13171-1-AP

antibody from Proteintech Group

Targeting: HSP90AA1 FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA

Provider product page for 13171-1-AP

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Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [118]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [2]

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Product number: 13171-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#13171-1-AP, RRID:AB_2120924
Product name: HSP90 antibody
Antibody type: Polyclonal
Description: KD/KO validated HSP90 antibody (Cat. #13171-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

HSP90AA1 protein structure - 13171-1-AP shown in red.

Submitted references NudC L279P Mutation Destabilizes Filamin A by Inhibiting the Hsp90 Chaperoning Pathway and Suppresses Cell Migration.

Liu M, Xu Z, Zhang C, Yang C, Feng J, Lu Y, Zhang W, Chen W, Xu X, Sun X, Yang M, Liu W, Zhou T, Yang Y
Frontiers in cell and developmental biology 2021;9:671233

Plasma HSP90AA1 Predicts the Risk of Breast Cancer Onset and Distant Metastasis.

Liu H, Zhang Z, Huang Y, Wei W, Ning S, Li J, Liang X, Liu K, Zhang L
Frontiers in cell and developmental biology 2021;9:639596

The Formation of Melanocyte Apoptotic Bodies in Vitiligo and the Relocation of Vitiligo Autoantigens under Oxidative Stress.

Tian J, Wang Y, Ding M, Zhang Y, Chi J, Wang T, Jiao B, Jian Z, Yi X, Huang Y, Liu L, Li K, Chen J, Wang G, Gao T, Li C, Li Q
Oxidative medicine and cellular longevity 2021;2021:7617839

SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation.

Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J, Cheng J, Wu X
Theranostics 2021;11(8):3981-3995

Osteosarcoma Cell-Derived Small Extracellular Vesicles Enhance Osteoclastogenesis and Bone Resorption Through Transferring MicroRNA-19a-3p.

Luo T, Zhou X, Jiang E, Wang L, Ji Y, Shang Z
Frontiers in oncology 2021;11:618662

The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum.

Wang F, Wang Q, Liu B, Mei L, Ma S, Wang S, Wang R, Zhang Y, Niu C, Xiong Z, Zheng Y, Zhang Z, Shi J, Song X
Cell death and differentiation 2021 Sep;28(9):2634-2650

Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.

Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B
Cell reports 2021 Sep 21;36(12):109742

High-dose VitC plus oncolytic adenoviruses enhance immunogenic tumor cell death and reprogram tumor immune microenvironment.

Ma J, Zhang C, Shi G, Yue D, Shu Y, Hu S, Qi Z, Chen Y, Zhang B, Zhang Y, Huang A, Su C, Zhang Y, Deng H, Cheng P
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Sep 20;

Quantitative proteomic analysis of the effects of dietary deprivation of methionine and cystine on A549 xenograft and A549 xenograft-bearing mouse.

Yang H, Zheng H, Pan Y, Zhang W, Yang M, Du H, Yu A, Li P, Chen X, Xie W, Ren K, Zhao Y, Wang T, He X, Zhou Z
Proteomics 2021 Oct;21(20):e2100007

Mt-Keima detects PINK1-PRKN mitophagy in vivo with greater sensitivity than mito-QC.

Liu YT, Sliter DA, Shammas MK, Huang X, Wang C, Calvelli H, Maric DS, Narendra DP
Autophagy 2021 Nov;17(11):3753-3762

Anakinra restores cellular proteostasis by coupling mitochondrial redox balance to autophagy.

van de Veerdonk FL, Renga G, Pariano M, Bellet MM, Servillo G, Fallarino F, De Luca A, Iannitti RG, Piobbico D, Gargaro M, Manni G, D'Onofrio F, Stincardini C, Sforna L, Borghi M, Castelli M, Pieroni S, Oikonomou V, Villella VR, Puccetti M, Giovagnoli S, Galarini R, Barola C, Maiuri L, Maria Agnese DF, Cellini B, Talesa V, Dinarello CA, Costantini C, Romani L
The Journal of clinical investigation 2021 Nov 30;

Formation and persistence of polyglutamine aggregates in mistranslating cells.

Lant JT, Kiri R, Duennwald ML, O'Donoghue P
Nucleic acids research 2021 Nov 18;49(20):11883-11899

Hsp90 and its co-chaperone Sti1 control TDP-43 misfolding and toxicity.

