GTX10372

antibody from GeneTex

Targeting: TH DYT5b

Western blot (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

GTX10372

Provider

GeneTex

Proper citation

GeneTex Cat#GTX10372, RRID:AB_373127

Product name

Tyrosine Hydroxylase antibody [185]

Antibody type

Monoclonal

Reactivity

Human, Mouse, Rat

Host

Mouse

References

Submitted references

Two Subpopulations of Noradrenergic Neurons in the Locus Coeruleus Complex Distinguished by Expression of the Dorsal Neural Tube Marker Pax7.

Plummer NW, Scappini EL, Smith KG, Tucker CJ, Jensen P
Frontiers in neuroanatomy 2017;11:60

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Critical role of TRPC1 in thyroid hormone-dependent dopaminergic neuron development.

Chen C, Ma Q, Deng P, Yang J, Yang L, Lin M, Yu Z, Zhou Z
Biochimica et biophysica acta. Molecular cell research 2017 Oct;1864(10):1900-1912

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Uncovering diversity in the development of central noradrenergic neurons and their efferents.

Robertson SD, Plummer NW, Jensen P
Brain research 2016 Jun 15;1641(Pt B):234-44

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Expanding the power of recombinase-based labeling to uncover cellular diversity.

Plummer NW, Evsyukova IY, Robertson SD, de Marchena J, Tucker CJ, Jensen P
Development (Cambridge, England) 2015 Dec 15;142(24):4385-93

Immunocytochemistry

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

Immunoperoxidase (A and C) and immunofluorescent (B, D¡VH) labeling of intrinsic cardiac adrenergic (ICA) cells in human hearts are shown. ICA cells expressing tyrosine hydroxylase (TH) immunoreactivity (red) are distributed diffusely throughout the left ventricular (LV) myocardium. Perivascular location is a frequent feature of ICA cells. C, arrow: terminal arteriole. E: abundant ICA cells in the smooth muscle layers of epicardial circumflex coronary artery. TH-expressing sympathetic nerve fibers (D and G, arrows) can occasionally be seen in the field. B and D, insets: magnified ICA cell images (arrows). TH immunoreactivity (green) was identified in ICA cells and sympathetic nerve fibers in the sinoatrial nodal tissue (G). ICA cells are seen in transplanted human LV tissue (H). Scale bars = 10 ?m, except in B (20 ?m)

Immunohistochemistry

Supportive validation

Submitted by

GeneTex (provider)

Main image

Experimental details

TH staining of human mid-brain. Note cytoplasmic staining of catecholaminergic cells and their processes. Paraffin section (Peroxidase substrate: nickel DAB, Counterstain: eosin).