abx015954

antibody from Abbexa

Targeting: PAX5 BSAP

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

abx015954

Provider

Abbexa

Product name

Paired Box Protein Pax-5 (PAX5) Antibody

Antibody type

Monoclonal

Description

This gene encodes a member of the paired box (PAX) family of transcription factors.The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box.PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation.This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation.Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis.This gene is located at 9p13, which is involved in t (9;14) (p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas.This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas.Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 µl

Concentration

1 mg/ml

Storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.