
Ouabain modulates ciliogenesis in epithelial cells.
Larre I, Castillo A, Flores-Maldonado C, Contreras RG, Galvan I, Muñoz-Estrada J, Cereijido M
Proceedings of the National Academy of Sciences of the United States of America 2011 Dec 20;108(51):20591-6
Proceedings of the National Academy of Sciences of the United States of America 2011 Dec 20;108(51):20591-6
Minimized and conventional cardiopulmonary bypass damage intestinal mucosal integrity.
Rimpiläinen R, Vakkala M, Rimpiläinen E, Jensen H, Rimpiläinen J, Erkinaro T, Kiviluoma K, Meriläinen S, Pokela M, Karttunen T, Juvonen T
Scandinavian cardiovascular journal : SCJ 2011 Aug;45(4):236-46
Scandinavian cardiovascular journal : SCJ 2011 Aug;45(4):236-46
Ovarian hormones control the changing expression of claudins and occludin in rat uterine epithelial cells during early pregnancy.
Nicholson MD, Lindsay LA, Murphy CR
Acta histochemica 2010;112(1):42-52
Acta histochemica 2010;112(1):42-52
Tumor-associated calcium signal transducer 2 is required for the proper subcellular localization of claudin 1 and 7: implications in the pathogenesis of gelatinous drop-like corneal dystrophy.
Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, Tanioka H, Nagata-Takaoka M, Hamuro J, Kinoshita S
The American journal of pathology 2010 Sep;177(3):1344-55
The American journal of pathology 2010 Sep;177(3):1344-55
Twist is inversely associated with claudins in germ cell tumors of the testis.
Väre P, Soini Y
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010 Sep 1;118(9):640-7
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 2010 Sep 1;118(9):640-7
Receptor tyrosine kinase and downstream signalling analysis in diffuse malignant peritoneal mesothelioma.
Perrone F, Jocollè G, Pennati M, Deraco M, Baratti D, Brich S, Orsenigo M, Tarantino E, De Marco C, Bertan C, Cabras A, Bertulli R, Pierotti MA, Zaffaroni N, Pilotti S
European journal of cancer (Oxford, England : 1990) 2010 Oct;46(15):2837-48
European journal of cancer (Oxford, England : 1990) 2010 Oct;46(15):2837-48
Somatostatin regulates tight junction function and composition in human keratinocytes.
Vockel M, Breitenbach U, Kreienkamp HJ, Brandner JM
Experimental dermatology 2010 Oct;19(10):888-94
Experimental dermatology 2010 Oct;19(10):888-94
c-Jun N-terminal kinase is largely involved in the regulation of tricellular tight junctions via tricellulin in human pancreatic duct epithelial cells.
Kojima T, Fuchimoto J, Yamaguchi H, Ito T, Takasawa A, Ninomiya T, Kikuchi S, Ogasawara N, Ohkuni T, Masaki T, Hirata K, Himi T, Sawada N
Journal of cellular physiology 2010 Nov;225(3):720-33
Journal of cellular physiology 2010 Nov;225(3):720-33
Deoxynivalenol impairs porcine intestinal barrier function and decreases the protein expression of claudin-4 through a mitogen-activated protein kinase-dependent mechanism.
Pinton P, Braicu C, Nougayrede JP, Laffitte J, Taranu I, Oswald IP
The Journal of nutrition 2010 Nov;140(11):1956-62
The Journal of nutrition 2010 Nov;140(11):1956-62
Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung.
Kaarteenaho R, Merikallio H, Lehtonen S, Harju T, Soini Y
Respiratory research 2010 May 17;11(1):59
Respiratory research 2010 May 17;11(1):59
Human peripheral lymphoid tissues contain autoimmune regulator-expressing dendritic cells.
Poliani PL, Kisand K, Marrella V, Ravanini M, Notarangelo LD, Villa A, Peterson P, Facchetti F
The American journal of pathology 2010 Mar;176(3):1104-12
The American journal of pathology 2010 Mar;176(3):1104-12
Expression pattern and prognostic significance of claudins 1, 4, and 7 in nasopharyngeal carcinoma.
Hsueh C, Chang YS, Tseng NM, Liao CT, Hsueh S, Chang JH, Wu IC, Chang KP
Human pathology 2010 Jul;41(7):944-50
Human pathology 2010 Jul;41(7):944-50
Transcriptional control of tight junction proteins via a protein kinase C signal pathway in human telomerase reverse transcriptase-transfected human pancreatic duct epithelial cells.
Yamaguchi H, Kojima T, Ito T, Kimura Y, Imamura M, Son S, Koizumi J, Murata M, Nagayama M, Nobuoka T, Tanaka S, Hirata K, Sawada N
The American journal of pathology 2010 Aug;177(2):698-712
The American journal of pathology 2010 Aug;177(2):698-712
Association of the NOD2 genotype with bacterial translocation via altered cell-cell contacts in Crohn's disease patients.
Kosovac K, Brenmoehl J, Holler E, Falk W, Schoelmerich J, Hausmann M, Rogler G
Inflammatory bowel diseases 2010 Aug;16(8):1311-21
Inflammatory bowel diseases 2010 Aug;16(8):1311-21
Allogeneic human mesenchymal stem cells restore epithelial protein permeability in cultured human alveolar type II cells by secretion of angiopoietin-1.
Fang X, Neyrinck AP, Matthay MA, Lee JW
The Journal of biological chemistry 2010 Aug 20;285(34):26211-22
The Journal of biological chemistry 2010 Aug 20;285(34):26211-22
Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma.
Kojima F, Ishida M, Takikita-Suzuki M, Hotta M, Katsura K, Nagata A, Enoki Y, Kato G, Okabe H
Oncology reports 2010 Apr;23(4):927-31
Oncology reports 2010 Apr;23(4):927-31
Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma.
