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FHIT
Fragile histidine triad diadenosine triphosphataseAP3Aase, FRA3B
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Top validated antibodies |
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| Invitrogen Antibodies |  71-9000 |
13 references | Polyclonal |
WB
EL
ICC
IHC
OA
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| antibodies-online | ABIN394498 |
5 references | Monoclonal |
WB
EL
IHC
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| Proteintech Group | 66086-1-Ig |
2 references | Monoclonal |
WB
EL
ICC
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| Atlas Antibodies | HPA018840 |
1 references | Polyclonal |
WB
IHC
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| Boster Biological Technology | A01200-1 |
Polyclonal |
WB
ICC
IP
IHC
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