Lin LT, Razzaq A, Di Gregorio SE, Hong S, Charles B, Lopes MH, Beraldo F, Prado VF, Prado MAM, Duennwald ML
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 May;35(5):e21594

LIMIT is an immunogenic lncRNA in cancer immunity and immunotherapy.

Li G, Kryczek I, Nam J, Li X, Li S, Li J, Wei S, Grove S, Vatan L, Zhou J, Du W, Lin H, Wang T, Subramanian C, Moon JJ, Cieslik M, Cohen M, Zou W
Nature cell biology 2021 May;23(5):526-537

A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin_2α-induced corpus luteum regression.

Li D, Chen J, Guo J, Li L, Cai G, Chen S, Huang J, Yang H, Zhuang Y, Wang F, Wang X
eLife 2021 May 24;10

Ubc13 Promotes K63-Linked Polyubiquitination of NLRP3 to Activate Inflammasome.

Ni J, Guan C, Liu H, Huang X, Yue J, Xiang H, Jiang Z, Tao Y, Cao W, Liu J, Wang Z, Wang Y, Wu X
Journal of immunology (Baltimore, Md. : 1950) 2021 May 15;206(10):2376-2385

Inhibition of heat shock protein 90 alleviates cholestatic liver injury by decreasing IL-1β and IL-18 expression.

Tong C, Li J, Lin W, Cen W, Zhang W, Zhu Z, Lu B, Yu J
Experimental and therapeutic medicine 2021 Mar;21(3):241

Single-cell RNA sequencing reveals that targeting HSP90 suppresses PDAC progression by restraining mitochondrial bioenergetics.

Hu LP, Zhou KX, Huo YM, Liu DJ, Li Q, Yang MW, Huang PQ, Xu CJ, Tian GA, Yao LL, Zhang XL, Wang YH, Li J, Zhang ZG, Jiang SH, Xing X, Wang X, Qin WT, Yang Q
Oncogenesis 2021 Mar 3;10(3):22

Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.

Zheng S, Cao P, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X
Food & function 2021 Mar 15;12(5):2323-2334

Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.

Wang D, Yin Z, Ma L, Han L, Chen Y, Pan W, Gong K, Gao Y, Yang X, Chen Y, Han J, Duan Y
Food & function 2021 Jun 7;12(11):4842-4854

Procyanidin B2 Reduces Vascular Calcification through Inactivation of ERK1/2-RUNX2 Pathway.

Liang Y, Chen G, Zhang F, Yang X, Chen Y, Duan Y, Yu M, Zhang S, Han J
Antioxidants (Basel, Switzerland) 2021 Jun 5;10(6)

Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells.

Aaron N, Kraakman MJ, Zhou Q, Liu Q, Costa S, Yang J, Liu L, Yu L, Wang L, He Y, Fan L, Hirakawa H, Ding L, Lo J, Wang W, Zhao B, Guo E, Sun L, Rosen CJ, Qiang L
eLife 2021 Jun 22;10

UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model.

Zhang K, Wang A, Zhong K, Qi S, Wei C, Shu X, Tu WY, Xu W, Xia C, Xiao Y, Chen A, Bai L, Zhang J, Luo B, Wang W, Shen C
Neuron 2021 Jun 16;109(12):1949-1962.e6

Identification of exosome miRNAs in bronchial epithelial cells after PM2.5 chronic exposure.

Wang Y, Zhong Y, Sun K, Fan Y, Liao J, Wang G
Ecotoxicology and environmental safety 2021 Jun 1;215:112127

Zinc Alleviates Arsenic-Induced Inflammation and Apoptosis in the Head Kidney of Common Carp by Inhibiting Oxidative Stress and Endoplasmic Reticulum Stress.

Xing P, Zhang Y, Chi Q, Li S
Biological trace element research 2021 Jul 21;

LYSMD3: A mammalian pattern recognition receptor for chitin.

He X, Howard BA, Liu Y, Neumann AK, Li L, Menon N, Roach T, Kale SD, Samuels DC, Li H, Kite T, Kita H, Hu TY, Luo M, Jones CN, Okaa UJ, Squillace DL, Klein BS, Lawrence CB
Cell reports 2021 Jul 20;36(3):109392

The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer.

