60085

antibody from STEMCELL Technologies Inc

Targeting: SPN CD43, GPL115, LSN

Immunoprecipitation (Recommended by provider)

Flow cytometry (Recommended by provider)

Functional assay (Recommended by provider)

Antibody Data

Product number

60085

Provider

STEMCELL Technologies Inc

Product name

Anti-Human CD43 Antibody, Clone CD43-10G7

Antibody type

Monoclonal

Description

The CD43-10G7 antibody reacts with human CD43, a type I transmembrane sialoglycoprotein expressed on the surface of most human hematopoietic cells, including thymocytes, peripheral T cells, NK cells, monocytes, granulocytes, some B cells (activated B cells and an early B cell subset in bone marrow), plasma cells, and hematopoietic progenitor cells. Low expression levels are observed on platelets. CD43 exhibits different glycoforms in the range of ~95 - 135 kDa, depending on the cell type. It binds ligands such as CD54 and CD169 (Siglec-1) and plays regulatory roles in cell adhesion and activation, apoptosis and tumor progression, and is used a marker for discriminating normal from neoplastic T cells and B cells within tissues. Binding of the CD43-10G7 antibody to CD43 on neutrophils reportedly induces homotypic cell adhesion.

Reactivity

Human

Host

Human

Isotype

IgG

Vial size

100 µg

Storage

2 - 8°C