Antibody data
- Antibody Data
- Antigen structure
- References [43]
- Comments [0]
- Validations [0]
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- Product number
- 28459-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Collagen Type II antibody
- Antibody type
- Polyclonal
- Description
- Collagen Type II antibody (Cat. #28459-1-AP) is a rabbit polyclonal antibody that shows reactivity with Human and has been validated for the following applications: IHC,ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Folic Acid Inhibits Aging-Induced Telomere Attrition and Apoptosis in Astrocytes In Vivo and In Vitro.
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Deletion of p16 accelerates fracture healing in geriatric mice.
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Maresin-1 suppresses IL-1β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction.
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen.
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects.
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Silencing LCK inactivates the NF-κB pathway to attenuate cartilage injury in osteoarthritis: an in vivo and in vitro study.
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Simultaneous Recruitment of Stem Cells and Chondrocytes Induced by a Functionalized Self-Assembling Peptide Hydrogel Improves Endogenous Cartilage Regeneration.
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound.
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
MSCs reduce airway remodeling in the lungs of asthmatic rats through the Wnt/β-catenin signaling pathway.
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
L-polylactic acid porous microspheres enhance the mechanical properties and in vivo stability of degummed silk/silk fibroin/gelatin scaffold.
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Overexpression of miR-10a-5p facilitates the progression of osteoarthritis.
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Li Z, Zhou D, Zhang D, Zhao J, Li W, Sun Y, Chen Y, Liu H, Wilson JX, Qian Z, Huang G
Cerebral cortex (New York, N.Y. : 1991) 2022 Jan 10;32(2):286-297
Cerebral cortex (New York, N.Y. : 1991) 2022 Jan 10;32(2):286-297
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Lin Z, Ni L, Teng C, Zhang Z, Wu L, Jin Y, Lu X, Lin Z
Frontiers in cell and developmental biology 2021;9:745621
Frontiers in cell and developmental biology 2021;9:745621
Reducing Inflammation and Vascular Invasion in Intervertebral Disc Degeneration via Cystathionine-γ-Lyase Inhibitory Effect on E-Selectin.
Xu H, Wei K, Tu J, Chen Y, He Y, Ding Y, Xu H, Bao X, Xie H, Fang H, Wang H
Frontiers in cell and developmental biology 2021;9:741046
Frontiers in cell and developmental biology 2021;9:741046
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201
Frontiers in cell and developmental biology 2021;9:648201
Exosomes Isolated From Bone Marrow Mesenchymal Stem Cells Exert a Protective Effect on Osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p.
Wang X, Li Z, Cui Y, Cui X, Chen C, Wang Z
Frontiers in cell and developmental biology 2021;9:644380
Frontiers in cell and developmental biology 2021;9:644380
Autophagic Degradation of Gasdermin D Protects against Nucleus Pulposus Cell Pyroptosis and Retards Intervertebral Disc Degeneration In Vivo.
Liao Z, Li S, Liu R, Feng X, Shi Y, Wang K, Li S, Zhang Y, Wu X, Yang C
Oxidative medicine and cellular longevity 2021;2021:5584447
Oxidative medicine and cellular longevity 2021;2021:5584447
MCC950, the NLRP3 Inhibitor, Protects against Cartilage Degradation in a Mouse Model of Osteoarthritis.
Ni B, Pei W, Qu Y, Zhang R, Chu X, Wang Y, Huang X, You H
Oxidative medicine and cellular longevity 2021;2021:4139048
Oxidative medicine and cellular longevity 2021;2021:4139048
Aberrant Fluid Shear Stress Contributes to Articular Cartilage Pathogenesis via Epigenetic Regulation of ZBTB20 by H3K4me3.
Jin Y, Li Z, Wu Y, Li H, Liu Z, Liu L, Ouyang N, Zhou T, Fang B, Xia L
Journal of inflammation research 2021;14:6067-6083
Journal of inflammation research 2021;14:6067-6083
Deletion of p16 accelerates fracture healing in geriatric mice.
Ding Q, Liu H, Liu L, Ma C, Qin H, Wei Y, Ren Y
American journal of translational research 2021;13(10):11107-11125
American journal of translational research 2021;13(10):11107-11125
Microbial Metabolite Sodium Butyrate Attenuates Cartilage Degradation by Restoring Impaired Autophagy and Autophagic Flux in Osteoarthritis Development.
Zhou H, Li G, Wang Y, Jiang R, Li Y, Wang H, Wang F, Ma H, Cao L
Frontiers in pharmacology 2021;12:659597
Frontiers in pharmacology 2021;12:659597
Maresin-1 suppresses IL-1β-induced MMP-13 secretion by activating the PI3K/AKT pathway and inhibiting the NF-κB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise.
Lu J, Feng X, Zhang H, Wei Y, Yang Y, Tian Y, Bai L
Connective tissue research 2021 Sep;62(5):508-518
Connective tissue research 2021 Sep;62(5):508-518
Combination of graphene oxide and platelet-rich plasma improves tendon-bone healing in a rabbit model of supraspinatus tendon reconstruction.
