PAB12253

antibody from Abnova Corporation

Targeting: MDM2 HDM2, MGC5370

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

PAB12253

Provider

Abnova Corporation

Proper citation

Abnova Corporation Cat#PAB12253, RRID:AB_10552048

Product name

MDM2 polyclonal antibody

Antibody type

Polyclonal

Description

Rabbit polyclonal antibody raised against synthetic peptide of MDM2.

Antigen sequence

AISET


Storage

Store at -20°C.Aliquot to avoid repeated freezing and thawing.

References

Submitted references

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus.

Mayo LD, Donner DB
Proceedings of the National Academy of Sciences of the United States of America 2001 Sep 25;98(20):11598-603

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation.

Zhou BP, Liao Y, Xia W, Zou Y, Spohn B, Hung MC
Nature cell biology 2001 Nov;3(11):973-82

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p300/MDM2 complexes participate in MDM2-mediated p53 degradation.

Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM
Molecular cell 1998 Oct;2(4):405-15

Immunocytochemistry

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Immunofluorescence staining of methanol-fixed HeLa cells using MDM2 polyclonal antibody (Cat # PAB12253, Red).

Validation comment

Immunofluorescence

Immunohistochemistry

Supportive validation

Submitted by

Abnova Corporation (provider)

Main image

Experimental details

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using MDM2 polyclonal antibody (Cat # PAB12253).

Validation comment

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)