523003

antibody from BioLegend

Targeting: CCL17 ABCD-2, SCYA17, TARC

ELISA (Data presented on provider website)

Antibody Data

Product number

523003

Provider

BioLegend

Proper citation

BioLegend Cat#523003, RRID:AB_2562795

Product name

Biotin anti-human CCL17 (TARC)

Antibody type

Polyclonal

Antigen

Recombinant human CCL17

Description

CCL17 was initially isolated from phytohemagglutinin-stimulated PBMCs. CCL17 is constitutively expressed in the thymus and, under activation, in several cell types. CCL17-mediated recruitment of Th2 cells and CLA+ CD4+ T cells plays a key role in allergic diseases like atopic dermatitis, allergic asthma, allergic rhinitis, and allergic contact dermatitis. In addition, CCL17 has been detected in idiopathic pulmonary fibrosis. Also, CCL17 and CCL22 secreted by dendritic cells seem to mediate the recruitment of regulatory T cells to sites of inflammation in patients with chronic hepatitis. CCL17 is upregulated by several combinations of cytokines: TNF-α, IL-4, and IFN-γ in bronchial epithelial cells; TGF-β1, TNF-α, and IFN-γ in human keratinocyte cell lines; and histamine and prostaglandin E2P in immature dendritic cells.    

Reactivity

Human

Host

Goat

Conjugate

Biotin

Antibody clone number

Poly5230

Vial size

50 µg

Storage

2°C-8°C

Handling

Ambient RT