Bao D, Sun J, Gong M, Shi J, Qin B, Deng K, Liu G, Zeng S, Xiang Z, Fu S
Regenerative biomaterials 2021 Oct;8(6):rbab045
Regenerative biomaterials 2021 Oct;8(6):rbab045
The biological effect of cobalt chloride mimetic-hypoxia on nucleus pulposus cells and the comparability with physical hypoxia in vitro.
Gao XX, Liu CH, Hu ZL, Li HY, Chang X, Li YY, Zhang YY, Zhai Y, Li CQ
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Frontiers in bioscience (Landmark edition) 2021 Oct 30;26(10):799-812
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Li S, Liu J, Liu S, Jiao W, Wang X
Journal of nanobiotechnology 2021 Oct 26;19(1):343
Journal of nanobiotechnology 2021 Oct 26;19(1):343
SP600125 Restored TNF-α-Induced Impaired Chondrogenesis in Bone Mesenchymal Stem Cells and Its Antiosteoarthritis Effect in Mice.
Ding N, Zeng MY, Song WJ, Xiao CX, Li EM, Wei B
Stem cells and development 2021 Oct 15;30(20):1028-1036
Stem cells and development 2021 Oct 15;30(20):1028-1036
Interleukin‑Iβ promotes cartilage degeneration by regulating forkhead box protein O4 and type Ⅱ collagen.
Wu J, Zhang H, Deng R, Xing L, Hu M, Fu X
Molecular medicine reports 2021 Nov;24(5)
Molecular medicine reports 2021 Nov;24(5)
LncRNA NONHSAT030515 promotes the chondrogenic differentiation of human adipose-derived stem cells via regulating the miR-490-5p/BMPR2 axis.
Yang Q, Guo J, Ren Z, Li B, Huang H, Yang Z
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Journal of orthopaedic surgery and research 2021 Nov 6;16(1):658
Hyaluronic acid hydrogel encapsulated BMP-14-modified ADSCs accelerate cartilage defect repair in rabbits.
Liu H, Rui Y, Liu J, Gao F, Jin Y
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
Journal of orthopaedic surgery and research 2021 Nov 3;16(1):657
SNHG16/miR-485-5p/BMP7 axis modulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells.
Asila A, Yang X, Kaisaer Y, Ma L
The journal of gene medicine 2021 Mar;23(3):e3296
The journal of gene medicine 2021 Mar;23(3):e3296
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Comparison of chondrogenesis-related biological behaviors between human urine-derived stem cells and human bone marrow mesenchymal stem cells from the same individual.
Sun J, Xing F, Zou M, Gong M, Li L, Xiang Z
Stem cell research & therapy 2021 Jun 28;12(1):366
Stem cell research & therapy 2021 Jun 28;12(1):366
Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.
Wu Y, Hong Z, Xu W, Chen J, Wang Q, Chen J, Ni W, Mei Z, Xie Z, Ma Y, Wang J, Lu J, Chen C, Fan S, Shen S
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):308-323
Molecular therapy : the journal of the American Society of Gene Therapy 2021 Jan 6;29(1):308-323
Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration.
Guo Z, Qiu C, Mecca C, Zhang Y, Bian J, Wang Y, Wu X, Wang T, Su W, Li X, Zhang W, Chen B, Xiang H
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
BMC musculoskeletal disorders 2021 Jan 13;22(1):77
Silencing BLNK protects against interleukin-1β-induced chondrocyte injury through the NF-κB signaling pathway.
Cheng Y, Li F, Zhang WS, Zou GY, Shen YX
Cytokine 2021 Dec;148:155686
Cytokine 2021 Dec;148:155686
The characterization, cytotoxicity, macrophage response and tissue regeneration of decellularized cartilage in costal cartilage defects.
Changchen W, Hongquan W, Bo Z, Leilei X, Haiyue J, Bo P
Acta biomaterialia 2021 Dec;136:147-158
Acta biomaterialia 2021 Dec;136:147-158
Role of the hippo signaling pathway in the extracellular matrix degradation of chondrocytes induced by fluoride exposure.
Yu FF, Zuo J, Fu X, Gao MH, Sun L, Yu SY, Li Z, Zhou GY, Ba Y
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Ecotoxicology and environmental safety 2021 Dec 1;225:112796
Sulforaphane protects against oxidative stress‑induced apoptosis via activating SIRT1 in mouse osteoarthritis.
Chen M, Huang L, Lv Y, Li L, Dong Q
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Silencing LCK inactivates the NF-κB pathway to attenuate cartilage injury in osteoarthritis: an in vivo and in vitro study.
Chen X, Li Y, Zhang M, Wu X, Zhu J
The journal of gene medicine 2021 Aug 10;:e3387
The journal of gene medicine 2021 Aug 10;:e3387
ZIP8 mediates the extracellular matrix degradation of nucleus pulposus cells via NF-κB signaling pathway.
