Antibody data
- Antibody Data
- Antigen structure
- References [24]
- Comments [0]
- Validations
- Western blot [1]
- Immunoprecipitation [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 10654-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10654-1-AP, RRID:AB_2120153
- Product name
- Hsc70 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Hsc70 antibody (Cat. #10654-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references MAPK-RAP1A Signaling Enriched in Hepatocellular Carcinoma Is Associated With Favorable Tumor-Infiltrating Immune Cells and Clinical Prognosis.
Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H2S therapy of cancer.
Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2.
Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.
The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons.
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk.
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.
hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.
Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.
Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer.
MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562.
PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line.
Chaperone-mediated autophagy degrades mutant p53.
Proteomic profiling of the 11-dehydrosinulariolide-treated oral carcinoma cells Ca9-22: effects on the cell apoptosis through mitochondrial-related and ER stress pathway.
An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.
Li H, Han G, Li X, Li B, Wu B, Jin H, Wu L, Wang W
Frontiers in oncology 2021;11:649980
Frontiers in oncology 2021;11:649980
Sulourea-coordinated Pd nanocubes for NIR-responsive photothermal/H2S therapy of cancer.
Guo X, Liu J, Jiang L, Gong W, Wu H, He Q
Journal of nanobiotechnology 2021 Oct 14;19(1):321
Journal of nanobiotechnology 2021 Oct 14;19(1):321
Melatonin potentiates the cytotoxic effect of Neratinib in HER2+ breast cancer through promoting endocytosis and lysosomal degradation of HER2.
Liu Z, Sang X, Wang M, Liu Y, Liu J, Wang X, Liu P, Cheng H
Oncogene 2021 Nov;40(44):6273-6283
Oncogene 2021 Nov;40(44):6273-6283
Discovery of LAMP-2A as potential biomarkers for glioblastoma development by modulating apoptosis through N-CoR degradation.
Wang Y, Zhang B, Wang J, Wu H, Xu S, Zhang J, Wang L
Cell communication and signaling : CCS 2021 Mar 24;19(1):40
Cell communication and signaling : CCS 2021 Mar 24;19(1):40
The potential LXRβ agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons.
Haque MN, Hannan MA, Dash R, Choi SM, Moon IS
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153415
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Jan;81:153415
Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI.
Chen C, Wang D, Yu Y, Zhao T, Min N, Wu Y, Kang L, Zhao Y, Du L, Zhang M, Gong J, Zhang Z, Zhang Y, Mi X, Yue S, Tan X
Cell death & disease 2021 Jan 11;12(1):65
Cell death & disease 2021 Jan 11;12(1):65
Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk.
Kadota T, Fujita Y, Araya J, Watanabe N, Fujimoto S, Kawamoto H, Minagawa S, Hara H, Ohtsuka T, Yamamoto Y, Kuwano K, Ochiya T
Journal of extracellular vesicles 2021 Aug;10(10):e12124
Journal of extracellular vesicles 2021 Aug;10(10):e12124
USP19 (ubiquitin specific peptidase 19) promotes TBK1 (TANK-binding kinase 1) degradation via chaperone-mediated autophagy.
Zhao X, Di Q, Yu J, Quan J, Xiao Y, Zhu H, Li H, Ling J, Chen W
Autophagy 2021 Aug 26;:1-18
Autophagy 2021 Aug 26;:1-18
A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1.
Tao P, Sun J, Wu Z, Wang S, Wang J, Li W, Pan H, Bai R, Zhang J, Wang Y, Lee PY, Ying W, Zhou Q, Hou J, Wang W, Sun B, Yang M, Liu D, Fang R, Han H, Yang Z, Huang X, Li H, Deuitch N, Zhang Y, Dissanayake D, Haude K, McWalter K, Roadhouse C, MacKenzie JJ, Laxer RM, Aksentijevich I, Yu X, Wang X, Yuan J, Zhou Q
Nature 2020 Jan;577(7788):109-114
Nature 2020 Jan;577(7788):109-114
hnRNP K Is a Novel Internal Ribosomal Entry Site-Transacting Factor That Negatively Regulates Foot-and-Mouth Disease Virus Translation and Replication and Is Antagonized by Viral 3C Protease.
Liu W, Yang D, Sun C, Wang H, Zhao B, Zhou G, Yu L
Journal of virology 2020 Aug 17;94(17)
Journal of virology 2020 Aug 17;94(17)
Molecular identification of HSPA8 as an accessory protein of a hyperpolarization-activated chloride channel from rat pulmonary vein cardiomyocytes.
Okamoto Y, Nagasawa Y, Obara Y, Ishii K, Takagi D, Ono K
The Journal of biological chemistry 2019 Nov 1;294(44):16049-16061
The Journal of biological chemistry 2019 Nov 1;294(44):16049-16061
Chaperone-mediated autophagy is involved in the execution of ferroptosis.
Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 19;116(8):2996-3005
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 19;116(8):2996-3005
Exosomes derived from breast cancer lung metastasis subpopulations promote tumor self-seeding.
Huang H, Zheng X, Cai C, Yao Z, Lu S, Meng X, Miao Y, He Z, Cai C, Zou F
Biochemical and biophysical research communications 2018 Sep 3;503(1):242-248
Biochemical and biophysical research communications 2018 Sep 3;503(1):242-248
Synergistic effect of a novel autophagy inhibitor and Quizartinib enhances cancer cell death.
Ouchida AT, Li Y, Geng J, Najafov A, Ofengeim D, Sun X, Yu Q, Yuan J
Cell death & disease 2018 Jan 26;9(2):138
Cell death & disease 2018 Jan 26;9(2):138
Oncoprotein HBXIP enhances HOXB13 acetylation and co-activates HOXB13 to confer tamoxifen resistance in breast cancer.
Liu B, Wang T, Wang H, Zhang L, Xu F, Fang R, Li L, Cai X, Wu Y, Zhang W, Ye L
Journal of hematology & oncology 2018 Feb 23;11(1):26
Journal of hematology & oncology 2018 Feb 23;11(1):26
MAPKs and Hsc70 are critical to the protective effect of molecular hydrogen during the early phase of acute pancreatitis.
Han B, Zhou H, Jia G, Wang Y, Song Z, Wang G, Pan S, Bai X, Lv J, Sun B
The FEBS journal 2016 Feb;283(4):738-56
The FEBS journal 2016 Feb;283(4):738-56
Degradation of HK2 by chaperone-mediated autophagy promotes metabolic catastrophe and cell death.
Xia HG, Najafov A, Geng J, Galan-Acosta L, Han X, Guo Y, Shan B, Zhang Y, Norberg E, Zhang T, Pan L, Liu J, Coloff JL, Ofengeim D, Zhu H, Wu K, Cai Y, Yates JR, Zhu Z, Yuan J, Vakifahmetoglu-Norberg H
The Journal of cell biology 2015 Aug 31;210(5):705-16
The Journal of cell biology 2015 Aug 31;210(5):705-16
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Liu YZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR
Cancer cytopathology 2014 Nov;122(11):833-41
Cancer cytopathology 2014 Nov;122(11):833-41
Proteomic study reveals a co-occurrence of gallic acid-induced apoptosis and glycolysis in B16F10 melanoma cells.
Liu C, Lin JJ, Yang ZY, Tsai CC, Hsu JL, Wu YJ
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80
Journal of agricultural and food chemistry 2014 Dec 3;62(48):11672-80
hERG potassium channel blockage by scorpion toxin BmKKx2 enhances erythroid differentiation of human leukemia cells K562.
Ma J, Hu Y, Guo M, Huang Z, Li W, Wu Y
PloS one 2013;8(12):e84903
PloS one 2013;8(12):e84903
PKCι counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line.
Wang BS, Yang Y, Yang H, Liu YZ, Hao JJ, Zhang Y, Shi ZZ, Jia XM, Zhan QM, Wang MR
Cell stress & chaperones 2013 May;18(3):359-66
Cell stress & chaperones 2013 May;18(3):359-66
Chaperone-mediated autophagy degrades mutant p53.
Vakifahmetoglu-Norberg H, Kim M, Xia HG, Iwanicki MP, Ofengeim D, Coloff JL, Pan L, Ince TA, Kroemer G, Brugge JS, Yuan J
Genes & development 2013 Aug 1;27(15):1718-30
Genes & development 2013 Aug 1;27(15):1718-30
Proteomic profiling of the 11-dehydrosinulariolide-treated oral carcinoma cells Ca9-22: effects on the cell apoptosis through mitochondrial-related and ER stress pathway.
Liu CI, Wang RY, Lin JJ, Su JH, Chiu CC, Chen JC, Chen JY, Wu YJ
Journal of proteomics 2012 Oct 22;75(18):5578-89
Journal of proteomics 2012 Oct 22;75(18):5578-89
An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells.
Su CC, Su JH, Lin JJ, Chen CC, Hwang WI, Huang HH, Wu YJ
Marine drugs 2011 Dec;9(12):2622-42
Marine drugs 2011 Dec;9(12):2622-42
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 10654-1-AP(HSPA8 antibody) at dilution of 1:800
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-HSPA8 (IP:10654-1-AP, 3ug; Detection:10654-1-AP 1:1000) with HEK-293 cells lysate 2500ug.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The Hsc70 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Hsc70. This antibody recognizes human,mouse,rat antigen. The Hsc70 antibody has been validated for the following applications: ELISA, IHC, IP, WB analysis.