Qian W, Chen K, Qin T, Xiao Y, Li J, Yue Y, Zhou C, Ma J, Duan W, Lei J, Han L, Li L, Shen X, Wu Z, Ma Q, Wang Z
Journal of experimental & clinical cancer research : CR 2021 Jan 9;40(1):25

Cytoprotective Effects of Taurine on Heat-Induced Bovine Mammary Epithelial Cells In Vitro.

Bai H, Li T, Yu Y, Zhou N, Kou H, Guo Y, Yang L, Yan P
Cells 2021 Jan 28;10(2)

Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90.

Xu G, Fu S, Zhan X, Wang Z, Zhang P, Shi W, Qin N, Chen Y, Wang C, Niu M, Guo Y, Wang J, Bai Z, Xiao X
JCI insight 2021 Jan 25;6(2)

Hydrogen Peroxide-Induced Senescence Reduces the Wound Healing-Promoting Effects of Mesenchymal Stem Cell-Derived Exosomes Partially via miR-146a.

Xu M, Su X, Xiao X, Yu H, Li X, Keating A, Wang S, Zhao RC
Aging and disease 2021 Feb;12(1):102-115

CRISPR screens unveil signal hubs for nutrient licensing of T cell immunity.

Long L, Wei J, Lim SA, Raynor JL, Shi H, Connelly JP, Wang H, Guy C, Xie B, Chapman NM, Fu G, Wang Y, Huang H, Su W, Saravia J, Risch I, Wang YD, Li Y, Niu M, Dhungana Y, Kc A, Zhou P, Vogel P, Yu J, Pruett-Miller SM, Peng J, Chi H
Nature 2021 Dec;600(7888):308-313

Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues.

Xu Y, Shi T, Cui X, Yan L, Wang Q, Xu X, Zhao Q, Xu X, Tang QQ, Tang H, Pan D
The EMBO journal 2021 Dec 15;40(24):e108069

PWWP2B Fine-Tunes Adipose Thermogenesis by Stabilizing HDACs in a NuRD Subcomplex.

Yan L, Jin W, Zhao Q, Cui X, Shi T, Xu Y, Li F, Jin W, Zhang Z, Zhang Z, Tang QQ, Pan D
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Aug;8(16):e2102060

Exosomal miR-193b-5p as a regulator of LPS-induced inflammation in dairy cow mammary epithelial cells.

Xu H, Zhang T, Hu X, Xie Y, Wu R, Lian S, Wang J
In vitro cellular & developmental biology. Animal 2021 Aug;57(7):695-703

Augmentation of the heat shock axis during exceptional longevity in Ames dwarf mice.

Trivedi R, Knopf B, Tripathi JK, Rakoczy S, Manocha GD, Brown-Borg H, Jurivich DA
GeroScience 2021 Aug;43(4):1921-1934

Amiodarone, Unlike Dronedarone, Activates Inflammasomes via Its Reactive Metabolites: Implications for Amiodarone Adverse Reactions.

Kato R, Ijiri Y, Hayashi T
Chemical research in toxicology 2021 Aug 16;34(8):1860-1865

Lamin-A interacting protein Hsp90 is required for DNA damage repair and chemoresistance of ovarian cancer cells.

Wang Y, Chen Q, Wu D, Chen Q, Gong G, He L, Wu X
Cell death & disease 2021 Aug 12;12(8):786

Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect.

Zhu D, Li S, Chen C, Wang S, Zhu J, Kong L, Luo J
Pharmacological research 2021 Apr;166:105523

Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction.

Kato R, Ijiri Y, Hayashi T, Uetrecht J
The Journal of toxicological sciences 2020;45(11):673-680

OSCC Exosomes Regulate miR-210-3p Targeting EFNA3 to Promote Oral Cancer Angiogenesis through the PI3K/AKT Pathway.

Wang H, Wang L, Zhou X, Luo X, Liu K, Jiang E, Chen Y, Shao Z, Shang Z
BioMed research international 2020;2020:2125656

17-Allylamino-Demethoxygeldanamycin Ameliorate Microthrombosis Via HSP90/RIP3/NLRP3 Pathway After Subarachnoid Hemorrhage in Rats.

Zuo Y, He T, Liao P, Zhuang K, Yan X, Liu F
Acta neurochirurgica. Supplement 2020;127:69-75

Influenza A Virus Induces Autophagy by Its Hemagglutinin Binding to Cell Surface Heat Shock Protein 90AA1.