Kojima F, Ishida M, Takikita-Suzuki M, Hotta M, Katsura K, Nagata A, Enoki Y, Kato G, Okabe H
Oncology reports 2010 Apr;23(4):927-31
Oncology reports 2010 Apr;23(4):927-31
Intraductal oncocytic papillary neoplasm of the bile duct: clinicopathologic and immunohistochemical characteristics of 6 cases.
Tanaka M, Fukushima N, Noda N, Shibahara J, Kokudo N, Fukayama M
Human pathology 2009 Nov;40(11):1543-52
Human pathology 2009 Nov;40(11):1543-52
The food contaminant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression.
Pinton P, Nougayrède JP, Del Rio JC, Moreno C, Marin DE, Ferrier L, Bracarense AP, Kolf-Clauw M, Oswald IP
Toxicology and applied pharmacology 2009 May 15;237(1):41-8
Toxicology and applied pharmacology 2009 May 15;237(1):41-8
Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer.
Lanigan F, McKiernan E, Brennan DJ, Hegarty S, Millikan RC, McBryan J, Jirstrom K, Landberg G, Martin F, Duffy MJ, Gallagher WM
International journal of cancer 2009 May 1;124(9):2088-97
International journal of cancer 2009 May 1;124(9):2088-97
Tight junction proteins in human Schwann cell autotypic junctions.
Alanne MH, Pummi K, Heape AM, Grènman R, Peltonen J, Peltonen S
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Jun;57(6):523-9
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 Jun;57(6):523-9
Claudin expression in rectal well-differentiated endocrine neoplasms (carcinoid tumors).
Ishida M, Kushima R, Okabe H
Oncology reports 2009 Jan;21(1):113-7
Oncology reports 2009 Jan;21(1):113-7
Expression and localization of tricellulin in human nasal epithelial cells in vivo and in vitro.
Ohkuni T, Kojima T, Ogasawara N, Masaki T, Ninomiya T, Kikuchi S, Go M, Takano K, Himi T, Sawada N
Medical molecular morphology 2009 Dec;42(4):204-11
Medical molecular morphology 2009 Dec;42(4):204-11
Expression of tight-junction proteins in the inflamed and clinically uninvolved skin in patients with venous leg ulcers.
Zorko MS, Veranic P, Leskovec NK, Pavlović MD, Lunder T
Clinical and experimental dermatology 2009 Dec;34(8):e949-52
Clinical and experimental dermatology 2009 Dec;34(8):e949-52
Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells.
Natoli M, Felsani A, Ferruzza S, Sambuy Y, Canali R, Scarino ML
Toxicology in vitro : an international journal published in association with BIBRA 2009 Dec;23(8):1510-5
Toxicology in vitro : an international journal published in association with BIBRA 2009 Dec;23(8):1510-5
Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9.
Cao D, Polyak K, Halushka MK, Nassar H, Kouprina N, Iacobuzio-Donahue C, Wu X, Sukumar S, Hicks J, De Marzo A, Argani P
Breast cancer research : BCR 2008;10(5):R91
Breast cancer research : BCR 2008;10(5):R91
Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation.
Weber CR, Nalle SC, Tretiakova M, Rubin DT, Turner JR
Laboratory investigation; a journal of technical methods and pathology 2008 Oct;88(10):1110-20
Laboratory investigation; a journal of technical methods and pathology 2008 Oct;88(10):1110-20
Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma.
Vermi W, Lonardi S, Bosisio D, Uguccioni M, Danelon G, Pileri S, Fletcher C, Sozzani S, Zorzi F, Arrigoni G, Doglioni C, Ponzoni M, Facchetti F
The Journal of pathology 2008 Nov;216(3):356-64
The Journal of pathology 2008 Nov;216(3):356-64
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line.
Aono S, Hirai Y
Experimental cell research 2008 Nov 1;314(18):3326-39
Experimental cell research 2008 Nov 1;314(18):3326-39
Salinity regulates claudin mRNA and protein expression in the teleost gill.
Tipsmark CK, Baltzegar DA, Ozden O, Grubb BJ, Borski RJ
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Mar;294(3):R1004-14
American journal of physiology. Regulatory, integrative and comparative physiology 2008 Mar;294(3):R1004-14
Expression of tight junction proteins in epithelium including Ck20-positive M-like cells of human adenoids in vivo and in vitro.
Takano K, Kojima T, Ogasawara N, Go M, Kikuchi S, Ninomiya T, Kurose M, Koizumi J, Kamekura R, Murata M, Tanaka S, Chiba H, Himi T, Sawada N
Journal of molecular histology 2008 Jun;39(3):265-73
Journal of molecular histology 2008 Jun;39(3):265-73
Osmoregulation and expression of ion transport proteins and putative claudins in the gill of southern flounder (Paralichthys lethostigma).
Tipsmark CK, Luckenbach JA, Madsen SS, Kiilerich P, Borski RJ
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2008 Jul;150(3):265-73
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 2008 Jul;150(3):265-73
Early events in HIV transmission through a human reconstructed vaginal mucosa.
Bouschbacher M, Bomsel M, Verronèse E, Gofflo S, Ganor Y, Dezutter-Dambuyant C, Valladeau J
AIDS (London, England) 2008 Jul 11;22(11):1257-66
AIDS (London, England) 2008 Jul 11;22(11):1257-66
Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms.
Tzelepi VN, Tsamandas AC, Vlotinou HD, Vagianos CE, Scopa CD
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Jan;21(1):22-30
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2008 Jan;21(1):22-30
Low claudin expression is associated with high Gleason grade in prostate adenocarcinoma.
Väre P, Loikkanen I, Hirvikoski P, Vaarala MH, Soini Y
Oncology reports 2008 Jan;19(1):25-31
Oncology reports 2008 Jan;19(1):25-31
Hepatitis C virus receptor expression in normal and diseased liver tissue.
Reynolds GM, Harris HJ, Jennings A, Hu K, Grove J, Lalor PF, Adams DH, Balfe P, Hübscher SG, McKeating JA
Hepatology (Baltimore, Md.) 2008 Feb;47(2):418-27
Hepatology (Baltimore, Md.) 2008 Feb;47(2):418-27
Histopathologic determinants of regional lymph node metastasis in early colorectal cancer.
Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Yokoo T, Ishii T, Toho Study Group for Cancer Biological Behavior
Cancer 2008 Feb 15;112(4):924-33
Cancer 2008 Feb 15;112(4):924-33
Distribution of tight junction proteins in adult human salivary glands.
Maria OM, Kim JW, Gerstenhaber JA, Baum BJ, Tran SD
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Dec;56(12):1093-8
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008 Dec;56(12):1093-8
Expression of claudins 1, 4, 5, and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue.
Bello IO, Vilen ST, Niinimaa A, Kantola S, Soini Y, Salo T
Human pathology 2008 Aug;39(8):1212-20
Human pathology 2008 Aug;39(8):1212-20
Alpha-1-antitrypsin-positive "signet-ring" bile duct adenoma in a patient with M(MALTON) mutation.
Gambarotti M, Medicina D, Baronchelli C, Bercich L, Bonetti F, Facchetti F
International journal of surgical pathology 2008 Apr;16(2):218-21
International journal of surgical pathology 2008 Apr;16(2):218-21
Claudin-1 and claudin-5 expression patterns differentiate lung squamous cell carcinomas from adenocarcinomas.
Paschoud S, Bongiovanni M, Pache JC, Citi S
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007 Sep;20(9):947-54
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007 Sep;20(9):947-54
Pathophysiological role of the activation of p38 mitogen-activated protein kinases in poorly differentiated gastric cancer.
Atsumi T, Kato K, Uno K, Iijima K, Koike T, Imatani A, Ohara S, Shimosegawa T
Pathology international 2007 Oct;57(10):635-44
Pathology international 2007 Oct;57(10):635-44
Expression profile of tight junction protein claudin 3 and claudin 4 in ovarian serous adenocarcinoma with prognostic correlation.
Choi YL, Kim J, Kwon MJ, Choi JS, Kim TJ, Bae DS, Koh SS, In YH, Park YW, Kim SH, Ahn G, Shin YK
Histology and histopathology 2007 Nov;22(11):1185-95
Histology and histopathology 2007 Nov;22(11):1185-95
Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis.
Peltonen S, Riehokainen J, Pummi K, Peltonen J
The British journal of dermatology 2007 Mar;156(3):466-72
The British journal of dermatology 2007 Mar;156(3):466-72
Differentiation potential of urothelium from patients with benign bladder dysfunction.
Southgate J, Varley CL, Garthwaite MA, Hinley J, Marsh F, Stahlschmidt J, Trejdosiewicz LK, Eardley I
BJU international 2007 Jun;99(6):1506-16
BJU international 2007 Jun;99(6):1506-16
Differences in claudin synthesis in primary cultures of acinar cells from rat salivary gland are correlated with the specific three-dimensional organization of the cells.
Qi B, Fujita-Yoshigaki J, Michikawa H, Satoh K, Katsumata O, Sugiya H
Cell and tissue research 2007 Jul;329(1):59-70
Cell and tissue research 2007 Jul;329(1):59-70
Tight junctions containing claudin 4 and 6 are essential for blastocyst formation in preimplantation mouse embryos.
Moriwaki K, Tsukita S, Furuse M
Developmental biology 2007 Dec 15;312(2):509-22
Developmental biology 2007 Dec 15;312(2):509-22
Decreased expression of claudin-1 correlates with recurrence status in breast cancer.
Morohashi S, Kusumi T, Sato F, Odagiri H, Chiba H, Yoshihara S, Hakamada K, Sasaki M, Kijima H
International journal of molecular medicine 2007 Aug;20(2):139-43
International journal of molecular medicine 2007 Aug;20(2):139-43
Loss of claudins-1 and -7 and expression of claudins-3 and -4 correlate with prognostic variables in prostatic adenocarcinomas.
Sheehan GM, Kallakury BV, Sheehan CE, Fisher HA, Kaufman RP Jr, Ross JS
Human pathology 2007 Apr;38(4):564-9
Human pathology 2007 Apr;38(4):564-9
Expression of claudins 1, 4, 5, and 7 in ovarian tumors of diverse types.
Soini Y, Talvensaari-Mattila A
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2006 Oct;25(4):330-5
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2006 Oct;25(4):330-5
Cellular networks of human thymic medullary stromas coordinated by p53-related transcription factors.
Ichimiya S, Kojima T
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Nov;54(11):1277-89
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2006 Nov;54(11):1277-89
Claudins in differential diagnosis between mesothelioma and metastatic adenocarcinoma of the pleura.
Soini Y, Kinnula V, Kahlos K, Pääkkö P
Journal of clinical pathology 2006 Mar;59(3):250-4
Journal of clinical pathology 2006 Mar;59(3):250-4
Claudin-4 differentiates biliary tract cancers from hepatocellular carcinomas.
Lódi C, Szabó E, Holczbauer A, Batmunkh E, Szíjártó A, Kupcsulik P, Kovalszky I, Paku S, Illyés G, Kiss A, Schaff Z
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006 Mar;19(3):460-9
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2006 Mar;19(3):460-9
Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine.
Schierack P, Nordhoff M, Pollmann M, Weyrauch KD, Amasheh S, Lodemann U, Jores J, Tachu B, Kleta S, Blikslager A, Tedin K, Wieler LH
Histochemistry and cell biology 2006 Mar;125(3):293-305
Histochemistry and cell biology 2006 Mar;125(3):293-305
Endothelia of term human placentae display diminished expression of tight junction proteins during preeclampsia.
Liévano S, Alarcón L, Chávez-Munguía B, González-Mariscal L
Cell and tissue research 2006 Jun;324(3):433-48
Cell and tissue research 2006 Jun;324(3):433-48
Claudins 1, 3, 4 and 5 in gastric carcinoma, loss of claudin expression associates with the diffuse subtype.
