CABT-BL8287

antibody from Creative Diagnostics

Targeting: SPN CD43, GPL115, LSN

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

CABT-BL8287

Provider

Creative Diagnostics

Product name

Anti-SPN Monoclonal antibody, clone S3/70

Antibody type

Monoclonal

Description

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumour suppressor p53 protein, but in case of p53 and ARF defficiency CD43 promotes tumour proliferation and viability. It appears to be an important modulator of leukocyte functions.

Reactivity

Mouse

Host

Rat

Conjugate

Unconjugated

Isotype

IgM

Antibody clone number

S3/70

Vial size

500 ug