Wang X, Zheng T, Lin L, Zhang Y, Peng X, Yan Y, Lei J, Zhou J, Hu B
Frontiers in microbiology 2020;11:566348

The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer.

Chou CW, Yang RY, Chan LC, Li CF, Sun L, Lee HH, Lee PC, Sher YP, Ying H, Hung MC
American journal of cancer research 2020;10(8):2621-2634

Hsp90 inhibitor HSP990 in very low dose upregulates EAAT2 and exerts potent antiepileptic activity.

Sha L, Chen T, Deng Y, Du T, Ma K, Zhu W, Shen Y, Xu Q
Theranostics 2020;10(18):8415-8429

Multifactorial Attenuation of the Murine Heat Shock Response With Age.

Jurivich DA, Manocha GD, Trivedi R, Lizakowski M, Rakoczy S, Brown-Borg H
The journals of gerontology. Series A, Biological sciences and medical sciences 2020 Sep 25;75(10):1846-1852

Heat shock protein 90 inhibitors suppress pyroptosis in THP-1 cells.

Zhou Z, Li X, Qian Y, Liu C, Huang X, Fu M
The Biochemical journal 2020 Oct 30;477(20):3923-3934

Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer.

Zhang P, Li C, Li H, Yuan L, Dai H, Peng Z, Deng Z, Chang Z, Cui CP, Zhang L
Cell death and differentiation 2020 Nov;27(11):3177-3195

Inhibitory effect of edible natural compounds with di- and tri-carboxyl moiety on endogenous protease inducing disassembly and degradation of myofibrils from grass carp (Ctenopharyngodon idella).

Ge L, Zhao N, Miao Y, Zhang S, Zhao M, Luo Y, Lai H, Huang Y, Wang Y
Food research international (Ottawa, Ont.) 2020 Nov;137:109457

CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.

Shen Y, Zou Y, Li J, Chen F, Li H, Cai Y
International journal of molecular sciences 2020 Nov 9;21(21)

Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.

Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882

Exogenous spermine attenuates rat diabetic cardiomyopathy via suppressing ROS-p53 mediated downregulation of calcium-sensitive receptor.

Wang Y, Chen J, Li S, Zhang X, Guo Z, Hu J, Shao X, Song N, Zhao Y, Li H, Yang G, Xu C, Wei C
Redox biology 2020 May;32:101514

Light-activated oxygen self-supplied starving therapy in near-infrared (NIR) window and adjuvant hyperthermia-induced tumor ablation with an augmented sensitivity.

Ren J, Zhang L, Zhang J, Zhang W, Cao Y, Xu Z, Cui H, Kang Y, Xue P
Biomaterials 2020 Mar;234:119771

LongShengZhi capsule inhibits doxorubicin-induced heart failure by anti-oxidative stress.

Xu S, Wang Y, Yu M, Wang D, Liang Y, Chen Y, Liao C, Xie Z, Zhao B, Han J, Duan Y, Yang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Mar;123:109803

Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC.

Guo Y, Wang J, Zhou K, Lv J, Wang L, Gao S, Keller ET, Zhang ZS, Wang Q, Yao Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7927-7940

The Activation of Heat-Shock Protein After Copper(II) and/or Arsenic(III)-Induced Imbalance of Homeostasis, Inflammatory Response in Chicken Rectum.

Yang X, Zhao H, Wang Y, Liu J, Guo M, Fei D, Mu M, Xing M
Biological trace element research 2020 Jun;195(2):613-623

Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.

Liu YT, Huang X, Nguyen D, Shammas MK, Wu BP, Dombi E, Springer DA, Poulton J, Sekine S, Narendra DP
Human molecular genetics 2020 Jun 3;29(9):1547-1567

Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.

Di Nardo A, Lenoël I, Winden KD, Rühmkorf A, Modi ME, Barrett L, Ercan-Herbst E, Venugopal P, Behne R, Lopes CAM, Kleiman RJ, Bettencourt-Dias M, Sahin M
Cell reports 2020 Jun 23;31(12):107780

SIRT2 suppresses expression of inflammatory factors via Hsp90-glucocorticoid receptor signalling.