Soini Y, Tommola S, Helin H, Martikainen P
Virchows Archiv : an international journal of pathology 2006 Jan;448(1):52-8
Virchows Archiv : an international journal of pathology 2006 Jan;448(1):52-8
PPARgamma-regulated tight junction development during human urothelial cytodifferentiation.
Varley CL, Garthwaite MA, Cross W, Hinley J, Trejdosiewicz LK, Southgate J
Journal of cellular physiology 2006 Aug;208(2):407-17
Journal of cellular physiology 2006 Aug;208(2):407-17
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells.
Prasad S, Mingrino R, Kaukinen K, Hayes KL, Powell RM, MacDonald TT, Collins JE
Laboratory investigation; a journal of technical methods and pathology 2005 Sep;85(9):1139-62
Laboratory investigation; a journal of technical methods and pathology 2005 Sep;85(9):1139-62
Inducible expression of Snail selectively increases paracellular ion permeability and differentially modulates tight junction proteins.
Carrozzino F, Soulié P, Huber D, Mensi N, Orci L, Cano A, Féraille E, Montesano R
American journal of physiology. Cell physiology 2005 Oct;289(4):C1002-14
American journal of physiology. Cell physiology 2005 Oct;289(4):C1002-14
Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition.
Willemsen LE, Hoetjes JP, van Deventer SJ, van Tol EA
Clinical and experimental immunology 2005 Nov;142(2):275-84
Clinical and experimental immunology 2005 Nov;142(2):275-84
Claudins upregulation in human colorectal cancer.
de Oliveira SS, de Oliveira IM, De Souza W, Morgado-Díaz JA
FEBS letters 2005 Nov 7;579(27):6179-85
FEBS letters 2005 Nov 7;579(27):6179-85
Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin.
Santin AD, Cané S, Bellone S, Palmieri M, Siegel ER, Thomas M, Roman JJ, Burnett A, Cannon MJ, Pecorelli S
Cancer research 2005 May 15;65(10):4334-42
Cancer research 2005 May 15;65(10):4334-42
Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells.
Yu AS, McCarthy KM, Francis SA, McCormack JM, Lai J, Rogers RA, Lynch RD, Schneeberger EE
American journal of physiology. Cell physiology 2005 Jun;288(6):C1231-41
American journal of physiology. Cell physiology 2005 Jun;288(6):C1231-41
Differentiation of epithelial Na+ channel function. An in vitro model.
Shlyonsky V, Goolaerts A, Van Beneden R, Sariban-Sohraby S
The Journal of biological chemistry 2005 Jun 24;280(25):24181-7
The Journal of biological chemistry 2005 Jun 24;280(25):24181-7
Phosphorylation of claudin-3 at threonine 192 by cAMP-dependent protein kinase regulates tight junction barrier function in ovarian cancer cells.
D'Souza T, Agarwal R, Morin PJ
The Journal of biological chemistry 2005 Jul 15;280(28):26233-40
The Journal of biological chemistry 2005 Jul 15;280(28):26233-40
Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells.
Lipschutz JH, Li S, Arisco A, Balkovetz DF
The Journal of biological chemistry 2005 Feb 4;280(5):3780-8
The Journal of biological chemistry 2005 Feb 4;280(5):3780-8
Claudin expression in gastric adenocarcinomas: a tissue microarray study with prognostic correlation.
Resnick MB, Gavilanez M, Newton E, Konkin T, Bhattacharya B, Britt DE, Sabo E, Moss SF
Human pathology 2005 Aug;36(8):886-92
Human pathology 2005 Aug;36(8):886-92
Claudin-3 and claudin-4 expression in ovarian epithelial cells enhances invasion and is associated with increased matrix metalloproteinase-2 activity.
Agarwal R, D'Souza T, Morin PJ
Cancer research 2005 Aug 15;65(16):7378-85
Cancer research 2005 Aug 15;65(16):7378-85
Cultured monolayers of the dog jejunum with the structural and functional properties resembling the normal epithelium.
Weng XH, Beyenbach KW, Quaroni A
American journal of physiology. Gastrointestinal and liver physiology 2005 Apr;288(4):G705-17
American journal of physiology. Gastrointestinal and liver physiology 2005 Apr;288(4):G705-17
Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study.
Resnick MB, Konkin T, Routhier J, Sabo E, Pricolo VE
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005 Apr;18(4):511-8
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005 Apr;18(4):511-8
Estrogen abrogates transcervical tight junctional resistance by acceleration of occludin modulation.
Zeng R, Li X, Gorodeski GI
The Journal of clinical endocrinology and metabolism 2004 Oct;89(10):5145-55
The Journal of clinical endocrinology and metabolism 2004 Oct;89(10):5145-55
Paracellular Cl- permeability is regulated by WNK4 kinase: insight into normal physiology and hypertension.
Kahle KT, Macgregor GG, Wilson FH, Van Hoek AN, Brown D, Ardito T, Kashgarian M, Giebisch G, Hebert SC, Boulpaep EL, Lifton RP
Proceedings of the National Academy of Sciences of the United States of America 2004 Oct 12;101(41):14877-82
Proceedings of the National Academy of Sciences of the United States of America 2004 Oct 12;101(41):14877-82
Gene expression profiling identifies genes associated with invasive intraductal papillary mucinous neoplasms of the pancreas.
Sato N, Fukushima N, Maitra A, Iacobuzio-Donahue CA, van Heek NT, Cameron JL, Yeo CJ, Hruban RH, Goggins M
The American journal of pathology 2004 Mar;164(3):903-14
The American journal of pathology 2004 Mar;164(3):903-14
Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment.
Ivanov AI, Nusrat A, Parkos CA
Molecular biology of the cell 2004 Jan;15(1):176-88
Molecular biology of the cell 2004 Jan;15(1):176-88
Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney cells.
Singh AB, Harris RC
The Journal of biological chemistry 2004 Jan 30;279(5):3543-52
The Journal of biological chemistry 2004 Jan 30;279(5):3543-52
Claudin 4 protein expression in primary and metastatic pancreatic cancer: support for use as a therapeutic target.
