Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations
- Flow cytometry [1]
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Validation data
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- Product number
- 313009 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#313009, RRID:AB_314972
- Product name
- LEAF™ Purified anti-human CD40 [HB14]
- Antibody type
- Monoclonal
- Antigen
- CD40
- Description
- CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The HB14 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially block CD40 binding to CD40L and rescue B cells from apoptosis.
- Reactivity
- Human, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 50 µg
- Concentration
- 1 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4 °C. This LEAF™ solution contains no preservative; handle under aseptic conditions.
Submitted references Leishmania major infection activates NF-kappaB and interferon regulatory factors 1 and 8 in human dendritic cells.
Jayakumar A, Donovan MJ, Tripathi V, Ramalho-Ortigao M, McDowell MA
Infection and immunity 2008 May;76(5):2138-48
Infection and immunity 2008 May;76(5):2138-48
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Supportive validation
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- BioLegend (provider)
- Main image
- Experimental details
- Human peripheral blood lymphocytes stained with LEAF™ purified HB14, followed by anti-mouse IgGs FITC
- Conjugate
- Unconjugated