18202-1-AP

antibody from Proteintech Group

Targeting: CCNA2 CCN1, CCNA

Provider product page for 18202-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [74]
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Validations
Western blot [1]
Immunocytochemistry [1]

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Product number: 18202-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18202-1-AP, RRID:AB_10597084
Product name: Cyclin A2 antibody
Antibody type: Polyclonal
Description: KD/KO validated Cyclin A2 antibody (Cat. #18202-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CCNA2 protein structure - 18202-1-AP shown in red.

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Frontiers in oncology 2021;11:661184

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Journal of clinical medicine 2021 Oct 20;10(21)

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Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S
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Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706

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Zhang L, Wang Y, Wu G, Rao L, Wei Y, Yue H, Yuan T, Yang P, Xiong F, Zhang S, Zhou Q, Chen Z, Li J, Mo BW, Zhang H, Xiong W, Wang CY
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Sun H, Yang B, Zhang H, Song J, Zhang Y, Xing J, Yang Z, Wei C, Xu T, Yu Z, Xu Z, Hou M, Ji M, Zhang Y
International journal of biological sciences 2019;15(3):533-543

Enhanced anti-tumor effect of liposomal Fasudil on hepatocellular carcinoma in vitro and in vivo.

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PloS one 2019;14(10):e0223232

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OncoTargets and therapy 2019;12:6361-6370

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Tian F, Yu C, Wu M, Wu X, Wan L, Zhu X
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Yang J, Zeng Z, Qiao L, Jiang X, Ma J, Wang J, Ye S, Ma Q, Wei J, Wu M, Huang X, Ma D, Gao Q
Molecular cancer research : MCR 2019 Oct;17(10):2015-2028

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Qin C, Zhang Q, Wu G
Oncology letters 2019 May;17(5):4409-4416

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Liu Y, Dong N, Miao J, Li C, Wang X, Ruan J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 May;113:108742

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Journal of virology 2018 Oct 15;92(20)

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Oncology reports 2017 Apr;37(4):1998-2006

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BioMed research international 2016;2016:5230642

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Oncotarget 2016 May 3;7(18):25478-92

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Wang W, Wang HJ, Wang B, Li Y, Qin Y, Zheng LS, Zhou JS, Qu PH, Shi JH, Zhang HS
DNA and cell biology 2016 Jan;35(1):24-32

HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.

Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X, Ye L
Cancer research 2016 Jan 15;76(2):293-304

Modulation of cyclins and p53 in mesangial cell proliferation and apoptosis during Habu nephritis.

Lu Y, Wen J, Chen D, Wu L, Li Q, Xie Y, Wu D, Liu X, Chen X
Clinical and experimental nephrology 2016 Apr;20(2):178-86

Doxorubicin-poly (ethylene glycol)-alendronate self-assembled micelles for targeted therapy of bone metastatic cancer.

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Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Song X, Li L, Shi Q, Lehmler HJ, Fu J, Su C, Xia X, Song E, Song Y
Chemical research in toxicology 2015 Nov 16;28(11):2160-9

Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.

Hsu TI, Wang MC, Chen SY, Huang ST, Yeh YM, Su WC, Chang WC, Hung JJ
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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HL-60 cells were subjected to SDS PAGE followed by western blot with 18202-1-AP(CCNA2 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of MCF-7 cells, using CCNA2 antibody 18202-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line