Nichols LS, Ashfaq R, Iacobuzio-Donahue CA
American journal of clinical pathology 2004 Feb;121(2):226-30
American journal of clinical pathology 2004 Feb;121(2):226-30
Expression and function of tight junctions in the crypt epithelium of human palatine tonsils.
Go M, Kojima T, Takano K, Murata M, Ichimiya S, Tsubota H, Himi T, Sawada N
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Dec;52(12):1627-38
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Dec;52(12):1627-38
Claudins 2, 3, 4, and 5 in Paget's disease and breast carcinoma.
Soini Y
Human pathology 2004 Dec;35(12):1531-6
Human pathology 2004 Dec;35(12):1531-6
Effect of formalin, acetone, and RNAlater fixatives on tissue preservation and different size amplicons by real-time PCR from paraffin-embedded tissue.
Páska C, Bögi K, Szilák L, Tokés A, Szabó E, Sziller I, Rigó J Jr, Sobel G, Szabó I, Kaposi-Novák P, Kiss A, Schaff Z
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2004 Dec;13(4):234-40
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2004 Dec;13(4):234-40
Effect of formalin, acetone, and RNAlater fixatives on tissue preservation and different size amplicons by real-time PCR from paraffin-embedded tissue.
Páska C, Bögi K, Szilák L, Tokés A, Szabó E, Sziller I, Rigó J Jr, Sobel G, Szabó I, Kaposi-Novák P, Kiss A, Schaff Z
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2004 Dec;13(4):234-40
Diagnostic molecular pathology : the American journal of surgical pathology, part B 2004 Dec;13(4):234-40
Tight junction proteins ZO-1, occludin, and claudins in developing and adult human perineurium.
Pummi KP, Heape AM, Grénman RA, Peltonen JT, Peltonen SA
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Aug;52(8):1037-46
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2004 Aug;52(8):1037-46
Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium.
Acharya P, Beckel J, Ruiz WG, Wang E, Rojas R, Birder L, Apodaca G
American journal of physiology. Renal physiology 2004 Aug;287(2):F305-18
American journal of physiology. Renal physiology 2004 Aug;287(2):F305-18
Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen's disease.
Morita K, Tsukita S, Miyachi Y
The British journal of dermatology 2004 Aug;151(2):328-34
The British journal of dermatology 2004 Aug;151(2):328-34
Role of claudin interactions in airway tight junctional permeability.
Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG
American journal of physiology. Lung cellular and molecular physiology 2003 Nov;285(5):L1166-78
American journal of physiology. Lung cellular and molecular physiology 2003 Nov;285(5):L1166-78
Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.
Yu AS, Enck AH, Lencer WI, Schneeberger EE
The Journal of biological chemistry 2003 May 9;278(19):17350-9
The Journal of biological chemistry 2003 May 9;278(19):17350-9
Claudin extracellular domains determine paracellular charge selectivity and resistance but not tight junction fibril architecture.
Colegio OR, Van Itallie C, Rahner C, Anderson JM
American journal of physiology. Cell physiology 2003 Jun;284(6):C1346-54
American journal of physiology. Cell physiology 2003 Jun;284(6):C1346-54
Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas.
Rangel LB, Agarwal R, D'Souza T, Pizer ES, Alò PL, Lancaster WD, Gregoire L, Schwartz DR, Cho KR, Morin PJ
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Jul;9(7):2567-75
Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Jul;9(7):2567-75
Reversal of charge selectivity in cation or anion-selective epithelial lines by expression of different claudins.
Van Itallie CM, Fanning AS, Anderson JM
American journal of physiology. Renal physiology 2003 Dec;285(6):F1078-84
American journal of physiology. Renal physiology 2003 Dec;285(6):F1078-84
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, Nusrat A
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms.
Bruewer M, Luegering A, Kucharzik T, Parkos CA, Madara JL, Hopkins AM, Nusrat A
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 1;171(11):6164-72
Defining desmosomal plakophilin-3 interactions.
Bonné S, Gilbert B, Hatzfeld M, Chen X, Green KJ, van Roy F
The Journal of cell biology 2003 Apr 28;161(2):403-16
The Journal of cell biology 2003 Apr 28;161(2):403-16
Changes in gene expression during the early to mid-luteal (receptive phase) transition in human endometrium detected by high-density microarray screening.
Carson DD, Lagow E, Thathiah A, Al-Shami R, Farach-Carson MC, Vernon M, Yuan L, Fritz MA, Lessey B
Molecular human reproduction 2002 Sep;8(9):871-9
Molecular human reproduction 2002 Sep;8(9):871-9
Claudins create charge-selective channels in the paracellular pathway between epithelial cells.
Colegio OR, Van Itallie CM, McCrea HJ, Rahner C, Anderson JM
American journal of physiology. Cell physiology 2002 Jul;283(1):C142-7
American journal of physiology. Cell physiology 2002 Jul;283(1):C142-7
Mechanisms of diarrhea in collagenous colitis.
Bürgel N, Bojarski C, Mankertz J, Zeitz M, Fromm M, Schulzke JD
Gastroenterology 2002 Aug;123(2):433-43
Gastroenterology 2002 Aug;123(2):433-43
Mechanisms of diarrhea in collagenous colitis.