Sun K, Wang X, Fang N, Xu A, Lin Y, Zhao X, Nazarali AJ, Ji S
Journal of cellular and molecular medicine 2020 Jul;24(13):7439-7450

NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90.

Chen W, Wang W, Sun X, Xie S, Xu X, Liu M, Yang C, Li M, Zhang W, Liu W, Wang L, Zhou T, Yang Y
Cell death & disease 2020 Jul 14;11(7):534

Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways.

Zhang X, Chen B, Wu J, Sha J, Yang B, Zhu J, Sun J, Hartung J, Bao E
Cells 2020 Jan 18;9(1)

Hsp90 Relieves Heat Stress-Induced Damage in Mouse Kidneys: Involvement of Antiapoptotic PKM2-AKT and Autophagic HIF-1α Signaling.

Chen B, Yang B, Zhu J, Wu J, Sha J, Sun J, Bao E, Zhang X
International journal of molecular sciences 2020 Feb 28;21(5)

Zinc application alleviates the adverse renal effects of arsenic stress in a protein quality control way in common carp.

Wang Y, Zhao H, Nie X, Guo M, Jiang G, Xing M
Environmental research 2020 Dec;191:110063

Dual-specificity phosphatase 29 is induced during neurogenic skeletal muscle atrophy and attenuates glucocorticoid receptor activity in muscle cell culture.

Cooper LM, West RC, Hayes CS, Waddell DS
American journal of physiology. Cell physiology 2020 Aug 1;319(2):C441-C454

Carnosol inhibits inflammasome activation by directly targeting HSP90 to treat inflammasome-mediated diseases.

Shi W, Xu G, Zhan X, Gao Y, Wang Z, Fu S, Qin N, Hou X, Ai Y, Wang C, He T, Liu H, Chen Y, Liu Y, Wang J, Niu M, Guo Y, Xiao X, Bai Z
Cell death & disease 2020 Apr 20;11(4):252

The 2-Hydroxyiminostilbene Metabolite of Carbamazepine or the Supernatant from Incubation of Hepatocytes with Carbamazepine Activates Inflammasomes: Implications for Carbamazepine-Induced Hypersensitivity Reactions.

Kato R, Ijiri Y, Hayashi T, Uetrecht J
Drug metabolism and disposition: the biological fate of chemicals 2019 Oct;47(10):1093-1096

The LIV-1-GRPEL1 axis adjusts cell fate during anti-mitotic agent-damaged mitosis.

Chen P, Wang B, Mo Q, Wu P, Fang Y, Tian Y, Jin X, Gao Y, Wu Y, Cao Y, Zhang Y, Xi L, Wang S, Hu J, Ma D, Zhou J, Gao Q, Chen G
EBioMedicine 2019 Nov;49:26-39

First Insights on the Presence of the Unfolded Protein Response in Human Spermatozoa.

Santiago J, Silva JV, Fardilha M
International journal of molecular sciences 2019 Nov 5;20(21)

Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent.

Hong W, Guo F, Yang M, Xu D, Zhuang Z, Niu B, Bai Q, Li X
Lipids in health and disease 2019 Nov 22;18(1):203

A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network.

Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL
iScience 2019 Jun 28;16:177-191

Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system.

Rinaldi L, Delle Donne R, Catalanotti B, Torres-Quesada O, Enzler F, Moraca F, Nisticò R, Chiuso F, Piccinin S, Bachmann V, Lindner HH, Garbi C, Scorziello A, Russo NA, Synofzik M, Stelzl U, Annunziato L, Stefan E, Feliciello A
Nature communications 2019 Jun 12;10(1):2572

Identification and validation of circulating exosomes-based liquid biopsy for esophageal cancer.

Zhao A, Guo L, Xu J, Zheng L, Guo Z, Ling Z, Wang L, Mao W
Cancer medicine 2019 Jul;8(7):3566-3574

Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum.

Niu L, Ma T, Yang F, Yan B, Tang X, Yin H, Wu Q, Huang Y, Yao ZP, Wang J, Guo Y, Hu J
Proceedings of the National Academy of Sciences of the United States of America 2019 Jul 9;116(28):14029-14038

Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons.

Wang S, Huang Y, Yan Y, Zhou H, Wang M, Liao L, Wang Z, Chen D, Ji D, Xia X, Liu F, Huang J, Xiong K
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 2019 Jan;221:57-67

Chaperone-mediated autophagy is involved in the execution of ferroptosis.

