304826
antibody from BioLegend
Targeting: SELL
CD62L, hLHRc, LAM-1, LAM1, Leu-8, LNHR, LSEL, Lyam-1, LYAM1, PLNHR
Antibody data
- Antibody Data
- Antigen structure
- References [4]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 304826 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#304826, RRID:AB_2186977
- Product name
- Pacific Blue™ anti-human CD62L [DREG-56]
- Antibody type
- Monoclonal
- Antigen
- CD62L
- Description
- CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis x (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naive lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.
- Reactivity
- Human, Bovine, Simian
- Host
- Mouse
- Conjugate
- Blue dye
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Ly6G+ neutrophils are dispensable for defense against systemic Listeria monocytogenes infection.
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function.
Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination.
Shi C, Hohl TM, Leiner I, Equinda MJ, Fan X, Pamer EG
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 15;187(10):5293-8
Journal of immunology (Baltimore, Md. : 1950) 2011 Nov 15;187(10):5293-8
Basophils and the T helper 2 environment can promote the development of lupus nephritis.
Charles N, Hardwick D, Daugas E, Illei GG, Rivera J
Nature medicine 2010 Jun;16(6):701-7
Nature medicine 2010 Jun;16(6):701-7
Human T cells express CD25 and Foxp3 upon activation and exhibit effector/memory phenotypes without any regulatory/suppressor function.
Kmieciak M, Gowda M, Graham L, Godder K, Bear HD, Marincola FM, Manjili MH
Journal of translational medicine 2009 Oct 22;7:89
Journal of translational medicine 2009 Oct 22;7:89
Differential expression of the human CD8beta splice variants and regulation of the M-2 isoform by ubiquitination.
Thakral D, Dobbins J, Devine L, Kavathas PB
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7431-42
Journal of immunology (Baltimore, Md. : 1950) 2008 Jun 1;180(11):7431-42
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Supportive validation
- Submitted by
- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with DREG-56 Pacific Blue™
- Conjugate
- Blue dye