Bürgel N, Bojarski C, Mankertz J, Zeitz M, Fromm M, Schulzke JD
Gastroenterology 2002 Aug;123(2):433-43
Gastroenterology 2002 Aug;123(2):433-43
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot analysis of Claudin-4 was performed by loading 20 µg of Mouse Small Intestine (lane1) and PC-3 (lane2) lysates using Novex® NuPAGE® 4-12 % Bis-Tris gel (Product # NP0321BOX), XCell SureLock Electrophoresis System (Product # EI0002), Novex® Sharp Pre-Stained Protein Standard (LC5800), and iBlot® Dry Blotting System (IB21001). Proteins were transferred to a nitrocellulose membrane and blocked with 5 % skim milk at 4°C overnight. Claudin-4 was detected at ~27 kDa using Claudin-4 Mouse Monoclonal Antibody (Product # 32-9400) at 1-3 µg/mL in 2.5 % skim milk for 3 hours at room temperature on a rocking platform. Goat Anti-Mouse IgG - HRP Secondary Antibody (Product # 62-6520) at 1:4000 dilution was used and chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Knockdown of Claudin 4 was achieved by transfecting MCF7 with CLDN4 specific siRNAs (Silencer® select Product # s223316, s3441). Western blot analysis (Fig. a) was performed using membrane enriched extracts from CLDN4 knockdown cells (Lane 3), non-specific scrambled siRNA transfected cells (Lane 2) and untransfected cells (Lane 1). The blot was probed with Claudin 4 Monoclonal Antibody (3E2C1) (Product # 32-9400, 1.5 µg/ml) and Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:4000 dilution). Densitometric analysis of this western blot is shown in histogram (Fig. b). Decrease in signal upon siRNA mediated knock down confirms that antibody is specific to CLDN4..
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western blot was performed using Anti- Claudin 4 Monoclonal Antibody (3E2C1) (Product # 32-9400) and a 18 kDa band corresponding to CLDN4 was observed across the positive cells lines tested (MCF7 and HT-29) and not in the negative models (A549 and HeLa) as reported. Membrane enriched extracts (30 µg lysate) of MCF7 (Lane 1), HT-29 (Lane 3), A549 (Lane 2) and HeLa (Lane 4) were electrophoresed using Novex® NuPAGE® 12 % Bis-Tris gel (Product # NP0342BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with the primary antibody (1.5 µg/ml) and detected by chemiluminescence with Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:4000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005). [doi: 10.3892/ijo.2013.1881].
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- FIGURE 10: Overexpression of either GFP-Rab11-FIP2-WT or GFP-Rab11-FIP2 (S227E) altered the claudin content of tight junctions. GFP-Rab11-FIP2-WT-on and GFP-Rab11-FIP2(S227E)-on and -off were grown for 5 d postconfluence on Transwell filters. The cells were fixed then stained for claudin-1 (A), claudin-2 (B), or claudin-4 (C) and ZO-1. In the merged image, GFP-Rab11-FIP2s are pseudocolored green, the claudins are red, and ZO-1 is blue. (D) Cells were grown as described, then lysed, run on Western blots, and probed for the different claudins and VDAC. Three separate blots were scanned and quantified using ImageJ and normalized to control (VDAC). *p
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 1 Comparison of expression levels of claudins- 1 (1A), 2 (1B), 4 (1C) and 7(1D) in Misoprostol treated (M+) (samples 1+ to 7+) versus untreated (M-) (samples 1- to 5-) cervix . Representative immunoblots in the top panels whilst box plots, lower panel, represent mean (SE) relative optical densities (ROD) for all studied tissues: M+ (n = 10) vs. M- (n = 5). Block arrows showing Gbetaeta as internal loading control at 35 kDa. C-positive control in the first lane. C-1 = claudin-1; C-2 = claudin-2; C-4 = claudin-4; C-7 = claudin-7. ROD- relative optical density in Arbitrary Units (AU).
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 4 Effects of claudin-2 knockout on the localization of other claudins. (A) Immunofluorescence analysis of claudins in co-culture of control MDCK II cells and claudin-2 knockout clone 1 (KO 1). Claudin-1, -3, -4, and -7 showed clearer and stronger signals at TJs in claudin-2 knockout cells than in control cells. Scale bar = 10 mum. (B) Quantification analysis of signal intensity of claudins at TJs in control MDCK II cells and claudin-2 knockout clones. The signal intensity of claudins at TJs in control cells and claudin-2 knockout clones was measured as described in Materials and Methods , and the relative signal intensity of each claudin was calculated as the ratio of the signal intensity in control cells (CTL) and claudin-2 knockout clones (KO 1 and 2) to the signal intensity in control cells. N = 4 for each experiment. * p < 0.05, ** p < 0.01 compared with control.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 5 Localization of claudins in z-axis plane in control and claudin-2 knockout cells. Immunofluorescence analysis of claudins and occludin in co-culture of control MDCK II cells and claudin-2 knockout clone 1 (KO 1) in z-axis plane. The signals of claudin-1, -3, -4 and -7 were stronger at TJs in claudin-2 knockout cells compared with control cells, and lateral localization of these claudins was similar between control and claudin-2 knockout cells. Scale bar = 5 mum.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 8 Effects of claudin-2 re-expression on the localization of other claudins in claudin-2 knockout cells. (A) Immunofluorescence analysis of claudins and FLAG in co-culture of claudin-2 knockout cells and F2 or F4 clones. Claudin-1, -3, -4, and -7 staining at TJs in F2 and F4 clones was weaker than those in claudin-2 knockout cells. Scale bar = 10 mum. (B) Quantification analysis of the signal intensity of claudins at TJs in F2 and F4 clones. The signal intensity of claudin-1, -3, -4, and -7 at TJs in F2 and F4 clones was compared with that in claudin-2 knockout cells. N = 4 for each experiment. * p < 0.05, ** p < 0.01 compared with claudin-2 knockout cells.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 11 Localization of claudins at TJs between control and their respective knockout cells. (A-E) Immunofluorescence analysis of claudins and ZO-1 or ZO-3 in MDCK II cells transfected with the TALEN constructs for claudin-1, -2, -3, -4, or-7 gene knockouts. After transfection, cells were subcultured on filter inserts for 4 days before the analysis of claudin-2 and -3 (B and C), and for 2 days before the analysis of claudin-1, -4, and -7 (A, D, and E). (F) Immunofluorescence analysis of claudin-2 and ZO-1. TALEN constructs for the claudin-2 gene knockout were transfected into MDCK II cells, which were subcultured on filter inserts for 2 days before analysis. (G) Immunofluorescence analysis of claudin-2 and ZO-1 in a co-culture of wild-type and claudin-2 expressing MDCK I cells. Cells were cultured on filter inserts for 4 days before analysis. Scale bar = 10 mum.