Ding W, Ge Y, Sun H, Xu J, Gu H, Bian C, Chen H, Jiang L, Yin X
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Biochemical and biophysical research communications 2021 Apr 23;550:30-36
Simultaneous Recruitment of Stem Cells and Chondrocytes Induced by a Functionalized Self-Assembling Peptide Hydrogel Improves Endogenous Cartilage Regeneration.
Lv X, Sun C, Hu B, Chen S, Wang Z, Wu Q, Fu K, Xia Z, Shao Z, Wang B
Frontiers in cell and developmental biology 2020;8:864
Frontiers in cell and developmental biology 2020;8:864
OPN Deficiency Increases the Severity of Osteoarthritis Associated with Aberrant Chondrocyte Senescence and Apoptosis and Upregulates the Expression of Osteoarthritis-Associated Genes.
Tian J, Cheng C, Kuang SD, Su C, Zhao X, Xiong YL, Li YS, Gao SG
Pain research & management 2020;2020:3428587
Pain research & management 2020;2020:3428587
Steady Augmentation of Anti-Osteoarthritic Actions of Rapamycin by Liposome-Encapsulation in Collaboration with Low-Intensity Pulsed Ultrasound.
Chen CH, Kuo SM, Tien YC, Shen PC, Kuo YW, Huang HH
International journal of nanomedicine 2020;15:3771-3790
International journal of nanomedicine 2020;15:3771-3790
Matrisome Provides a Supportive Microenvironment for Skin Functions of Diverse Species.
Liu B, Zhang S, Wang W, Yun Z, Lv L, Chai M, Wu Z, Zhu Y, Ma J, Leng L
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
ACS biomaterials science & engineering 2020 Oct 12;6(10):5720-5733
MSCs reduce airway remodeling in the lungs of asthmatic rats through the Wnt/β-catenin signaling pathway.
Song J, Zhu XM, Wei QY
European review for medical and pharmacological sciences 2020 Nov;24(21):11199-11211
European review for medical and pharmacological sciences 2020 Nov;24(21):11199-11211
Long non-coding RNA SNHG15 is a competing endogenous RNA of miR-141-3p that prevents osteoarthritis progression by upregulating BCL2L13 expression.
Zhang X, Huang CR, Pan S, Pang Y, Chen YS, Zha GC, Guo KJ, Zheng X
International immunopharmacology 2020 Jun;83:106425
International immunopharmacology 2020 Jun;83:106425
MicroRNA-675-3p regulates IL-1β-stimulated human chondrocyte apoptosis and cartilage degradation by targeting GNG5.
Shen XF, Cheng Y, Dong QR, Zheng MQ
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Biochemical and biophysical research communications 2020 Jun 25;527(2):458-465
Sialic acid-modified chitosan oligosaccharide-based biphasic calcium phosphate promote synergetic bone formation in rheumatoid arthritis therapy.
Xu XL, Shu GF, Wang XJ, Qi J, Jin FY, Shen QY, Ying XY, Ji JS, Du YZ
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
Journal of controlled release : official journal of the Controlled Release Society 2020 Jul 10;323:578-590
L-polylactic acid porous microspheres enhance the mechanical properties and in vivo stability of degummed silk/silk fibroin/gelatin scaffold.
Li T, Liu B, Jiang Y, Lou Y, Chen K, Zhang D
Biomedical materials (Bristol, England) 2020 Dec 17;16(1):015025
Biomedical materials (Bristol, England) 2020 Dec 17;16(1):015025
Glycitin Suppresses Cartilage Destruction of Osteoarthritis in Mice.
Wang W, Yang R, Zhang M, Li J, Peng J, Xu M, Zhao Y, Li H, Pan X
Inflammation 2020 Aug;43(4):1312-1322
Inflammation 2020 Aug;43(4):1312-1322
p-Coumaric Acid Attenuates IL-1β-Induced Inflammatory Responses and Cellular Senescence in Rat Chondrocytes.
Huang X, You Y, Xi Y, Ni B, Chu X, Zhang R, You H
Inflammation 2020 Apr;43(2):619-628
Inflammation 2020 Apr;43(2):619-628
Overexpression of miR-10a-5p facilitates the progression of osteoarthritis.
Li HZ, Xu XH, Lin N, Wang DW, Lin YM, Su ZZ, Lu HD
Aging 2020 Apr 13;12(7):5948-5976
Aging 2020 Apr 13;12(7):5948-5976
MicroRNA-132 upregulation promotes matrix degradation in intervertebral disc degeneration.
Liu W, Xia P, Feng J, Kang L, Huang M, Wang K, Song Y, Li S, Wu X, Yang S, Yang C
Experimental cell research 2017 Oct 1;359(1):39-49
Experimental cell research 2017 Oct 1;359(1):39-49
Simvastatin Inhibits IL-1β-Induced Apoptosis and Extracellular Matrix Degradation by Suppressing the NF-kB and MAPK Pathways in Nucleus Pulposus Cells.
Tu J, Li W, Zhang Y, Wu X, Song Y, Kang L, Liu W, Wang K, Li S, Hua W, Yang C
Inflammation 2017 Jun;40(3):725-734
Inflammation 2017 Jun;40(3):725-734
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