Ab096310

antibody from Aladdin Scientific Corporation

Targeting: CHEK1 CHK1

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

Ab096310

Provider

Aladdin Scientific Corporation

Product name

Chk1 Mouse mAb

Antibody type

Monoclonal

Description

Mouse Monoclonal (2G1D5) to CHK1, could be used for WB and ELISA.Application:WB: 1/500 - 1/2000 ELISA: 1/10000Protein Function:CHK1, also known as CHEK1, it is a kinase that phosphorylates cdc25, an important phosphatase in cell cycle control, particularly for entry into mitosis. Cdc25, when phosphorylated on serine 216 by chk1 becomes bound by an adaptor protein in the cytoplasm. Therefore it is inhibited from removing the inhibiting phosphate from MPF (mitotic/maturation promoting factor) added by Wee1. Consequently, a cell is prevented from entering mitosis. Chk1 can also phosphorylate p53 at Ser20 in vitro.

Reactivity

Human, Mouse

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

AA: 207-421


Isotype

IgG

Antibody clone number

2G1D5

Vial size

100μl,10μl,1ml,50μl

Concentration

1 mg/ml

Storage

Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze/thaw cycle.