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 4 Western blot and immunofluorescence analysis of parental bipotent cells and MPCs using various markers from the signature of claudin-low breast cancer subtype. ( A ) Western blot analysis of cell lysates from exponentially proliferating bipotent cells and MPCs were analyzed for expression of indicated markers using specific antibodies. Breast cancer cell lines MDA-MB-231, MCF-7, and Hs578T were used as controls. ( B ) Immunofluorescence staining using CD24 antibody (red), nuclei (blue) represent DAPI staining.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- FIGURE 6: Rab25 depletion alters the transepithelial resistance and claudin expression. (A) TER was measured in all cell lines from day 3 to day 15 on Transwell filters. During this period, the media were changed every day, and TER was measured in 24-well Transwell inserts. Results are expressed in ohm-cm 2 and are representative of three separate experiments. (B) Equal amounts of total protein lysates (20 mug) from Control, Rab25KD, and Rescue cells were analyzed by Western blots for tight junction proteins. The blots were subsequently stripped and reprobed for beta-actin as a loading control. The results are representative of three separate experiments.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 6 Expression of TJ proteins in transmigrating cells favors their passage across RBMECs. A) Analysis by Western blots of the expression of occludin, claudins 1 to 5 and CRTAM in NIH-3T3and L-fibroblasts, ReNcells CX and RBMECs. B) The transmigration of NIH-3T3 and L-fibroblasts acrossRBMECs is independent of the CM present in the basal compartment, but is significantly higher inNIH-3T3 fibroblasts that express claudin-2 than in L-fibroblast that do not express TJ proteins.N = 3, F(1,6) = 232.22, ***P
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 2 Cldn6 induces the formation of cell-cell junctions and apicobasal cell polarity in F9 stem cells. (A and D) X-Y and Z projections of F9:Cldn6 cells stained for Cldn6 together with the tight-junction markers (Cldn7, Ocln, ZO-1, and ZO-1alpha+ variant), the basolateral maker (E-Cad), and the apical markers (ezrin, radixin, and EBP50). The arrowhead indicates the recruitment of Ocln to a part of Cldn6-positive premmature cell-cell junctions. The asterisk shows the absence of EBP50 on the apical surfaces of undifferentiated cells possessing Cldn6-positive premature cell-cell junctions. Scale bars, 20 um. (B) Confocal images of undifferentiated areas of F9:Cldn6 cells stained for Cldn6 together with Ocln. The arrowheads indicate the partial recruitment of Ocln to Cldn6-positive cell borders of undifferentiated cells. Scale bar, 20 um. (C) Confocal images of F9:Cldn6 cells stained for Cldn6 together with Cldn4 and DAPI. Scale bar, 20 um.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 4. Expression and localization of tight junction (TJ) proteins in cell lines expressing typical hepatocyte polarity. Fully polarized cultures were examined. ( A ) western blot. Each lane was loaded with a cell lysate aliquot containing 25 mug total protein. ( B ) RT-PCR. For western blot and RT-PCR, experiments were performed three times with lysates or RNA preparations from two to three independent cultures; one representative experiment is shown. ( C ) Summary of the localization of ten TJ proteins. Experiments were performed at least three times on three independent cultures. ( D ) Images of the localization of some TJ proteins; for each case, the corresponding phase-contrast image is given on the left. Some bile canaliculi (BC) are indicated by arrows (short arrows for BC formed between two cells, long arrows for extended BC). Bar, 10 mum
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 4 Quantitative cell targeting using QD-FcR-Ab conjugates. (A) phaseand fluorescence images of Panc-1 cells incubated with different concentrationsof QD-FcR-aCLDN4 conjugates. (B) The fluorescence of known concentrationsof QD suspensions is used for calibration (see Materialsand Methods for details). (C) Calibration curve showing averagefluorescence intensity per unit area versus QD concentration per unitarea. The calibration curve is used to convert the fluorescence intensityper unit area on the cell surface to an expression level per unitarea. (D) Average fluorescence intensity per unit area for CLDN4 expressionon Panc-1 cells versus QD concentration. Error bars represent standarderror. Each point represents the average intensity from at least 200cells.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 3 The expression of tight junction mRNA and proteins in Caco-2 EP2 receptor transfectants. (A) The mRNA expression for tight junction proteins (ZO-1, occludin, claudin-1, claudin-2 and claudin-4) in Caco-2 EP2S and EP2A cells was measured by Q-PCR. The expression of gene of interest (GOI) was normalized with the internal control (Actin) and expressed as fold changes with that of the vector control. (B) A representative immunoblot showing constitutive expression of the important tight junction proteins (ZO-1, occludin, claudin-1, claudin-2 and claudin-4) in EP2S, EP2A and vector control cells. Actin used as internal control. (C) Densitometry analysis for claudin-4 expression in EP2S, EP2A and vector control cells. EP2A compared statistically with the vector control. p
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 3 Tight junction proteins occludin and claudin-4 are co-expressed in Xenopus corneal epithelium lateral membranes and are disrupted at night. Double-label confocal immunocytochemistry was performed on whole flat-mounted preparations of Xenopus corneas that were obtained from animals in the late afternoon (DAY; 9 hours after lights on in a 12L:12D cycle) and in the late night (NIGHT; 3 hours before lights on). ( A ) In the late afternoon, occludin (green) was uniformly primarily localized to the lateral membranes of the surface CE. ( B ) The same specimen as in A was labeled for the presence of claudin-4 (red), and was also uniformly primarily localized to the lateral membranes of the surface CE. ( C ) Merged green/red images from A and B demonstrate a high degree of co-localization in the surface cell CE lateral membranes, as indicated by the yellow signal. ( D ) In the late night, occludin (green) was localized to the CE surface cell lateral membranes as during the day, but the pattern of labeling was often interrupted in some clusters of cells (arrows). ( E ) The same specimen as in D was labeled for the presence of claudin-4 (red), and was also localized to the CE surface cell lateral membranes, but the pattern of labeling was also interrupted in the same clusters of cells (arrows). ( F ) Merged green/red images from D and F demonstrate a high degree of co-localization in the surface cell CE lateral membranes, as indicated by the yellow signal, with a similar level
