ABIN266969

antibody from antibodies-online

Targeting: HSP90AA1 FLJ31884, Hsp89, Hsp90, HSP90N, HSPC1, HSPCA

Western blot (Supportive data in Antibodypedia)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

ABIN266969

Provider

antibodies-online

Product name

anti-Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 2 (HSP90AA2) antibody

Antibody type

Polyclonal

Description

Immunogen affinity purified

Reactivity

Human, Mouse, Rat, Rabbit, Sheep, Simian

Host

Rabbit

Isotype

IgG

Vial size

0.1 mg

Storage

Store at -20°C. Avoid freeze-thaw cycles.

Handling

Avoid freeze-thaw cycles

References

Submitted references

Tumor-targeted SN38 inhibits growth of early stage non-small cell lung cancer (NSCLC) in a KRas/p53 transgenic mouse model.

Deneka AY, Haber L, Kopp MC, Gaponova AV, Nikonova AS, Golemis EA
PloS one 2017;12(4):e0176747

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Inhibiting heat shock protein 90 (HSP90) limits the formation of liver cysts induced by conditional deletion of Pkd1 in mice.

Smithline ZB, Nikonova AS, Hensley HH, Cai KQ, Egleston BL, Proia DA, Seeger-Nukpezah T, Golemis EA
PloS one 2014;9(12):e114403

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Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease.

Seeger-Nukpezah T, Proia DA, Egleston BL, Nikonova AS, Kent T, Cai KQ, Hensley HH, Ying W, Chimmanamada D, Serebriiskii IG, Golemis EA
Proceedings of the National Academy of Sciences of the United States of America 2013 Jul 30;110(31):12786-91

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KU135, a novel novobiocin-derived C-terminal inhibitor of the 90-kDa heat shock protein, exerts potent antiproliferative effects in human leukemic cells.

Shelton SN, Shawgo ME, Matthews SB, Lu Y, Donnelly AC, Szabla K, Tanol M, Vielhauer GA, Rajewski RA, Matts RL, Blagg BS, Robertson JD
Molecular pharmacology 2009 Dec;76(6):1314-22

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A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.

De Nardo D, Masendycz P, Ho S, Cross M, Fleetwood AJ, Reynolds EC, Hamilton JA, Scholz GM
The Journal of biological chemistry 2005 Mar 18;280(11):9813-22

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Zonal expression of endothelial nitric oxide synthase in sheep and rhesus adrenal cortex.

Peterson JK, Moran F, Conley AJ, Bird IM
Endocrinology 2001 Dec;142(12):5351-63

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Localization and characterization of the 86- and 84-kDa heat shock proteins in Hepa 1c1c7 cells.

Perdew GH, Hord N, Hollenback CE, Welsh MJ
Experimental cell research 1993 Dec;209(2):350-6

Western blot

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

WB

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

WB

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

WB

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

WB

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

WB

Immunoprecipitation

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

IP

Immunohistochemistry

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

IHC

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

IHC

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

IHC

Supportive validation

Submitted by

antibodies-online (provider)

Main image

Experimental details

IHC