50-0729-42

antibody from Invitrogen Antibodies
Targeting: CD72 CD72b, LYB2
Provider product page for 50-0729-42

Antibody data

Product number
50-0729-42 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD72 Monoclonal Antibody (J4-117), eFluor™ 660, eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The monoclonal antibody J4-117 reacts with human CD72, a 45 kDa type II transmembrane glycoprotein that belongs to the C-type lectin superfamily. This glycoprotein is expressed on B cells at all stages of maturation except for plasma cells. CD72 is also expressed on dendritic cells, mast cells, and some macrophages. This receptor contains an immune-receptor tyrosine-base inhibition motif (ITIM) that associates with a tyrosine phosphatase, SHP-1. CD72 negatively regulates the major signal transduction pathways activated by the B cell receptor (BCR). Studies have demonstrated that the ligand for CD72 is CD100 (also known as Semaphorin 4D). CD72 can also react with CD5 to provide signaling between T and B cells. Finally, this receptor also prevents naive B cells from producing Ig and differentiating into B cells, and plays a role in controlling autoimmunity by enhancing apoptosis after Ag-specific BCR stimulation.
Antibody clone number
J4-117
Concentration
5 µL/Test
CD72 protein structure - 50-0729-42 shown in red.