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 5 Claudin-4 expression on Xenopus surface CE is disrupted at night, and is inversely associated with MMP-2 expression. Flat-mounted whole corneas were double-labeled for localization of claudin-4 and MMP-2 immunoreactivity in the late afternoon (DAY; 9 hours after lights on in a 12L:12D cycle) and in the late night (NIGHT; 3 hours before lights on). ( A ) In the late afternoon, claudin-4 (green) immunolabeling of the lateral membranes of the surface CE was generally intact, and some sporadic labeling of MMP-2 (red) was also present on the lateral membranes and/or cytoplasm (arrows) which was sometimes co-localized (yellow) with occludin. ( B ) During the late night, most of the surface CE cells exhibited intact claudin-4 (green) labeling on their lateral membranes, but there were also many clusters of surface CE cells in which the claudin-4 immunoreactivity was disrupted (arrows) and was accompanied by high levels of MMP-2 immunoreactivity. Specimens were stained with the blue nuclear DAPI stain. Scale bar = 20 um.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 7 Membrane type 1-MMP is expressed in surface CE cells and associates with lateral membranes at nighttime. Flat-mounted whole corneas were double-labeled for localization of claudin-4 and membrane type 1-MMP (MT1-MMP) immunoreactivity in the late afternoon (DAY; 9 hours after lights on in a 12L:12D cycle) and in the late night (NIGHT; 3 hours before lights on). ( A ) In the late afternoon, claudin-4 (red) immunolabeling of the surface CE cell lateral membranes was generally intact and uniform. MT1-MMP (green) labeling, when present, was observed almost exclusively in cytoplasmic compartments of the surface CE. ( B, C ) Two examples are presented to illustrate that during the late night, a majority of the surface CE cells exhibited intact claudin-4 (green) labeling on their lateral membranes, but there were also many clusters of surface CE cells in which the claudin-4 immunoreactivity was disrupted. Also at nighttime, MT1-MMP labeling was present both in the cytoplasm and intermittently associated with the surface CE cell lateral membranes (arrows). The membrane co-localization of the red claudin-4 and green MT1-MMP resulted in a merged yellow labeling of the lateral membranes in some areas (arrows). Specimens were stained with the blue nuclear DAPI stain. Scale bar = 20 um.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 3 Protein expression (Western blot) of claudin-1, claudin-3, claudin-4, claudin-5, claudin-7, and claudin-8 after treatment with bacterial strains (Ecf, ETEC, and Ecf + ETEC). (a) Protein expression relative to respective controls [means +- SEM]. Samples were taken after 8 h. No differences were observed between treatment groups. N = 3 independent experiments per bar. (b) Exemplarily, data of one Western blot is shown. 1 = control (8 h), 2 = Ecf (8 h), 3 = ETEC (8 h), 4 = Ecf (8 h) + ETEC (6 h), and 5 = Ecf (10 h) + ETEC (8 h). Sample 4 was included as a control to rule out effects of longer total bacterial incubation (preincubation) and was not included in the statistical analysis shown in (a).
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 12 Effects of ZO-1 knockout on the localization and expression levels of claudins. (A) Effects of ZO-1 knockout on the localization of claudins. Control and ZO-1 knockout cells of clone 1 were co-cultured on filter inserts. Signal intensity of claudins on lines shown in confocal microscopic images ( arrows ) were analyzed. Claudin-2 fluorescent signal at TJs was increased but claudin-1 and -7 signals at TJs were reduced in ZO-1 knockout cells. Scale bar, 10 um. (B) Immunoblots of claudins in control MDCK II cells and ZO-1 knockout clones. Similar expression levels of claudins were observed in control and knockout cells.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig 3 Effects of claudin-2 knockout on the localization of other TJ proteins and cytoskeleton. (A) Immunofluorescence analysis of claudin-1, -3, -4, -7, ZO-1, occludin, F-actin, and myosin heavy chain II-B (MHC-B) in control and claudin-2 knockout cells. Claudin-1 and -7 showed a tendency to be more clearly localized at TJs in claudin-2 knockout cells. Scale bar = 10 mum. (B) Immunoblots of claudin-1, -3, -4, and -7 in control MDCK II cells and claudin-2 knockout clones. Similar expression levels of claudin-1, -3, -4, and -7 were observed in control cells and knockout clones.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 1. Examples of CD24, CD44 and claudin 4 and 7 immunostaining in mammary invasive carcinomas (scale bar, 100 um). (A) Claudin-negative; (B) CD24-negative; (C) CD44-negative; (D) claudin 4 2+; (E) claudin 7 2+; (F) CD24-positive; (G) claudin 4 3+; (H) claudin 7 3+; (I) CD44-positive.
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 7 rEhCP112a degrades claudin-1 and increases claudin-2 expression in Caco-2 cells. (A) Caco-2 cells incubated with rEhCP112a for different times or with live trophozoites (T) for 10 min, submitted to WB using antibodies against TJ proteins indicated at left and alpha-tubulin as a loading control. (B) Densitometry analysis of bands obtained in (A) for each TJs protein with regards to tubulin. * p
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Figure 8 rEhCP112p binds to claudin-1 and claudin-2. Confluent Caco-2 cell monolayers were incubated for 10 min with rEhCP112p, then, cell lysates were immunoprecipitated (IP) in the presence of protease inhibitors, using alpha-EhCP112 antibody or pre-immune serum (PS). Immunoprecipitates, rEhCP112p and Caco-2 cell lysates (Caco-2) were submitted to WB assays and revealed using the antibodies indicated at left.