20700-1-AP

antibody from Proteintech Group

Targeting: RUNX2 AML3, CBFA1, CCD, CCD1, PEBP2A1, PEBP2aA1

Provider product page for 20700-1-AP

Western blot

ELISA

Immunocytochemistry

Antibody data

Antibody Data
Antigen structure
References [38]
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Validations
Western blot [1]

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Product number: 20700-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20700-1-AP, RRID:AB_2722783
Product name: RUNX2 antibody
Antibody type: Polyclonal
Description: RUNX2 antibody (Cat. #20700-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IF, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

RUNX2 protein structure - 20700-1-AP shown in red.

Submitted references MACF1 promotes osteoblastic cell migration by regulating MAP1B through the GSK3beta/TCF7 pathway.

Su P, Tian Y, Yin C, Wang X, Li D, Yang C, Pei J, Deng X, King S, Li Y, Qian A
Bone 2022 Jan;154:116238

Long Non-coding RNAs LOC100126784 and POM121L9P Derived From Bone Marrow Mesenchymal Stem Cells Enhance Osteogenic Differentiation via the miR-503-5p/SORBS1 Axis.

Xu Y, Xin R, Sun H, Long D, Li Z, Liao H, Xue T, Zhang Z, Kang Y, Mao G
Frontiers in cell and developmental biology 2021;9:723759

LINC00370 modulates miR-222-3p-RGS4 axis to protect against osteoporosis progression.

Li L, Zheng B, Zhang F, Luo X, Li F, Xu T, Zhao H, Shi G, Guo Y, Shi J, Sun J
Archives of gerontology and geriatrics 2021 Nov-Dec;97:104505

Total glycosides from Eucommia ulmoides seed promoted osteogenic differentiation of adipose-derived mesenchymal stem cells and bone formation in ovariectomized rats through regulating Notch signaling pathway.

Zhou YH, Xie Q
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):660

miR-142a-5p promoted osteoblast differentiation via targeting nuclear factor IA.

Yuan H, Li M, Feng X, Zhu E, Wang B
Journal of cellular physiology 2021 Mar;236(3):1810-1821

Hydrogen sulfide inhibits aortic valve calcification in heart via regulating RUNX2 by NF-κB, a link between inflammation and mineralization.

Éva Sikura K, Combi Z, Potor L, Szerafin T, Hendrik Z, Méhes G, Gergely P, Whiteman M, Beke L, Fürtös I, Balla G, Balla J
Journal of advanced research 2021 Jan;27:165-176

Citrate regulates extracellular matrix mineralization during osteoblast differentiation in vitro.

Wu X, Dai H, Yu S, Zhao Y, Long Y, Li W, Tu J
Journal of inorganic biochemistry 2021 Jan;214:111269

A polydopamine-assisted strontium-substituted apatite coating for titanium promotes osteogenesis and angiogenesis via FAK/MAPK and PI3K/AKT signaling pathways.

Sun Y, Li Y, Zhang Y, Wang T, Lin K, Liu J
Materials science & engineering. C, Materials for biological applications 2021 Dec;131:112482

The effects of Omarigliptin on promoting osteoblastic differentiation.

Liao F, Hu X, Chen R
Bioengineered 2021 Dec;12(2):11837-11846

The Role of Tantalum Nanoparticles in Bone Regeneration Involves the BMP2/Smad4/Runx2 Signaling Pathway.

Zhang G, Liu W, Wang R, Zhang Y, Chen L, Chen A, Luo H, Zhong H, Shao L
International journal of nanomedicine 2020;15:2419-2435

The p53/miR-145a Axis Promotes Cellular Senescence and Inhibits Osteogenic Differentiation by Targeting Cbfb in Mesenchymal Stem Cells.

Xia C, Jiang T, Wang Y, Chen X, Hu Y, Gao Y
Frontiers in endocrinology 2020;11:609186

Rosamultin Attenuates Acute Hypobaric Hypoxia-Induced Bone Injuries by Regulation of Sclerostin and Its Downstream Signals.

