AMM01906G

antibody from Leading Biology
Targeting: RUNX2 AML3, CBFA1, CCD, CCD1, PEBP2A1, PEBP2aA1
Provider product page for AMM01906G
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
AMM01906G - Provider product page
Provider
Leading Biology
Product name
CBFA1 / RUNX2 Antibody (clone 1D8)
Antibody type
Monoclonal
Description
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
Reactivity
Human
Host
Mouse
Antibody clone number
1D8
Storage
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
RUNX2 protein structure - AMM01906G shown in red.