BS64039

antibody from Bioworld Technology, Inc
Targeting: BCL2L11 BIM, BimEL, BimL, BimS, BOD
Provider product page for BS64039

Antibody data

Product number
BS64039 - Provider product page
Provider
Bioworld Technology, Inc
Product name
Bim (phospho S69/S65) polyclonal antibody
Antibody type
Polyclonal
Antigen
A synthetic peptide corresponding to residues in Human Bim around the phosphorylation site of Ser69.
Description
Pro-apototic Bcl-2 family members promote cell death by neutralizing their anti-apoptotic relatives, which otherwise maintain cell viability by regulating caspase activity. Bim belongs to the BH3-only subgroup of Bcl-2 related proteins, and exists in three distinct isoforms, BimS (short), BimL (long) and BimEL (extra long). ERK1/2 phosphorylates BimEL, resulting in rapid degradation of the isoform via the proteasome pathway. At least three sites for ERK1/2 phosphorylation exist on BimEL, whereas ERK1/2 does not effect BimS and BimL, implying a unique role for BimEL in cell survival signaling.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -22°C long term. Avoid freeze-thaw cycles.
BCL2L11 protein structure - BS64039 shown in red.