Wang XM, Liu H, Li JY, Wei JX, Li X, Zhang YL, Li LZ, Zhang XZ
High altitude medicine & biology 2020 Sep;21(3):273-286

Celastrol attenuates arterial and valvular calcification via inhibiting BMP2/Smad1/5 signalling.

Su Z, Zong P, Chen J, Yang S, Shen Y, Lu Y, Yang C, Kong X, Sheng Y, Sun W
Journal of cellular and molecular medicine 2020 Nov;24(21):12476-12490

Magnesium Calcium Phosphate Cement Incorporating Citrate for Vascularized Bone Regeneration.

Wu X, Dai H, Yu S, Zhao Y, Long Y, Li W, Tu J
ACS biomaterials science & engineering 2020 Nov 9;6(11):6299-6308

Tensile force-induced PDGF-BB/PDGFRβ signals in periodontal ligament fibroblasts activate JAK2/STAT3 for orthodontic tooth movement.

Jin Y, Ding L, Ding Z, Fu Y, Song Y, Jing Y, Li Q, Zhang J, Ni Y, Hu Q
Scientific reports 2020 Jul 9;10(1):11269

VPS4B mutation impairs the osteogenic differentiation of dental follicle cells derived from a patient with dentin dysplasia type I.

Li Q, Lu F, Chen T, Zhang K, Lu Y, Li X, Wang Y, Liu L, Tian Q, Xiong F, Chen D
International journal of oral science 2020 Jul 31;12(1):22

Hydrogen sulfide inhibits calcification of heart valves; implications for calcific aortic valve disease.

Sikura KÉ, Potor L, Szerafin T, Oros M, Nagy P, Méhes G, Hendrik Z, Zarjou A, Agarwal A, Posta N, Torregrossa R, Whiteman M, Fürtös I, Balla G, Balla J
British journal of pharmacology 2020 Feb;177(4):793-809

Effects Of Triptolide On Tooth Movement And Root Resorption In Rats.

Yang F, Wang XX, Ma D, Cui Q, Zheng H, Liu XC, Zhang J
Drug design, development and therapy 2019;13:3963-3975

TMEM18 inhibits osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells by inactivating β-catenin.

Zhang Y, Wang H, Yin T, Liu Y, Zhou W, Fan X, Wu L, Song C, Shao J, Yang T
Experimental cell research 2019 Oct 1;383(1):111491

ZnO nanoparticles inhibit the activity of Porphyromonas gingivalis and Actinomyces naeslundii and promote the mineralization of the cementum.

Wang J, Du L, Fu Y, Jiang P, Wang X
BMC oral health 2019 May 14;19(1):84

Potential Role of H-Ferritin in Mitigating Valvular Mineralization.

Sikura KÉ, Potor L, Szerafin T, Zarjou A, Agarwal A, Arosio P, Poli M, Hendrik Z, Méhes G, Oros M, Posta N, Beke L, Fürtös I, Balla G, Balla J
Arteriosclerosis, thrombosis, and vascular biology 2019 Mar;39(3):413-431

Histone demethylase KDM7A reciprocally regulates adipogenic and osteogenic differentiation via regulation of C/EBPα and canonical Wnt signalling.

Yang X, Wang G, Wang Y, Zhou J, Yuan H, Li X, Liu Y, Wang B
Journal of cellular and molecular medicine 2019 Mar;23(3):2149-2162

Citric acid enhances the physical properties, cytocompatibility and osteogenesis of magnesium calcium phosphate cement.

Wang S, Xu C, Yu S, Wu X, Jie Z, Dai H
Journal of the mechanical behavior of biomedical materials 2019 Jun;94:42-50

Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcification.

Gu J, Lu Y, Deng M, Qiu M, Tian Y, Ji Y, Zong P, Shao Y, Zheng R, Zhou B, Sun W, Kong X
Experimental & molecular medicine 2019 Jul 10;51(7):1-14

Enhancement of tenogenic differentiation of rat tendon-derived stem cells by biglycan.

Zhang YJ, Qing Q, Zhang YJ, Ning LJ, Cui J, Yao X, Luo JC, Ding W, Qin TW
Journal of cellular physiology 2019 Feb 4;

LncRNA ODIR1 inhibits osteogenic differentiation of hUC-MSCs through the FBXO25/H2BK120ub/H3K4me3/OSX axis.

