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Western blot
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- 681902 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#681902, RRID:AB_2566566
- Product name
- Purified anti-Cyclin D1
- Antibody type
- Monoclonal
- Antigen
- Full length recombinant human Cyclin D1
- Description
- Cyclin D1, which forms a complex with CDK4 and CDK6, plays central roles in cell cycle transition from G1 to S phase. It also participates in the induction of cellular migration and invasion, enhancement of angiogenesis, inhibition of mitochondrial metabolism, regulation of transcription factor signaling via DNA binding, induction of chromosomal instability, enhancement of DNA damage sensing, and DNA damage repair. The activation of the cyclin D1 oncogene is a major driver of multiple types of human tumors including breast and squamous cell cancers, B-cell lymphoma, myeloma, and parathyroid adenoma.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Antibody clone number
- DCS-6
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- 2°C-8°C
- Handling
- Ambient RT
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- BioLegend (provider)
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- Experimental details
- Western blot analysis of cell lysates from HeLa (lane 1), MCF-7 (lane 2), and NIH3T3 (lane 3). Anti-Cyclin D1 antibody (clone DCS-6) was used and then was followed by HRP anti-mouse IgG antibody. GAPDH (clone poly6314) was used as loading control.
- Conjugate
- Unconjugated
