11-8001-25

antibody from ABEOMICS Inc.
Targeting: RUNX2 AML3, CBFA1, CCD, CCD1, PEBP2A1, PEBP2aA1
Provider product page for 11-8001-25

Antibody data

Product number
11-8001-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-RUNX2 Antibody
Antibody type
Polyclonal
Description
Runt-related transcription factor 2 (Runx2) is also known as core-binding factor subunit alpha-1 (CBF-alpha-1). RunX2 is one of the three mammalian transcription factors sharing the highly conserved DNA-binding Runt domain that represents a key class of lineage-specific gene regulators and is associated with different micro-environments during the cell cycle. RUNX2 has a primary role in the differentiation of osteoblasts and hypertrophy of cartilage at the growth plate, cell migration and vascular invasion of bone and is also expressed in vascular endothelial cells and breast cancer cells. It is a heterodimer of an alpha and a beta subunit. RUNX2 plays a role in the disease metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly, and cleidocranial dysplasia. By alternative splicing, several isoforms exist.
Reactivity
Human
Host
Rabbit
Antigen sequence
A partial length recombinant RUNX2
protein (amino acids 161-482) was u
sed as the immunogen for this antib
ody.
Vial size
25 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freezing and thawing
RUNX2 protein structure - 11-8001-25 shown in red.