Antibody data
- Antibody Data
- Antigen structure
- References [11]
- Comments [0]
- Validations
- Immunohistochemistry [1]
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- Product number
- AF1274 - Provider product page
- Provider
- R&D Systems
- Product name
- Human SLPI Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human SLPI in direct ELISAs and Western blots. In direct ELISAs, less than 15% cross-reactivity with mouse SLPI is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Profiling human breast epithelial cells using single cell RNA sequencing identifies cell diversity.
Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-β signaling protein Smad2.
Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinoma.
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients.
The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils.
The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells.
cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model.
Antimicrobial components of vaginal fluid.
Antimicrobial components of vaginal fluid.
Nguyen QH, Pervolarakis N, Blake K, Ma D, Davis RT, James N, Phung AT, Willey E, Kumar R, Jabart E, Driver I, Rock J, Goga A, Khan SA, Lawson DA, Werb Z, Kessenbrock K
Nature communications 2018 May 23;9(1):2028
Nature communications 2018 May 23;9(1):2028
Secretory leukocyte protease inhibitor reverses inhibition by CNS myelin, promotes regeneration in the optic nerve, and suppresses expression of the transforming growth factor-β signaling protein Smad2.
Hannila SS, Siddiq MM, Carmel JB, Hou J, Chaudhry N, Bradley PM, Hilaire M, Richman EL, Hart RP, Filbin MT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 20;33(12):5138-51
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 20;33(12):5138-51
Secretory leukocyte protease inhibitor (SLPI) expression and tumor invasion in oral squamous cell carcinoma.
Wen J, Nikitakis NG, Chaisuparat R, Greenwell-Wild T, Gliozzi M, Jin W, Adli A, Moutsopoulos N, Wu T, Warburton G, Wahl SM
The American journal of pathology 2011 Jun;178(6):2866-78
The American journal of pathology 2011 Jun;178(6):2866-78
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
Edström AM, Malm J, Frohm B, Martellini JA, Giwercman A, Mörgelin M, Cole AM, Sørensen OE
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 1;181(5):3413-21
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 1;181(5):3413-21
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
Edström AM, Malm J, Frohm B, Martellini JA, Giwercman A, Mörgelin M, Cole AM, Sørensen OE
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 1;181(5):3413-21
Journal of immunology (Baltimore, Md. : 1950) 2008 Sep 1;181(5):3413-21
Use of an immunoaffinity-mass spectrometry-based approach for the quantification of protein biomarkers from serum samples of lung cancer patients.
Nicol GR, Han M, Kim J, Birse CE, Brand E, Nguyen A, Mesri M, FitzHugh W, Kaminker P, Moore PA, Ruben SM, He T
Molecular & cellular proteomics : MCP 2008 Oct;7(10):1974-82
Molecular & cellular proteomics : MCP 2008 Oct;7(10):1974-82
The secretory leukocyte protease inhibitor (SLPI) and the secondary granule protein lactoferrin are synthesized in myelocytes, colocalize in subcellular fractions of neutrophils, and are coreleased by activated neutrophils.
Jacobsen LC, Sørensen OE, Cowland JB, Borregaard N, Theilgaard-Mönch K
Journal of leukocyte biology 2008 May;83(5):1155-64
Journal of leukocyte biology 2008 May;83(5):1155-64
The alarm anti-protease, secretory leukocyte protease inhibitor, is a proliferation and survival factor for ovarian cancer cells.
Simpkins FA, Devoogdt NM, Rasool N, Tchabo NE, Alejandro EU, Kamrava MM, Kohn EC
Carcinogenesis 2008 Mar;29(3):466-72
Carcinogenesis 2008 Mar;29(3):466-72
cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model.
Kluger HM, Kluger Y, Gilmore-Hebert M, DiVito K, Chang JT, Rodov S, Mironenko O, Kacinski BM, Perkins AS, Sapi E
Laboratory investigation; a journal of technical methods and pathology 2004 Mar;84(3):320-31
Laboratory investigation; a journal of technical methods and pathology 2004 Mar;84(3):320-31
Antimicrobial components of vaginal fluid.
Valore EV, Park CH, Igreti SL, Ganz T
American journal of obstetrics and gynecology 2002 Sep;187(3):561-8
American journal of obstetrics and gynecology 2002 Sep;187(3):561-8
Antimicrobial components of vaginal fluid.
Valore EV, Park CH, Igreti SL, Ganz T
American journal of obstetrics and gynecology 2002 Sep;187(3):561-8
American journal of obstetrics and gynecology 2002 Sep;187(3):561-8
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- SLPI in Human Lung. SLPI was detected in immersion fixed paraffin-embedded sections of human lung using Goat Anti-Human SLPI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1274) at 10 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Specific staining was localized to cell surfaces and cytoplasm. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.