Wu Z, Geng Y, Lu X, Shi Y, Wu G, Zhang M, Shan B, Pan H, Yuan J
Proceedings of the National Academy of Sciences of the United States of America 2019 Feb 19;116(8):2996-3005

Cross-Species Suppression of Hepatoma Cell Growth and Migration by a Schistosoma japonicum MicroRNA.

Lin Y, Zhu S, Hu C, Wang J, Jiang P, Zhu L, Li Z, Wang S, Zhang Y, Xu X, Pan W
Molecular therapy. Nucleic acids 2019 Dec 6;18:400-412

Vesicular Stomatitis Virus Transcription Is Inhibited by TRIM69 in the Interferon-Induced Antiviral State.

Kueck T, Bloyet LM, Cassella E, Zang T, Schmidt F, Brusic V, Tekes G, Pornillos O, Whelan SPJ, Bieniasz PD
Journal of virology 2019 Dec 15;93(24)

KRAB-Zinc Finger Protein ZNF268a Deficiency Attenuates the Virus-Induced Pro-Inflammatory Response by Preventing IKK Complex Assembly.

Liu Y, Yin W, Wang J, Lei Y, Sun G, Li W, Huang Z, Guo M
Cells 2019 Dec 10;8(12)

SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.

Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J
Molecular cell 2019 Aug 22;75(4):823-834.e5

Porcine Reproductive and Respiratory Syndrome Virus nsp11 Antagonizes Type I Interferon Signaling by Targeting IRF9.

Wang D, Chen J, Yu C, Zhu X, Xu S, Fang L, Xiao S
Journal of virology 2019 Aug 1;93(15)

Visualizing tRNA-dependent mistranslation in human cells.

Lant JT, Berg MD, Sze DHW, Hoffman KS, Akinpelu IC, Turk MA, Heinemann IU, Duennwald ML, Brandl CJ, O'Donoghue P
RNA biology 2018;15(4-5):567-575

KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.

Xu W, Zhou B, Zhao X, Zhu L, Xu J, Jiang Z, Chen D, Wei Q, Han M, Feng L, Wang S, Wang X, Zhou J, Jin H
International journal of biological sciences 2018;14(9):1122-1132

Inhibition of Heat Shock Protein 90 by 17-AAG Reduces Inflammation via P2X7 Receptor/NLRP3 Inflammasome Pathway and Increases Neurogenesis After Subarachnoid Hemorrhage in Mice.

Zuo Y, Wang J, Liao F, Yan X, Li J, Huang L, Liu F
Frontiers in molecular neuroscience 2018;11:401

Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells.

Gao P, Wang X, Jin Y, Hu W, Duan Y, Shi A, Du Y, Song D, Yang M, Li S, Han B, Zhao G, Zhang H, Fan Z, Miao QR
Breast cancer research : BCR 2018 Sep 12;20(1):112

Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase.

Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T, Yanai K, Taki H, Kanai H, Osumi N, Shimokawa H
Brain stimulation 2018 Sep - Oct;11(5):959-973

Melanoma cell-secreted exosomal miR-155-5p induce proangiogenic switch of cancer-associated fibroblasts via SOCS1/JAK2/STAT3 signaling pathway.

Zhou X, Yan T, Huang C, Xu Z, Wang L, Jiang E, Wang H, Chen Y, Liu K, Shao Z, Shang Z
Journal of experimental & clinical cancer research : CR 2018 Oct 3;37(1):242

Impacts of simultaneous exposure to arsenic (III) and copper (II) on inflammatory response, immune homeostasis, and heat shock response in chicken thymus.

Liu J, Zhao H, Wang Y, Shao Y, Zhang L, Xing M
International immunopharmacology 2018 Nov;64:60-68

Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4.

Jia W, Zhao X, Zhao L, Yan H, Li J, Yang H, Huang G, Liu J
Oncogene 2018 Mar;37(13):1685-1698

Arsenic and/or copper caused inflammatory response via activation of inducible nitric oxide synthase pathway and triggered heat shock protein responses in testis tissues of chicken.

Shao Y, Zhao H, Wang Y, Liu J, Li J, Chai H, Xing M
Environmental science and pollution research international 2018 Mar;25(8):7719-7729

Intestinal Epithelial Cell-Derived LKB1 Suppresses Colitogenic Microbiota.

