DCABH-1626

CDC25B antibody from Creative Diagnostics
Western blot
Recommended by provider
Immunoprecipitation
Recommended by provider

Antibody data

Product number
DCABH-1626
Provider
Creative Diagnostics
Proper citation
Creative Diagnostics Cat#DCABH-1626, RRID:AB_2475586
Product name
Rabbit Anti-Human Cdc25B monoclonal antibody, clone KK102-3
Provider product page
Creative Diagnostics - DCABH-1626
Antibody type
Monoclonal
Description
The Cdc2/cyclin B enzyme, involved in regulation of mitosis in eukaryotic cells, is subject to multiple levels of control. Among these, the regulation of the catalytic subunit by Tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/cyclin B complex, while Tyrosine dephosphorylation, which occurs at the onset of mitosis, directly activates the pre-MPH complex. The Cdc25 gene serves as a rate-limiting mitotic activator, apparently due to its action as the Cdc2 Tyrosine phosphatase. In the absence of Cdc25, Cdc2 accumulates in a Tyrosine phosphorylated state. In addition, Cdc25 proteins from a variety of species have been shown to share a low degree of sequence similarity with other Tyrosine phosphatases. The Cdc25 gene family consists of at least three members that share approximately 40% identity in their most conserved carboxy-terminal sequences.
Reactivity
Human
Host
Rabbit
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
KK102-3
Vial size
100 _l
Storage
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Provider Type Product Number
- No reagents -