He S, Yang S, Zhang Y, Li X, Gao D, Zhong Y, Cao L, Ma H, Liu Y, Li G, Peng S, Shuai C
Cell death & disease 2019 Dec 11;10(12):947

Inhibition of pyroptosis attenuates Staphylococcus aureus-induced bone injury in traumatic osteomyelitis.

Zhu X, Zhang K, Lu K, Shi T, Shen S, Chen X, Dong J, Gong W, Bao Z, Shi Y, Ma Y, Teng H, Jiang Q
Annals of translational medicine 2019 Apr;7(8):170

The microRNA-10a/ID3/RUNX2 axis modulates the development of Ossification of Posterior Longitudinal Ligament.

Xu C, Zhang H, Gu W, Wu H, Chen Y, Zhou W, Sun B, Shen X, Zhang Z, Wang Y, Liu Y, Yuan W
Scientific reports 2018 Jun 15;8(1):9225

Aryl Hydrocarbon Receptor Antagonists Mitigate the Effects of Dioxin on Critical Cellular Functions in Differentiating Human Osteoblast-Like Cells.

Yun C, Katchko KM, Schallmo MS, Jeong S, Yun J, Chen CH, Weiner JA, Park C, George A, Stupp SI, Hsu WK, Hsu EL
International journal of molecular sciences 2018 Jan 11;19(1)

APE1/Ref-1 Inhibits Phosphate-Induced Calcification and Osteoblastic Phenotype Changes in Vascular Smooth Muscle Cells.

Lee KM, Lee EO, Lee YR, Joo HK, Park MS, Kim CS, Choi S, Jeong JO, Jeon BH
International journal of molecular sciences 2017 Sep 25;18(10)

Effect of pioglitazone on the calcification of rat vascular smooth muscle cells through the downregulation of the Wnt/β‑catenin signaling pathway.

Gao M, Chen T, Wu L, Zhao X, Mao H, Xing C
Molecular medicine reports 2017 Nov;16(5):6208-6213

Graphene/single-walled carbon nanotube hybrids promoting osteogenic differentiation of mesenchymal stem cells by activating p38 signaling pathway.

Yan X, Yang W, Shao Z, Yang S, Liu X
International journal of nanomedicine 2016;11:5473-5484

The In Vitro and In Vivo Osteogenic Capability of the Extraction Socket-Derived Early Healing Tissue.

Luo J, Xu J, Cai J, Wang L, Sun Q, Yang P
Journal of periodontology 2016 Sep;87(9):1057-66

Osteogenic differentiation of human lens epithelial cells might contribute to lens calcification.

Balogh E, Tóth A, Tolnai E, Bodó T, Bányai E, Szabó DJ, Petrovski G, Jeney V
Biochimica et biophysica acta 2016 Sep;1862(9):1724-31

Resveratrol Ameliorated Vascular Calcification by Regulating Sirt-1 and Nrf2.

Zhang P, Li Y, Du Y, Li G, Wang L, Zhou F
Transplantation proceedings 2016 Dec;48(10):3378-3386

Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.

Zhang W, Li Y, Ding H, Du Y, Wang L
Renal failure 2016 Aug;38(7):1099-106

The Role and Mechanism of α-Klotho in the Calcification of Rat Aortic Vascular Smooth Muscle Cells.

Chen T, Mao H, Chen C, Wu L, Wang N, Zhao X, Qian J, Xing C
BioMed research international 2015;2015:194362

Apelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK and PI3-K/Akt pathways.

Yuan ZS, Zhou YZ, Liao XB, Luo JW, Shen KJ, Hu YR, Gu L, Li JM, Tan CM, Chen HM, Zhou XM
Amino acids 2015 Dec;47(12):2475-82

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: ROS1728 cells were subjected to SDS PAGE followed by western blot with 20700-1-AP( RUNX2 Antibody) at dilution of 1:600
Other comments: WB
Appendix: 20700-1-AP.pdf

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