Liu X, Lu J, Liu Z, Zhao J, Sun H, Wu N, Liu H, Liu W, Hu Z, Meng G, Shen L, Miller AW, Su B, Li X, Kang Z
Journal of immunology (Baltimore, Md. : 1950) 2018 Mar 1;200(5):1889-1900

Inhibition of HSP90α protects cultured neurons from oxygen-glucose deprivation induced necroptosis by decreasing RIP3 expression.

Wang Z, Guo LM, Wang Y, Zhou HK, Wang SC, Chen D, Huang JF, Xiong K
Journal of cellular physiology 2018 Jun;233(6):4864-4884

HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma.

Xiao X, Wang W, Li Y, Yang D, Li X, Shen C, Liu Y, Ke X, Guo S, Guo Z
Journal of experimental & clinical cancer research : CR 2018 Aug 28;37(1):201

A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans.

Jiang W, Wei Y, Long Y, Owen A, Wang B, Wu X, Luo S, Dang Y, Ma DK
eLife 2018 Apr 17;7

Nogo-B receptor increases the resistance of estrogen receptor positive breast cancer to paclitaxel.

Jin Y, Hu W, Liu T, Rana U, Aguilera-Barrantes I, Kong A, Kumar SN, Wang B, Gao P, Wang X, Duan Y, Shi A, Song D, Yang M, Li S, Han B, Zhao G, Fan Z, Miao QR
Cancer letters 2018 Apr 10;419:233-244

HAX-1 Protects Glioblastoma Cells from Apoptosis through the Akt1 Pathway.

Deng X, Song L, Zhao W, Wei Y, Guo XB
Frontiers in cellular neuroscience 2017;11:420

Assessment of arsenic trioxide toxicity on cock muscular tissue: alterations of oxidative damage parameters, inflammatory cytokines and heat shock proteins.

Li SW, Guo Y, He Y, Sun X, Zhao HJ, Wang Y, Wang YJ, Xing MW
Ecotoxicology (London, England) 2017 Oct;26(8):1078-1088

Jolkinolide B induces apoptosis of colorectal carcinoma through ROS-ER stress-Ca²⁺-mitochondria dependent pathway.

Zhang J, Wang Y, Zhou Y, He QY
Oncotarget 2017 Oct 31;8(53):91223-91237

LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection.

Liu W, Liu X, Li Y, Zhao J, Liu Z, Hu Z, Wang Y, Yao Y, Miller AW, Su B, Cookson MR, Li X, Kang Z
The Journal of experimental medicine 2017 Oct 2;214(10):3051-3066

Proteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats.

Zeng HL, Yang Q, Du H, Li H, Shen Y, Liu T, Chen X, Kamal GM, Guan Q, Cheng L, Wang J, Xu F
Oncotarget 2017 Nov 24;8(60):102020-102032

Copper or/and arsenic induce oxidative stress-cascaded, nuclear factor kappa B-dependent inflammation and immune imbalance, trigging heat shock response in the kidney of chicken.

Wang Y, Zhao H, Shao Y, Liu J, Li J, Xing M
Oncotarget 2017 Nov 17;8(58):98103-98116

Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.

Zhang F, Hao M, Jin H, Yao Z, Lian N, Wu L, Shao J, Chen A, Zheng S
British journal of pharmacology 2017 Mar;174(5):409-423

Identification of two p53 isoforms from Litopenaeus vannamei and their interaction with NF-κB to induce distinct immune response.

Li H, Wang S, Chen Y, Lǚ K, Yin B, Li S, He J, Li C
Scientific reports 2017 Mar 31;7:45821

Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins.

Li R, Yuan F, Fu W, Zhang L, Zhang N, Wang Y, Ma K, Li X, Wang L, Zhu WG, Zhao Y
The Journal of biological chemistry 2017 Feb 17;292(7):2830-2841

Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.

Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314

Synergistic inhibition of tumor growth by combination treatment with drugs against different subpopulations of glioblastoma cells.

Chang CH, Liu WT, Hung HC, Gean CY, Tsai HM, Su CL, Gean PW
BMC cancer 2017 Dec 29;17(1):905

Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells.

Sun B, Bai Y, Zhang L, Gong L, Qi X, Li H, Wang F, Chi X, Jiang Y, Shao S
PloS one 2016;11(9):e0163622

SILAC-based quantitative proteomic analysis of secretome of Marc-145 cells infected with porcine reproductive and respiratory syndrome virus.

Zhao F, Fang L, Wang D, Song T, Wang T, Xin Y, Chen H, Xiao S
Proteomics 2016 Oct;16(20):2678-2687

Cytoskeleton-centric protein transportation by exosomes transforms tumor-favorable macrophages.

Chen Z, Yang L, Cui Y, Zhou Y, Yin X, Guo J, Zhang G, Wang T, He QY
Oncotarget 2016 Oct 11;7(41):67387-67402

Geldanamycin, an inhibitor of Hsp90, increases paclitaxel-mediated toxicity in ovarian cancer cells through sustained activation of the p38/H2AX axis.

Mo Q, Zhang Y, Jin X, Gao Y, Wu Y, Hao X, Gao Q, Chen P
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Nov;37(11):14745-14755

Exogenous Estradiol Benzoate Induces Spermatogenesis Disorder through Influencing Apoptosis and Oestrogen Receptor Signalling Pathway.

Lei X, Cui K, Liu Q, Zhang H, Li Z, Huang B, Shi D
Reproduction in domestic animals = Zuchthygiene 2016 Feb;51(1):75-84

Bioinformatics analysis of proteomics profiles in senescent human primary proximal tubule epithelial cells.

Lu Y, Wang J, Dapeng C, Wu D, Cai G, Chen X
BMC nephrology 2016 Apr 1;17:39

Changes in gene expression and content of Hsp70 and Hsp90 in striated muscles of mice after 30-day space flight on the biosatellite Bion-M1.

Gritsyna YV, Abdusalamova ZR, Vikhlyantsev IM, Ulanova AD, Shenkman BS, Podlubnaya ZA, Kozlovskaya IB
Doklady. Biochemistry and biophysics 2015;463:199-202

Tom70 mediates Sendai virus-induced apoptosis on mitochondria.

Wei B, Cui Y, Huang Y, Liu H, Li L, Li M, Ruan KC, Zhou Q, Wang C
Journal of virology 2015 Apr;89(7):3804-18

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis.

Li D, Xu T, Cao Y, Wang H, Li L, Chen S, Wang X, Shen Z
Proceedings of the National Academy of Sciences of the United States of America 2015 Apr 21;112(16):5017-22

Dynamic expression patterns of differential proteins during early invasion of hepatocellular carcinoma.

Chen RX, Song HY, Dong YY, Hu C, Zheng QD, Xue TC, Liu XH, Zhang Y, Chen J, Ren ZG, Liu YK, Cui JF
PloS one 2014;9(3):e88543

Identification of Hsf1 as a novel androgen receptor-regulated gene in mouse Sertoli cells.

Yang L, Wang Y, Zhang Q, Lai Y, Li C, Zhang Q, Huang W, Duan Y, Jiang Z, Li X, Cai Z, Mou L, Gui Y
Molecular reproduction and development 2014 Jun;81(6):514-23

PP2A-AMPKα-HSF1 axis regulates the metal-inducible expression of HSPs and ROS clearance.

Zhu XN, Chen LP, Bai Q, Ma L, Li DC, Zhang JM, Gao C, Lei ZN, Zhang ZB, Xing XM, Liu CX, He ZN, Li J, Xiao YM, Zhang AH, Zeng XW, Chen W
Cellular signalling 2014 Apr;26(4):825-32

Tom70 mediates activation of interferon regulatory factor 3 on mitochondria.

Liu XY, Wei B, Shi HX, Shan YF, Wang C
Cell research 2010 Sep;20(9):994-1011

Salivary monitoring related to major surgery.

Ullmann Y, Klein Y, Savulescu D, Borovoi I, Egozi D, Gavish M, Nagler R
European journal of clinical investigation 2010 Dec;40(12):1074-80

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: K-562 cells were subjected to SDS PAGE followed by western blot with 13171-1-AP(HSP90 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using HSP90AA1 antibody 13171-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-HSP90 (IP:13171-1-AP, 3ug; Detection:13171-1-AP 1:500) with K-562 cells lysate 2000ug.
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver cancer using 13171-1-AP(HSP90 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human liver cancer using 13171-1-AP(HSP90 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue